Evaluating the Effect on Total Daily Insulin Dose in Adult Patients with Type 1 Diabetes Managed with Metformin and/or GLP-1 or GLP-1/GIP Receptor Agonists by Mayeesha Ahmed, Emily Pierson, Molly Webster

“… Purpose: There are few studies that have assessed the utility of metformin and glucagon-like peptide-1 receptor agonists (GLP-1 RA) in type 1 diabetes (T1D), specifically looking at glucose control indices. …”
Get full text

New Sodium Intercalation Cathode Prepared by Sodiation of Delithiated Host LiNi1/3Mn1/3Co1/3O2 by Van Hoang Nguyen, Le Minh Nguyen, Tuyen Thi Kim Huynh, Van Man Tran, My Loan Phung Le

“…In this work, the layered structure LiNi1/3Mn1/3Co1/3O2 (LiNMC) served as a host to enable sodium-ion intercalation. …”
Get full text

An integrative analysis of ASCL1 in breast cancer and inhibition of ASCL1 increases paclitaxel sensitivity by activating ferroptosis via the CREB1/GPX4 axis by Xiaolu Yang, Xiaolu Yang, Yilun Li, Yilun Li, Yaqi Peng, Yuan Chang, Binglu He, Binglu He, Tianqi Zhang, Tianqi Zhang, Shiyu Zhang, Cuizhi Geng, Yunjiang Liu, Xiaolong Li, Jun Hao, Li Ma

Subjects: Get full text

The crystal structure of 3-nitrobenzene-1,2-dicarboxylic acid–2-ethoxybenzamide (1/1), C17H16N2O8 by Lin Shu-Ting, Huang Shen-Yang, Zou Jing, Jiang Cheng-Jun

Get full text

Carvedilol Confers Ferroptosis Resistance in HL-1 Cells by Upregulating GPX4, FTH1, and FTL1 and Inducing Metabolic Remodeling Under Hypoxia/Reoxygenation by Yi-Chin Li, Mei-Ling Cheng

“…Also, Carvedilol promoted ferroptosis-related genes, ferritin heavy chain 1 (<i>FTH1</i>) and ferritin light chain 1 (<i>FTL1</i>) mRNA levels, to reduce lipid peroxidation under both hypoxia and HR. …”
Get full text

IL-1β-Induced Matrix Metalloprotease-1 Promotes Mesenchymal Stem Cell Migration via PAR1 and G-Protein-Coupled Signaling Pathway by Ming-Siou Chen, Cheng-Yu Lin, Yun-Hsuan Chiu, Chie-Pein Chen, Pei-Jiun Tsai, Hwai-Shi Wang

“…The cDNA microarray data show that IL-1β induces matrix metalloproteinase-1 (MMP-1) expression. …”
Get full text

Anticonvulsant Potential of Certain New (2E)-2-[1-Aryl-3-(1H-imidazol-1-yl)propylidene]-N-(aryl/H)hydrazinecarboxamides by Mohamed I. Attia, Mohamed N. Aboul-Enein, Aida A. El-Azzouny, Yousreya A. Maklad, Hazem A. Ghabbour

Get full text

超高效液相色谱-三重四极杆串联质谱法同时 测定植物油中4种维生素E异构体Simultaneous determination of four vitamin E isomers in vegetable oil by ultra-high performance liquid chromatography- triple quadrupole... by 李彩玲1，张见1,2，刘元法1,3，王晓超1，梅东旭1 LI Cailing1, ZHANG Jian1,2, LIU Yuanfa1,3, WANG Xiaochao1, MEI Dongxu1

“…结果表明：0.5 g样品经10 mL甲醇提取，35 mg C18粉末净化后，采用Kintex F5色谱柱（2.1 mm × 100 mm，1.7 μm）分离，以0.1%甲酸水溶液和0.1%甲酸-甲醇溶液为流动相梯度洗脱，流速0.4 mL/min,电喷雾离子源在正离子模式下进行多反应监测扫描，采用外标法对4种维生素E异构体进行定量；在该条件下，4种维生素E异构体在1～100 ng/mL质量浓度范围内线性关系良好，相关系数（R2）均在0.998以上，检出限均为6 ng/g，定量限均为20 ng/g，加标回收率范围为92.0%～108.0%，相对标准偏差为0.7%～7.1%,与国标方法测定结果相对误差在-4.3%~5.1%。…”
Get full text

Crystal structure of 1,1′-(butane-1,4-diyl)bis(3-propyl-1H-imidazol-3-ium) bis(hexafluoridophosphate), C32H56F24N8P4 by Zhou Yao-Hong, Nie Xu-Liang, Xiong Wan-Ming, Peng Da-Yong, Zhang Xiao-Hua

“…C32H56F24N8P4, triclinic, P1‾$P&#x203e;{1}$ (no. 2), a = 8.6769(13) Å, b = 9.8858(14) Å, c = 14.510(2) Å, α = 102.564(2)°, β = 94.461(3)°, γ = 92.152(3)°, V = 81.710(2) Å3, Z = 1, Rgt(F) = 0.0692, wRref(F2) = 0.2245, T = 296(2) K.…”
Get full text

The crystal structure of (N-([1,1′:4′,1″-terphenyl]-4,4′-diethyl)-2-(bis(pyridin-2-ylmethyl)amino)acetamide-κ4N,N,N″, O)tri(nitrato-kO, O′) samarium(III) - methanol - acetonitrile (1/1/1), C40H39SmN8O14 by Wang Hai-Ping, Zhang Ci-Mao, Huang Guo-Peng, Liang Jia-Jun

“…C40H39SmN8O14, triclinic, P1̄ (no. 2), a = 8.2799(1) Å, b = 16.6666(5) Å, c = 17.1471(3) Å, α = 73.549(2)∘$73.549{(2)}^{\circ }$, β = 89.123(1)∘$89.123{(1)}^{\circ }$, γ = 83.045(2)°, V = 2252.2(1) Å3, Z = 2, Rgt${R}_{gt}$ (F) = 0.0592, wRref$w{R}_{ref}$ (F2) = 0.1438, T = 297.71(13) K.…”
Get full text

Combination of Gilbert's syndrome and gastrointestinal diseases by G. M. Dubrovina, O. K. Botvinyev, A. I. Kolotilina

Subjects: “…uridine-diphosphate glucuronosyltransferase 1а1 (ugt 1а1)…”
Get full text

花椒油中邻苯二甲酸酯类塑化剂的污染现状 及来源分析Pullution status and source analysis of phthalate plasticizers in Zanthoxylum bungeanum oil by 张家余1,2，张逸飞2，薛楚玲1，文成刚1，赵麟1，代倩1，朱翔1, 2 ZHANG Jiayu1,2, ZHANG Yifei2, XUE Chuling1, WEN Chenggang1, ZHAO Lin1,DAI Qian1, ZHU Xiang1, 2"

“…结果表明：目前市场上的花椒油产品存在不同程度的塑化剂污染，其中DBP检出率为74.00%，含量范围为0.07~10.59 mg/kg，DEHP检出率为93.48%，含量范围为0.07~1.86 mg/kg，DBP和DEHP超标率分别为17.39%和1.09%；花椒油中DBP和DEHP的检出率和平均含量随麻度增加有上升趋势；花椒原料及生产接触材料是花椒油中塑化剂主要污染来源。…”
Get full text

磷脂在蛋白质乳液中的作用研究进展Research progress on the role of phospholipids in protein-based emulsions by 李雪阳1，邹依彤1，涂向辉1，祁冰洁1，刘新2， 杨庆余1，王丽娟1 " LI Xueyang1, ZOU Yitong1, TU Xianghui1, QI Bingjie1, LIU Xin2 , YANG Qingyu1，WANG Lijuan1"

Get full text

A Novel Role for Brain Natriuretic Peptide: Inhibition of IL-1β Secretion via Downregulation of NF-kB/Erk 1/2 and NALP3/ASC/Caspase-1 Activation in Human THP-1 Monocyte by Letizia Mezzasoma, Cinzia Antognelli, Vincenzo Nicola Talesa

“…Interleukin-1β (IL-1β) is a pleiotropic cytokine and a crucial mediator of inflammatory and immune responses. …”
Get full text

Синтез и строениe 1-алкокси-1,4- диоксо-2-алкенолятов натрия и бис-(4-алкил(арил)-1-оксо-1-алкоксиалкан-2,4- дионато)металлов(II) на их основе by Кунавина Е.А.

The crystal structure of N-(2′-hydroxymethyl-5′-phenyl-3′,4′-dihydro-[1,1′:3′,1″-terphenyl]- 1′(2′H)-yl)-P,P-diphenylphosphinic amide, C37H34NO2P by Jian Jinzhen, Ye Jianghai, Luo Guoyong, Lang Tianqiong

Get full text

Differences between Influenza H5N1, A/H1N1 2009, and SARS-CoV-2 in a pandemic risk scenario by Pablo I. Plaza, Sergio A. Lambertucci

Get full text

The suppression of the SPHK1/S1P/S1PR3 signaling pathway diminishes EGFR activation and increases the sensitivity of non-small cell lung cancer to gefitinib by Jing Zhang, Zequn Wang, Xihua Wei, Mengyuan Han, Ribai Yan, Lijie Ma, Yan Pan

Subjects: “…Sphingosine kinase 1…”
Get full text

Altered Viral Replication and Cell Responses by Inserting MicroRNA Recognition Element into PB1 in Pandemic Influenza A Virus (H1N1) 2009 by Xiaoyue Shen, Wenkui Sun, Yi Shi, Zheng Xing, Xin Su

“…Engineering mutant viruses by inserting cell-specific miRNA recognition element (MRE) into viral genome may alter viral infectivity and host responses in vital tissues and organs infected with pandemic influenza A virus (H1N1) 2009 (H1N1pdm). Methods. In this study, we employed reverse genetics approach to generate a recombinant H1N1pdm with a cell-specific miRNA target sequence inserted into its PB1 genomic segment to investigate whether miRNAs are able to suppress H1N1pdm replication. …”
Get full text

Mechanical Stress-Induced IGF-1 Facilitates col-I and col-III Synthesis via the IGF-1R/AKT/mTORC1 Signaling Pathway by Bin Yan, Canjun Zeng, Yuhui Chen, Minjun Huang, Na Yao, Jie Zhang, Bo Yan, Jiajun Tang, Liang Wang, Zhongmin Zhang

“…Interestingly, col-I protein, col-I mRNA, col-III protein, col-III mRNA, and IGF-1 protein, but not IGF-1 mRNA, were inhibited by IGF-1 neutralizing antibody. …”
Get full text