New Possibilities for the Treatment of Crohn’s Disease by Z. A. Mamieva, E. A. Poluektova, O. S. Shifrin

“…The drug interrupts the cascade of humoral and cellular reactions leading to transmural inflammation of the intestinal wall by blocking the interaction of the p40 subunit with the IL-12Rβ1 chain on the surface of T-lymphocytes and NK cells. …”
Get full text

MicroRNA as a Potential Biomarker and Treatment Strategy for Ischemia-Reperfusion Injury by Mingming Cao, Wenjing Song, Runyu Liang, Lili Teng, Mei Zhang, Jiyao Zhang, Luwen Zhu

“…Ischemia-reperfusion (I/R) injury is a progressive injury that aggravates the pathological state when the organ tissue restores blood supply after a certain period of ischemia, including the myocardial, brain, liver, kidney, and intestinal. With growing evidence that microRNAs (miRNAs) play an important role as posttranscription gene silencing mediators in many I/R injury, in this review, we highlight the microRNAs that are related to I/R injury and their regulatory molecular pathways. …”
Get full text

Possible Involvement of Liver Resident Macrophages (Kupffer Cells) in the Pathogenesis of Both Intrahepatic and Extrahepatic Inflammation by Yuki Kakinuma, Takuya Kimura, Yoshifumi Watanabe

“…Administration of clodronate liposomes resulted in the KC deletion and in the suppression of liver injury in T cell-mediated hepatitis by ConA as a local acute inflammation model, while the treatment did not influence dextran sulfate sodium- (DSS-) induced colitis featured by weight loss, intestinal shrink, and pathological observation as an ectopic local acute inflammation model. …”
Get full text

Bacteroides utilization for dietary polysaccharides and their beneficial effects on gut health by Jiaobo Cheng, Jielun Hu, Fang Geng, Shaoping Nie

“…SCFAs could act as energy substrates for intestinal epithelial cells, inhibit histone deacetylases and activate G protein-coupled receptors. …”
Get full text

Calcium Alginate and Calcium Alginate-Chitosan Beads Containing Celecoxib Solubilized in a Self-Emulsifying Phase by Lorena Segale, Lorella Giovannelli, Paolo Mannina, Franco Pattarino

“…In this work alginate and alginate-chitosan beads containing celecoxib solubilized into a self-emulsifying phase were developed in order to obtain a drug delivery system for oral administration, able to delay the drug release in acidic environment and to promote it in the intestinal compartment. The rationale of this work was linked to the desire to improve celecoxib therapeutic effectiveness reducing its gastric adverse effects and to favor its use in the prophylaxis of colon cancer and as adjuvant in the therapy of familial polyposis. …”
Get full text

Antin-diabetic cognitive dysfunction effects and underpinning mechanisms of phytogenic bioactive peptides: a review by Xiaoli Liu, Xiaoli Liu, Shenglian Mao, Shenglian Mao, Yuxue Yuan, Yuxue Yuan, Zilin Wang, Zilin Wang, Yang Tian, Yang Tian, Yang Tian, Liang Tao, Liang Tao, Jiahe Dai, Jiahe Dai

“…., α-glucosidase, α-amylase) to improve blood glucose levels and increase antioxidant activity, modulate inflammatory mediators, and address intestinal dysbiosis. In conclusion, plant-derived active peptides show strong potential to improve diabetic cognitive impairment.…”
Get full text

Design of 3‐aminophenol‐grafted polymer‐modified zinc sulphide nanoparticles as drug delivery system by Milad Abniki, Zahra Azizi, Homayon Ahmad Panahi

“…The famotidine‐releasing process was investigated in simulated biological fluids (intestinal fluid at pH of 7.4 and gastric fluid at pH of 1.2) and demonstrated 65% and 73% famotidine release during periods of 30 h (pH = 7.4) and 60 min (pH = 1.2), respectively. …”
Get full text

Vitamin D Effects on Osteoblastic Differentiation of Mesenchymal Stem Cells from Dental Tissues by Francesca Posa, Adriana Di Benedetto, Graziana Colaianni, Elisabetta A. Cavalcanti-Adam, Giacomina Brunetti, Chiara Porro, Teresa Trotta, Maria Grano, Giorgio Mori

“…1α,25-Dihydroxyvitamin D3 (1,25(OH)2D3), the active metabolite of vitamin D (Vit D), increases intestinal absorption of calcium and phosphate, maintaining a correct balance of bone remodeling. …”
Get full text

Unexpected events trigger task-independent signaling in VIP and excitatory neurons of mouse visual cortex by Farzaneh Najafi, Simone Russo, Jérôme Lecoq

“…Cortical inhibitory neurons, particularly vasoactive intestinal polypeptide (VIP) interneurons, play a critical role in representing unexpected stimuli. …”
Get full text

Review – H. pylori and non-malignant diseases by D. Bordin, M. Livzan, O. Gaus, S. Mozgovoi

“…Eradication of H. pylori can significantly improve morphologic features of atrophic gastritis and the severity of intestinal metaplasia at an early stage. The increased risk of gastric cancer in patients with autoimmune gastritis may be the result of previously unrecognized H. pylori infection. …”
Get full text

The Role of Laparoscopy in the Management of a Diagnostic Dilemma: Jejunal Ectopic Pancreas Developing into Jejunojejunal Intussusception by Alessio Giordano, Giovanni Alemanno, Carlo Bergamini, Paolo Prosperi, Alessandro Bruscino, Andrea Valeri

“…We decided to perform an emergency diagnostic exploratory laparoscopy in a 29-year-old man with an acute abdomen and nonspecific radiological images for intestinal occlusion. A jejunojejunal intussusception was found, caused by a mass. …”
Get full text

A Comprehensive Dataset on Microbiome Dynamics in Rheumatoid Arthritis from a Large-Scale Cohort Study by Jing Li, Jun Xu, Jiayang Jin, Congmin Xu, Yuzhou Gan, Yifan Wang, Ruiling Feng, Wenqiang Fan, Yingni Li, Xiaozhen Zhao, Yucui Li, Shushi Gong, Linchong Su, Yueming Cai, Lianjie Shi, Xiaolin Sun, Yang Xiang, Qingwen Wang, Ru Li, Jinxia Zhao, Yulan Liu, Junjie Qin, Zhanguo Li, Jing He

“…Abstract Alterations in intestinal microbiota have been identified as a key risk factor in rheumatoid arthritis (RA). …”
Get full text

Diagnostic Colonoscopy Leading to Perforated Appendicitis: A Case Report and Systematic Literature Review by Daniel Paramythiotis, Konstantinia Kofina, Vasileios Papadopoulos, Antonios Michalopoulos

“…Introduction. Intestinal perforation is a known complication after colonoscopy. …”
Get full text

Ultra-Wideband Antennas for Wireless Capsule Endoscope System: A Review by Ben Li, Yifan Wang, Junchi Zhao, Jingjing Shi

“…Wireless capsule endoscopy (WCE) systems are used to capture images of the human digestive tract for medical applications, especially the noninvasive diagnostics and treatments of small intestinal diseases. As an important part of the WCE system, the antenna plays a crucial role in transmitting and receiving data. …”
Get full text

Abdominal Ultrasonography in Healthy Female Standard Donkeys by Lucrezia Accorroni, Marilena Bazzano, Andrea Marchegiani, Andrea Spaterna, Fulvio Laus

“…The wall thickness of the colon was confirmed as higher compared to horses, while other intestinal tracts were found to be comparable. A correlation between body weight and organ measurements was only found for the length of both kidneys.…”
Get full text

Novel 2-Thiazolylhydrazone with Druggable Properties for Antifungal Application by Wallace Cordeiro de Morais, Gustavo Henrique Oliveira Costa, Vinícius Leal Pitcella, João Victor Vanolli Protti, Carolina Paula de Souza Moreira, José Eduardo Gonçalves, Susana Johann, Renata Barbosa de Oliveira

“…RW3 showed favorable solubility and high intestinal permeability, indicating potential for oral administration. …”
Get full text

Navigating a challenging path: precision disease treatment with tailored oral nano-armor-probiotics by Anmei Chen, Ying Gong, Shaoquan Wu, Ye Du, Zhijun Liu, Yuhong Jiang, Jiahong Li, Yang-Bao Miao

“…Furthermore, the review explores the potential clinical applications of nano-armored probiotics in precision therapeutics, critically addressing safety and regulatory considerations, and proposing the innovative concept of ‘probiotic intestinal colonization with nano armor’ for brain-targeted therapies. …”
Get full text

Right Traumatic Diaphragmatic Hernia: A Case Report and A review by Thaimi Conde Cueto, Ivette Cepero Pérez, Francisco Olascoaga Pérez, Martha Yudey Rodríguez Pino

“…The computerized axial tomography revealed a right hemithorax filled with intestinal loops, liver and gallbladder. The patient was surgically treated realizing the presence of a right multivisceral diaphragmatic hernia which was corrected by hernioplasty with prothesis of the polypropylene. …”
Get full text

Amoebic Liver Abscess and Indigenous Alcoholic Beverages in the Tropics by T. Kumanan, V. Sujanitha, S. Balakumar, N. Sreeharan

“…Amoebic liver abscess (ALA) seen commonly in the tropics is predominantly confined to adult males, especially those who consume locally brewed alcohol, although intestinal amoebiasis occurs in all age groups and in both genders. …”
Get full text

Beneficial effects of fermented jujube pulp in relieving loperamide hydrochloride-induced constipation in male ICR mice by Jing Li, Xinyue Yu, Xinxing Xu, Peipei Tang, Shuang Bi, Xiaopu Ren, Yong Shi, Jihong Wu, Fei Lao

“…Results showed that high-dose FJP could protect intestinal mucosa tissue, shorten the first black feces defecating time by 17 % and increase the number and wet weights of black feces by 72 % and 71 %, respectively, within 6 h. …”
Get full text