Single-cell transcriptome-wide Mendelian randomization and colocalization reveals immune-mediated regulatory mechanisms and drug targets for COVID-19Research in context by Hui Ying, Xueyan Wu, Xiaojing Jia, Qianqian Yang, Haoyu Liu, Huiling Zhao, Zhihe Chen, Min Xu, Tiange Wang, Mian Li, Zhiyun Zhao, Ruizhi Zheng, Shuangyuan Wang, Hong Lin, Yu Xu, Jieli Lu, Weiqing Wang, Guang Ning, Jie Zheng, Yufang Bi

“…Integrating the above evidence with drug trial information, we developed a tier system and prioritized 37 drug targets for COVID-19. Interpretation: Our study showcased the central role of immune-mediated regulatory mechanisms for COVID-19 and prioritized drug targets that might inform interventions for viral infectious diseases. …”
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Continuous Speech-Based Fatigue Detection and Transition State Prediction for Air Traffic Controllers by Susmitha Vekkot, Surya Teja Chavali, Charan Tej Kandavalli, Rama Sai Abhishek Podila, Deepa Gupta, Mohammed Zakariah, Yousef Ajami Alotaibi

“…The ensemble algorithms demonstrated the best performance, achieving a maximum accuracy of 100% on the XGBoost test set. Further, interpretability was analyzed using the SHAP tool, which identified the prominent features for the task. …”
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Oral human papillomavirus (HPV) prevalence and genotyping among healthy adult populations in the United States and Europe: results from the PROGRESS (PRevalence of Oral hpv infecti... by Laia Alemany, Marisa Felsher, Anna R. Giuliano, Tim Waterboer, Haitham Mirghani, Hisham Mehanna, Craig Roberts, Ya-Ting Chen, Núria Lara, Mark Lynam, Mayara Torres, Montse Pedrós, Emilio Sanchez, Jacque Spitzer, Bradley Sirak, Beatriz Quirós, Gema Carretero, Sonia Paytubi, Edith Morais, Miquel Angel Pavón

“…HR infection among women was associated with lifetime marijuana use (AOR 2.33; 95% CI: 1.18–4.60) and by country, residing in France compared to Spain (AOR 4.46; 95% CI: 1.26–15.77). Interpretation: Oral HPV burden was highest among older men who may be at risk of developing OPSCC. …”
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The use of patient-generated health data in the management of low anterior resection syndrome: a qualitative study by Olivia Monton, Olivia Monton, Allister Smith, Sarah Sabboobeh, Marie Demian, Julie Cornish, Steven D. Wexner, Peter Christensen, Peter Christensen, Amandeep Ghuman, Liliana G. Bordeianou, Liliana G. Bordeianou, Liliana G. Bordeianou, Celia Keane, Celia Keane, Syed Husain, Alessandra Gasior, Alessandra Gasior, Natalie Leon, Julie Savard, Lieba R. Savitt, Margit Majgaard, Gitte Kjær Sørensen, Melanie Mills, Fateme Rajabiyazdi, Marylise Boutros, Marylise Boutros

“…Most participants described finding it difficult to interpret the data and identified time constraints, legibility, and completeness as the most common barriers to reviewing data in clinic. …”
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Expedited Colorectal Cancer Detection Through a Dexterous Hybrid CADx System With Enhanced Image Processing and Augmented Polyp Visualization by Akella Subrahmanya Narasimha Raju, K. Venkatesh, Ranjith Kumar Gatla, Marwa M. Eid, Aymen Flah, Zdenek Slanina, Ramy N. R. Ghaly

“…The model showed a high performance in wide classes of samples such as esophagitis, polyps, and ulcerative colitis, with an accuracy rate of 92.5% and Area Under Curve (AUC) values 1.00 on the Kvasir dataset. We applied Local Interpretable Model-Agnostic Explanations (LIME) visualizations to both datasets, which proved to be an insightful identification of regions that the model relied on during the polyp detection process. …”
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Exploring cement Production's role in GDP using explainable AI and sustainability analysis in Nepal by Ramhari Poudyal, Biplov Paneru, Bishwash Paneru, Tilak Giri, Bibek Paneru, Tim Reynolds, Khem Narayan Poudyal, Mohan B. Dangi

“…The SHAP (SHapley Additive exPlanations) interpretability analysis indicates that population is the primary factor influencing GDP estimates. …”
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A Wideband Chemical Survey of Massive Star-forming Regions at Subarcsecond Resolution with the Submillimeter Array by Charles J. Law, Qizhou Zhang, Arielle C. Frommer, Karin I. Öberg, Roberto Galván-Madrid, Eric Keto, Hauyu Baobab Liu, Paul T. P. Ho, Andrés F. Izquierdo, L. Ilsedore Cleeves

“…Thus, to establish an interpretative framework for these efforts, detailed observations that simultaneously provide high sensitivity, spatial resolution, and large bandwidths for a subset of diverse sources are needed. …”
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Safe, effective and cost-effective oxygen saturation targets for children and adolescents with respiratory distress: protocol for a randomised controlled trial (OxyKids study) by Jolita Bekhof, Eleni-Rosalina Andrinopoulou, J Bosmans, Gerard Koppelman, Karlijn J van Stralen, Anja Vaessen-Verberne, Sam Louman, Caroline Brackel, Arvid W A Kamps, Ismé de Kleer, Walter Balemans, Mirjam Scheffer, Marianne Brouwer, Marije van den Beukel, Mariëlle W H Pijnenburg, Annemie L M Boehmer

“…Parents of patients and patient representatives are involved in all stages of the study, from design to results, interpretation and dissemination. The results of this trial will be disseminated via lay publications, peer-reviewed scientific journals and academic conferences.Trial registration number NCT06016244.…”
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Modelling the epidemiological and economic impact of digital adherence technologies with differentiated care for tuberculosis treatment in Ethiopia by Richard White, Katherine L Fielding, Salome Charalambous, Nicola Foster, Degu Jerene, Andrew Mganga, Taye Letta, Job van Rest, Amare Worku Tadesse, Rein MGJ Houben, Ahmed Bedru, Kristian van Kalmthout, Christopher Finn McQuaid, Lara Goscé, Jense van der Wal, Martin J Harker, Norma Madden, Tofik Abdurhman, Demekech Gadissa, Tanyaradzwa N Dube, Jason Alacapa, Natasha Deyanova

“…The maximum possible epidemiological impact a theoretical DAT intervention could achieve over the same timescale would be a 3% (95% UI 1.4%; 5.5%) reduction in incident TB and an 8.2% (95% UI 4.4%; 12.8%) reduction in TB deaths.Interpretation DAT interventions, while showing limited epidemiological impact, could substantially reduce TB treatment costs for both patients and the healthcare provider.…”
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Discovery and Spectroscopic Confirmation of Aquarius III: A Low-mass Milky Way Satellite Galaxy by W. Cerny, A. Chiti, M. Geha, B. Mutlu-Pakdil, A. Drlica-Wagner, C. Y. Tan, M. Adamów, A. B. Pace, J. D. Simon, D. J. Sand, A. P. Ji, T. S. Li, A. K. Vivas, E. F. Bell, J. L. Carlin, J. A. Carballo-Bello, A. Chaturvedi, Y. Choi, A. Doliva-Dolinsky, O. Y. Gnedin, G. Limberg, C. E. Martínez-Vázquez, S. Mau, G. E. Medina, M. Navabi, N. E. D. Noël, V. M. Placco, A. H. Riley, I. U. Roederer, G. S. Stringfellow, C. R. Bom, P. S. Ferguson, D. J. James, D. Martínez-Delgado, P. Massana, D. L. Nidever, J. D. Sakowska, L. Santana-Silva, N. F. Sherman, E. J. Tollerud, DELVE Collaboration

“…Based on calcium-triplet metallicities of the six brightest red giant members, we find that Aquarius III is very metal-poor ([Fe/H]= − 2.61 ± 0.21) with a statistically significant metallicity spread ( ${\sigma }_{[\mathrm{Fe}/{\rm{H}}]}={0.46}_{-0.14}^{+0.26}$ dex). We interpret this metallicity spread as strong evidence that the system is a dwarf galaxy as opposed to a star cluster. …”
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Modeling the tropical fish community related to land uses and environmental determinants by N. Takarina, O. Chuan, M. Afifudin, L. Tristan, I. Arif, A. Adiwibowo

“…Land uses at the sites were interpreted using satellite imagery. Fish diversity was determined using the Shannon–Wiener index, rarefaction curve, and Lorenz graph. …”
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From across the globe – traumatic injuries are an international concern at the US-Mexico border wall by Allison E Berndtson, Jay Doucet, Todd W Costantini, Laura Haines, Sarah Lagan, Laura Adams, Jarrett Santorelli, Gabriella Waters

“…When considering regions of the world other than Mexico, patients were most commonly from Africa, South America and Central America.Conclusion The increased volume of trauma associated with the US-Mexico border wall is a humanitarian and health crisis.(1) The diverse national origin of patients admitted after injury from border wall falls has shed new light on the social and interpreter services needed to care for these border injury patients and the challenges that exist in their post-discharge care.…”
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Pharmacological management of gambling disorder: A systematic review and network meta-analysis by Konstantinos Ioannidis, Cinzia Del Giovane, Charidimos Tzagarakis, Jeremy E. Solly, Samuel J. Westwood, Valeria Parlatini, Henrietta Bowden-Jones, Jon E. Grant, Samuele Cortese, Samuel R. Chamberlain

“…Nalmefene [Odds Ratio (OR): 7.55; 95 %CI: (2.24–25.41)] and naltrexone (OR: 7.82; 95 %CI: (1.26–48.70)) had significantly higher dropout due to side effects (lower tolerability) compared with placebo. Interpretation: Based on NMA, nalmefene and naltrexone currently have the most supportive evidence for the pharmacological treatment of gambling disorder. …”
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Solid and Gaseous Methane in IRAS 23385+6053 as Seen with Open JWST Data by Ruslan Nakibov, Varvara Karteyeva, Igor Petrashkevich, Maksim Ozhiganov, Mikhail Medvedev, Anton Vasyunin

“…The band at 7.58–7.8 μ m (1320–1280 cm ^−1 ) is interpreted as a wide solid absorption methane feature overlapped by the sharp features of the methane emission. …”
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Analytical Accuracy of a Continuous Glucose Monitor in Adult Diabetic KetoacidosisTake-Home Points by Nathan L. Haas, MD, Lynn Ang, MD, Nazanene H. Esfandiari, MD, Ahsan M. Khan, MBBS, James A. Cranford, PhD, Ashley Cohen, MD, Jordan Sell, MD, Mostafa Abdel-Hamid, MD, Kevin E. Romanchik, BSN, RN, Frederick K. Korley, MD, PhD

“…The first incidence of glucose < 150 mg/dL (n = 14) was detected 28.9 minutes earlier by CGM than POCBG measurements. Interpretation: In this study, CGM provided accurate measurements of blood glucose and identified missed opportunities for earlier intervention in adults with DKA. …”
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A randomized, double-blind, Phase 1, single- and multiple-dose placebo-controlled study of the safety and pharmacokinetics of IN-006, an inhaled antibody treatment for COVID-19 in... by Thomas R. Moench, Lakshmi Botta, Brian Farrer, Jason D. Lickliter, Hyunah Kang, Yoona Park, Cheolmin Kim, Marshall Hoke, Miles Brennan, Morgan D. McSweeney, Zachary Richardson, John B. Whelan, Jong Moon Cho, Soo Young Lee, Frances Faurot, Jeff Hutchins, Samuel K. Lai

“…Geometric mean serum levels in the multiple dose cohort peaked at 0.51 μg/mL 3 days after the final dose. Interpretation: IN-006 was well-tolerated and achieved concentrations in the respiratory tract orders of magnitude above the IC50 range typical of antiviral mAbs. …”
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Experimental medicine study with stabilised native-like HIV-1 Env immunogens drives long-term antibody responses, but lacks neutralising breadthResearch in context by Katrina M. Pollock, Hannah M. Cheeseman, Leon R. McFarlane, Suzanne Day, Monica Tolazzi, Hannah L. Turner, Jennifer Joypooranachandran, Katsiaryna Shramko, Stefania Dispinseri, Philipp Mundsperger, Ilja Bontjer, Nana-Marie Lemm, Sofia Coelho, Maniola Tanaka, Tom Cole, Bette Korber, Dietmar Katinger, Quentin J. Sattentau, Andrew B. Ward, Gabriella Scarlatti, Rogier W. Sanders, Robin J. Shattock

“…Neutralising antibody function correlated with binding to V1/V3 and V5 epitopes and peaked after the third injection. Interpretation: Rationally designed prefusion-stabilised native-like Env trimers are robustly immunogenic in a prime-boost schedule. …”
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The influence of post-processing methods and frequency bands on rs-fMRI: An example of electroacupuncture at Zusanli (ST36) by YingJie Kang, YiLei Chen, ZhiGang Gong, YanWen Huang, Hui Wang, Jiling Huang, SongHua Zhan, YiJing Li, WenLi Tan

“…Conclusion: Post-processing methods affect the interpretation of brain effects caused by electroacupuncture at ST36. …”
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Psychoeducation of higher education seekers with using of the resource-oriented model of stress resiliency in war conditions by V.V. Ogorenko, A.E. Nikolenko, T.Y. Shusterman, V.O. Kokashynskyi, A.B. Khotimska, M.H. Koren

“…During psychoeducational work with higher education seekers, their resiliency models were analyzed, interpreted, and balanced. Study results should be taken into account in psychological support efforts for higher education seekers in war and post-war time.…”
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Planetary health education in undergraduate medical education in Germany: results from structured interviews and an online survey within the national PlanetMedEd Project by Fabio Grieco, Sandra Parisi, Anne Simmenroth, Michael Eichinger, Michael Eichinger, Janina Zirkel, Janina Zirkel, Sarah König, Jana Jünger, Jana Jünger, Eva Geck, Eva-Maria Schwienhorst-Stich

“…In contrast to mandatory educational activities, student involvement was reported for the majority of electives and was significantly associated with transformative learning objectives.InterpretationDespite a steady rise in teaching activities, mandatory Planetary Health Education remains insufficiently integrated into undergraduate medical education in Germany. …”
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