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8301
Multi-task aquatic toxicity prediction model based on multi-level features fusion
Published 2025-02-01“…Moreover, ATFPGT-multi utilizes attention scores to identify molecular fragments associated with fish toxicity in organic molecules, as demonstrated by two organic molecule examples in the main text, demonstrating the interpretability of ATFPGT-multi. Conclusion: In summary, ATFPGT-multi provides important support and reference for the further development of aquatic toxicity assessment. …”
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8302
Cortical lesions impact cognitive decline in multiple sclerosis via volume loss of nonlesional cortex
Published 2025-01-01“…Mediation analysis showed that the effect of cortical lesions on future cognition was mediated by volume loss of the normal‐appearing instead of lesional cortex, independent of white matter lesion volume. Interpretation Multiple sclerosis‐related cortical thinning was worse in lesional compared to normal‐appearing cortex, while volume loss of normal‐appearing cortex was most predictive of subsequent cognitive decline, particularly in the default mode network. …”
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8303
Insights on the effect of mega-carcass abundance on the population dynamics of a facultative scavenger predator and its prey
Published 2024-05-01“…Although our results support a predominant role of bottom-up mechanisms, whereby hyaena density is driven by herbivore density, itself driven by resources availability, some subtle patterns of densities could be interpreted as consequences of changes in predation pressure following changes in scavenging opportunities. …”
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8304
Visualization of Right Adrenal Vein in Non‐Contrast‐Enhanced MDCT and Its Guiding Role for Right Adrenal Venous Sampling
Published 2025-01-01“…Furthermore, RAV images obtained from non‐contrast‐enhanced MDCT are highly consistent with those from AVS, indicating that interpretation of non‐contrast‐enhanced MDCT before AVS can reduce the failure rate of RAV cannulation.…”
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8305
Accumulation conditions and target area evaluation of coalbed methane in eastern uplift of Junggar Basin
Published 2025-01-01“…Utilizing well logging data, core analysis test results, and seismic data, well-seismic calibration and seismic profile interpretation were carried out. Connecting-well profiles and thickness distribution maps for coal seams in the Jurassic Xishanyao and Badaowan formations were compiled. …”
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8306
Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort studyResearch in context
Published 2025-01-01“…In regression models, differences at 5 and 12 months were attenuated after adjustment for BMI and presence of other long-term conditions. Interpretation: People with diabetes reported worse physical outcomes up to 12 months after hospital discharge with COVID-19 compared to those without diabetes. …”
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8307
Socioeconomic characteristics and relapse-free and overall survival from childhood cancer – a nationwide study based on data from the Danish Childhood Cancer Registry
Published 2025-01-01“…Cox proportional hazards models were used to estimate the association between SEP indicators and 5-year RFS and OS. Results and interpretation: Tendencies towards lower 5-year RFS and OS were observed among children whose parents were unemployed/not in workforce (RFS: HR [hazard ratio] = 1.14, 95% CI [confidence interval]: 0.90–1.45, OS: HR = 1.28, 95% CI: 0.95–1.71) or from non-Western countries (RFS: HR = 1.21 95% CI: 0.96–1.52, OS: HR = 1.44, 95% CI: 1.09–1.90). …”
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8308
Development and validation of a prognostic prediction model for elderly gastric cancer patients based on oxidative stress biochemical markers
Published 2025-02-01“…The SHapley Additive exPlanations (SHAP) method was used for model interpretation. Results This study included a total of 1,859 older patients. …”
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8309
Disparities in stage at diagnosis of head and neck tumours in Brazil: a comprehensive analysis of hospital-based cancer registriesResearch in context
Published 2025-02-01“…Furthermore, we observed a dose–response effect of a statistically significant reduction in the prevalence of cases diagnosed in advanced stages as the patients' age group or education level increased. Interpretation: Diagnosis of HNSCC at advanced clinical stages in Brazil was associated with age, primary tumour site, and socioeconomic factors that must be mitigated, allowing more universal and equitable access and diagnosis at earlier stages. …”
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8310
Synthesis of Nanocrystalline Mn-Doped Bi<sub>2</sub>Te<sub>3</sub> Thin Films via Magnetron Sputtering
Published 2025-01-01“…Structural analysis indicated the presence of a secondary <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><mrow><msub><mi>MnTe</mi><mi>x</mi></msub></mrow></semantics></math></inline-formula> phase, which complicates the interpretation of the magnetic properties. Additionally, the incorporation of Mn ions within the van der Waals gap and substitutional doping on Bi sites contributes to the observed complex magnetic properties. …”
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8311
Peripheral blood age-sensitive immune markers in multiple sclerosis: relation to sex, cytomegalovirus status, and treatmentResearch in context
Published 2025-02-01“…Finally, lower levels of IL-6, TNF, IL-10, and β-NGF were observed at baseline in PwMS who subsequently experienced clinical failure after DMTs initiation. Interpretation: Age, sex, CMV status, and specific DMTs significantly influence levels of age-sensitive immune biomarkers associated with MS and must be considered when investigating inflammation-related biomarkers. …”
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8312
Investigation of a Novel Noninvasive Risk Analytics Algorithm With Laboratory Central Venous Oxygen Saturation Measurements in Critically Ill Pediatric Patients
Published 2025-01-01“…The central venous oxygen saturation (Svo2) enables an estimate of cardiac output yet obtaining these clinical data requires invasive procedures and repeated blood sampling. Interpretation remains subjective and vulnerable to error. …”
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8313
Exploring the role of splicing in TP53 variant pathogenicity through predictions and minigene assays
Published 2025-01-01“…We additionally applied the splicing results for TP53 variant classification using an approach consistent with the ClinGen Sequence Variant Interpretation Splicing Subgroup recommendations. Results Aberrant transcript profile consistent with loss of function, and for which a PVS1 (RNA) code would be assigned, was observed for 42 (71%) of prioritised variants, of which aberrant transcript expression was over 50% for 26 variants, and over 80% for 15 variants. …”
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8314
Multiple patterns of EEG parameters and their role in the prediction of patients with prolonged disorders of consciousness
Published 2025-02-01“…A combination of machine learning and SHapley Additive exPlanations (SHAP) were used to develop predictive model and interpret the results.ResultsThe results indicated significant abnormalities in low-frequency spectral power, microstate parameters, and amplitudes of MMN and P3a in MCS and UWS. …”
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8315
Circulating tumor DNA for surveillance in high-risk melanoma patients: a study protocol
Published 2025-02-01“…This allows determination of the value and sensitivity of ctDNA for early detection of recurrence. Results and Interpretation: For validation purposes, we conducted a small pilot study using blood samples from 10 patients who had experienced recurrence and had a clinically confirmed BRAF V600E mutation. …”
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8316
A clinical decision model for failed adrenal vein sampling in primary aldosteronism
Published 2025-01-01“…Published literature aligns with our results on cut-off values.ConclusionsUtilizing the LAV/IVC index, over 70% of unsuccessful AVS procedures due to failed right adrenal cannulation could be interpreted with over 90% certainty regarding the PA subtype, preventing unnecessary resampling and aiding in determining the preferred treatment.…”
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8317
Germline BRCA testing in Denmark following invasive breast cancer: Progress since 2000
Published 2025-01-01“…BRCA test rates were higher for oestrogen receptor-negative/human epidermal growth factor receptor 2-negative BC (25% in 2000–2005 vs. 38% in 2012–2017), and these findings were confirmed in multivariate regression models. Interpretation: Our results indicate a critical need for an intensified focus on BRCA testing among BC patients older than 40, where a mainstreamed testing approach might overcome delayed or missed testing. …”
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8318
Les textiles dans les tombes gauloises à dépôt de crémation en vase métallique : usages pratiques, mises en scène et perspectives anthropologiques (seconde moitié du vie s.-ve s. a...
Published 2022-12-01“…Considerations of the anthropological interpretation of textile use are based on Greek written sources prior to or contemporary with the 5th c. …”
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8319
Feedback of aggregate patient-reported outcomes (PROs) data to clinicians and hospital end users: findings from an Australian codesign workshop process
Published 2022-07-01“…At the final workshop, recommendations to enhance communication of PROs data for comparing health service performance were made including tailoring feedback to professional roles and use of case-mix adjustment to ensure fair comparisons.Conclusions Our research provides guidance on PROs reporting for optimising data interpretation and comparing hospital performance.…”
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8320
Typological and cumulative approaches to risk and adversity in Child and Adolescent Mental Health Services (CAMHS): Retrospective cohort analysis in South London
Published 2025-02-01“…Associations between individual risk typologies and psychiatric diagnosis and service activity are discussed. Interpretation: Our findings suggest that typological and cumulative approaches to risk and adversity can produce unique insights about diagnostic practices and service activity. …”
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