Impact of Weed Infestation on Growth and Yield of Carrot Plants. by Mutabazi, Cosma

“…Quantitative data was used during data analysis and it involved the use of frequencies, and tables against their percentages and aided in data interpretation, data analysis, and presentations of findings. …”
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A qualitative study on general practitioners’ perspectives on late-life depression in Singapore—part II: system- and physician-related factorsResearch in context by Anna Szücs, V Vien Lee, Laurie J. Goldsmith, Alicia H. Ong, Tim J. Hart, Victor W.K. Loh, Monica Lazarus, Choon Kit Leong, Vivien M.E. Lee, Foon Leng Leong, Doris Young, Andrea B. Maier, Jose M. Valderas

“…Although GPs acknowledged the usefulness of public care services, they felt that collaborative care was hindered by a lack of efficient communication channels between providers and appropriate financial coverage to coordinate the frequently complex care of depressed older adults. Interpretation: Current resources and practices to manage late-life depression vary greatly between private GPs in Singapore. …”
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What are the gaps in cardiovascular risk assessment and management in primary care for Māori and Pacific people in Aotearoa New Zealand? Protocol for a systematic review by Vanessa Selak, Matire Harwood, Shanthi Ameratunga, Corina Grey, Janine Paynter, Karen Marie Brewer, Julie Winter-Smith, Sandra Hanchard

“…Data analysis and interpretation will involve critical inquiry and a strength-based approach that is inclusive of Māori and Pacific values. …”
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Differences in technical and clinical perspectives on AI validation in cancer imaging: mind the gap! by Ioanna Chouvarda, Sara Colantonio, Ana S. C. Verde, Ana Jimenez-Pastor, Leonor Cerdá-Alberich, Yannick Metz, Lithin Zacharias, Shereen Nabhani-Gebara, Maciej Bobowicz, Gianna Tsakou, Karim Lekadir, Manolis Tsiknakis, Luis Martí-Bonmati, Nikolaos Papanikolaou

“…Key Points Clinical and technical researchers emphasise interpretability, external validation with diverse data, and bias awareness in AI validation for cancer imaging. …”
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Changing or validating physician opioid prescribing behaviors through audit and feedback and academic detailing interventions in primary care by Celia Laur, Natasha Kithulegoda, Nicola McCleary, Emily Nicholas Angl, Michael Strange, Barbara Sklar, Thivja Sribaskaran, Gail Dobell, Sharon Gushue, Jonathan M. C. Lam, Lindsay Bevan, Victoria Burton, Lena Salach, Justin Presseau, Laura Desveaux, Noah Ivers

“…Patient partners informed the interpretation of results through ongoing group discussions of preliminary findings. …”
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A 3D Clinical Face Phenotype Space of Genetic Syndromes Using a Triplet-Based Singular Geometric Autoencoder by Soha S. Mahdi, Eduarda Caldeira, Harold Matthews, Michiel Vanneste, Nele Nauwelaers, Meng Yuan, Giorgos Bouritsas, Gareth S. Baynam, Peter Hammond, Richard Spritz, Ophir D. Klein, Michael Bronstein, Benedikt Hallgrimsson, Hilde Peeters, Peter Claes

“…As a facial matching tool for clinical genetics, such CFPS can enhance clinical diagnosis. It helps to interpret facial dysmorphisms of a subject by placing them within the space of known dysmorphisms. …”
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Work ability following breast cancer – the MyHealth randomized controlled trial by Trine A. Horsbøl, Lena Saltbæk, Caroline Urhammer, Randi V. Karlsen, Christoffer Johansen, Pernille E. Bidstrup, Beverley L. Høeg, Vibeke Zoffmann, Federica Belmonte, Ingelise Andersen, Anne S. Friberg, Mads N. Svendsen, Helle G. Christensen, Vesna Glavicic, Dorte L. Nielsen, Susanne O. Dalton

“…Differences in mean WAS between patients in MyHealth and control follow-up were non-significant and close to zero at all time points (–0.21 to 0.48). Interpretation: The MyHealth follow-up program had no additional effect on self-reported work ability compared to regular follow-up. …”
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Examining Specific Theory-of-Mind Aspects in Amnestic and Non-Amnestic Mild Cognitive Impairment: Their Relationships with Sleep Duration and Cognitive Planning by Areti Batzikosta, Despina Moraitou, Paschalis Steiropoulos, Georgia Papantoniou, Georgios A. Kougioumtzis, Ioanna-Giannoula Katsouri, Maria Sofologi, Magda Tsolaki

“…ToM assessment included tasks measuring the understanding and interpretation of non-literal speech, proverbs and metaphors, as well as an emotion-recognition test. …”
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Cholangiocarcinoma combined with biliary obstruction: an exosomal circRNA signature for diagnosis and early recurrence monitoring by Ningyuan Wen, Dingzhong Peng, Xianze Xiong, Geng Liu, Guilin Nie, Yaoqun Wang, Jianrong Xu, Shaofeng Wang, Sishu Yang, Yuan Tian, Bei Li, Jiong Lu, Nansheng Cheng

“…Diagnostic and prognostic models were established and verified by two independent cohorts (training cohort, n = 184; validation cohort, n = 105). An interpreter-free diagnostic model disclosed the diagnostic power of biliary exosomal circRNA signature (Bile-DS, AUROC = 0.947, RR = 6.05) and serum exosomal circRNA signature (Serum-DS, AUROC = 0.861, RR = 4.04) compared with conventional CA19-9 (AUROC = 0.759, RR = 2.08). …”
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Laser interstitial thermal therapy in the management of bottom‐of‐sulcus dysplasia‐related epilepsy by Bowen Yang, Chao Zhang, Xiu Wang, Baotian Zhao, Jiajie Mo, Weiyuan Luo, Xiaoqiu Shao, Jianguo Zhang, Kai Zhang, Wenhan Hu

“…The hospital stay (days) after MRgLITT (6 [5.0, 7.5]) was significantly shorter (p < 0.001) than that of OS (11.0 [9.0, 13.5]). Interpretation MRgLITT has advantages over OS, including comparable seizure control and adverse event profiles, along with reduced removal ratios, shorter operative time, and shorter hospital stays.…”
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Progress in voluntary medical male circumcision for HIV prevention supported by the US President’s Emergency Plan for AIDS Relief through 2017: longitudinal and recent cross-sectio... by Carlos Toledo, Melissa Habel, Stephanie M Davis, Jonas Z Hines, Jonathan M Grund, Renee Ridzon, Brittney Baack, Jonathan Davitte, Anne Thomas, Valerian Kiggundu, Naomi Bock, Paran Pordell, Caroline Cooney, Irum Zaidi

“…Objective This article provides an overview and interpretation of the performance of the US President’s Emergency Plan for AIDS Relief’s (PEPFAR’s) male circumcision programme which has supported the majority of voluntary medical male circumcisions (VMMCs) performed for HIV prevention, from its 2007 inception to 2017, and client characteristics in 2017.Design Longitudinal collection of routine programme data and disaggregations.Setting 14 countries in sub-Saharan Africa with low baseline male circumcision coverage, high HIV prevalence and PEPFAR-supported VMMC programmes.Participants Clients of PEPFAR-supported VMMC programmes directed at males aged 10 years and above.Main outcome measures Numbers of circumcisions performed and disaggregations by age band, result of HIV test offer, procedure technique and follow-up visit attendance.Results PEPFAR supported a total of 15 269 720 circumcisions in 14 countries in Southern and Eastern Africa. …”
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Treatable traits in idiopathic pulmonary fibrosis: focus on respiratory tract infections—a systematic review and a meta-analysisResearch in context by Zsombor Matics, Anna Bardóczi, Csongor Galkó, Bence Szabó, Noémi Gede, Zsolt Molnár, Gábor Duray, Caner Turan, Péter Hegyi, Gábor Horváth, Veronika Müller

“…For antifibrotics, RTI incidence was similar with pirfenidone treatment compared to nintedanib (RR: 0.98 CI: [0.71; 1.36]) and compared to placebo (RR: 0.88 CI: [0.69; 1.10]) and nintedanib compared to placebo (RR: 0.89 CI: [0.71; 1.12]). Interpretation: RTIs are frequently reported adverse events in IPF patients over a one-year period, with different investigated treatments showing no profound impact compared to placebo. …”
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Archeohandi: protocol for a national disabilities database in archaeology in France by Rozenn Colleter, Valérie Delattre, Cyrille Le Forestier, Alex Baiet, Philippe Blanchard, Fanny Chenal, Anne-Sophie Coupey, Stéphanie Desbrosse-Degobertière, Sylvie Duchesne, Cécile Durin, Jean-Luc Gisclon, Noémie Gryspeirt, Fanny La Rocca, Raphaëlle Lefebvre, Jérôme Livet, Cécile Paresys, Mikaël Rouzic, Isabelle Souquet, Florence Tane, Aminte Thomann, Ivy Thomson, Émilie Trébuchet, Marie-Cécile Truc, Jean-Baptiste Barreau

“…A database is designed within an interpretive, consensual framework, that can be adapted to overcome limitations and promote open-minded research on the care of the disabled in their own communities. …”
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CONSORT-DEFINE explanation and elaboration: recommendations for enhancing reporting quality and impact of early phase dose-finding clinical trialsResearch in context by Jan Rekowski, Christina Guo, Olga Solovyeva, Munyaradzi Dimairo, Mahtab Rouhifard, Dhrusti Patel, Emily Alger, Deborah Ashby, Jordan Berlin, Oliver Boix, Melanie Calvert, An-Wen Chan, Courtney H. Coschi, Johann de Bono, Thomas R. Jeffry Evans, Elizabeth Garrett–Mayer, Robert M. Golub, Kathryn S. Hayward, Sally Hopewell, John D. Isaacs, S. Percy Ivy, Thomas Jaki, Olga Kholmanskikh, Andrew Kightley, Shing Lee, Rong Liu, Israel Maia, Adrian Mander, Lynley V. Marshall, James Matcham, Richard Peck, Khadija Rerhou Rantell, Dawn P. Richards, Lesley Seymour, Yoshiya Tanaka, Moreno Ursino, Christopher J. Weir, Christina Yap

“…Comprehensive and transparent reporting of these studies is critical for their accurate and critical interpretation, which may improve and expedite therapeutic development. …”
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Empowering integration of culture and tourism with new quality productive forces from the perspective of rural revitalization: Scientific issues and strategic paths by WANG Jinwei, HUANG Zhenfang, WANG Zhaofeng, MING Qingzhong, WU Zhicai, LI Yanqin, SU Mingming, XU Dong, ZHOU Cheng, ZHANG Ke, LIU Lei, WANG Bowen, LUO Xiangyang

“…This study not only deepens the theoretical interpretation of issues related to the deep integration of culture and tourism empowered by new quality productive forces, but also provides decision-making references for relevant policy makers to formulate industrial policies and development strategies.…”
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Brodifacoum causes coagulopathy, hemorrhages, and mortality in rainbow trout (Oncorhynchus mykiss) at environmentally relevant hepatic residue concentrations by Hannah Schmieg, Hermann Ferling, Karina Annika Bucher, Stefanie Jacob, Julia Regnery, Hannah Schrader, Julia Schwaiger, Anton Friesen

“…However, no sufficient data exist to interpret the effects of these findings on fish health. …”
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Biological subphenotypes in patients hospitalized with suspected infection in Thailand: a secondary analysis of a prospective observational studyResearch in context by Prapassorn Poolchanuan, Taylor D. Coston, Viriya Hantrakun, Parinya Chamnan, Gumphol Wongsuvan, Pavan K. Bhatraju, Narisara Chantratita, Direk Limmathurotsakul, T. Eoin West, Shelton W. Wright

“…A parsimonious three-biomarker model identified subphenotypes in an internal validation cohort (LBP-1: area under the receiver operating curve [AUC] 0.96, 95% CI: 0.94–0.98; LBP-2: AUC 0.77, 95% CI 0.71–0.83; LBP-3: AUC 0.99, 95% CI 0.98–1.00). Interpretation: We identified three biological subphenotypes of patients with suspected infection in rural Thailand, where the burden of infection is high but understudied. …”
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The clinical impact of recent amphetamine exposure in aneurysmal subarachnoid hemorrhage patients by Jeffrey R. Vitt, Roger C. Cheng, Jason Chung, Travis Caton, Bo Zhou, Nerissa Ko, Karl Meisel, Edilberto Amorim

“…There was no difference in delayed cerebral ischemia incidence, length of hospital stay, need for ventriculoperitoneal shunt placement, functional outcome at discharge or hospital mortality based on amphetamine use.InterpretationRecent amphetamine use was not associated with worse vasospasm severity or delayed cerebral ischemia in aneurysmal subarachnoid hemorrhage patients. …”
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A Simple Machine Learning-Based Quantitative Structure–Activity Relationship Model for Predicting pIC₅₀ Inhibition Values of FLT3 Tyrosine Kinase by Jackson J. Alcázar, Ignacio Sánchez, Cristian Merino, Bruno Monasterio, Gaspar Sajuria, Diego Miranda, Felipe Díaz, Paola R. Campodónico

“…<b>Results:</b> Key molecular descriptors influencing the inhibitor potency were identified, thereby improving the interpretability of structural requirements. Additionally, a user-friendly computational tool was developed to enable rapid prediction of pIC₅₀ values and facilitate ligand-based virtual screening, leading to the identification of promising FLT3 inhibitors. …”
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Enhancing chemotherapy response prediction via matched colorectal tumor-organoid gene expression analysis and network-based biomarker selection by Wei Zhang, Chao Wu, Hanchen Huang, Paulina Bleu, Wini Zambare, Janet Alvarez, Lily Wang, Philip B. Paty, Paul B. Romesser, J. Joshua Smith, X. Steven Chen

“…The matched tumor-organoid data approach proved effective in capturing relevant biomarkers, enhancing prediction reliability. Interpretation: This study provides a robust framework for improving CRC chemotherapy response predictions by leveraging matched tumor and organoid gene expression data. …”
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