Orthoweb: a software package for evolutionary analysis of gene networks by R. A. Ivanov, A. M. Mukhin, F. V. Kazantsev, Z. S. Mustafin, D. A. Afonnikov, Y. G. Matushkin, S. A. Lashin

“…The software offers advanced visualization tools, such as gene network mapping and graphical representations of phylostratigraphic index distributions of network elements, ensur­ing intuitive interpretation of complex evolutionary relationships. …”
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White matter hyperintensities and cholinergic degeneration as Lewy body disease by Sungwoo Kang, Seun Jeon, Yeoju Kim, Su‐Hee Jeon, Minsun Choi, Young‐gun Lee, Mijin Yun, Byoung Seok Ye

“…Both lower BF volume and DAT‐AC were independently associated with widespread cognitive impairment, whereas higher anterior periventricular WMH volume was associated with executive dysfunction. Interpretation BF cholinergic degeneration and anterior periventricular WMHs are closely associated with dopaminergic degeneration. …”
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Clinical evaluation of long-read sequencing-based episignature detection in developmental disorders by Mathilde Geysens, Benjamin Huremagic, Erika Souche, Jeroen Breckpot, Koenraad Devriendt, Hilde Peeters, Griet Van Buggenhout, Hilde Van Esch, Kris Van Den Bogaert, Joris Robert Vermeesch

“…In addition, we identified all underlying pathogenic single nucleotide and structural variants and showed haplotype-aware skewed X-inactivation evaluation directs clinical interpretation. Conclusion This proof-of-concept study demonstrates nanopore sequencing enables episignature detection. …”
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Karhunen–Loeve orthogonal decomposition method for problems of EEG assessment of patients with migraine by Egorov, Evgenij Nikolaevich, Zhuravlev, Maksim Olegovich, Runnova, Anastasia Evgenevna, Evstropov, Maksim Arkad`evich, Redzhepova, Alena Садуллаевна

“…The obtained data were processed using the Karhunen–Loeve transformation, which allows one to interpret the complex dynamics of the system from the point of view of the coexistence and interaction of coherent orthogonal space-time structures. …”
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Culture-independent detection of Mycobacterium tuberculosis complex DNA using targeted next generation sequencing in African buffalo (Syncerus caffer) oronasal swabs in South Afric... by Sinegugu Kholeka Mhlophe, Charlene Clarke, Giovanni Ghielmetti, Giovanni Ghielmetti, Megan Matthews, Tanya Jane Kerr, Michele Ann Miller, Wynand Johan Goosen, Wynand Johan Goosen

“…These findings highlight the value of accurately distinguishing between mycobacterial species in complex samples, especially in high-value animals, to facilitate accurate interpretation of immunological test results and management of aTB.…”
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Assessing Thermospheric Neutral Density Models Using GEODYN's Precision Orbit Determination by Z. C. Waldron, K. Garcia‐Sage, J. P. Thayer, E. K. Sutton, V. Ray, D. D. Rowlands, F. G. Lemoine, S. B. Luthcke, M. Kuznetsova, R. Ringuette, L. Rastaetter, G. D. Berland

“…Assessment results and interpretations are dictated by the timescale at which the scaling occurs. …”
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Artificial neural network systems to predict the response to sintilimab in squamous-cell non-small-cell lung cancer based on data of ORIENT-3 study by Tongji Xie, Guangyu Fan, Le Tang, Puyuan Xing, Yuankai Shi

“…The mechanism exploration on the spatial level indicated that patients with better response to immunotherapy had fewer clusters of both tumor and cytotoxicity T cell spots. Interpretation The four ANN systems showed high accuracy, robustness and stability in predicting the response to sintilimab for patients with sqNSCLC.…”
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A practical guide to FAIR data management in the age of multi-OMICS and AI by Douaa Mugahid, Jared Lyon, Charlie Demurjian, Nathan Eolin, Charlie Whittaker, Mark Godek, Douglas Lauffenburger, Sarah Fortune, Stuart Levine

“…However, the mathematical frameworks and computational tools needed to analyze and interpret such data are often still nascent, limiting the biological insights that can be obtained without years of computational method development and validation. …”
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Effectiveness of multimedia tools in enhancing consonant-vowel-consonant reading performance and phonics interest and enthusiasm among kindergarten ESL students by Rhazhiel Dominica P. Pesebre, Rosario F. Quicho, Leila M. Collantes, Carlos N. Lamson Jr., Jupeth T. Pentang

“…Data obtained were analyzed and interpreted using IBM SPSS Statistics. The findings revealed a partial enhancement in CVC reading performance and a notable increase in students' interest and enthusiasm for phonics, particularly in the participants’ positive attitudes. …”
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Gene signatures derived from transcriptomic-causal networks stratify colorectal cancer patients for effective targeted therapy by Akram Yazdani, Heinz-Josef Lenz, Gianluigi Pillonetto, Raul Mendez-Giraldez, Azam Yazdani, Hanna Sanoff, Reza Hadi, Esmat Samiei, Alan P. Venook, Mark J. Ratain, Naim Rashid, Benjamin G. Vincent, Xueping Qu, Yujia Wen, Michael Kosorok, William F. Symmans, John Paul Y. C. Shen, Michael S. Lee, Scott Kopetz, Andrew B. Nixon, Monica M. Bertagnolli, Charles M. Perou, Federico Innocenti

“…Conclusions This study underscores the utility of gene signatures derived from transcriptomic-causal networks in patient stratification for effective therapies. The interpretability of the findings, supported by replication, highlights the potential of these signatures to identify patients likely to benefit from cetuximab or bevacizumab.…”
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Horses are worthy of care: Horse sector participants’ attitudes towards animal sentience, welfare, and well-being by Julie M Fiedler, Margaret L Ayre, Sarah Rosanowski, Josh D Slater

“…Theme one related to respondents’ understanding of sentience and how sentience informed their interpretations of horse behaviours and the making of inferences regarding the equine mental state. …”
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Assessing research methodologies used to evaluate inequalities in end-of-life cancer care research: a scoping review protocol by Sam Harper, Natalie G Coburn, Alyson L Mahar, Laura E Davis, Julie Hallet, Peter Tanuseputro, Geetanjali D Datta, Colleen Webber, Allison Wiens, Lauren Konikoff

“…Study design, measurement and analytical decisions made by researchers are a function of their social systems, academic training, values and biases, which influence both the findings and interpretation of whether inequalities or inequities exist. …”
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Molecular structure, UV–Visible spectra and other molecular properties of (E)-2-(2-hydroxy-5-methoxybenzylidene)hydrazinecarbothioamide and its n-methyl variant by using DFT method... by K. Srishailam, L. Ravindranath, Gaddam. Ramesh, D. Praveena, Sunil kumar V, Danikonda.Suresh Kumar, S. Muthu, G.Ramana Rao

“…NBO analysis of hyper conjugate interactions made it possible to interpret the molecules NLO behavior in terms of intramolecular charge transfer (ICT). …”
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Genetic Characteristics of the Rat Fibroblast Cell Line Rat-1 by Thomas Liehr, Stefanie Kankel, Eva Miriam Buhl, Sarah K. Schröder-Lange, Ralf Weiskirchen

“…This lack of comprehensive genetic characterization can limit the interpretation of experimental results and requires caution when generalizing findings from studies using this cell line. …”
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Association of combined pulmonary fibrosis and emphysema in rheumatoid arthritis with high titer of rheumatoid factor and autoimmunity to the lung by Aiping Ma, Renliang Huang, Jiaxi Guo, Guangdong Wang, Heqing Huang, Xinze Li, Shan Zhong, Yan Huang, Shaowei Lin, Yikai Lin, Qiaomiao Zhou, Susanne Krauss-Etschmann, Frank Petersen, Zhanxiang Wang, Xinhua Yu, Xinhua Yu

“…Additionally, levels of IgG and IgM autoantibodies to HBEC were elevated in RA-CPFE patients compared to healthy controls and positively correlated with RF levels.InterpretationThis study is the first to demonstrate the association of RA-CPFE with high titer of RF and the presence of autoantibodies against HBEC, suggesting a link between autoimmunity to the lung and RA-CPFE.…”
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Increased DNA Copy Number Variation Mosaicism in Elderly Human Brain by Darine Villela, Claudia K. Suemoto, Renata Leite, Carlos Augusto Pasqualucci, Lea T. Grinberg, Peter Pearson, Carla Rosenberg

“…Nearly all evidence of genome structural variation in human brains comes from studies detecting changes in single cells which were interpreted as derived from independent, isolated mutational events. …”
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Equipping our public health nutrition workforce to promote planetary health: a case example of tertiary education co-designed with students by Ka Po Chau, Wing Chong, Raquel Londono, Beau Cubillo, Julia McCartan, Liza Barbour

“…Design: A mixed-methods approach was used to collect and interpret student responses to four interactive tasks facilitated during an in-person workshop. …”
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Genetic factors shaping the plasma lipidome and the relations to cardiometabolic risk in children and adolescentsResearch in context by Yun Huang, Sara Elizabeth Stinson, Malte Thodberg, Louise Aas Holm, Roman Thielemann, Karolina Sulek, Morten Asp Vonsild Lund, Cilius Esmann Fonvig, Min Kim, Kajetan Trost, Helene Bæk Juel, Trine Nielsen, Peter Rossing, Maja Thiele, Aleksander Krag, Cristina Legido-Quigley, Jens-Christian Holm, Torben Hansen

“…Two-sample MR using adult-based summary statistics showed consistent direction of associations and indicated additional causal links, specifically between ceramides and elevated HbA1c levels, and phosphatidylinositols with elevated liver enzymes. Interpretation: These findings highlight the potential long-term implications of plasma lipid genetic determinants on cardiometabolic risk. …”
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Real‐world efficacy of transfusion with liberal or restrictive strategy in traumatic brain injury by Liang‐Wen Cui, Nian Liu, Chao Yu, Ming Fang, Rui Huang, Cheng Zhang, Min Shao

“…The subgroup analysis indicated a beneficial effect of liberal transfusion on mortality in hemodynamically unstable patients. Interpretation Compared with the restrictive strategy, the liberal strategy does not improve the short‐term neurological prognosis and death among patients with TBI in a real‐world situation. …”
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Skin Lesion Classification Through Test Time Augmentation and Explainable Artificial Intelligence by Loris Cino, Cosimo Distante, Alessandro Martella, Pier Luigi Mazzeo

“…Additionally, the research investigates the impact of Test Time Augmentation (TTA) on the performance of six Convolutional Neural Network (CNN) architectures, which include models from the EfficientNet, ResNet (Residual Network), and ResNeXt (an enhanced variant of ResNet) families. To improve the interpretability of the models’ decision-making processes, techniques such as t-distributed Stochastic Neighbor Embedding (t-SNE) and Gradient-weighted Class Activation Mapping (Grad-CAM) are employed. t-SNE is utilized to visualize the high-dimensional latent features of the CNNs in a two-dimensional space, providing insights into how the models group different skin lesion classes. …”
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