Structural bioinformatics for rational drug design by Soroush Mozaffari, Agnethe Moen, Che Yee Ng, Gerry A.F. Nicolaes, Kanin Wichapong

“…Despite these advancements, challenges remain in terms of accuracy, interpretability, and the needed computational power. This review explores the state of the art in computational drug discovery, examining the latest methods and technologies, their transformative impact on the drug development pipeline, and the future directions needed to overcome remaining limitations. …”
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Potentially commercializable nerve guidance conduits for peripheral nerve injury: Past, present, and future by Chundi Liu, Mouyuan Sun, Lining Lin, Yaxian Luo, Lianjie Peng, Jingyu Zhang, Tao Qiu, Zhichao Liu, Jun Yin, Mengfei Yu

“…This review aims to interpret nerve guidance conduits and their commercialization from both clinical and laboratory perspectives. …”
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Are Anesthesiology Providers Good Guessers? Heart Rate and Oxygen Saturation Estimation in a Simulation Setting by Efrain Riveros Perez, Enoe Jimenez, Camila Albo, Yashi Sanghvi, Nianlan Yang, Alexander Rocuts

“…Anesthesia providers may need to interpret the output of vital sign monitors based on auditory cues, in the context of multitasking in the operating room. …”
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A model-based factorization method for scRNA data unveils bifurcating transcriptional modules underlying cell fate determination by Jun Ren, Ying Zhou, Yudi Hu, Jing Yang, Hongkun Fang, Xuejing Lyu, Jintao Guo, Xiaodong Shi, Qiyuan Li

“…While current manifold-learning methods provide insights into cell fate by inferring graph-based trajectory at cell level, challenges remain to retrieve interpretable biology underlying the diverse cellular states. …”
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Cytokine and Chemokine Profile in Patients with Multiple Myeloma Treated with Bortezomib by Paweł Robak, Edyta Węgłowska, Izabela Dróżdż, Damian Mikulski, Dariusz Jarych, Magdalena Ferlińska, Ewa Wawrzyniak, Małgorzata Misiewicz, Piotr Smolewski, Wojciech Fendler, Janusz Szemraj, Tadeusz Robak

“…However, a single measurement of serum cytokines should be interpreted with caution and further studies are needed.…”
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Protocol for a systematic review on tertiary prevention interventions for patients with stroke in African countries by Adamu Addissie, Eva Johanna Kantelhardt, Thomas Frese, Eric Sven Kroeber, Lucas Adam, Alexander Bauer, Susanne Unverzagt

“…This description will be visualised in structured tables to aid interpretation of study characteristics, intervention effects and certainty of the evidence.Ethics and dissemination No ethical approval is necessary. …”
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Neolithic introgression of IL23R-related protection against chronic inflammatory bowel diseases in modern EuropeansResearch in context by Ben Krause-Kyora, Nicolas Antonio da Silva, Elif Kaplan, Daniel Kolbe, Inken Wohlers, Hauke Busch, David Ellinghaus, Amke Caliebe, Efe Sezgin, Almut Nebel, Stefan Schreiber, Sabine Schade-Lindig, Joachim Wahl, Carola Berszin, Michael Francken, Irina Görner, Kerstin Schierhold, Joachim Pechtl, Gisela Grupe, Johannes Müller

“…The geographic distribution of rs11209026-A may influence the gradient in IBD incidence rates that are highest in northern and eastern Europe. Interpretation: Given the dramatic changes from hunting and gathering to agriculture during the Neolithic, AF might have been exposed to selective pressures from a pro-inflammatory lifestyle and diet. …”
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Outcomes of people with TB reported to the WHO Global Clinical Platform of COVID-19 by M. Bastard, D. Falzon, S. Bertagnolio, R. Silva, S.S. Thwin, C. Siquiera Boccolini, J. Rylance, J. Diaz, M. Zignol

“…CONCLUSION: Current or past TB were independent risk factors for in-hospital mortality regardless of illness severity at admission. Caveats for interpretation include changes during the data collection period (viral variation, vaccination coverage) and opportunistic sampling. …”
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MO-GCN: A multi-omics graph convolutional network for discriminative analysis of schizophrenia by Haiyuan Wang, Runlin Peng, Yuanyuan Huang, Liqin Liang, Wei Wang, Baoyuan Zhu, Chenyang Gao, Minxin Guo, Jing Zhou, Hehua Li, Xiaobo Li, Yuping Ning, Fengchun Wu, Kai Wu

“…In particular, the accuracy of the best model by 5-fold cross-validation reached 84.0 %. Interpretability analysis revealed that the top 10 important brain features were primarily from the hippocampus, olfactory, fusiform and pallidum, which were involved in the brain systems of memory, learning and emotion. …”
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Sonographic and Clinical Features of Upper Extremity Deep Venous Thrombosis in Critical Care Patients by Michael Blaivas, Konstantinos Stefanidis, Serafim Nanas, John Poularas, Mitchell Wachtel, Rubin Cohen, Dimitrios Karakitsos

“…Additionally, a standardized ultrasound scan was performed to detect the extent of the thrombus. Images were interpreted offline by two independent readers. Results. …”
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GBM-Reservoir: Brain tumor (Glioblastoma Multiforme) MRI dataset collection with ground truth segmentation masksfigshare by Naida Solak, André Ferreira, Gijs Luijten, Behrus Puladi, Victor Alves, Jan Egger

“…The first mask is the raw output from the registration process and is provided for all samples, while the second mask, provided particularly for synthetic samples, is a post-processed version of the first, designed to simplify interpretation and optimize it for network training. These samples have been acquired via registration process of 438 samples available at the moment of registration from the original dataset provided by the BraTS 2022 Challenge. …”
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Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population by Tharanga Mudalige, Vindya Pathiraja, Gayathri Delanerolle, Heitor Cavalini, Shuqi Wu, Julie Taylor, Om Kurmi, Kathryn Elliot, Sharron Hinchliff, Carol Atkinson, Kristina Potocnik, Paula Briggs, Lucky Saraswat, Helen Felicity Kemp, George Eleje, Toh Teck Hock, Cristina Laguna Benetti‐Pinto, Irfan Muhammad, Rabia Kareem, Yassine Bouchareb, Peter Phiri, Ruishu Zhang, Yunfei Weng, Ieera Aggarwal, Jian Qing Shi, Ashish Shetty, Ian Litchfield, Nirmala Rathnayake, Sohier Elneil

“…Sixteen studies focused on patients who had undergone hysterectomy alongside prolapse repair. Interpretation Patients who underwent vaginal prolapse surgery with hysterectomy experienced higher operative and postoperative complication rates than those without hysterectomy. …”
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The Effect of Shear Force on Skin Viability in Patients with Type 2 Diabetes by Luuk A. de Wert, Margot Geerts, Sander van der Brug, Laura Adriaansen, Martijn Poeze, Nicolaas Schaper, Nicole D. Bouvy

“…The reactive hyperaemic response was negatively correlated with the blood glucose level but did not correlate with the DNP severity score. Interpretation. Shear is important in the development of tissue damage, but the reparative responses to shear are impaired in patients with type 2 DM. …”
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The Validation of the sickle scan technique used to diagnose sickle cell disease by Magain Mihatano Barihuta, Guelord Inkalaba, Jocelyn Kakumba Mankulu, Olivier Nzingula, Maguy Luvandu Mbenza, Nicole M. Misengabu, M Ndeme, Michel Diyi, Mbembe Bitengeli, Tresor Bayebila Menanzambi, Nsimba Miezi, José Lami Nzunzu, Fridolin Kodondi Kule-koto

“…This test can also be applied to samples collected on blotting paper. The interpretation time should not exceed 2 minutes, contrary to the manufacturer's claims. …”
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Etodolac Single Dose Metabolic Profile Elucidation: Pharmacokinetics and Adverse Events in Healthy Volunteers by Karen Sánchez-Luquez, Anne Michelli Reis Silveira, Salvador Sánchez-Vinces, Alex Ap. Rosini Silva, Joyce Barreto, Rhubia Bethania Socorro Lemos de Brito, Caroline de Moura Garcia, Ana Lais Vieira, Marcia Ap. Antonio, Patrícia de Oliveira Carvalho

“…Network analysis was employed to interpret the data. Results: Correlations were observed between metabolomic profiles and pharmacokinetic parameters as well as clinical characteristics. …”
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Cognitive Distortions and Decision-Making in Women Victims of Intimate Partner Violence: A Scoping Review by Marta Badenes-Sastre, Patricia Medinilla-Tena, Chelsea M. Spencer, Francisca Expósito

“…However, women face various obstacles in doing so, such as cognitive distortions that affect their interpretation of the reality of violence, trapping them and significantly influencing their decision to leave. …”
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SensorDBSCAN: Semi-Supervised Active Learning Powered Method for Anomaly Detection and Diagnosis by Petr Ivanov, Maria Shtark, Alexander Kozhevnikov, Maksim Golyadkin, Dmitry Botov, Ilya Makarov

“…The proposed approach combines a transformer-based encoder trained with a triplet-based contrastive learning objective and the classical density-based clustering algorithm DBSCAN, enabling strong feature extraction, efficient and interpretable feature space organization and simple clustering algorithm. …”
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Computational assessment of measurable residual disease in acute myeloid leukemia using mixture models by Tim R. Mocking, Angèle Kelder, Tom Reuvekamp, Lok Lam Ngai, Philip Rutten, Patrycja Gradowska, Arjan A. van de Loosdrecht, Jacqueline Cloos, Costa Bachas

“…Methods We propose a computational pipeline based on Gaussian mixture modeling that allows a fully automated assessment of MRD status while remaining completely interpretable for clinical diagnostic experts. Our pipeline requires limited training data, which makes it easily transferable to other medical centers and cytometry platforms. …”
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Understanding the synergistic interaction between a 1,3,4-thiadiazole derivative and amphotericin B using spectroscopic and theoretical studies by Lidia Ślusarczyk, Klaudia Rząd, Grzegorz Niedzielski, Mikołaj Gurba, Jose Chavez, Luca Ceresa, Joe Kimball, Ignacy Gryczyński, Zygmunt Gryczyński, Mariusz Gagoś, James Hooper, Arkadiusz Matwijczuk

“…The spectroscopic results were further corroborated, analyzed, and interpreted using the methods of quantum mechanical modelling. …”
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Effects of therapeutic alliance on patients with major depressive disorder: a literature review by Giovanni Videtta, Silvia Busilacchi, Giulia Bartoccioni, Luisa Cirella, Ylenia Barone, Giuseppe Delvecchio

“…Overall, the results suggest a bidirectional relationship between therapeutic alliance and symptom improvement, indicating that a stronger alliance often predicts better outcomes and symptom reduction can further enhance the alliance. However, the interpretation of these results must consider certain methodological limitations. …”
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