Expression pattern of lncRNA H19 in oral squamous cell carcinoma tissues in comparison to normal tissues. A systematic review by Ramya Sekar, Selvaraj Jayaraman, Saranya Varadarajan, Thodur Madapusi Balaji, Vishnupriya Veeraraghavan, Prabhu Shankar Dayasankar, Dharshini Devi J

“…H19, reactivated in cancers, interacts with microRNAs and signaling pathways such as p53 and PI3K/AKT to affect tumor growth, invasion, and metastasis. …”
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Hybridization-based discovery of novel quinazoline-2-indolinone derivatives as potent and selective PI3Kα inhibitors by Changqun Liu, Yuening Cao, Yi Zuo, Chaozheng Zhang, Senmiao Ren, Xin Zhang, Chuanqi Wang, Yingjie Zeng, Jie Ling, Yilan Liu, Zixian Chen, Xiujun Cao, Zhengzhi Wu, Chuantao Zhang, Jun Lu

“…Molecular hybridization, with the advantage of simplified pharmacokinetics and drug-drug interactions, emerged as one of the important avenues for discovering potential drugs. …”
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CitySEIRCast: an agent-based city digital twin for pandemic analysis and simulation by Shakir Bilal, Wajdi Zaatour, Yilian Alonso Otano, Arindam Saha, Ken Newcomb, Soo Kim, Jun Kim, Raveena Ginjala, Derek Groen, Edwin Michael

“…Here, we describe how we have coupled advances in the construction of digital or virtual models of real-world cities with an agile, modular, agent-based model of viral transmission and data from navigation and social media interactions, to overcome these challenges in order to provide a new simulation tool, CitySEIRCast, that can model viral spread at the sub-national level. …”
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Surface functionalization of titanium implants with controlled-release glutathione conjugate for antioxidant and osteogenesis by Huichuan Xu, Kosuke Nozaki, Ziniu Yu, Nobuyuki Kawashima, Takeshi Ueno, Huaze Wu, Hao Wu, Noriyuki Wakabayashi

“…Oxidative stress induced by the overproduction of reactive oxygen species (ROS) during the interaction between titanium (Ti) surfaces and cells commonly results in delayed or compromised osteogenic differentiation. …”
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Monitoring poultry social dynamics using colored tags: Avian visual perception, behavioral effects, and artificial intelligence precision by Florencia B. Rossi, Nicola Rossi, Gabriel Orso, Lucas Barberis, Raul H. Marin, Jackelyn M. Kembro

“…Additionally, fewer aggressive interactions were observed in groups with orange tags compared to groups with other colors, except for red. …”
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Assessing the Impact of Climate Change on the Landscape Stability in the Mediterranean World Heritage Site Based on Multi-Sourced Remote Sensing Data: A Case Study of the Causses a... by Mingzhuo Zhu, Daoye Zhu, Min Huang, Daohong Gong, Shun Li, Yu Xia, Hui Lin, Orhan Altan

“…The results demonstrated that (1) the climate showed a warming and drying pattern during the study period, with distinct climate characteristics in different zones. (2) The dominance of woodland decreased (area proportion dropped from 76% to 66.5%); transitions primarily occurred among woodland, cropland, shrubland, and grasslands; landscape fragmentation intensified; and development towards diversification and uniformity was observed. (3) Significant spatiotemporal differences in landscape stability within the heritage site were noted, with an overall downward trend. (4) Precipitation had a high contribution rate in factor detection, with the interactive enhancement effects between temperature and precipitation being the most prominent. …”
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戶外教育課程評估指標建構之研究 Indicators for Evaluating Outdoor Education Curricula by 鄭智明 Chi Meng Cheang, 陳美燕 Mei-Yen Chen, 郭雄軍 Husing-Chun Kuo

“…According to these principles, students should be self-motivated and active learners and schools should foster students’ learning motivation and enthusiasm and help them cultivate their abilities to meaningfully interact with themselves, others, society, and nature. …”
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Identifying factors affecting the commercialization of products of knowledge-based companies based in science and technology parks and growth centers by yousef sofi, Vahid Reza Mirabi, Rahim Sarvar

“…The results of the research showed that the model designed was identified by 14 indicators that includes causal conditions (management factors, information factors, financial factors), background conditions (laws and regulations, technological capabilities), core category (market factors, product factors), strategies (strengthening interactions, marketing and sales capabilities), consequences (economic development, knowledge-based economy, entrepreneurship development), intervening conditions (individual factors, cultural-social factors); explaining the components of commercialization of products of knowledge-based companies. …”
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Rh-relaxin-2 attenuates oxidative stress and neuronal apoptosis via ERK-nNOS-NO pathway after germinal matrix hemorrhage in rats by Jun Liu, Yonghua Cai, Khalil ur Rahman, Qixiong Zhou, Guangjie Liu, Huibin Kang, Mingzhou Li, Shichao Zhang, Gang Wang, Wenfeng Feng, Xi’an Zhang, Guozhong Zhang, Ye Song, Peng Li

“…We found endogenous relaxin-2 interacts with RXFP1 and both protein colocalized in neurons on the first day after GMH. …”
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Spectroscopic analysis (UV-VIS-NIR) for predictive modeling of macro and micronutrients in grapevine leaves by J.I. Manzano, M. Rodríguez-Febereiro, M. Fandiño, M. Vilanova, J.J. Cancela

“…In contrast, reflectances in the near-infrared region (NIR) had a greater impact on macronutrient prediction, particularly for P and Mg, due to their stronger interaction with organic compounds. The ultraviolet (UV) range played a minor role, highlighting the predominant importance of the VIS-NIR regions in spectroscopic analyses.Finally, the results support the potential of this technique for swiftly and non-invasively predicting both macro and micronutrient levels in grapevine plants, and facilitate the fertilization planning using variety-specific reference levels, or precision viticulture adapted to site-specific demands, including spatial intra-plot variability.…”
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Core microbe Bifidobacterium in the hindgut of calves improves the growth phenotype of young hosts by regulating microbial functions and host metabolism by Yimin Zhuang, Duo Gao, Wen Jiang, Yiming Xu, Guanglei Liu, Guobin Hou, Tianyu Chen, Shangru Li, Siyuan Zhang, Shuai Liu, Jingjun Wang, Jianxin Xiao, Mengmeng Li, Wei Wang, Shengli Li, Zhijun Cao

“…Conclusions In summary, cluster analysis has proved to be a feasible and reliable approach for identifying phenotypic subgroups of calves, prompting further exploration of host-microbiome interactions. Bifidobacterium as a core microbe in the hindgut of calves may play a crucial probiotic role in host phenotypic differentiation. …”
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Knowledge, attitudes and behaviour towards ticks and tick-borne diseases—A survey among Lyme borreliosis cases in Bavaria in 2019 by Stefanie Böhm, Volker Fingerle, Andreas Beyerlein, Manfred Wildner, Merle M. Böhmer

“…Addressing identified gaps in education campaigns, specifically targeting people living in rural areas, and utilising physician-patient interactions for education are promising entry points to increase awareness and prevent TBDs. …”
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Ten pressure points in primary care during COVID-19: findings from an international narrative review by Sally Hall Dykgraaf, Anne Parkinson, Michael Wright, William C. W. Wong, Jane Desborough, Lauren Ball, Elizabeth Sturgiss, Garang M. Dut, Katelyn Barnes, Danielle Butler, Steph Davis, Kirsty Douglas, Candan Kendir, Danielle Martin, Robert Marten, Katherine Rouleau, Shannon Barkley, Lucas de Toca, Michael Kidd

“…Ten ‘pressure points’ affecting PC during COVID-19 were identified, clustered in four themes: demand to adopt new ways of working; pressure to respond to fluctuating community needs; strain on PC resources and systems; and ambiguity in interactions with the broader health and social care system. …”
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Exploring sex differences in Alzheimer’s disease: a comprehensive analysis of a large patient cohort from a memory unit by Maitee Rosende-Roca, Fernando García-Gutiérrez, Yahveth Cantero-Fortiz, Montserrat Alegret, Vanesa Pytel, Pilar Cañabate, Antonio González-Pérez, Itziar de Rojas, Liliana Vargas, Juan Pablo Tartari, Ana Espinosa, Gemma Ortega, Alba Pérez-Cordón, Mariola Moreno, Sílvia Preckler, Susanna Seguer, Miren Jone Gurruchaga, Lluís Tárraga, Agustín Ruiz, Sergi Valero, Mercè Boada, Marta Marquié

“…However, we observed that women diagnosed with mild AD dementia progressed more rapidly based on their CDR score (HR = 2.57, 95%CI:2.33–2.84) than men (HR = 2.03, 95%CI: 1.71–2.41) (p-interaction = 0.01). Conclusions Our findings do not strongly support the notion that sex significantly modifies the clinical progression of AD dementia based on cognitive data. …”
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Exploration of linear and interpretable models for quantification of cell parameters via contactless short-wave infrared hyperspectral sensing by Anjana Hevaganinge, Eva Lowenstein, Anna Filatova, Mihir Modak, Nandi Thales Mogo, Bryana Rowley, Jenny Yarmowsky, Joshua Ehizibolo, Ravidu Hevaganinge, Amy Musser, Abbey Kim, Anthony Neri, Jessica Conway, Yiding Yuan, Maurizio Cattaneo, Sui Seng Tee, Yang Tao

“…Further, these models are also able to handle quantification of a metabolite like fructose in the presence of high background concentration of similar metabolite with almost identical chemical interactions in water like glucose. The model achieves reasonable quantification performance for large fructose level (100–1000 mg/dL) quantification (r2 = 0.92, MAE = 25.1 mg/dL) and small fructose level (< 60 mg/dL) concentrations (r2 = 0.85, MAE = 4.97 mg/dL) in complex media like Fetal Bovine Serum (FBS). …”
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Integrative computational analysis of anti-influenza potential in Caesalpinia mimosoides Lamk hydroethanolic extract by Anuwatchakij Klamrak, Shaikh Shahinur Rahman, Napapuch Nopkuesuk, Jaran Nabnueangsap, Jaraspim Narkpuk, Piyapon Janpan, Yutthakan Saengkun, Thananya Soonkum, Supawadee Sriburin, Samaporn Teeravechyan, Poramet Sitthiwong, Nisachon Jangpromma, Sirinan Kulchat, Kiattawee Choowongkomon, Rina Patramanon, Arunrat Chaveerach, Jureerut Daduang, Sakda Daduang

“…Molecular docking analyses revealed that the identified phytochemicals can simultaneously interact with the “drug-target binding sites” of neuraminidase (NA) and PB2 subunit of influenza RNA polymerase, indicating their potential polypharmacological effects. …”
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Hypothermia regulates mitophagy and apoptosis via PINK1/Parkin-VDAC 3 signaling pathway during oxygen-glucose deprivation/recovery injury by Luying Zhang, Song Yang, Hao Cui, Chenchen Hang, Xingsheng Wang, Le An, Zhenyu Shan, Zhen Liang, Rui Shao, Ziren Tang

“…Expression of mitophagy-related proteins (Cleaved PINK1, Parkin, SQSTM1/p62, Beclin-1, LC3B II/LC3B I), apoptosis-related proteins (Bcl-2, Cytochrome C, caspase-3, cleaved caspase3) and VDAC3 were assessed using western blot analysis and quantitative real-time PCR. The interaction between Parkin and VDAC3 was confirmed by immunofluorescence colocalization. …”
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Pancreatic cancer cell-intrinsic transglutaminase-2 promotes T cell suppression through microtubule-dependent secretion of immunosuppressive cytokines by Anton Wellstein, Thomas Seufferlein, Alexander Kleger, Tim Eiseler, Anton Lahusen, Nora Minhöfer, Kim-André Lohse, Christine Blechner, Jessica Lindenmayer, Sabine Windhorst, Yuan-Na Lin

“…The action of TGM2 via interaction with tubulin and the impact of microtubule dynamics and vesicle trafficking were evaluated by protein analyses and live-cell imaging. …”
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Culturally appropriate terminologies in health research: a participatory study with pregnant and breastfeeding mothers in Uganda by Ritah Nakijoba, Adelline Twimukye, Josephine Bayigga, Aida N. Kawuma, Simon Peter Asiimwe, Fredrick Byenume, Jacqueline Kyeyune, Sylvia Nabukenya, Francis Williams Ojara, Francis Williams Ojara, Catriona Waitt, Catriona Waitt

“…For healthcare workers, training in empathetic communication and cultural competence is crucial to improve patient interactions and promote dignity in healthcare settings.…”
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RETRACTED ARTICLE: Synthesis of silver nanoparticles using Plantago lanceolata extract and assessing their antibacterial and antioxidant activities by Muhammad Zahir Shah, Zheng-Hui Guan, Ala Ud Din, Amjad Ali, Ata Ur Rehman, Kashif Jan, Shah Faisal, Shah Saud, Muhammad Adnan, Fazli Wahid, Saud Alamri, Manzer H. Siddiqui, Shamsher Ali, Wajid Nasim, Hafiz Mohkum Hammad, Shah Fahad

“…The TEM image showed aggregations of NPs and physical interaction. Ag. NPs formation also confirmed by XPS, DRS and BET studies. …”
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