Understanding “Alert Fatigue” in Primary Care: Qualitative Systematic Review of General Practitioners Attitudes and Experiences of Clinical Alerts, Prompts, and Reminders by Illin Gani, Ian Litchfield, David Shukla, Gayathri Delanerolle, Neil Cockburn, Anna Pathmanathan

“…ObjectiveThis systematic review aims to synthesize current qualitative research on GPs’ attitudes toward CRs, enabling an exploration of the interacting influences on the occurrence of alert fatigue in GPs, including the deployment, design, and perceived efficacy of CRs. …”
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Dihydrotanshinone I enhanced BRAF mutant melanoma treatment efficacy by inhibiting the STAT3/SOX2 signaling pathway by Xing Luo, Yi Duan, Jinwei He, CongGai Huang, Jun Liu, Yifan Liu, Mengdei Xu, Qiong Dai, Zhihui Yang

“…The diameter and weight of tumours in each group were then measured, and IHC and HE staining were used to assess the expression of two pathways and cytotoxicity, respectively.ResultsThis study found that DHT directly interacts with STAT3 protein and it can stop the feedback activation of the STAT3/SOX2 pathway caused by the use of MAPK pathway inhibitors. …”
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Oxaliplatin-Loaded Chitosan Nanoparticles Decorated with Cetuximab Single-Chain Variable Fragment for Human Colorectal Cancer Treatment by Khadijeh Falahzadeh, Fariba Esmaeili, Leila Nematollahi, Elham Bayat, Mehdi Khoobi, Mohammadali Mazloomi, Masumeh Jalalvand, Reza Faridi Majidi, Babak Negahdari

“…The western blotmethod and cell-based ELISA revealed successful purification of scFv and its attachment to EGFR on HCT 116 cells.The FTIR analysis determined the interactions between the scFv and OXPT-CS NPs. According to MTT and flowcytometry results, the targeted delivery system significantly reduced HCT 116 cancer cell viability and increasedapoptosis induction up to 99.8%.Conclusion: The scFv-OXPT-CS NPs demonstrated an increased cytotoxic function due to the presence of scFv in itsformulation. …”
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Six-Gene Signature Associated with Immune Cells in the Progression of Atherosclerosis Discovered by Comprehensive Bioinformatics Analyses by Bin Zhao, Dan Wang, Yanling Liu, Xiaohong Zhang, Zheng Wan, Jinling Wang, Ting Su, Linshan Duan, Yan Wang, Yuehua Zhang, Yilin Zhao

“…Methods. 29 samples of atherosclerosis-related gene expression profiling, including 16 human advanced atherosclerosis plaque (AA) and 13 human early atherosclerosis plaque (EA) samples from the Gene Expression Omnibus (GEO) database, were analyzed to get differentially expressed genes (DEGs) and the construction of protein and protein interaction (PPI) networks. Besides, we detected the relative fraction of 22 immune cell types in atherosclerosis by using the deconvolution algorithm of “cell type identification by estimating relative subsets of RNA transcripts (CIBERSORT).” …”
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Effect of different diets on the fatty acid composition of buffalo bulk milk by Sebastiana Failla, Giuliano Palocci, Michela Contò, Gianluca Renzi, Chiara Evangelista, Loredana Basiricò, Umberto Bernabucci

“…Data was analyzed through a bifactorial model with interaction (season x diet), using GLM procedure and the statement “contrast” by SAS Software to highlight the effect of the diet constituents. …”
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Identifikasi Emosi Pengguna Konferensi Video Menggunakan Convolutional Neural Network by Lina Lina, Arthur Adhitya Marunduh, Wasino Wasino, Daniel Ajienegoro

“…With the use of this technology, users can interact with each other visually and verbally.  Generally, video conference participants can easily receive verbal signals from the speaker. …”
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Ultrasonic Assisted Environmentally Friendly Extraction of Natural Dyes From Beta vulgaris for the Coloration of Silk Fabric Using Different Mordants by Rony Mia, Tafsir Uddin, A. Z. M. Mofasser, Nadim Ibn Sayed, Al Mojnun Shamim, Sanjida Islam, Khandaker Akil Mahadi Ohi, Moonis Ali Khan, Burhan Uddin Banna

“…For the characterization of the extracted dye, undyed, dyed, and mordanted silk fabric, infrared spectroscopy was performed. To observe the interaction of extracted dye and silk fabric, scanning electron microscopy was also accomplished. …”
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Political economy analysis of health financing reforms in times of crisis: findings from three case studies in south-east Asia by Sophie Witter, Maria Paola Bertone, Sushil Baral, Ghanshyam Gautam, Saugat K. C. Pratap, Aungsumalee Pholpark, Nurmala Selly Saputri, Arif Budi Darmawan, Nina Toyamah, Rizki Fillaili, Valeria de Oliveira Cruz, Susan Sparkes

“…However, successful health financing reforms involve complex interactions among a range of stakeholders, as well as with context factors, including shocks and crises of different nature. …”
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Rehydrated corn grain silage with wet brewery residue and different inoculants by E. L. L. Lelis, V. B. Tavares, R. M. A. Teixeira, B. G. C. Homem, C. H. Nogueira, J. M. Silva

“…There was a significant interaction between the inoculant LB and the silages, with 47% (DM45) and 56% (DM55) DM for the Crude Protein (CP) levels. …”
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The necroptosis-related lncRNA ENSG00000253385.1 promotes the progression of esophageal squamous cell carcinoma by targeting the miR-16-2-3p/VDAC1 axis by Xiaoyang Duan, Jian Shi, Ran Hou, Yajie Huang, Chunyan Wang, Huazhen Du

“…Knockdown of the lncRNA ENSG00000253385.1 could inhibit the proliferation, migration and invasion, promote the apoptosis, and result in increases in the necroptosis-related proteins p-receptor-interacting protein kinase 3 (RIPK3)/RIPK3 and p-mixed lineaae kinase domain-like protein (MLKL)/MLKL and a decrease in the VDAC1 protein levels in ESCC cells, whereas miR-16-2-3p inhibition rescued these effects. …”
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Evaluating ChatGPT’s diagnostic potential for pathology images by Liya Ding, Lei Fan, Lei Fan, Miao Shen, Miao Shen, Yawen Wang, Kaiqin Sheng, Zijuan Zou, Huimin An, Zhinong Jiang

“…BackgroundChat Generative Pretrained Transformer (ChatGPT) is a type of large language model (LLM) developed by OpenAI, known for its extensive knowledge base and interactive capabilities. These attributes make it a valuable tool in the medical field, particularly for tasks such as answering medical questions, drafting clinical notes, and optimizing the generation of radiology reports. …”
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First genome-scale insights into the virulence of the snow mold causal fungus Microdochium nivale by Ivan Tsers, Ekaterina Marenina, Azat Meshcherov, Olga Petrova, Olga Gogoleva, Alexander Tkachenko, Natalia Gogoleva, Yuri Gogolev, Evgenii Potapenko, Olga Muraeva, Mira Ponomareva, Viktor Korzun, Vladimir Gorshkov

“….), the performed analysis pointed to a crucial role of host plant lipid destruction and fungal lipid metabolism modulation in plant-M. nivale interactions.…”
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Pregnancy stressors and postpartum symptoms of depression and anxiety: the moderating role of a cognitive–behavioural therapy (CBT) intervention by Ahmed Zaidi, Atif Rahman, Pamela J Surkan, Najia Atif, Abid Malik, Yunxiang Sun, Soim Park

“…The effect of the intervention on this relationship was examined by adding an interaction term to the regression model.Results Hassles frequency measured in the third trimester was positively associated with depression (B=0.22, 95% confidence interval (CI): 0.09 to 0.36) and anxiety (B=0.19, 95% CI: 0.08to 0.30). …”
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Identifying the causes and consequences of pregnancy in Iranian Kurdish women under the age of 18: A grounded theory study by Javad Yoosefi lebni, Ahmad Ahmadi, Seyed Fahim Irandoost, Mandana Saki, Hossein Safari, Nafiul Mehedi

“…Results: After the data analysis and coding process, the conceptual model of causes and consequences of pregnancy in adolescents emerged, including 1) predisposing conditions (sociocultural factors: Social learning, misconceptions about fertility and childbirth, preventing stigma), 2) causal conditions (individual factors: lack of knowledge on how to prevent pregnancy, improper use of contraceptives, inadequate knowledge about the risks of pregnancy in adolescence, fear of the side effects of using contraceptives, filling the vacuum of loneliness, family factors: husband's and his family's pressure, committing her husband to life, consolidating her position in family), 3) intervening conditions (structural factors: no barriers to pregnancy, difficult access to contraceptives), 4) strategies and interactions (positive reactions: trying to prepare herself for raising a child, taking better care of herself and her child, negative reactions: trying to kill herself and the kid, fear and concealment), and 5) consequences (destructive consequences: threats to the health of the child, threat to mother's health, inadequate access to health services, constructive consequences: increase of support, strengthen the sense of empowerment). …”
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Barriers and drivers to exclusive breastfeeding in Kyrgyzstan: a qualitative study with mothers and health workers by Cath Jackson, Marina Duishenkulova, Nurila Altymysheva, Jyldyz Artykbaeva, Raisa Asylbasheva, Eleonora Jumalieva, Anastasia Koylyu, Sian Lickess, Tursun Mamyrbaeva, Veerle Snijders, Julianne Williams, Tiina Likki

“…Health workers were recommending and supporting women with exclusive breastfeeding during multiple antenatal and postnatal interactions during the initial six months. They were knowledgeable and motivated to do this. …”
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LncRNA-ANRIL regulates CDKN2A to promote malignant proliferation of Kasumi-1 cells by Jianxia Xu, Jingxin Zhang, Chengsi Zhang, Huali Hu, Siqi Wang, Fahua Deng, Wu Zhou, Yuancheng Liu, Chenlong Hu, Hai Huang, Sixi Wei

“…RIP analysis confirmed a physical interaction between ANRIL and CDKN2A. Furthermore, CDKN2A downregulation inhibited cell proliferation and reversed GSK3β/β-catenin/cyclin D1 pathway activation mediated by ANRIL upregulation. …”
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Effects of stair riser height on ankle proprioception in individuals with and without chronic ankle stability by Xueying Wang, Xueying Wang, Zheng Wang, Roger Adams, Roger Adams, Yang Gao, Jie Lyu, Jia Han, Jia Han

“…Significant differences in proprioceptive acuity were found between 15 cm and higher risers (p < 0.001), but not between 17.5 cm and 20 cm (p = 0.675), alongside a significant linear downward trend with increasing riser height (F = 15.476, p < 0.001). No significant interaction was observed between the group and riser height (F = 0.745, p = 0.478).ConclusionThe presence of ankle instability and increased riser height significantly negatively affected ankle inversion proprioceptive performance during stair descent, which may increase the risk of ankle sprain.ApplicationPotential applications of this research include the assessment of ankle proprioception during stair descent attributable to effective ankle instability rehabilitation and riser height selection for safe stair design.…”
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Green synthesis of magnetic type Zeolites 4A as catalyst for the elimination of quinoline yellow by the Fenton process: Optimization and kinetic investigation by Roland Urselin Noumsi Foko, Cyrille Ghislain Fotsop, Donald Raoul Tchuifon Tchuifon, Charles Banenzoué, Anatole Guy Blaise Azebaze

“…XRD, FTIR, SEM, EDX, NMR-MAS and TGA-DSC characterizations show that Zeo-4A is crystalline with cubic morphology, while Zeo-4A@Fe3O4 exhibits a bonding interaction between zeolite and Fe3O4 nanoparticle leading to morphological structural changes. …”
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Informal Caregivers Connecting on the Web: Content Analysis of Posts on Discussion Forums by Michelle L Foster, Chinenye Egwuonwu, Erin Vernon, Mohammad Alarifi, M Courtney Hughes

“…Negative interpersonal interactions were mentioned 123 times, with 77 posts describing challenging situations with extended family. …”
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EPIGENETICS TODAY AND TOMORROW by B. F. Vanyushin

“…The resulting m5C residues in DNA influence substantially the interaction of DNA with different proteins including regulatory ones. …”
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