Lipids and C-reactive protein predict anhedonia and reward circuit functional connectivity responses to anti-cytokine and dopaminergic therapies in patients with depression by Aditya Singh, Mandakh Bekhbat, David R. Goldsmith, Ngoc-Anh Le, Evanthia C. Wommack, Zhihao Li, Ebrahim Haroon, Jennifer C. Felger

“…A treatment by inflammation interaction revealed lower anhedonia after infliximab versus placebo (F[1,49] = 5.5, p < 0.05) in patients with, but not without, CRP>3 mg/L (n = 27). …”
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Multi-omics unveils strain-specific neuroactive metabolite production linked to inflammation modulation by Bacteroides and their extracellular vesicles by Basit Yousuf, Walid Mottawea, Galal Ali Esmail, Nazila Nazemof, Nour Elhouda Bouhlel, Emmanuel Njoku, Yingxi Li, Xu Zhang, Zoran Minic, Riadh Hammami

“…Bacteroides species are key members of the human gut microbiome and play crucial roles in gut ecology, metabolism, and host-microbe interactions. This study investigated the strain-specific production of neuroactive metabolites by 18 Bacteroidetes (12 Bacteroides, 4 Phocaeicola, and 2 Parabacteroides) using multi-omics approaches. …”
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Evaluation of Elexacafor/Tezacaftor/Ivacaftor therapy after lung transplantation in Cystic Fibrosis: The Dutch National KOALA study by Johanna P. van Gemert, Bart Luijk, Merel E. Hellemons, Klara A. Visser, Carina.M.E. Hansen, Renske van der Meer, C. Tji Gan, Hester van der Vaart, Onno W. Akkerman, Willie N. Steenhuis, Marieke Verkleij, Harry G.M. Heijerman, Erik A.M. Verschuuren

“…Background: Elexacaftor/Tezacaftor/Ivacaftor (ETI) for people with CF (PwCF) after lung transplantation (LTx) has been restrained due to uncertainties regarding efficacy and drug interactions. Given the persistence of extrapulmonary symptoms post-LTx, this prospective study aims to investigate the benefits and safety of ETI for PwCF post-LTx. …”
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Flavonoids and anthocyanins in seagrasses: implications for climate change adaptation and resilience by Jana Botes, Jana Botes, Xiao Ma, Xiao Ma, Jiyang Chang, Jiyang Chang, Yves Van de Peer, Yves Van de Peer, Yves Van de Peer, Yves Van de Peer, Dave Kenneth Berger, Dave Kenneth Berger

“…Certain features, such as catalytic promiscuity and metabolon interactions, allow flavonoid metabolism to expand to produce novel compounds and respond to a variety of stimuli. …”
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Association of Genetic Variants of KCNJ11 and KCNQ1 Genes with Risk of Type 2 Diabetes Mellitus (T2DM) in the Indian Population: A Case-Control Study by Vasiuddin Khan, Amit Kumar Verma, Deepti Bhatt, Shahbaz Khan, Rameez Hasan, Yamini Goyal, Sowmya Ramachandran, Mohammed A. Alsahli, Arshad Husain Rahmani, Ahmad Almatroudi, M. Y. Shareef, Babita Meena, Kapil Dev

“…Type 2 diabetes mellitus (T2DM) is a polygenic metabolic disease described by hyperglycemia, which is caused by insulin resistance or reduced insulin secretion. The interaction between various genetic variants and environmental factors triggers T2DM. …”
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Large-scale high purity and brightness structural color generation in layered thin film structures via coupled cavity resonance by Wang Danyan, Ji Chengang, Li Moxin, Xing Zhenyu, Gao Hao, Li Xiaochan, Zhou Huixian, Hu Yuhui, Lin Zhelin, Zhang Cheng

“…Structural colors, resulting from the interaction of light with nanostructured materials rather than pigments, present a promising avenue for diverse applications ranging from ink-free printing to optical anti-counterfeiting. …”
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Una nueva estrategia integral para modelar materiales urbanos para ciudades térmicamente habitables. Un caso de estudio en Madrid = A new integrated strategy for modelling urban ma... by Emanuela Giancola, Helena López, Silvia Soutullo, M. Nuria Sánchez, Luis F. Zarzalejo, Ana Gamarra, Israel Herrera, J. Antonio Ferrer, Emanuele Naboni

“…In building energy simulation, little attention has been paid to the non-negligible interactions between the external building envelope, energy demand and its impact on the urban microclimate. …”
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A Network Pharmacology-Based Strategy for Unveiling the Mechanisms of Tripterygium Wilfordii Hook F against Diabetic Kidney Disease by Yuyang Wang, Tongtong Liu, Fang Ma, Xiaoguang Lu, Huimin Mao, Weie Zhou, Liping Yang, Ping Li, Yongli Zhan

“…Then, we obtained DKD targets from GeneCards and OMIM and collected and analyzed TwHF-DKD common targets using the STRING database. Protein-protein interaction (PPI) network was established by Cytoscape and analyzed by MCODE plugin to get clusters. …”
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Lidar estimates of birch pollen number, mass, and CCN-related concentrations by M. Filioglou, P. Tiitta, P. Tiitta, X. Shang, A. Leskinen, P. Ahola, S. Pätsi, A. Saarto, V. Vakkari, V. Vakkari, U. Isopahkala, M. Komppula

“…Lidars capable of vertically resolving aerosol optical properties have been increasingly utilized to study aerosol–cloud interactions, allowing for estimations of cloud-relevant microphysical properties. …”
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Identification and validation of glycolysis-related diagnostic signatures in diabetic nephropathy: a study based on integrative machine learning and single-cell sequence by Xiaoyin Wu, Xiaoyin Wu, Buyu Guo, Buyu Guo, Xingyu Chang, Xingyu Chang, Yuxuan Yang, Yuxuan Yang, Qianqian Liu, Qianqian Liu, Jiahui Liu, Jiahui Liu, Yichen Yang, Yichen Yang, Kang Zhang, Yumei Ma, Songbo Fu, Songbo Fu, Songbo Fu

“…Single-cell RNA sequence data was used to identify cell subtypes and interactive signals. The cMAP database was used to find potential therapeutic agents targeting GScore for DN. …”
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Neighborhood environment associations with cognitive function and structural brain measures in older African Americans by Dima L. Chaar, Le Tu, Kari Moore, Jiacong Du, Lauren A Opsasnick, Scott M Ratliff, Thomas H Mosley, Sharon L. R. Kardia, Wei Zhao, Xiang Zhou, Ana V Diez Roux, Fazlay S Faruque, Kenneth R Butler, Jennifer A Smith

“…Conclusions The presence of fast food destinations and unfavorable food stores with alcohol was associated cognitive measures, possibly due to greater social interaction provided in these venues. However, replication of these findings is necessary. …”
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Based on bioinformatics, SESN2 negatively regulates ferroptosis induced by ischemia reperfusion via the System Xc−/GPX4 pathway by Jiejie Hu, Lijun Qin, Guoqiang Zhu, Jingjing Ren, Hongxia Wang, Jing Jin, Haixue Zheng, Dan Li, Zhaoming Ge

“…Differentially expressed gene (DEG) enrichment analysis highlighted ferroptosis-related pathways.ResultsUsing Venn analysis, nine ferroptosis-related DEGs were identified, namely, Slc3a2, Slc7a11, Ccn2, Tfrc, Atf3, Chac1, Gch1, Lcn2, and Sesn2. Protein–protein interaction (PPI) analysis combined with molecular complex detection (MCODE) identified six hub genes, namely, Ddit3, Atf3, Sesn2, Trib3, Ppp1r15a, and Gadd45a. …”
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The impact of multiple exposures and movement on the fear response of poultry by Alexandra Jackson, Marcela Quino, Anusha Gautam, Melissa Gilpin, Katie Still, Denise Landers, Bethany Baker-Cook

“…Both latency to human approach and latency to novel object interaction were longest on 23d, then 30d, and shortest on 37d (P<0.01). …”
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Identification of promising SARS-CoV-2 main protease inhibitor through molecular docking, dynamics simulation, and ADMET analysis by Ganesh Sharma, Neeraj Kumar, Chandra Shekhar Sharma, Taha Alqahtani, Yewulsew Kebede Tiruneh, Sharifa Sultana, Gabriel Vinícius Rolim Silva, Gabriela de Lima Menezes, Magdi E. A. Zaki, Jonas Ivan Nobre Oliveira

“…Molecular docking studies showed that 4896 − 4038 has a strong binding affinity to the active site of Mpro and forms key interactions, such as hydrogen bonds, carbon-hydrogen bonds, pi-sulfur, and multiple van der Waals and pi-pi stacked bonds. …”
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Effects of cage size on the natural behavior, serum parameters, production performance and hypothalamic mRNA expression profiles of laying hens by Yi Wan, Ruiyu Ma, Renrong Qi, Dawei Jiang, Helong Guan, Wei Liu, Junying Li, Yan Li, Kai Zhan

“…A majority of these DEGs were involved primarily in neuroactive ligand‒receptor interactions, focal adhesion and calcium signaling pathways, which are associated with the regulation of behavioral patterns, the stress response and follicular development. …”
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The Impact of Artificial Intelligence on Healthcare: A Comprehensive Review of Advancements in Diagnostics, Treatment, and Operational Efficiency by Md. Faiyazuddin, Syed Jalal Q. Rahman, Gaurav Anand, Reyaz Kausar Siddiqui, Rachana Mehta, Mahalaqua Nazli Khatib, Shilpa Gaidhane, Quazi Syed Zahiruddin, Arif Hussain, Ranjit Sah

“…The study aims to describe AI in healthcare, including important technologies like robotics, machine learning (ML), deep learning (DL), and natural language processing (NLP), and to investigate how these technologies are used in patient interaction, predictive analytics, and remote monitoring. …”
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Identification of Co-Expression Modules of Cotton Plant Height-Related Genes Based on Weighted Gene Co-Expression Network Analysis by Qian Huang, Li Liu, Hang Li, Xuwen Wang, Aijun Si, Liangrong He, Yu Yu

“…Further analysis of gene connectivity within these modules identified 10 core genes (<i>Gohir.D03G105600</i>, <i>Gohir.A03G060400</i>, <i>Gohir.A05G333400</i>, <i>Gohir.D09G243300</i>, <i>Gohir.D12G213500</i>, <i>Gohir.A04G065185</i>, <i>Gohir.A04G039105</i>, <i>Gohir.D08G127760</i>, <i>Gohir.A09G103348</i>, and <i>Gohir.A04G039120</i>) and enabled the establishment of a gene interaction regulation network. Functional predictions suggest that these candidate genes may play key roles in the regulation of cotton plant height. …”
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Presenting the model of social entrepreneurship in the development of rural tourism in the target villages of Gilan province by Fatemeh Doozandeh Ziabari, hamed fallah tafti, Mir Mohammad Asadi, Mahdi Basouli

“…This is due to the drastic changes caused by technology innovation; like entrepreneurship through the sharing economy, which leads to direct interaction of people with tourism services (Yu & Wang, 2019). …”
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MUC5B modulation of early oral biofilm glucose metabolism by Carolina Robertsson, Carolina Robertsson, Julia Davies, Gunnel Svensäter, Anders Bay Nord, Niclas Norrström, Claes Wickström

“…Studying the metabolic interactions between commensal members of oral biofilms and modulatory effects of host factors such as glycoproteins in saliva during the metabolism of substrates that are potential drivers of dysbiosis, such as glucose, is essential to understand the roles of oral microbial ecosystems in oral health and disease.…”
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Research on the multi-agent motivation coupling evolution and synergy improvement for farmland ecological protection in China by Adila Ainiwaerjiang, Xueying Jin, Zhen Xie, Tian Tian, Yuxuan Dang

“…In these systematic, multi-agent projects, the long-term viability of farmland ecological protection rests significantly upon the alignment and synergistic interaction of the primary agents involved. Beginning in 2017, the Chinese government prioritized farmland ecological protection, instituting a collaborative governance structure involving policymakers, policy implementers, and agricultural producers. …”
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