Rosiglitazone, a Ligand to PPARγ, Improves Blood Pressure and Vascular Function through Renin-Angiotensin System Regulation by María Sánchez-Aguilar, Luz Ibarra-Lara, Leonardo Del Valle-Mondragón, María Esther Rubio-Ruiz, Alicia G. Aguilar-Navarro, Absalom Zamorano-Carrillo, Margarita del Carmen Ramírez-Ortega, Gustavo Pastelín-Hernández, Alicia Sánchez-Mendoza

“…The in silico analysis is a valuable tool to predict the interaction between PPARγ and RAS.…”
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Hierarchizing multi-scale environmental effects on agricultural pest population dynamics: a case study on the annual onset of Bactrocera dorsalis population growth in Senegalese or... by Caumette, Cécile, Diatta, Paterne, Piry, Sylvain, Chapuis, Marie-Pierre, Faye, Emile, Sigrist, Fabio, Martin, Olivier, Papaïx, Julien, Brévault, Thierry, Berthier, Karine

“…Implementing integrated pest management programs to limit agricultural pest damage requires an understanding of the interactions between the environmental variability and population demographic processes. …”
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Cisplatin resistance alters ovarian cancer spheroid formation and impacts peritoneal invasion by Lydia C. Powell, Marcos Quintela, David W. James, Emenike Onyido, David Howard, Kadie Edwards, Jordan L. Turney, Charlotte R. Morgan, Jenny Worthington, Nicole Williams, Alexander Dulebo, Heiko Haschke, Deyarina Gonzalez, R. Steven Conlan, Lewis W. Francis

“…Furthermore, the CR spheroids demonstrated altered interactions with a surface that mimics the peritoneal lining post mesothelial clearance (Matrigel). …”
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Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis by Meng Wang, Xing Huang, Tingbo Liang, Tianyu Tang, Gang Zhang, Minghao Lu, Zhengtao Hong, Junming Huang, Xiao Zhi

“…As regards the mechanism, ATP11B interacted with PD-L1 in a CKLF-like MARVEL transmembrane domain containing 6 (CMTM6)-dependent manner. …”
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Effects of entinostat, quisinostat, and tubastatin-A on alcohol consumption in male high ethanol consuming rats by Sheketha R. Hauser, Sheketha R. Hauser, Laura B. Ferguson, Laura B. Ferguson, Tiebing Liang, Erin E. Jarvis, R. Dayne Mayfield, Richard L. Bell, Richard L. Bell

“…BackgroundThe interaction between genetics, epigenetics, and the environment plays a key role in the development of alcohol use disorder (AUD). …”
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Extracellular vimentin is a damage-associated molecular pattern protein serving as an agonist of TLR4 in human neutrophils by Łukasz Suprewicz, Krzysztof Fiedoruk, Karol Skłodowski, Evan Hutt, Magdalena Zakrzewska, Alicja Walewska, Piotr Deptuła, Agata Lesiak, Sławomir Okła, Peter A. Galie, Alison E. Patteson, Paul A. Janmey, Robert Bucki

“…Results Both eVim and CitVim interact with and trigger TLR4, leading to increased neutrophil migration and adhesion. …”
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Effectiveness of advanced cardiovascular life support in hyperkalemic cardiac arrest: A randomized experimental study in pigs by Najmiddin Mamadjonov, Wan Young Heo, Kyung Woon Jeung, Yong Hun Jung, Hyoung Youn Lee, Seok Jin Ryu, Byung Kook Lee, Yong Soo Cho, Tag Heo

“…The decrease in end-diastolic volume over time was significantly less pronounced in the hyperkalemic arrest group (group-time interaction, P = 0.010). Coronary perfusion pressure (group effect, P = 0.041) and cerebral perfusion pressure (group effect, P = 0.020) were significantly lower in the hyperkalemic arrest group. …”
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Factors affecting implementation of interventions for oral health, substance use, smoking and diet for people with severe and multiple disadvantage: a community-based qualitative s... by Sheena E Ramsay, Richard G Watt, Falko F Sniehotta, Eileen Kaner, Martha Paisi, Neha Jain, Martin Burrows, Emma A Adams, Gillian McLellan, Emma C Joyes, Laura J McGowan, David Landes, Lorenzo Iafrate

“…Environmental factors included funding and integrated services; organisational factors included inclusive services, health promotion, prevention and training healthcare providers; interpersonal factors included the presence of support workers and motivation among service providers.Conclusion The implementation and sustainability of health interventions for people experiencing SMD are influenced by factors across environmental, organisational and interpersonal levels that interact with the inherent challenges of disadvantaged groups. …”
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Salivary peptidomic profiling of chronic gingivostomatitis in cats by matrix‐assisted laser desorption/ionization‐time‐of‐flight mass spectrometry and nanoscale liquid chromatograp... by Sekkarin Ploypetch, Apisit Pornthummawat, Sittiruk Roytrakul, Janthima Jaresitthikunchai, Narumon Phaonakrop, Sabrina Wahyu Wardhani, Sitthichok Lacharoje, Somporn Techangamsuwan

“…Protein‐anti‐inflammatory drug interaction networks were observed. Conclusions and Clinical Importance Peptide mass fingerprint and peptide profiles identified distinct clusters between FCGS and healthy cats. …”
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Understanding the Molecular Mechanisms of Incomptine A in Treating Non-Hodgkin Lymphoma Associated with U-937 Cells: Bioinformatics Approaches, Part I by Fernando Calzada, Normand García-Hernández, Elihú Bautista, José Manuel Sánchez-López, Miguel Valdes, Claudia Velázquez, Elizabeth Barbosa

“…The molecular docking analysis, which used 23 altered proteins as targets, revealed that <b>IA</b> interacted with all the proteins used. <b>Conclusions</b>: The results obtained using the five bioinformatic approaches provide information and show that <b>IA</b> could be used to treat non-Hodgkin lymphoma induced with the U-937 cell line. …”
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Gut microbiome-derived bacterial extracellular vesicles in patients with solid tumours by Surbhi Mishra, Mysore Vishakantegowda Tejesvi, Jenni Hekkala, Jenni Turunen, Niyati Kandikanti, Anna Kaisanlahti, Marko Suokas, Sirpa Leppä, Pia Vihinen, Hanne Kuitunen, Kaisa Sunela, Jussi Koivunen, Arja Jukkola, Ilja Kalashnikov, Päivi Auvinen, Okko-Sakari Kääriäinen, T. Peñate Medina, O. Peñate Medina, Juha Saarnio, Sanna Meriläinen, Tero Rautio, Raila Aro, Reetta Häivälä, Juho Suojanen, Mikael Laine, Pande Putu Erawijattari, Leo Lahti, Peeter Karihtala, Terhi S. Ruuska, Justus Reunanen

“…Objectives: Analyzing the functionality of bEVs using (meta)genomics and proteomics could highlight the unique aspects of host–gut microbiome interactions in solid tumor patients. Therefore, we performed a comparative analysis of the proteome and microbiota composition of gut microbiome-derived bEVs isolated from patients with solid tumors and healthy controls. …”
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Smoking and secondhand smoke exposure and carotid intima-media thickness: Baseline data from the Aidai Cohort Study in Japan by Makoto Saito, Yoshihiro Miyake, Keiko Tanaka, Chisato Nagata, Hidenori Senba, Yasuko Hasebe, Toyohisa Miyata, Takashi Higaki, Eizen Kimura, Bunzo Matsuura, Osamu Yamaguchi, Ryuichi Kawamoto

“…Such positive associations with maximum CIMT were found only in men; however, interactions between smoking and sex were not significant.…”
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Use of the FM Systems for the Auditory and Speech Perception Improvements in Children with ASD. Pilot Study by U.A. Mamokhina, K.A. Fadeev, D.E. Goyaeva, A.A. Ilyunceva, T.M. Ovsyannikova, T.S. Obukhova, K.R. Salimova, A.M. Rytikova, D.V. Davydov

“…However, the integration of FM systems into the school process requires further research on their effectiveness in real conditions, as well as adaptations to minimize discomfort for children and improve interaction with teachers and tutors.</p>…”
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Evolution paths of urban forms influenced by landforms: Asynchrony but convergence by Chao Yang, Qiyan Huang, Qiong Xian, Meng Yuan, Xiaoming Cong, Lisha Xun, Jianxiong Cheng, Hongyi Pan

“…Current dynamic indices often overlook the global physical gravitation and the interactions between new and old urban patches, leading to errors in assessing their agglomeration effects. …”
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Genome-wide identification and characterization of WRKYs family involved in responses to Cylindrocarpon destructans in Panax notoginseng by Manqiao Li, Xiaoli Che, Qiwen Liang, Kuixiu Li, Guisheng Xiang, Xuyan Liu, Yan Zhao, Fugang Wei, Shengchao Yang, Guanze Liu

“…KEGG enrichment analysis of 547 differentially expressed genes (DEGs) indicated their involvement pathways related to disease resistance, including the biosynthesis of sesquiterpenes and triterpenes, JA biosynthesis, plant-pathogen interactions and the MAPK signaling pathway. Conclusion This study demonstrated that the WRKY family in P. notoginseng plays a significant role in resistance to root rot disease. …”
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Controls on coastal saline groundwater across North America by Daniel V Kretschmer, Holly A Michael, Nils Moosdorf, Gualbert H P Oude Essink, Marc F P Bierkens, Thorsten Wagener, Robert Reinecke

“…However, no factor controls coastal groundwater salinization alone, suggesting that parameter interactions are important. Using G ^3 M-D based on G ^3 M, a model that previous work found to be strongly controlled by topography, we find no controlling influence of recharge variability on the saline groundwater distribution in North America. …”
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High-resolution Cryo-EM Structure Determination of a-Synuclein—A Prototypical Amyloid Fibril by Juan Sanchez, Joshua Pierson, Collin Borcik, Chad Rienstra, Elizabeth Wright

“…The physiological role of a-synuclein (a-syn), an intrinsically disordered presynaptic neuronal protein, is believed to impact the release of neurotransmitters through interactions with the SNARE complex. However, under certain cellular conditions that are not well understood, a-syn will self-assemble into β-sheet-rich fibrils that accumulate and form insoluble neuronal inclusions. …”
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Age-Related Macular Degeneration (AMD) Transmitochondrial Cybrids Protected from Cellular Damage and Death by Human Retinal Progenitor Cells (hRPCs) by Jeffrey J. Yu, Daniel B. Azzam, Marilyn Chwa, Kevin Schneider, Jang-Hyeon Cho, Chinhui Hsiang, Henry Klassen, M. Cristina Kenney, Jing Yang

“…Our results suggest that bidirectional interactions exist between hRPCs and AMD cybrids such that hRPCs release trophic factors that protect the cybrids against the cellular and mitochondrial changes involved in AMD pathogenesis while, conversely, AMD cybrids upregulate the release of these neuroprotective factors by hRPCs while promoting hRPC differentiation. …”
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Cadmium and polyvinyl chloride microplastics induce mitochondrial damage and apoptosis under oxidative stress in duck kidney by Hui Zou, Jie Song, Xianzu Luo, Waseem Ali, Sifan Li, Ling Xiong, Yan Chen, Yan Yuan, Yonggang Ma, Xishuai Tong, Zongping Liu

“…Polyvinyl chloride microplastics (PVC-MPs) and Cadmium (Cd) are widely occurring water pollutants that interact with each other to exert toxic effects. As a waterfowl, Muscovy duck is more susceptible to PVC-MPs and Cd than land poultry. …”
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Structural Properties, Cytotoxicity, and Anti-Inflammatory Activity of Silver(I) Complexes with tris(p-tolyl)Phosphine and 5-Chloro-2-Mercaptobenzothiazole by L. Kyros, N. Kourkoumelis, M. Kubicki, L. Male, M. B. Hursthouse, I. I. Verginadis, E. Gouma, S. Karkabounas, K. Charalabopoulos, S. K. Hadjikakou

“…., 2009) was re-determined at 120(2) K and possible Ag-Ag interactions were analyzed. The compounds 1–4 were characterized by X-ray crystallography at r.t (1) and 120 K (2–4). …”
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