Exploring the inhibitory effect and mechanism of isorhamnetin therapy on oral squamous cell carcinoma based on network pharmacology and molecular docking by YU Fangfang, ZHOU Jingjing, YANG Jie, QU Huijuan, HUI Guangyan

“…Methods The key targets were obtained by constructing the PPI protein interaction network based on the common intersection targets of Iso-OSCC. …”
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LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…Therefore, to improve the current prophylaxis and treatment scheme, offering a favorable strategy efficient against CRC is urgently needed.Methods: Here, we developed a nanovaccine (LBP-CD155L NVs) loaded with CD155 gene in liposome, which was modified by Lycium barbarum polysaccharides (LBP) through electrostatic interaction. The nanovaccine was characterized by transmission electron microscopy and Zetasizer. …”
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Comprehensive Analysis of Competing Endogenous RNA Network Focusing on Long Noncoding RNA Involved in Cirrhotic Hepatocellular Carcinoma by Yuli Zhang, Dinggui Chen, Miaomiao Yang, Xianfeng Qian, Chunmei Long, Zhongwei Zheng

“…The role of long noncoding RNAs- (lncRNAs-) associated competing endogenous RNA (ceRNA) in the field of hepatocellular carcinoma (HCC) biology is well established, but the involvement of lncRNAs competing interactions in the progression of liver cirrhosis to HCC is still unclear. …”
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Potential Value of Circular RNA circTBC1D4 in Gastrointestinal Stromal Tumors by null Chunyan-Zou, null Yanpeng-He, null Changshun-Xie, null Fulai-Gao, null Xiaoli-Xie, null Xiukun-Chai, null Chenxi-He, null Dongqiang-Zhao

“…The hub genes of protein-protein interaction (PPI) network and cytoHubba were also defined. …”
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Curing modes affects micro-tensile bond strength and durability of dual curing resin cements to dentin by Zimeng Li, Xiaoyuan Yan, Negin Toufani, Hidehiko Sano, Jiale Fu

“…Three-way ANOVA and Games-Howell test were performed by SPSS 19.0 (α = 0.05).ResultsThe Three-way ANOVA indicated that bonding performance was significantly affected by curing mode (p = 0.000, F = 1,237.510), resin cement (p = 0.000, F = 59.507) and storage time (p = 0.000, F = 97.888). The interaction of these three factors was significant (p = 0.017, F = 2.071).ConclusionThe bonding strength and durability of dual curing resin cements were significantly improved by light-curing process. …”
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Enhancing collaborative clinical reasoning among multidisciplinary healthcare teams in a neurosurgery ICU: insights from video-reflexive ethnography by Ching-Yi Lee, Ching-Hsin Lee, Sze-Yuen Yau, Hung-Yi Lai, Po-Jui Chen, Mi-Mi Chen

“…Data collection involved video recordings of daily ward rounds, field observations, and reflexive interviews where participants reviewed video clips of their interactions. Thematic analysis was conducted on the transcripts of video recordings and interview. …”
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Role of serum sodium on heart, anemia, and diabetes patients by Mahashweta Das, Sunit Kumar Medda, Shipra Banik, Rabindra Nath Das

“…It is derived herein that mean SNa is positively associated with the marginal effects of platelets count (PLC) (P = 0.0019), anemia status (ANS) (P = 0.1053) (partially), creatinine phosphokinase (CRP) (P = 0.0462), smoking habit (SMH) (P= 0.1017), SEX (P = 0.0029), and the joint interaction effects (JIEs) of ejection fraction (EJF) and the status of high blood pressure (HBP), i.e., EJF*HBP (P = 0.1398); ANS and death event (DEE), i.e., ANS*DEE (P = 0.0009); age and time to follow-up (TTF), i.e., AGE*TTF (P = 0.0700); age and serum creatinine (SEC), i.e., AGE*SEC (P = 0.0901); EJF and SEC, i.e., EJF*SEC (P = 0.0044); and CRP and TTF, i.e., CRP*TTF (P = 0.0021). …”
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Effects of photobiomodulation combined with rehabilitation exercise on pain, physical function, and radiographic changes in mild to moderate knee osteoarthritis: A randomized contr... by Yan Ling Tay, Mohd Azzuan Ahmad, Nor Hamdan Mohamad Yahaya, Devinder Kaur Ajit Singh

“…Data will be analyzed according to the intention-to-treat principle, with a two-way repeated measures ANOVA used to assess time, group, and interaction effects.<h4>Conclusion</h4>This study is expected to provide valuable insights into the sustained effects and potential disease-modifying properties of combining H-PBMT with rehabilitation exercises in managing KOA. …”
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Effects of exogenous SLs on growth and physiological characteristics of flue-cured tobacco seedlings under different degrees of drought stress by Xiao-dong Wang, Yi-nan Zhang, Xiao-guo Wang, Ye Zhuang, Shao-hua Ge

“…The results indicated that a concentration of 0.2 mg·L⁻¹ of strigolactones enhanced the drought tolerance of tobacco across different levels of drought stress and promoted the growth and development of flue-cured tobacco. However, the interactions between strigolactones and various hormones under drought stress require further investigation to elucidate the underlying molecular mechanisms. …”
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Environmental awareness and plastic use behavior during the Covid-19 pandemic by H. Herdiansyah, Nuraeni .

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Evaluation of two electronic-rehabilitation programmes for persistent knee pain: protocol for a randomised feasibility trial by Philip G Conaghan, Kim L Bennell, Mark Conner, Rana S Hinman, Sarah R Kingsbury, Elizabeth M A Hensor, Gretl A McHugh, Christine Comer, Dawn Groves-Williams, Rachel K Nelligan

“…The ‘My Knee UK’ intervention arm will receive a self-directed unsupervised internet-based home exercise programme plus short message service support (targeting exercise behaviour change) for 12 weeks; the ‘Group E-Rehab’ intervention arm will receive group-based physiotherapist-prescribed home exercises delivered via videoconferencing accompanied by internet-interactive educational sessions for 12 weeks; the control arm will receive usual physiotherapy care or continue with their usual self-management (depending on their recruitment path). …”
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Temporally enhanced RSEI and nighttime lights reveal long-term ecological changes and effective protection in China’s inaugural national parks by Chunhui Wen, Tengfei Long, Guojin He, Weili Jiao, Wei Jiang

“…The results indicate that: 1) The temporally enhanced RSEI (tRSEI) effectively integrates the dynamic changes of multiple variables and offers better temporal comparability for long-term ecological monitoring; 2) From 2000 to 2022, the ecological environment quality within the inaugural NPs significantly improved, with more noticeable improvements observed following the implementation of pilot conservation programs; 3) The spatial variation in ecological quality within these NPs is driven by the interaction of multiple factors, including human activities, climate variability, and topographical conditions, with significant differences among the parks; 4) Although overall NTL intensity both inside and outside the NPs increased between 2000 and 2022, especially with accelerated growth in surrounding areas post-pilot program implementation, NTL levels within the parks remained relatively low. …”
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The neighborhood walk: introducing first-year medical students to social determinants of health in underserved neighborhoods by Tien C. Nguyen, Lilly W. Tang, Emma Bryant, Awa S. Jobe, Amy J. Yu, Yui Sugiura, Thuy Bui

“…Given the limited research on the feasibility and educational effects of SDoH experiences implemented at the early stages of medical education, this study presents a unique perspective on an interactive learning opportunity during the preclinical curriculum. …”
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The Fake History: Soviet Totalitarianism and the Memory of the Guerrilla War by Bernardas Gailius

“…Riisen distinguishes four types of narratives: the traditional narrative, the exemplary narrative, the critical narrative, and the genetic narrative. The interaction of these types of narratives defines the dynamics of historical culture. …”
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Network pharmacology and experimental verification to investigate the mechanism of isoliquiritigenin for the treatment of Alzheimer’s disease by Waimao Gao, Guang Yang, Xinjuan Liu, Kaifan Hu, Jie Pan, Xingyu Wang, Yan Zhao, Ying Xu

“…The protein-protein interaction (PPI) network was constructed and clusters were obtained using the Molecular Complex Detection (MCODE) and the Cytohubba plugins. …”
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Experiences Using Media Health Claims to Teach Evidence-Based Practice to Healthcare Students: A Mixed Methods Study [version 3; peer review: 2 approved, 2 approved with reservatio... by Astrid Dahlgren, Marianne Molin, Jürgen Kasper, Lisa Garnweidner-Holme, Hilde Tinderholt Myrhaug, Ida-Kristin Orjasaeter Elvsaas

“…Background A multifaceted and interactive teaching approach is recommended for achieving proficiency in evidence-based practice, with critical thinking considered vital for connecting theory and practice. …”
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TAB2 deficiency induces dilated cardiomyopathy by promoting mitochondrial calcium overload in human iPSC-derived cardiomyocytes by Wenrui Sun, Jianchao Zhang, Shuang Li, Wanrong Fu, Yangyang Liu, Mengduan Liu, Jianzeng Dong, Xiaoyan Zhao, Xiaowei Li

“…Furthermore, TAB2 knockout activated receptor-interacting protein kinase 1 (RIPK1), leading to an increase in mitochondrial calcium uniporter (MCU) expression, thereby augmenting the uptake of mitochondrial calcium ions. …”
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Air Pollution Levels Related to Peak Expiratory Flow Rates among Adult Asthmatics in Lampang, Thailand by Wanwisa Chujit, Phongtape Wiwatanadate, Athavudh Deesomchok, Khajornsak Sopajaree, Kamal Eldeirawi, Ying I. Tsai

“…A positive correlation was found between the mean daily concentration of NO2 from 4 days prior (“lag 4”) and the PEFR upon waking (“morning PEFR”), with an increase of 1 ppb in the former being associated with an increase of 1.34 L min−1 (95% CI: 0.25, 2.44) in the latter. Also, the interaction between NO2 (lag 4) and PM10 (lag 6) was multiplicatively associated with a decrease of −0.015 L min−1 in the morning PEFR, which was also negatively associated with the maximum daily concentration (“max”) of NO2 (lag 2) and that of PM10 (lag 6), with coefficients of −0.07 and −0.013, respectively. …”
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Effects of Production System With or Without Growth-Promoting Technologies on Growth and Blood Expression of (Cyto)Chemokines and Heat Shock and Tight Junction Proteins in <i>Bos t... by Mark Branine, Ashley K. Schilling-Hazlett, Pedro H. V. Carvalho, Kim R. Stackhouse-Lawson, Edilane C. Martins, Julia T. da Silva, Laura Amundson, Chris Ashworth, Mike Socha, Sami Dridi

“…There was a significant period by production system as well as period by breed interactions. The expression of HSP1A1 increased in both breeds during October. …”
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Terminal drought effect on sugar partitioning and metabolism is modulated by leaf stay-green and panicle size in the stem of sweet sorghum (Sorghum bicolor L. Moench) by Thierry Klanvi Tovignan, Hubert Adoukonou-Sagbadja, Cyril Diatta, Anne Clément-Vidal, Armelle Soutiras, Ndiaga Cisse, Delphine Luquet

“…Analysis of variance was performed to test post-anthesis water treatment, accession, organ, year effects and their interactions on the studied traits. Results Panicle dry weight (PDW) was not affected by drought, but strongly varied among years and accessions. …”
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