An international consensus panel on the potential value of Digital Surgery by Anita Patel, Giuseppe Turchetti, Guy Maddern, Ataru Igarashi, Prasanna Sooriakumaran, Gretchen Purcell Jackson, Anastasia Chalkidou, Jamie Erskine, Jean-Christophe Bernhard, Payam Abrishami, Richard Charter, Richard Culbertson, Jo Carol Hiatt, Matthew Lien, Joseph Soon Yau Ng, Koon Ho Rha, Scott Tackett

“…Assessments to consider the value of the entire surgical ecosystem holistically are critical, especially as many digital technologies are likely to interact simultaneously in the operating theatre.…”
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Mapping the Gaps: A Scoping Review of Virtual Care Solutions for Caregivers of Children with Chronic Illnesses by Nicole Pope, Kathyrn A. Birnie, Melanie Noel, Justine Dol, Danyu Li, Megan Macneil, Darrel Zientek, Victoria Surry, Jennifer N. Stinson

“…We conducted a scoping review to create an interactive Evidence and Gap Map (EGM) of virtual care solutions across a stepped care continuum (i.e., from self-directed to specialized care) for caregivers of youth with chronic illnesses. …”
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Association between neutrophil-to-eosinophil ratio and efficacy outcomes with avelumab plus axitinib or sunitinib in patients with advanced renal cell carcinoma: post hoc analyses... by Brian Rini, Mariangela Mariani, Alessandra di Pietro, Paul Nathan, Christian Kollmannsberger, Marc-Oliver Grimm, Martin H Voss, Bradley A McGregor, Mehmet A Bilen, Yoshihiko Tomita, Bo Huang, Robert Amezquita, Matthew Tucker, Yu-Wei Chen

“…Within NER subgroups, analyses of PFS, OS and ORR favoured avelumab plus axitinib versus sunitinib treatment. Interaction tests that assessed the association between treatment and NER yielded conflicting results when NER was assessed as a dichotomised variable (median cut-off) or continuous variable.Conclusion Hypothesis-generating analyses suggest that baseline NER may be prognostic for longer OS irrespective of treatment. …”
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Clofarabine induces tumor cell apoptosis, GSDME-related pyroptosis, and CD8+ T-cell antitumor activity via the non-canonical P53/STING pathway by Jing Chen, Jie Wu, Xiang Chen, Qian Tao, Nian Liu, Cong Peng, Can Lu, Qiuqiu Li

“…Mechanistically, the administration of Clo induced the interaction of P53 with STING, which activated the non-canonical STING-NFκB pathway; consequently, NF-κB directly bound to the promoter regions of its target genes, including CCL5, CXCL10, HLAs and BAX. …”
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Polygenic prediction of human longevity on the supposition of pervasive pleiotropy by M. Reza Jabalameli, Jhih-Rong Lin, Quanwei Zhang, Zhen Wang, Joydeep Mitra, Nha Nguyen, Tina Gao, Mark Khusidman, Sanish Sathyan, Gil Atzmon, Sofiya Milman, Jan Vijg, Nir Barzilai, Zhengdong D. Zhang

“…Given the highly complex and non-linear interactions between the genetic determinants of longevity, we reasoned that a composite polygenic score would approximate a substantial portion of the variance in lifespan and developed the integrated longevity genetic scores (iLGSs) for distinguishing exceptional survival. …”
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Reducing the dietary starch:protein ratios in low-protein diets enhanced the growth performance of goslings from 1 to 28 days of age by Xucheng Zheng, Qian Lu, Chunhui Huang, Usman Nazir, Zhi Yang, Haiming Yang, Zhiyue Wang

“…The varied levels of protein and S: P ratio types interacted to influence the starch digestibility of distal jejunum. …”
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Genetic determinants of COVID-19 severity and mortality: ACE1 Alu 287 bp polymorphism and ACE1, ACE2, TMPRSS2 expression in hospitalized patients by João Locke Ferreira de Araújo, Átila Duque Rossi, Jessica Maciel de Almeida, Hugo José Alves, Isabela de Carvalho Leitão, Renata Eliane de Ávila, Anna Carla Pinto Castiñeiras, Jéssica da Silva Oliveira, Rafael Mello Galliez, Marlon Daniel Lima Tonini, Débora Souza Faffe, Shana Priscila Coutinho Barroso Barroso, Gustavo Gomes Resende, Cássia Cristina Alves Gonçalves, Terezinha Marta Pereira Pinto Castiñeiras, Amilcar Tanuri, Mauro Martins Teixeira, Renato Santana Aguiar, Cynthia Chester Cardoso, Renan Pedra de Souza

“…Background The angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) are central human molecules in the SARS-CoV-2 virus-host interaction. Evidence indicates that ACE1 may influence ACE2 expression. …”
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Bisecting GlcNAc modification of vesicular GAS6 regulates CAFs activation and breast cancer metastasis by Jing Li, Xueting Ren, Lin Cao, Kaixiang Min, Meng Wang, Shuai Lin, Lei Lei, Zengqi Tan, Xiaoliang Cheng, Xiang Li, Feng Guan

“…Breast cancer-derived sEVs stimulated the conversion of normal fibroblasts to CAFs, with GAS6 in sEVs playing a key role by interacting with AXL receptors on fibroblasts. Introducing GAS6 into normal fibroblasts induced their conversion into CAFs, which enhanced breast cancer cell metastasis. …”
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Dataset of microscale atmospheric flow and pollutant concentration large-eddy simulations for varying mesoscale meteorological forcing in an idealized urban environmentZenodo by Eliott Lumet, Thomas Jaravel, Mélanie C. Rochoux

“…Given these issues, the construction of CFD datasets that account for uncertainty would be an interesting avenue of research for microscale atmospheric science.In this context, we present the PPMLES (Perturbed-Parameter ensemble of MUST Large-Eddy Simulations) dataset, which consists of 200 large-eddy simulations (LES) characterizing the complex interactions between the turbulent airflow, the tracer dispersion, and an idealized urban environment. …”
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The use of human tissue surrogates in anatomical modeling for gunshot wounds simulations: an overview about “how to do” experimental terminal ballistics by Lucas Meciano Pereira dos Santos, Marcelo Rodrigues da Cunha, Carlos Henrique Bertoni Reis, Daniela Vieira Buchaim, Daniela Vieira Buchaim, Ana Paula Bernardes da Rosa, Leandro Moreira Tempest, José Augusto Parola da Cruz, Rogério Leone Buchaim, Rogério Leone Buchaim, João Paulo Mardegan Issa, João Paulo Mardegan Issa

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Analysis of Metabolic Risk Factors for Microcirculation Disorders Post-Percutaneous Coronary Intervention and Predictive Model Construction: A Study on Patients with Unstable Angin... by Kangming Li, Shuang Liu, Jing Wang, Zhen Liu, Chunmei Qi

“…Subgroup analysis confirmed no significant interaction between the model and sex (p > 0.05). A nomogram was constructed based on the training set, with the area under the curve (AUC) for the ROC of 0.824 in the training set and 0.746 in the validation set. …”
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Citizen engagement in public food procurement, a novel choose-your-own-adventure canteen campaign case study by Luke John Schafer, Anna Gundorph, Carla Mingolla, Christian Bugge Henriksen, Marin Lysak, Reni Todorova Boncheva, Maarten Crivits

“…This approach embedded the FoodSHIFT Citizen Empowerment Scheme, merging interactive engagement with flexible digital participation to enhance user input. …”
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Evaluating the dual impact of microbial activity and aged refuse layers on landfill leachate clogging: An experimental and LCA perspective by Zhaobin Li, Waifan Tang, Shulun Mak, Siukei Lam, Qingwen Li

“…Background: Leachate-induced clogging in landfill drainage systems significantly impairs operational efficiency while posing substantial environmental risks. The complex interactions among leachate components (e.g., organic matter, heavy metals, and inorganic salts), microbial communities, and inorganic precipitates lead to clogging that reduces hydraulic conductivity. …”
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The <i>Meq</i> Genes of Nigerian Marek’s Disease Virus (MDV) Field Isolates Contain Mutations Common to Both European and US High Virulence Strains by Joseph N. Patria, Luka Jwander, Ifeoma Mbachu, Levi Parcells, Brian Ladman, Jakob Trimpert, Benedikt B. Kaufer, Phaedra Tavlarides-Hontz, Mark S. Parcells

“…Several of the <i>meq</i> genes were cloned for expression and their localization ability to interact with the chicken NF-IL3 protein, a putative Meq dimerization partner, were assessed. …”
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What is the relationship between exposure to environmental pollutants and severe mental disorders? A systematic review on shared biological pathways by Pierluigi Catapano, Mario Luciano, Salvatore Cipolla, Daniela D'Amico, Alessandra Cirino, Maria Chiara Della Corte, Gaia Sampogna, Andrea Fiorillo

“…Severe mental disorders are multi-dimensional constructs, resulting from the interaction of genetic, biological, psychosocial, and environmental factors. …”
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Re-annotation of SARS-CoV-2 proteins using an HHpred-based approach opens new opportunities for a better understanding of this virus by Brézellec, Pierre

“…We first show that the C-terminal part of Spike S (the protein that binds the virion to the cell membrane by interacting with the host receptor, triggering infection) has similarities with the human prominin-1/CD133; after reviewing what is known about prominin-1/CD133, we suggest that the C-terminal part of Spike S could both improve the docking of Spike S to ACE2 (the main cell entry receptor for SARS-CoV-2) and be involved in the delivery of virions to regions where ACE2 is located in cells. …”
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UBE2J1 is identified as a novel plasma cell-related gene involved in the prognosis of high-grade serous ovarian cancer by Yunjie Tian, Ruoyu Dong, Yingxia Guan, Ying Wang, Wei Zhao, Jun Zhang, Shan Kang

“…Within HGSOC tissues, these plasma cells were found to interact with CD8 + T cells, fibroblasts and endothelial cells. …”
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Effects of dribbling restrictions in small-sided games on aerobic and anaerobic fitness in youth basketball players by Mingbang Li, Liang Tan, Hong Wu, Jianwei Wu

“…Statistical analysis was conducted using a mixed ANOVA to examine the interactions between time and group.ResultsComparisons of YYIRT between groups at post-intervention revealed that limitedD performed significantly better than both freeD (p = 0.035; d = 1.038) and the control group (p &lt; 0.001; d = 2.050), while freeD also showed significantly better performance (p = 0.021; d = 0.082) than the control group. …”
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Identification and verification of autophagy-related gene signatures and their association with immune infiltration and drug responsiveness in epilepsy by Han-han He, Xiao-ge Zhang, Fen-fang Chen

“…Subsequently, protein–protein interaction, transcription factors and miRNAs networks were constructed. …”
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Relationship Between the Salivary Microbiome and Oral Malodor Metabolites in Older Thai Individuals with Periodontitis and the Cytotoxic Effects of Malodor Compounds on Human Oral... by Witsanu Srila, Kritsana Sripilai, Thunwa Binlateh, Peungchaleoy Thammanichanon, Watcharaphol Tiskratok, Parinya Noisa, Paiboon Jitprasertwong

“…Additionally, we expanded the study to examine how oral malodorous compounds interact with human oral squamous carcinoma (HSC-4) cells. …”
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