Comprehensive Hematological and molecular Characterization of hemoglobin Hekinan [α27(B8)Glu→Asp(α1), HBA1:c.84G > T] in a Large Thai cohort by Amornchai Suksusut, Jidapa Jaitheang, Manussavee Prapphal, Pranee Sutcharitchan, Ponlapat Rojnuckarin, Noppacharn Uaprasert

“…Most cases are clinically benign, even when interacting with other thalassemia syndromes or Hb variants.…”
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A Resource-Efficient Multi-Entropy Fusion Method and Its Application for EEG-Based Emotion Recognition by Jiawen Li, Guanyuan Feng, Chen Ling, Ximing Ren, Xin Liu, Shuang Zhang, Leijun Wang, Yanmei Chen, Xianxian Zeng, Rongjun Chen

“…Emotion recognition is an advanced technology for understanding human behavior and psychological states, with extensive applications for mental health monitoring, human–computer interaction, and affective computing. Based on electroencephalography (EEG), the biomedical signals naturally generated by the brain, this work proposes a resource-efficient multi-entropy fusion method for classifying emotional states. …”
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Nano-delivery platform with strong protection and efficient delivery: preparation of self-assembled RNA pesticide with dual RNAi targets against Apolygus lucorum by Heng Qiao, Qinhong Jiang, Jing Zhao, Liubin Xiao, Keyan Zhu-Salzman, Dejin Xu, Guangchun Xu, Jie Shen, Aiguo Gu, Dejun Hao, Shuo Yan, Yongan Tan

“…Results The nanocarrier SPc was applied to assemble with dsRNA via electrostatic interaction, hydrogen bond and Van der Waals force, and the self-complexation with SPc formed nanoscale dsRNA/SPc complex. …”
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Therapeutic target genes and regulatory networks of gallic acid in cervical cancer by Zhixi You, Ye Lei, Yongkang Yang, Zhihui Zhou, Xu Chao, Keyi Ju, Songyi Wang, Yuanyuan Li, Yuanyuan Li

“…Subsequently, the function enrichment analysis and protein–protein interaction of the DEGs were conducted. The candidate genes were identified using the Cytoscape software Gentiscape2.2 and MCODE plug-ins. …”
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Non-Linear Biomechanical Evaluation and Comparison in the Assessment of Three Different Piece Dental Implant Systems for the Molar Region: A Finite Element Study by Jesus Alejandro Serrato-Pedrosa, Ignacio Villanueva-Fierro, Rodrigo Arturo Marquet-Rivera, Rosa Alicia Hernández-Vázquez, Salvador Cruz-Lopez, Verónica Loera-Castañeda

“…Understanding the biomechanical behavior of implant–tissue interactions is crucial for achieving successful and long-lasting implant therapy. …”
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Glucose‐induced LINC01419 reprograms the glycolytic pathway by recruiting YBX1 to enhance PDK1 mRNA stability in hepatocellular carcinoma by Yanfang Liu, Junjiao Song, Qili Shi, Bing Chen, Wenying Qiu, Yizhe Liu, Shenglin Huang, Xianghuo He

“…Mechanistically, LINC01419 directly interacted with Y‐box binding protein 1 (YBX1) in the cytoplasm and facilitated its binding to PDK1 mRNA, thus enhancing PDK1 mRNA stability and increasing lactate production. …”
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Acceptability and effectiveness of a study information video in improving the research consent process for youth: a non-inferiority trial by Sarah Bernays, Victoria Simms, Chido Dziva Chikwari, Katharina Kranzer, Tsitsi Bandason, Rashida Abbas Ferrand, Ethel Dauya, Constance R S Mackworth-Young, Mandikudza Tembo, Constancia Mavodza, Tinashe Cynthia Mwaturura, Som Kumar Shrestha, Salmaan Ferrand, Talent Shavani

“…Youth (N=90) described both consent methods as interactive and inclusive. Those in the video consent arm felt it was exciting and youth focused. …”
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Learning from wildfires: A scalable framework to evaluate treatment effects on burn severity by Caden P. Chamberlain, Garrett W. Meigs, Derek J. Churchill, Jonathan T. Kane, Astrid Sanna, James S. Begley, Susan J. Prichard, Maureen C. Kennedy, Craig Bienz, Ryan D. Haugo, Annie C. Smith, Van R. Kane, C. Alina Cansler

“…As wildfires and treatments continue to interact, managers require consistent approaches to evaluate treatment effectiveness at moderating burn severity. …”
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GWAS Identifies SNP Markers and Candidate Genes for Off-Flavours and Protein Content in Faba Bean (<i>Vicia faba</i> L.) by Antonio Lippolis, Boudewijn Hollebrands, Valentina Acierno, Catrienus de Jong, Laurice Pouvreau, João Paulo, Salvador A. Gezan, Luisa M. Trindade

“…The growing environment significantly affected all traits, with trait-specific genotype-by-year (GxY) interactions. Condensed tannins and fatty acids were the most stable across the two years and had the highest heritability estimates (<i>h</i>² > 0.6). …”
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Participant experiences in HIV cure-directed trial with an extended analytical treatment interruption in Philadelphia, United States by Andrea Bilger, Eion Plenn, Frances K. Barg, Katharine A. Rendle, William B. Carter, Andrea Lamour-Harrington, Nora Jones, Beth Peterson, John A. Sauceda, Pablo Tebas, Karam Mounzer, David Metzger, Luis J. Montaner, Karine Dubé

“…Although trial experiences were heterogeneous, participants unanimously had positive interactions with the clinical trial staff which facilitated their retention in the trial. …”
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Impact of prior CAR T-cell therapy on mosunetuzumab efficacy in patients with relapsed or refractory B-cell lymphomas by Elise A. Chong, Elicia Penuel, Ellen B. Napier, Rachel K. Lundberg, Lihua E. Budde, Mazyar Shadman, Matthew J. Matasar, Nancy L. Bartlett, Ian W. Flinn, Francesc Bosch, Keith Fay, Andre Goy, Anita Kumar, Loretta J. Nastoupil, Michael C. Wei, Mei Wu, Shen Yin, Joseph A. Fraietta, Emeline R. Chong, Stephen J. Schuster

“…These findings suggest an interaction between prior CAR-T and BsAb outcomes and have implications for optimal timing of BsAb after CAR-T. …”
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Dual-functional passivation on highly-efficient air-processed FAPbI₃ perovskite solar cells fabricated under high humidity without auxiliary equipment by Bo-Tau Liu, His-Sheng Su, I-Ru Chen, Rong-Ho Lee, Yi-Fang Su, Kai-Ting Sun, Shoaib Siddique

“…The MAA incorporation not only decreases pinholes in the perovskite layer but also passivates the deep-level defects through the interaction of carboxyl groups with formamidinium cations, resulting in a low trap-state density, high charge recombination resistance, and long charge lifetime. …”
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FadA antigen of Fusobacterium nucleatum: implications for ceRNA network in colorectal cancer and adenomatous polyps progression by Sama Rezasoltani, Elahe Shams, Moein Piroozkhah, Yaser Aidi, Mehdi Azizmohammad Looha, Parmida Bagheri, Roudabeh Behzadi Andouhjerdi, Amir Sadeghi, Leili Rejali, Ehsan Nazemalhosseini-Mojarad

“…According to our previous study to identify shared MicroRNA-Interaction-Targets (MITs) between ANXA2 and LINC00460, TargetScanHuman (V7.2) and miRDB databases have been used respectively. …”
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Integrated bioinformatics analysis of the effects of chronic pain on patients with spinal cord injury by Jinlong Zhang, Jinlong Zhang, Longju Qi, Yuyu Sun, Yuyu Sun, Shiyuan Chen, Jinyi Liu, Jiaxi Chen, Fangsu Yan, Wenqi Wang, Qinghua Wang, Liang Chen

“…Additionally, we conducted an in-depth examination of immune infiltration in SCI to elucidate its correlation with chronic pain.ResultsAnalyzing 101 DEGs associated with SCI and chronic pain, we constructed a protein interaction network and identified 15 hub genes. Using bioinformatics tools, we further identified 4 potential candidate genes. …”
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Body composition as an indicator of metabolic changes in mice obtained by <i>in vitro</i> fertilization by M. V. Anisimova, Yanli Gon, G. V. Kontsevaya, A. V. Romashchenko, N. V. Khotskin, A. K. Stanova, L. A. Gerlinskaya, M. P. Moshkin

“…At the same time, IVF offspring outperformed control individuals in relative fat content, but were behind in terms of lean mass. The effect of the interaction of factors was not statistically significant. …”
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Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson’s Disease Animal Models from a Molecular Signaling Perspective by Lucas Udovin, Cecilia Quarracino, María I. Herrera, Francisco Capani, Matilde Otero-Losada, Santiago Perez-Lloret

“…Another major pathway involves IκB kinase (IKK) downregulation by ARL6ip5 (ADP-ribosylation-like factor 6 interacting protein 5, encoded by the cell differentiation-associated, JWA, gene). …”
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Identification and validation of diagnostic genes IFI44 and IRF9 in insomnia-associated autoimmune uveitis by Chao Wu, Hui Feng, Meng Tian, Baorui Chu, Xianyang Liu, Shuhao Zeng, Yakun Wang, Hong Wang, Shengping Hou, Qingfeng Liang

“…Weighted gene co-expression network analysis (WGCNA), protein-protein interaction (PPI), functional enrichment, and CMap analyses were then performed to identify pathogenic genes, underlying mechanisms, and potential therapeutic drugs for insomnia-associated AU. …”
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Bradykinin B1 receptor signaling triggers complement activation on endothelial cells by Ingrid Lopatko Fagerström, Alexandra Gerogianni, Markus Wendler, Ida Arvidsson, Ashmita Tontanahal, Ann-Charlotte Kristoffersson, Fatimunnisa Qadri, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Michael Bader, Diana Karpman

“…IntroductionThe complement and kallikrein-kinin systems (KKS) are both activated during vascular inflammation, and there are many known interactions between the two systems. This study investigated if KKS activation induced complement activation on endothelial cells, and if activation was dependent on bradykinin B1 receptor (B1R) signaling.MethodsKKS was activated in normal human serum by kaolin or activated factor XII (FXIIa). …”
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Contrasting spatial variations between above and below-ground net primary productivity in global grasslands by Ying Hu, Yue Yang, Yu Wei, Xiaozhen Li, Yue Jiao, Jiapei Liao, Ruiyu Fu, Lichong Dai, Zhongmin Hu

“…In drier regions (MAP < 500 mm), a threshold effect was observed, while in more humid regions (MAP > 500 mm), the positive effect was more pronounced. The interaction of climate, soil and vegetation indices had the most significant explanatory power for productivity. …”
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Functionalization of sawdust biochar using Mg-Fe-LDH and sodium dodecyl sulfonate enhanced its stability and immobilization capacity for Cd and Pb in contaminated water and soil by Xin Pan, Shaoping Kuang, Xiao Wang, Habib Ullah, Zepeng Rao, Esmat F. Ali, Qumber Abbas, Sang Soo Lee, Sabry M. Shaheen

“…The higher removal/immobilization efficiency of MSB could be attributed to its alkalinity, and the enhanced synergistic interactions including surface precipitation, ion exchange, complexation, and hydrogen bonding. …”
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