An Exceptionally Powerful, Radiatively Driven Ultrafast Outflow in the Rapidly Accreting AGN RE J1034+396 by Chloe S. Taylor, Daniel R. Wilkins, Steven W. Allen

“…The high terminal velocity and substantial absorbing column density imply that the outflow carries sufficient momentum and energy to transform its environment, being capable of driving out essentially all dust and gas it interacts with along the line of sight, even if the AGN were initially surrounded by a Compton-thick absorber.…”
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Kaempferol protects against high-salt-induced hypertension and vascular endothelial injury by inhibiting ferroptosis through the ATF4/ACSL4 pathway by Qiuer Liang, Minghao Chen, Guangtian Chen, Pengli Xu, Lai Kwan Lam, Pengcheng Xie, Ting Xie, Wanqing Tu, Tianhao Liu, Xiaopeng Peng, Haoyao Yuan, Liguo Chen, Ya Xiao

“…Surface plasmon resonance and molecular docking analyses revealed that Kae directly binds to ATF4, while proteome microarray and co-immunoprecipitation assays demonstrated that ATF4 interacts with ACSL4 in HAECs. Furthermore, inhibition of ATF4 or ACSL4 effectively alleviated endothelial ferroptosis induced by high-salt stress. …”
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Density functional theory calculation for understanding the roles of biochar in immobilizing exchangeable Al3 + and enhancing soil quality in acidic soils by Debo He, Xinyi Liu, Dongni Hu, Ping Lei, Jinbo Zhang, Zhixin Dong, Bo Zhu

“…This preferential adsorption was attributed to the stronger interaction and higher bond dissociation energy between biochar functional groups and Al3+. …”
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Trends to shorter diagnostic delay in spondyloarthritis patients during the last decades and association with clinical presentation: data from ASAS-COMOSPA study by Robert Landewé, Désirée van der Heijde, Filip van den Bosch, Maxime Dougados, Anna Molto, Stefan Siebert, Juergen Braun, Yuko Kaneko, Adeline Ruyssen-Witrand, Martin Soubrier, Atsuo Taniguchi, Masato Okada, Alain Cantagrel, Shigeto Kobayashi, Jon Packham, Philippe Goupille, Rene-Marc Flipo, Alain Saraux, Philippe Gaudin, Roberto Caporali, Raj Sengupta, James Cheng-Chung Wei, Tetsuya Tomita, Fernando Pimentel-Santos, Alberto Ortiz, Gaëlle Varkas, Alejandro Martínez, Shigeyoshi Tsuji, Alejandro Alvarellos, José Maldonado-Cocco, Yoshinori Taniguchi, Fadoua Allali, Raquel Almodovar González, Elena Alonso Blanco-Morales, Maria Aparicio Espinar, Pamir Atagunduz, Pauline Bakker, Leila Benbrahim, Bahia Benchekroun, Alberto Berman, Pedro Carvalho, Gustavo Casado, Francisco Colombres, Eugenio del Miguel Mendieta, Vanesa Duarte, Cristina Fernandez Carballido, Manuel Fernandez-Prada, Pilar Font Ugalde, Dolors Grados Cánovas, Jordi Gratacós Masmitjá, Vittorio Grosso, Naomi Ichikawa, Hisashi Inoue, Taku Kawasaki, Manjari Lahiri, Hernán Maldonado-Ficco, Kazuo Matsui, Ramón Mazzuchelli Esteban, Corinne Micelli, Chisun Min, Mitsuhiro Morita, Juan Mulero Mendoza, Gisela Pendón, Dora Pereira, Hanan Rkain, Oscar Rillo, Carlos Rodriguez Lozano, Adrián Salas, Carlos Salinas-Ramos, Amelia Santosa, Caroline Spiegel, Carmen Stolwijk, Kurisu Tada, Naoho Takizawa, Chung Tei Chou, Lay-Keng Teoh, Wen-Chan Tsai, Olga Tsyplenkova, Kiana Vakil-Gilani, Rafael Valle-Oñate, Virginia Villaverde, Ai Yap, Pedro Zarco Montejo, Juan C Barreira, Juan D Diaz-Garcia, Michel De Bandt, Astrid van Tubergen, Rodolfo Pérez-Alamino, T Marhadour, Christian Waimann, Mari CruzFernandez Espartero, Jose Raul NogueraPons, José A PereiradaSilva

“…P value<0.05 was considered statistically significant. A possible interaction between decade of disease onset and initial clinical presentation was performed.Results The overall median delay from disease onset to SpA diagnosis was 2.9 (p25−75=0.3–9.8) years. …”
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Targeting of the HER2/HER3 signaling axis overcomes ligand‐mediated resistance to trastuzumab in HER2‐positive breast cancer by Satomi Watanabe, Kimio Yonesaka, Junko Tanizaki, Yoshikane Nonagase, Naoki Takegawa, Koji Haratani, Hisato Kawakami, Hidetoshi Hayashi, Masayuki Takeda, Junji Tsurutani, Kazuhiko Nakagawa

“…HER3 ligand (heregulin)‐dependent HER2‐HER3 interactions play a critical role in the evasion of apoptosis and are therefore a target for oncotherapy to treat HER2‐positive breast cancer. …”
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Exploring the impact of genetic factors and fatty acid quality on visceral and overall Fat levels in overweight and obese women: a genetic risk score study by Niloufar Rasaei, Atefeh Tavakoli, Saba Mohammadpour, Mehdi Karimi, Alireza Khadem, Azam Mohamadi, Seyedeh Fatemeh Fatemi, Fatemeh Gholami, Khadijeh Mirzaei

“…However, there was a notable interaction between the GRS and the N6/N3 score on VAI, suggesting that obese women with high obesity-related SNPs who consumed foods with a higher ratio of N6/N3 fatty acids tended to have an increased VAI. …”
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Efficacy and safety of edoxaban in patients with chronic thromboembolic pulmonary hypertension: protocol for a multicentre, randomised, warfarin-controlled, parallel group trial -... by Keiichi Fukuda, Satoshi Yasuda, Hiroyuki Tsutsui, Toyoaki Murohara, Kohtaro Abe, Koichiro Tatsumi, Junji Kishimoto, Yu Taniguchi, Yuichi Tamura, Koji Todaka, Shun Minatsuki, Kazuya Hosokawa, Yuko Kobayakawa, Takumi Inami, Nobutaka Ikeda

“…The anticoagulant activity of warfarin is affected by food and drug interactions, requiring regular monitoring of prothrombin time. …”
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Adsorption of Chromium(VI) onto Freshwater Snail Shell-Derived Biosorbent from Aqueous Solutions: Equilibrium, Kinetics, and Thermodynamics by Xuan Hoa Vu, Lan Huong Nguyen, Huu Tap Van, Dinh Vinh Nguyen, Thu Huong Nguyen, Quang Trung Nguyen, L. T. Ha

“…The adsorption mechanisms were electrostatic interaction and ion exchange. Simultaneously, this mechanism was also controlled by film diffusion. …”
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Strategies to mitigate the impact of the COVID-19 pandemic on child and youth well-being: a scoping review protocol by Jeanna Parsons Leigh, Henry T Stelfox, Perri R Tutelman, Diane L Lorenzetti, Melanie C Anglin, Kirsten M Fiest, Stephana Julia Moss, Emily A FitzGerald, Stacie Smith, Micaela Harley, Kathryn Birnie, Sara J Mizen

“…Findings of this study will be disseminated at national and international conferences and will inform our pan-Canadian multidisciplinary team of researchers, public, health professionals and knowledge users to codesign and pilot test a digital psychoeducational health tool—an interactive, web-based tool to help Canadian youth and their families address poor mental well-being resulting from and persisting beyond the COVID-19 pandemic.…”
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Evaluation of exo-long noncoding RNA MALAT1 in OSCC in comparison to dysplastic and normal: A cross-sectional study by Ramya Sekar, Selvaraj Jayaraman, VishnuPriya Veeraraghavan, Kalaiselvi Krishnamoorthy, Shubhra Chauhan Aramanai, Sathan Raj Natarajan

“…Continued research into MALAT1's regulatory roles and its interactions within the tumor microenvironment holds promise for uncovering novel therapeutic targets and biomarkers that could redefine the management of OSCC in the future.…”
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RIPK2-Mediated Autophagy and Negatively Regulated ROS-NLRP3 Inflammasome Signaling in GMCs Stimulated with High Glucose by Chenlin Gao, Jiao Chen, Fang Fan, Yang Long, Shi Tang, Chunxia Jiang, Jiying Wang, Youhua Xu, Yong Xu

“…Hyperglycemia plays a vital role in diabetic nephropathy (DN); autophagy and its potential upregulator receptor-interacting protein kinase 2 (RIPK2) are associated with ROS, which play a potential role in regulating NLRP3, and may be involved in inflammation in DN. …”
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MP-LLAVRec: an agricultural product recommendation algorithm based on LLAVA and user modal preference by Peishan Li, Peishan Li, Peishan Li, Lutao Gao, Lutao Gao, Lutao Gao, Lilian Zhang, Lilian Zhang, Lilian Zhang, Lin Peng, Lin Peng, Lin Peng, Chunhui Bai, Chunhui Bai, Chunhui Bai, Linnan Yang, Linnan Yang, Linnan Yang

“…It consisted of three main components: (1) LLAVA data enhancement, which introduced a multimodal macromodel to improve the understanding of node attributes; (2) agricultural product association relationship fusion, which constructed and improved the complex association network structure among products to ensure that the system can better understand the substitution relationship, complementary relationship, and implied consumption logic among products; (3) user modal preference feature extraction block, which deeply mined the interaction data between consumers and products, and advanced the effective user feature information from the correspondence between global user representations and local modal user representations.Results and DiscussionWe conduct experiments on a real dataset from Amazon's large-scale e-commerce platform to verify the effectiveness of MP-LLAVRec. …”
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Assessing the neuroprotective potential of Eucalyptus globulus essential oil in a 6-hydroxydopamine rat model of Parkinson's disease by Aracely Janneth Naranjo-Viteri, Matías Jávega Cometto, Matías Caverzan, Leandro Gabriel Champarini, María Paula Zunino, Rogelio E. Abburra, Claudia B. Hereñú, Rosana Crespo

“…Discussion: Although 1,8-cineole is a well-documented bioactive compound, further research is required to evaluate its potential synergistic or additive interactions with minor components. Our findings highlight the remarkable neuroprotective potential of EuEO and encourage further research of this very promising therapeutic alternative.…”
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A single-cell transcriptome analysis reveals astrocyte heterogeneity and identifies CHI3L1 as a diagnostic biomarker in Parkinson's disease by Zhongying Gong, Dan Guo, Yufeng Lin, Zhiwei Liu, Mengdi Lv, Xinxin Liu, Yang Yao, Sijia Wang, Yuan Wang, Zhiyun Wang

“…Astrocytes exhibiting elevated CHI3L1 levels demonstrated interactions with microglia in PD patients. Lastly, we discovered that CHI3L1 was significantly overexpressed in PD patients and exhibited strong diagnostic potential for the disease. …”
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Effect of triple-frequency sono-germination and soaking treatments on techno-functional characteristics of barley by Tabussam Tufail, Huma Bader Ul Ain, Jawad Ashraf, Muhammad Safiullah Virk, Zahoor Ahmed, Mokhtar Dabbour, Tawfiq Alsulami, Suleiman Althawab, Bin Xu

“…Strong intermolecular interactions were observed in both ZQ2000 and XMLY22 samples subjected to TFUT, GE, TFUT + GE, and TS, as validated by FTIR and molecular docking analyses. …”
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Black Carbon Exposure Characteristics in Diesel Engine Vehicle-related Jobs by Sangjun Choi, Ju-Hyun Park, Won Kim, Seung Won Kim, Kyong-Hui Lee, Taejin Chung, Jihoon Park, Seung-Hun Ryu, Jungah Shin, Dong-Hee Koh, Dong-Uk Park

“…After accounting for the random effects of the individual workers and working dates (evaluated per occupation) as well as the fixed effects of the determinants and their pairwise interaction terms (p < 0.001), we found that all four of the determinants significantly differed in their associated levels of BC exposure. …”
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Periplanta americana extract regulates the Th17/Treg cell balance via Notch1 in ulcerative colitis by Yanqiu Zheng, Yanqiu Zheng, Huibiao Li, Shiyu Qi, Fan Xiao, Jinbin Song, Shiyin Liu, Xinlin Chen, Yanwu Li, Muyuan Chen

“…Network pharmacological analysis showed that the targets of UC intervention by PAE may be closely related to Th17 cell differentiation, the IL-17 signaling pathway, and cytokine-cytokine receptor interaction. Mechanistically, PAE regulated the balance of Th17/Treg and inhibited the Notch1/Math1 pathway in the colon of UC mice. …”
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Drug Efficacy Recommendation System of Glioblastoma (GBM) Using Deep Learning by Sajid Naveed, Mujtaba Husnain, Ali Samad, Amna Ikram, Hina Afreen, Ghulam Gilanie, Najah Alsubaie

“…The Genomics of Drug Sensitivity in Cancer (GDSC) database was used as the primary data source, containing 135,242 cell line-drug interactions, inhibitory concentration of cancer drug for more than 800 cancer cell lines. …”
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Genome-wide identification and functional roles relating to anthocyanin biosynthesis analysis in maize by Xiaofang Wang, Huangai Li, Shuai Wang, Meiqi Ruan, Yiping Li, Lei Zhu, Zhenying Dong, Yan Long

“…Furthermore, the gene expression patterns of the ten highly expressed genes and their potential interacting transcriptional factors were analyzed across the four inbred lines. …”
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Insulin Resistance Associated with Plasma Xanthine Oxidoreductase Activity Independent of Visceral Adiposity and Adiponectin Level: MedCity21 Health Examination Registry by Masafumi Kurajoh, Shinya Fukumoto, Takayo Murase, Takashi Nakamura, Takuma Ishihara, Hirofumi Go, Kouji Yamamoto, Shinya Nakatani, Akihiro Tsuda, Tomoaki Morioka, Katsuhito Mori, Yasuo Imanishi, Masaaki Inaba, Masanori Emoto

“…Multiple regression analysis showed that HOMA-IR was significantly (p=0.020) associated with plasma XOR activity independent of other factors, including VFA and adiponectin level, as well as age, sex, alcohol drinking habit, smoking habit, alanine transaminase, HbA1c, and eGFR. The “sex∗HOMA−IR” interaction was not significant (p=0.89), indicating that sex difference does not have an effect on the relationship between HOMA-IR and plasma XOR activity. …”
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