Role of apoptosis genes in aggression revealed using combined analysis of ANDSystem gene networks, expression and genomic data in grey rats with aggressive behavior by A. O. Bragin, O. V. Saik, I. V. Chadaeva, P. S. Demenkov, A. L. Markel, Yu. L. Orlov, E. I.  Rogaev, I. N. Lavrik, V. A. Ivanisenko

“…It was shown that polymorphic and differentially expressed genes were statistically significantly overrepresented among ge nes interacting with neuronal apoptosis genes (p value < 0.01). …”
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Involvement of the Dectin-1 Receptor upon the Effector Mechanisms of Human Phagocytic Cells against Paracoccidioides brasiliensis by Juliana Carvalho de Quaglia e Silva, Amanda Manoel Della Coletta, Taiane Priscila Gardizani, Graziela Gorete Romagnoli, Ramon Kaneno, Luciane Alarcão Dias-Melicio

“…When the fungus reaches the lungs and interacts with the alveolar macrophages and other cells, phagocytic cells such as neutrophils and monocytes are immediately recruited to the injured site. …”
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The association between TyG index and cardiovascular mortality is modified by antidiabetic or lipid-lowering agent: a prospective cohort study by Changchang Fang, Nanqin Peng, Jiang Cheng, Xiyu Zhang, Wenli Gu, Zicheng Zhu, Xiaoping Yin, Zhiwei Yan, Jing Zhang, Peng Yu, Xiao Liu

“…The TyG index was significantly associated with all-cause and CVD mortality, and these associations were modified by the use of antidiabetic and hypolipidemic agents (p < 0.01). Significant interactions were observed between the TyG index and the use of these agents for mortality outcomes after full adjustments (p-value for interaction < 0.05). …”
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Single-cell sequencing reveals cell heterogeneity and aberrantly activated pathways associated with microvascular invasion in hepatocellular carcinoma by Jianwei Cui, Fanyi Zeng, Ming Tang, Ming Tang, Shiwu Yin, Shiwu Yin

“…The MARCKSL1 gene was predominantly expressed in MVI-positive malignant cells and may contribute to MVI progression by interacting with the PTN signalling network. Additionally, MARCKSL1 is linked to tumour resistance to multiple anticancer drugs.DiscussionThis study sheds light on the molecular characteristics and functional heterogeneity of MVI-associated malignant cell subpopulations. …”
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Association of blood cadmium and physical activity with mortality: A prospective cohort study by Yilin Chen, Cien Zhen, Lin Zeng, Hongliang Feng, Jinyu Wang, Qi Yong H. Ai, Sizhi Ai, Jihui Zhang, Yannis Yan Liang, Huachen Xue, Yujing Zhou

“…Blood cadmium and PA had multiplicative interactions on mortality risk (all P interaction < 0.05). …”
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Classic and Novel Sex Hormone Binding Globulin Effects on the Cardiovascular System in Men by Carla Basualto-Alarcón, Paola Llanos, Gerardo García-Rivas, Mayarling Francisca Troncoso, Daniel Lagos, Genaro Barrientos, Manuel Estrada

“…Although obesity and insulin resistance are associated with an increased incidence of cardiovascular disease, whether they lead to abnormal expression of circulating SHBG or its interaction with androgen signaling remains to be elucidated. …”
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Prognostic value of remnant-like particle cholesterol in ischemic heart failure patients following percutaneous coronary intervention by Xin Huang, Tienan Sun, Biyang Zhang, Meishi Ma, Zheng Chen, Zehao Zhao, Shutong Dong, Yujie Zhou

“…Subgroup analyses were performed and interactions were assessed.Result The study results showed a clear association between higher RLP-C levels and an increased incidence of MACE in the participants. …”
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Resveratrol-Based Carbamates as Selective Butyrylcholinesterase Inhibitors: Design, Synthesis, Computational Study and Biometal Complexation Capability by Maja Sviben, Ilijana Odak, Danijela Barić, Milena Mlakić, Ottó Horváth, Lajos Fodor, Sunčica Roca, Ivana Šagud, Irena Škorić

“…Molecular docking of the most promising inhibitor candidates, compounds <b>1</b> and <b>7</b>, revealed that stabilizing interactions between the active site residues of BChE and the ligands involve π-stacking, alkyl-π interactions, and, when the carbamate orientation allows, H-bond formation. …”
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Single‐cell RNA‐sequencing and spatial transcriptomic analysis reveal a distinct population of APOE− cells yielding pathological lymph node metastasis in papillary thyroid cancer... by Guohui Xiao, Rongli Xie, Jianhua Gu, Yishu Huang, Min Ding, Dongjie Shen, Jiqi Yan, Jianming Yuan, Qiong Yang, Wen He, Siyu Xiao, Haizhen Chen, Dan Xu, Jian Wu, Jian Fei

“…APOE− tumor cells may promote tumor growth by interacting with dendritic cells and CD4+ T cells via CD99‐ rather than CD6‐regulated signaling. …”
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The Addition of Pumpkin Flour Impacts the Functional and Bioactive Properties of Soft Wheat Composite Flour Blends by Durim Alija, Remigiusz Olędzki, Daniela Nikolovska Nedelkoska, Agata Wojciechowicz-Budzisz, Gafur Xhabiri, Ewa Pejcz, Eljesa Alija, Joanna Harasym

“…Pumpkin flour addition systematically modified blend properties, with higher fine particle content (13.26% < 80 μm), enhancing water interaction capabilities (WHC increased from 2.52 to 3.56). …”
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Factors associated with girl child marriage in Iran: a qualitative socio-ecological approach by Asma Pourtaheri, Mehrsadat Mahdizadeh, Mehrsadat Mahdizadeh, Hadi Tehrani, Hadi Tehrani, Jamshid Jamali, Jamshid Jamali, Nooshin Peyman, Nooshin Peyman

“…Girl child marriage is not merely a personal or familial decision; rather, it is influenced by the interactions of different systems that can either exacerbate or mitigate the issue. …”
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Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in ca... by Ghazi Elamin, Ghazi Elamin, Zhichao Zhang, Depika Dwarka, Kabange Kasumbwe, John Mellem, Nompumelelo P. Mkhwanazi, Paradise Madlala, Paradise Madlala, Mahmoud E. S. Soliman

“…Therefore, this study explores the association between SNPs in Bcl-2 and the structural, functional, protein-protein interactions (PPIs), drug binding and dynamic characteristics.MethodsComprehensive cross-validated bioinformatics tools and molecular dynamics (MD) simulations. …”
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An in vitro study on comparative evaluation of shear bond strength of bioactive composite to tooth structure with various dentin conditioning agents by Priyanka Pokkula, Shaik Mohammed Asif, Abdullah Alqarni, Shahabe Saquib Abullais, Shaik Mohamed Shamsudeen, Syed M Yassin, Abosofyan S. Atta, Wahaj Ahmad Khan

“…A potent resin hydroxyapatite complex is formed due to ionic interaction, further preventing microleakage. Applying citric acid and maleic acid is an added advantage in removing the formed smear layer during cavity preparation. …”
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Genome-Wide Identification and In Silico Expression Analysis of <i>CCO</i> Gene Family in <i>Citrus clementina</i> (Citrus) in Response to Abiotic Stress by Sadaf Sarwar, Adnan Sami, Muhammad Zeshan Haider, Layba Tasawar, Jannat Akram, Arsalan Ahmad, Muhammad Shafiq, Haitham E. M. Zaki, Gabrijel Ondrasek, Muhammad Shafiq Shahid

“…To identify their structural features, they employed phylogenetic analysis, protein interactions, localization, structure, miRNA targets, evolutionary analysis, and transcriptome studies. …”
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A Metapopulation Model to Assess Water Management Impacts on the Threatened Australian Lungfish, <i>Neoceratodus forsteri</i> by Charles R. Todd, Andrew J. McDougall, Scott M. C. Raymond, Robin Hale, Timothy R. Brown, John D. Koehn, Henry F. Wootton, Steven G. Brooks, Adrian M. Kitchingman, Tom Espinoza, Benjamin G. Fanson, Peter K. Kind, Sharon M. Marshall, David T. Roberts

“…The model highlights the longer-term interaction between dams and stream flows on habitat availability and subsequent recruitment. …”
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Systematic analysis of co-expression network and gene expression profile of differentially expressed lncRNA-mRNA one week after spinal cord injury by Yi Kang, Yijie Song, Zhongju Shi, Qiang Li, Yigang Lv, Mengfan Hou, Cui Ding, Jing Xie, Yongfu Lou, Chi Zhang, Huan Jian, Xueying Li, Hengxing Zhou, Shiqing Feng

“…Moreover, we constructed protein–protein interaction (PPI) networks, the STRING database, and identified the 10 high degree core nodes. …”
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Emerging Risk Management in Industry 4.0: An Approach to Improve Organizational and Human Performance in the Complex Systems by F. Brocal, C. González, D. Komljenovic, P. F. Katina, Miguel A. Sebastián

“…Therefore, the objective of this paper is to propose an organizational and human performance approach to improve the emerging risk management linked to the complex systems, like as Human-Machine Interactions (HMI) and Human-Robot Interaction (HRI). …”
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Driving brain state transitions via Adaptive Local Energy Control Model by Rong Yao, Langhua Shi, Yan Niu, HaiFang Li, Xing Fan, Bin Wang

“…The brain, as a complex system, achieves state transitions through interactions among its regions and also performs various functions. …”
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Association between TCF7L2 Genotype and Glycemic Control in Diabetic Patients Treated with Gliclazide by Martin Javorský, Eva Babjaková, Lucia Klimčáková, Zbynek Schroner, Jozef Židzik, Mária Štolfová, Ján Šalagovič, Ivan Tkáč

“…After introducing an interaction term between the TCF7L2 genotype and the sulfonylurea type into multivariate model, the interaction became a significant predictor (P=0.023) of ΔHbA1c. …”
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Design of an Integrated Model Combining CycleGAN, PPO, and Vision Transformer for Adaptive Scene Rendering in the Metaverse by Durga Prasad Kavadi, Kailash Chandra Mishra, Sai Babu Veesam, Mudimela Madhusudhan, Palacharla Ravi Kumar, Pannangi Naresh, Yuvaraju Chinnam

“…Methods used for scene generation and rendering usually fail to incorporate user interactions in real time, leading to resource inefficiency and reduced user experience. …”
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