Polymorphic variants of the <i>hOGG1, APEX1, XPD, SOD2</i>, and <i>CAT</i> genes involved in DNA repair processes and antioxidant defense and their association with breast cancer r... by А. А. Timofeeva, V. I. Minina, A. V. Torgunakova, О. А. Soboleva, R. А. Тitov, Ya. А. Zakharova, M. L. Bakanova, А. N. Glushkov

“…Using MDR analysis, the most optimal statistically significant 3-locus model of gene-gene interactions in the development of luminal B Her2-negative subtype breast cancer was found. …”
Get full text

Ecological risk assessment and response prediction caused by LUCC in the central Yunnan Province by Yongdong Zhang, Zisheng Yang, Renyi Yang, Fuhua Liu, Yimei He, Linlin Cao, Jinrong Yang, Jiayi Zhang

“…ER is influenced by a combination of natural factors, socio-economic factors, and distance factors, with some factors having strong interactions. In short, the future ERs of CYP have decreased, and the ERs corresponding to various ecosystem services (ESs) interact with each other, causing a ripple effect. …”
Get full text

Host-symbiont-gene phylogenetic reconciliation by Menet, Hugo, Trung, Alexia Nguyen, Daubin, Vincent, Tannier, Eric

“…Motivation Biological systems are made of entities organized at different scales (e.g. macro-organisms, symbionts, genes…) which evolve in interaction. These interactions range from independence or conflict to cooperation and coevolution, which results in them having a common history. …”
Get full text

Teleconnections detection of land use carbon emissions beyond geographical proximity promotes the construction of cross-city networks by Lei Shen, Yinghong Jiang, Duanqiang Zhai, Peng Wang

“…The Yangtze River Delta urban agglomeration (YRDUA), as one of China's most developed regions, has seen rapid growth in all aspects of the cities due to rapid urbanization. However, urban interactions in some areas can no longer meet the goal of regional integration for the YRDUA. …”
Get full text

Crustacean Zooplankton Ingestion of Potentially Toxic <i>Microcystis</i>: In Situ Estimation Using <i>mcyE</i> Gene Gut Content Detection in a Large Temperate Eutrophic Lake by Helen Agasild, Margarita Esmeralda Gonzales Ferraz, Madli Saat, Priit Zingel, Kai Piirsoo, Kätlin Blank, Veljo Kisand, Tiina Nõges, Kristel Panksep

“…While laboratory investigations have provided extensive knowledge on zooplankton and toxic cyanobacteria interactions, information on zooplankton feeding on toxin-producing cyanobacteria in natural water bodies remains scarce. …”
Get full text

Bidirectional approach of Punica granatum natural compounds: reduction in lung cancer and SARS-CoV-2 propagation by Md. Abul Barkat, Afreen Fatima, Bushra Riaz, Mohd. Zaheen Hassan, Tanveer Ahamad, Abdulkareem A. Alanezi, Harshita Barkat, Afaf F. Almuqati, Yahya I. Asiri, Sahabjada Siddiqui

“…The glide module of Maestro software was used to investigate the molecular-docking interaction of the constituents against main protease (Mpro) and papain-like protease (PLpro) of SARS-CoV-2. …”
Get full text

The effects of vessel speed and size on the lethality of strikes of large whales in U.S. waters by Lance P. Garrison, Niki E. Lisi, Meghan Gahm, Eric M. Patterson, Hannah Blondin, Hannah Blondin, Caroline P. Good

“…In this study, we reviewed and updated available data on observed whale-vessel interactions in U.S. waters and developed a new model characterizing the probability that an interaction will be lethal to the whale as a function of vessel speed, length (as a proxy for mass), and whale taxon. …”
Get full text

Polydomus karssenii gen. nov. sp. nov. is a dark septate endophyte with a bifunctional lifestyle parasitising eggs of plant parasitic cyst nematodes (Heterodera spp.) by Samad Ashrafi, Jan-Peer Wennrich, Yvonne Becker, Jose G. Maciá-Vicente, Anke Brißke-Rode, Matthias Daub, Torsten Thünen, Abdelfattah A. Dababat, Maria R. Finckh, Marc Stadler, Wolfgang Maier

“…The morphology, the interaction with nematodes and plants and the phylogenetic relationships of these strains originating from a broad geographic range covering Western Europe to Asia Minor were studied. …”
Get full text

Exploring the anti-metastatic potential of sunitinib and novel analogs in colorectal cancer: insights into HIF-1α mediated metastasis by Fatemeh B. Rassouli, Maryam M. Matin, Maryam M. Matin, Farzin Hadizadeh, Farzin Hadizadeh, Masoud Nejabat, Hossein Allahverdizadeh, Hamidreza Jamali, Shahin Gharedaghi, Halimeh Hassanzadeh

“…Molecular docking and dynamics simulations demonstrated favorable and stable interaction of sunitinib and three novel analogs with HIF-1α PAS-B domain. …”
Get full text

Late-time Optical and X-Ray Emission Evolution of the Oxygen-rich SN 1996cr by Daniel Patnaude, Kathryn E. Weil, Robert A. Fesen, Dan Milisavljevic, Ralph P. Kraft

“…When the ejecta of a supernova (SN) interact with the progenitor star's circumstellar environment, a strong shock is driven back into the ejecta, causing the material to become bright optically and in X-rays. …”
Get full text

Reduced functional independence and multimorbidity increases the risk of severe infection among older patients with Omicron: a multicenter retrospective cohort study by Wan Yu, Runnian Huang, Shuning Sun, Li Bu, Xin Chen, Yunhua Di, Shuwu Lin, Qian Li, Yang Yang, Xingyue Ye, Wenxu Wang, Rui Ren, Linze Xi, Ru Zhang, Yi Li, Xin Li, Tianbo Hou, Zibo Ning, Yang Peng, Difei Wang

“…Patients with severe dependency had 7.39 times (95% CI: [4.60, 12.15]) higher risk of serious or critical infections than those without dependency. An interaction was noted between reduced FI and multimorbidity (p for interaction < 0.001). …”
Get full text

Aerobic capacity and muscle proteome: Insights from a mouse model by Abel Plaza‐Florido, Alejandro Santos‐Lozano, Susana López‐Ortiz, Beatriz G. Gálvez, Joaquín Arenas, Miguel A. Martín, Pedro L. Valenzuela, Tomàs Pinós, Alejandro Lucia, Carmen Fiuza‐Luces

“…The quadriceps muscle proteome was studied using liquid chromatography with tandem mass spectrometry, with the Search Tool for the Retrieval of Interacting Genes/Proteins database used to generate protein–protein interaction (PPI) networks and enrichment analyses. …”
Get full text

Single‐cell dissection reveals immunosuppressive F13A1+ macrophage as a hallmark for multiple primary lung cancers by Chenglin Yang, Jiahao Qu, Jingting Wu, Songhua Cai, Wenyi Liu, Youjun Deng, Yiran Meng, Liuqing Zheng, Lishen Zhang, Li Wang, Xiaotong Guo

“…SPP1‐CD44/CCL13‐ACKR1 interactions are crucial in MPLC tumour microenvironment, indicating potential targets for therapeutic intervention.…”
Get full text

Association of weight-adjusted-waist index with type 2 diabetes mellitus in Chinese urban adults: a cross-sectional study by Qingzheng Wu, Bing Li, Yuepeng Wang, Yuepeng Wang, Yue Zhang, Qian Wang, Binqi Li, Binqi Li, Wei Jing, Jing Yang, Yiming Mu

“…After adjusting for all factors with the exception of the stratified variable, this association held true in age, sex, BMI, hypertension, and hyperlipidemia subgroup and was especially pronounced in those aged &lt;60 years, BMI ≥24 kg/m2, and males, with interactions between WWI and age, sex, and BMI (P for interaction &lt;0.05).ConclusionWWI was positively associated with T2DM in Chinese urban adults, especially in young and middle-aged males with BMI ≥24 kg/m2.…”
Get full text

Key regions aberrantly connected within cerebello-thalamo-cortical circuit and their genetic mechanism in schizophrenia: an fMRI meta-analysis and transcriptome study by Yarui Wei, Ziyu Wang, Kangkang Xue, Xiaoyu Niu, Longyao Ma, Shaoqiang Han, Baohong Wen, Yong Zhang, Huafu Chen, Jingliang Cheng

“…These findings suggest key regions aberrantly connected within CTCC in SCZ, which may indicate the neural substrate of “cognitive dysmetria” and be a consequence of complex interactions from a wide range of genes with diverse functional features.…”
Get full text

High Glucose Induces Endothelial COX2 and iNOS Expression via Inhibition of Monomethyltransferase SETD8 Expression by Jie Qi, Qichao Wu, Qian Cheng, Xiangyuan Chen, Minmin Zhu, Changhong Miao

“…Furthermore, SETD8 was found to interact with specificity protein 1 (SP1). Blockade of SP1 protected against high glucose-mediated endothelial injury. …”
Get full text

A New Prognostic Risk Model Based on PPAR Pathway-Related Genes in Kidney Renal Clear Cell Carcinoma by Yingkun Xu, Xiunan Li, Yuqing Han, Zilong Wang, Chenglin Han, Ningke Ruan, Jianyi Li, Xiao Yu, Qinghua Xia, Guangzhen Wu

“…Afterward, using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) website, we established the protein-protein interaction (PPI) network of genes related to the PPAR pathway. …”
Get full text

Comprehensive Assessment of the Risk of Symptomatic Embolism in Patients With Infective Endocarditis by Sebastian D. Santos‐Patarroyo, Juan A. Quintero‐Martinez, Brian D. Lahr, Supavit Chesdachai, Daniel C. DeSimone, Hector R. Villarraga, Hector I. Michelena, Larry M. Baddour

“…Vegetation length with interaction of IE type was also associated with embolic risk (P<0.001), with a stronger effect in native valve IE (P interaction=0.001). …”
Get full text

Biofilm characterisation of Mycoplasma bovis co-cultured with Trueperella pyogenes by Koji Nishi, Satoshi Gondaira, Yuki Hirano, Masahide Ohashi, Ayano Sato, Kazuya Matsuda, Tomohito Iwasaki, Takuya Kanda, Ryoko Uemura, Hidetoshi Higuchi

“…A recent study has shown that polymicrobial interactions between species are an important factor in biofilm formation, yet the precise mechanism of biofilm formation in M. bovis remains unknown. …”
Get full text

Differential Regulation of Methylation-Regulating Enzymes by Senescent Stromal Cells Drives Colorectal Cancer Cell Response to DNA-Demethylating Epi-Drugs by Khushboo Agrawal, Viswanath Das, Natálie Táborská, Ján Gurský, Petr Džubák, Marián Hajdúch

“…The heterocellular interactions between colon cancer cells and colon-unassociated fibroblasts at distant metastatic sites are important, yet these cell-cell interactions for therapeutic strategies for metastatic colon cancer remain underestimated. …”
Get full text