To Probe Full and Partial Activation of Human Peroxisome Proliferator-Activated Receptors by Pan-Agonist Chiglitazar Using Molecular Dynamics Simulations by Holli-Joi Sullivan, Xiaoyan Wang, Shaina Nogle, Siyan Liao, Chun Wu

“…Yet, it has no high-resolution complex structure with PPARs and its detailed interactions and activation mechanism remain unclear. …”
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Time in Russian and Japanese Lingo-cultures by N. E. Gorelova

“…In its turn, the definition of the limits and possibilities of matching cultures by comparing their lingvocultural axioms enables us to refine the boundaries of their communicative interactions, identifying areas of understanding /misunderstanding and the most constructive interaction /potentialproneness to conflict. …”
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Clinicians’ experience with infographic summaries from the BMJ Rapid Recommendations: a qualitative user-testing study among residents and interns at a large teaching hospital in S... by Thomas Agoritsas, Per Vandvik, Tiffany Hirschel

“…The BMJ Rapid Recommendations explore innovative ways to enhance dissemination and uptake, including multilayered interactive infographics linked to a digitally structured authoring and publication platform (the MAGICapp). …”
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Barriers Affecting Promotion of Active Transportation: A Study on Pedestrian and Bicycle Network Connectivity in Melbourne’s West by Isaac Oyeyemi Olayode, Hing-Wah Chau, Elmira Jamei

“…Our methodology is enshrined in the use of Social Pinpoint, which is an online interactive survey platform, and ground surveys (face-to-face interviews). …”
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A mechanism with positive feedback governing the transitions in super-low temperature physics studied via a two-species condensate with spin-1 atoms by Yanzhang He, Yimin Liu, Chengguang Bao

“…This is an important feature of multi-species spin-1 systems arising from the basic character of the inter-species interaction via a mechanism with positive feedback. …”
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Exposure to Lead (Pb) influences the outcomes of male-male competition during precopulatory intrasexual selection by Rosemary Patrick, Kim Colyvas, Andrea S. Griffin, Michael Stat, Wayne A. O’Connor, Mohammad Mahmudur Rahman, Mallavarapu Megharaj, Geoff R. MacFarlane

“…Exposed crabs (100 µg/L) were less successful than control crabs in chela size-matched paired competitive interactions, spent less time in burrows and predominantly lost burrow ownership. …”
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Antibacterial Potential of Crude Extracts from <i>Cylindrospermum alatosporum</i> NR125682 and <i>Loriellopsis cavernicola</i> NR117881 by Albert Olufemi Ikhane, Foluso Oluwagbemiga Osunsanmi, Rebamang Anthony Mosa, Andrew Rowland Opoku

“…The mechanism of action of the extracts including membrane damage, efflux pump, β-lactamase activity, DNA degradation, and extract–drug interaction was investigated using standard procedures. …”
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Evaluation of carrot (Daucus carota L.) varieties for growth and yield as affected by NPSB fertilizer rates in Gondar district, Ethiopia by Abebaw Mulugeta, Fentahun Asrat, Derajew Asres, Shiferaw Mebrat

“…The highest dry matter (13.67%), marketable (50.77 t ha-1) and total (55.32 t ha-1) root yields were recorded from the interaction of 162.3 kg NPSB ha-1 and Haramaya-I variety. …”
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The effect of air-pollution and weather exposure on mortality and hospital admission and implications for further research: A systematic scoping review. by Mary Abed Al Ahad, Frank Sullivan, Urška Demšar, Maya Melhem, Hill Kulu

“…Effect modification of important socio-demographics such as ethnicity and the interaction between air-pollution and weather is often missed in the literature. …”
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Vaccination coverage and its determinants in patients with multiple sclerosis—a multicenter cross-sectional study by Paula Schade, Hai-Anh Nguyen, Julia Steinle, Kerstin Hellwig, Teodor Pelea, Philipp Franken, Birte Elias-Hamp, Veit Becker, Stefan Merkelbach, Stephan Richter, Bert Wagner, Christian Geis, Matthias Schwab, Florian Rakers

“…Inconsistent vaccination recommendations from GPs due to uncertainties about vaccine safety and DMT interactions likely contribute.…”
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USING DIGITAL BUSINESS SIMULATORS IN ECONOMIC AND MANAGERIAL DEVELOPMENT OF MASTER’S IN INFORMATION TECHNOLOGIES by Dmytro S. Antoniuk, Oleg M. Spirin, Tetiana A. Vakaliuk

“…The concepts are crucial for future professionals working in IT, interacting in teams, and developing in people- and task-management areas. …”
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Effect of HLA-G5 Immune Checkpoint Molecule on the Expression of ILT-2, CD27, and CD38 in Splenic B cells by Hana Rohn, Cordula Lang, Sabine Schramm, Falko M. Heinemann, Mirko Trilling, Anja Gäckler, Oliver Witzke, Peter A. Horn, Vera Rebmann

“…The human leukocyte antigen G (HLA-G) is an immune checkpoint molecule with a complex network of interactions with several inhibitory receptors. Although the effect of HLA-G on T cells and NK cells is well studied, the effect of HLA-G on B cells is still largely elusive. …”
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Active Antialopecia Chemical Identification of Merremia peltata Leaves and Computational Study toward Androgen Receptor Using Molecular Docking and Molecular Dynamic Simulation by Syawal Abdurrahman, Ruslin Ruslin, Aliya N. Hasanah, Resmi Mustarichie, Mus Ifaya

“…An in silico study was then carried out using minoxidil as a comparison ligand; 17 compounds derived from M. peltata leaves were identified as antialopecia compounds through prediction of molecular interactions and molecular dynamics simulation and prediction of absorption, distribution, metabolism, excretion, and toxicology (ADME-Tox). …”
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Roles of retinoic acid-related orphan receptor α in high glucose-induced cardiac fibroblasts proliferation by Wenqing San, Qianyou Zhou, Danning Shen, Danyi Cao, Yun Chen, Guoliang Meng

“…Expressions of Collagen I, Collagen III, proliferating cell nuclear antigen (PCNA), α-smooth muscle actin (α-SMA), receptor-interacting protein kinase 1 (RIPK1) and receptor-interacting protein kinase 3 (RIPK3) were evaluated. …”
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Integrative analysis of Ewing’s sarcoma reveals that the MIF-CD74 axis is a target for immunotherapy by Fangzhou He, Jiuhui Xu, Fanwei Zeng, Boyang Wang, Yi Yang, Jie Xu, Xin Sun, Tingting Ren, Xiaodong Tang

“…Methods Since novel immunotherapies may address this need, we performed an integrative analysis involving single-cell RNA sequencing, cell function experiments, and humanized models to dissect the immunoregulatory interactions in EwS and identify strategies for optimizing immunotherapeutic efficacy. …”
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Simulation of discrete control systems with parallelism of behavior by D. I. Cheremisinov, L. D. Cheremisinova

“…The transaction level model describes a system as a set of interacting processes that run in parallel and determine the behavior of the system over time.Results. …”
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Adenosine-Induced NLRP11 in B Lymphoblasts Suppresses Human CD4+ T Helper Cell Responses by Irem Ozel, Ilgin Akkaya, Ece Oylumlu, Goksu Uzel, Ceren Ciraci

“…NLRP11 was significantly upregulated after induction with adenosine at both the mRNA and protein levels, which led to the interaction of endogenous NLRP11 with the ASC adaptor protein; however, this interaction did not result in the activation of the caspase-1 enzyme. …”
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The Role of NF-κB/MIR155HG in Regulating the Stemness and Radioresistance in Breast Cancer Stem Cells by Yunbao Xu, Lu Yang, Guangming Li, Chuangzhou Rao

“…To examine the binding interaction between RelA and MIR155HG promoter, chromatin immunoprecipitation was performed. …”
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Pharmacological and structural insights into nanvuranlat, a selective LAT1 (SLC7A5) inhibitor, and its N-acetyl metabolite with implications for cancer therapy by Chunhuan Jin, Xinyu Zhou, Minhui Xu, Hiroki Okanishi, Ryuichi Ohgaki, Yoshikatsu Kanai

“…This study provides a comprehensive pharmacological characterization of nanvuranlat and its N-acetyl metabolite, including structural insights into their LAT1 interactions. Both compounds demonstrated high selectivity for LAT1 over LAT2 and other amino acid transporters. …”
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Bioinformatics Analysis of Genes and Mechanisms in Postherpetic Neuralgia by Yong Qiu, Meng-Lei Hao, Xu-Tao Cheng, Zhen Hua

“…Functional analysis revealed that variations were predominantly enriched for genes involved in neuroactive ligand-receptor interactions, the Jak-STAT signaling pathway, and calcium channel activity. …”
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