Intravenous esketamine in pediatric Rett syndrome: An open-label, early phase 1 pilot study by Huiping Li, Shu Liu, Caimei Lin, Yuchao Wu, Xiuping Wu, Yukun Huang, Yajun Wu, Xiubin Tong, Xiu Xu

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Video-feedback intervention for promoting social engagement in children with neurodevelopmental disabilities by Rosario Montirosso, Serena Micheletti, Camilla Pisoni, Eleonora Mascheroni, Elisa Scarano, Elisa Scarano, Cecilia Naboni, Elisa Rosa, Annalisa Castagna, Margherita Bonino, Elisa Fazzi, Elisa Fazzi, Simona Orcesi, Simona Orcesi

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The efficacy and safety of half-dose glucocorticoids combined with rituximab versus high-dose glucocorticoids for initial treatment of minimal change disease: a single-center exper... by Xueting Li, Peng Yan, Lu Zhang, Wei Qiao, Zhengbiao Xue, Xiangdong Fang, Ben Ke, Shuying Zhu

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Outcomes, Healthcare Resource Utilization, and Costs of Overall, Community-Acquired, and Hospital-Acquired Acute Kidney Injury in COVID-19 Patients by Jay L. Koyner, Rachel H. Mackey, Ning A. Rosenthal, Leslie A. Carabuena, J. Patrick Kampf, Paul McPherson, Toni Rodriguez, Aarti Sanghani, Julien Textoris

“…In adjusted models, for patients with AKI vs no AKI and HA-AKI vs CA-AKI, odds ratios (ORs) (95% CI) were 3.70 (3.61-3.79) and 4.11 (3.92-4.31) for intensive care unit use and 3.52 (3.41-3.63) and 2.64 (2.52-2.78) for in-hospital mortality; mean length of stay (LOS) differences and LOS ratios (95% CI) were 1.8 days and 1.24 (1.23-1.25) and 5.1 days and 1.57 (1.54-1.59); and mean cost differences and cost ratios were $7163 and 1.35 (1.34-1.36) and $19&#8239;127 and 1.78 (1.75-1.81) (all _P_ < .001). …”
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To Hemoadsorb or Not to Hemoadsorb—Do We Have the Answer Yet? An Updated Meta-Analysis on the Use of CytoSorb in Sepsis and Septic Shock by Carmen Orban, Angelica Bratu, Mihaela Agapie, Tudor Borjog, Mugurel Jafal, Romina-Marina Sima, Oana Clementina Dumitrașcu, Mihai Popescu

“…We did not observe any significant difference in either intensive care unit length of stay (<i>p</i> = 0.93) or between end-of-treatment severity scores in the two groups (<i>p</i> = 0.24). …”
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Long COVID and its risk factors in migrants: a nationwide register study from Sweden by Agneta Cederström, George Frederick Mkoma, Thomas Benfield, Charles Agyemang, Marie Nørredam, Mikael Rostila

“…., whether the person was hospitalized (IRR: 18.6 CI: 17.3–20.0) or treated in an intensive care unit (IRR: 120.5 CI: 111.7–129.8), primarily contributed to the higher risk of long COVID found in migrants while the contribution of vaccinations and social conditions were moderate. …”
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Effects of 24-hour urine-output trajectories on the risk of acute kidney injury in critically ill patients with cirrhosis: a retrospective cohort analysis by Jia Wang, Dongdong Niu, Xiaolin Li, Yumei Zhao, Enlin Ye, Jiasheng Huang, Suru Yue, Xuefei Hou, Jiayuan Wu

“…Changes in the trajectories of urine output within 24 h after admission to the intensive care unit (ICU) were categorized using latent category trajectory modeling. …”
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Impact of dexmedetomidine-ropivacaine versus sufentanil-ropivacaine combination for epidural labour analgesia on neonatal outcomes: a pilot randomised clinical trial by Dong-Xin Wang, Chun-Mei Deng, Ke-Xin Jin, Ting Ding, Yuan Qu

“…Objective To investigate the impact of dexmedetomidine-ropivacaine combination versus sufentanil-ropivacaine combination for epidural labour analgesia on neonatal and maternal outcomes and test the feasibility of a future large, randomised trial.Design A randomised, double-blind, pilot clinical trial from 16 March 2023 to 15 June 2023.Setting A tertiary-care hospital in Beijing, China.Participants 200 women aged≥18 years who had full-term single pregnancy and were scheduled for vaginal delivery with epidural analgesia.Interventions Eligible participants were randomly assigned in a 1:1 ratio to receive self-controlled epidural labour analgesia using ropivacaine supplemented with either dexmedetomidine (0.45 µg/mL for induction and 0.36 µg/mL for maintenance) or sufentanil (0.45 µg/mL for induction and 0.36 µg/mL for maintenance).Main outcomes and measures The primary endpoint was a composite of neonatal morbidity, including 1- or 5 min Apgar score&lt;7, umbilical artery PH&lt;7.1, requirement for immediate assisted ventilation and admission to neonatal ward or intensive care unit within 24 hours. Secondary and other endpoints included effect of analgesia and occurrence of adverse events. …”
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Functional gastrointestinal disorders predictors in neonates and toddlers: A machine learning approach to risk assessment by Flavia Indrio, Elio Masciari, Flavia Marchese, Matteo Rinaldi, Gianfranco Maffei, Ilaria Gangai, Assunta Grillo, Roberta De Benedetto, Enea Vincenzo Napolitano, Isadora Beghetti, Luigi Corvaglia, Antonio Di Mauro, Arianna Aceti

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Right ventricular mechanical pattern in patients undergoing mitral valve surgery: a predictor of post‐operative dysfunction? by Márton Tokodi, Endre Németh, Bálint K. Lakatos, Erika Kispál, Zoltán Tősér, Levente Staub, Kristóf Rácz, Ádám Soltész, Szabolcs Szigeti, Tamás Varga, János Gál, Béla Merkely, Attila Kovács

“…Transthoracic three‐dimensional (3D) echocardiography was performed pre‐operatively, at intensive care unit discharge, and 6 months after surgery. …”
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Prediction model, risk factor score and ventilator-associated pneumonia: A two-stage case-control study by Hua Meng, Yuxin Shi, Kaming Xue, Di Liu, Xiongjing Cao, Yanyan Wu, Yunzhou Fan, Fang Gao, Ming Zhu, Lijuan Xiong

“…Background: Ventilator-associated pneumonia (VAP) is one of the most important hospital acquired infections in patients requiring mechanical ventilation (MV) in the intensive care unit, but the effective and robust predictable tools for VAP prevention were relatively lacked. …”
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Intravenous immunoglobulin for mortality and inflammatory status in patients with sepsis: a retrospective database study by Hayabusa Takano, Hayabusa Takano, Naoki Kanda, Naoki Kanda, Yuji Wakimoto, Hiroyuki Ohbe, Kensuke Nakamura, Kensuke Nakamura

“…Moreover, IVIG may favorably affect sepsis-induced immunosuppression like persistent inflammation, immunosuppression, and catabolism syndrome (PICS).MethodsThis study was a retrospective cohort study using inpatient claims database provided by Medical Data Vision, which included approximately 190,000 episodes of intensive care unit admissions in Japanese acute care hospitals between April 2008 and September 2021. …”
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In-Hospital Cardiac Arrest in the Cardiac Catheterization Laboratory: Effective Transition from an ICU- to CCU-Led Resuscitation Team by Rajat Sharma, Hilary Bews, Hardeep Mahal, Chantal Y. Asselin, Megan O’Brien, Lillian Koley, Brett Hiebert, John Ducas, Davinder S. Jassal

“…Although in-hospital resuscitation teams are often led by an Intensive Care Unit- (ICU-) trained physician and house staff, little is known on the role of a cardiologist in this setting. …”
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Risk factors for disease progression and clinical outcomes in patients with COVID-19 in Taiwan: a nationwide population-based cohort study by Raymond N. Kuo, Wanchi Chen, Wen-Yi Shau

“…Baseline and clinical characteristics were collected to verify the association with progression to severity outcomes, including hospital admission, intensive care unit (ICU) admission, invasive ventilatory support, fatal outcome, and the composite outcome of these four events. …”
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Combination of reverse shock index and simplified motor score as a strong discriminator of trauma outcomes by Meng-Yu Wu, Giou-Teng Yiang, Ding-Kuo Chien, Sy-Jou Chen, Chi-Ming Chu, Jui-Yuan Chung, Hon-Ping Ma, Mau-Roung Lin

“…Background The reverse shock index multiplied by simplified motor score (rSI-sMS) is a novel and rapid measure for assessing injury severity in patients with trauma in prehospital settings; however, its discriminant ability requires further validation.Methods A retrospective cohort study was conducted from trauma database of Taipei Tzu Chi Hospital to compare the accuracy of the rSI-sMS with that of the shock index, modified shock index, reverse shock index multiplied by the Glasgow Coma Scale (rSI-GCS), and the reverse shock index multiplied by GCS motor subscale (rSI-GCSM) for discriminating in-hospital mortality, intensive care unit (ICU) admissions, prolonged ICU stays ≥14 days, and prolonged hospital stays ≥30 days in patients with trauma.Results A total of 11,760 patients from the trauma database were included. rSI-sMS had significantly better accuracy in discriminating in-hospital mortality, ICU admissions, prolonged ICU stays (≥14 days), and prolonged hospital stays (≥30 days) than the shock index, modified shock index, and rSI-GCSM, whereas its accuracy was similar to that of the rSI-GCS. …”
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The Prechtl’s General Movement Assessment, Hammersmith Infant Neurological Examination and Sensory Profile-2 in Prediction of Cerebral Palsy at Two Years of Age in High-risk Infant... by Hatice ADIGÜZEL, Halil İbrahim ÇELİK, Yusuf Ünal SARIKABADAYI, Nevin ERGUN, Bülent ELBASAN

“…Methods: Thirty-four high-risk infants with a mean gestational age of 33.1±4.2, who were followed up in the physiotherapy unit after discharge from the neonatal intensive care unit, were recruited. Prechtl’s GMA results were collected for infants at 3rd month. …”
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Biomarkers troponin and procalcitonin in addition to CRB-65 enhance risk stratification in patients with community-acquired pneumonia by Imrana Farhat, Maciej Rosolowski, Katharina Ahrens, Jasmin Lienau, Peter Ahnert, Mathias Pletz, Gernot Rohde, Jan Rupp, Markus Scholz, Martin Witzenrath, the CAPNETZ Study Group

“…Background Community-acquired pneumonia (CAP) remains a leading cause of infectious disease mortality globally, necessitating intensive care unit (ICU) admission for ∼10% of hospitalised patients. …”
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Healthcare workers safety: a cohort study using healthcare utilisation databases on vaccination and vaccine timeliness impact against SARS-CoV-2 infection by Edlira Skrami, Andrea Faragalli, Marica Iommi, Marco Morbidoni, Cristina Mancini, Antonella Guidi, Annalisa Cardone, Marco Pompili, Pietro Serafini, Remo Appignanesi, Luigi Ferrante, Flavia Carle

“…The impact of vaccination status, time to vaccination, occupational role, age, gender, and health status on infection risk was analysed with a multiple Cox regression model, adjusting for vaccination coverage velocity, swabbing probability, and monthly intensive care unit admissions rate in each LHA. Of the cohort, 81.2% were fully vaccinated. …”
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Effectiveness of Continuous Glucose Monitoring on Short-Term, In-Hospital Mortality Among Frail and Critically Ill Patients With COVID-19: Randomized Controlled Trial by Jiawei Shang, Ziming Yuan, Zuoyan Zhang, Quanhong Zhou, Yan Zou, Wei Wang

“…Frail and critically ill patients with COVID-19 and previously normal glucose tolerance are also associated with variability in their glucose levels during their intensive care unit (ICU) stay. However, very limited evidence supports the use of CGM in ICU settings, especially among frail patients with COVID-19. …”
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Genome drafting of nosocomial infection CRE Klebsiella pneumoniae confirming resistance to colistin and eravacycline, carrying blaNDM-1, mcr-1, and blaKPC-2, in neonatology from No... by Xinlong Zhou, Kailash Wagh, Guizhen Lv, Devender Sharma, Wei Lei

“…In this study, we report an outbreak of CRKP in a neonatal intensive care unit (NICU) within a 200-bed tertiary hospital. …”
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