Economic and clinical burden associated with respiratory syncytial virus and impact of universal immunization with nirsevimab in Italy by Andrea Marcellusi, Chiara Bini, Barbara Muzii, Samira Soudani, Alexia Kieffer, Matthieu Beuvelet, Elena Bozzola, Fabio Midulla, Eugenio Baraldi, Paolo Bonanni, Sara Boccalini, Luigi Orfeo

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Delirium and Associated Length of Stay and Costs in Critically Ill Patients by Claudia Dziegielewski, Charlenn Skead, Toros Canturk, Colleen Webber, Shannon M. Fernando, Laura H. Thompson, Madison Foster, Vanja Ristovic, Peter G. Lawlor, Dipayan Chaudhuri, Chintan Dave, Brent Herritt, Shirley H. Bush, Salmaan Kanji, Peter Tanuseputro, Kednapa Thavorn, Erin Rosenberg, Kwadwo Kyeremanteng

“…Delirium frequently affects critically ill patients in the intensive care unit (ICU). The purpose of this study is to evaluate the impact of delirium on ICU and hospital length of stay (LOS) and perform a cost analysis. …”
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Improved Outcomes following the Establishment of a Neurocritical Care Unit in Saudi Arabia by Ibrahim Soliman, Waleed Tharwat Aletreby, Fahad Faqihi, Nasir Nasim Mahmood, Omar E. Ramadan, Ahmad Fouad Mady, Babar Kahlon, Abdulrahman Alharthy, Peter Brindley, Dimitrios Karakitsos

“…This is the first study in the Middle East to evaluate the clinical impact of a neurocritical care unit (NCCU) launched within the diverse clinical setting of a polyvalent intensive care unit (ICU). Design and Methods. A retrospective before and after cohort study comparing the outcomes of neurologically injured patients. …”
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Examining the association of elevated initial serum lactate with mortality and morbidity in trauma patients: a retrospective study by Pablo Rodríguez-Ortiz, Kyara Berríos-Toledo, Ediel O. Ramos-Meléndez, Lourdes Guerrios-Rivera

“…Initially, elevated iSL was associated with in-hospital mortality (OR: 2.18, 95%CI: 1.36–3.51, p < 0.001), traumatic intensive care unit (TICU) admission (OR: 2.06, 95%CI: 1.46–2.92, p < 0.001), and need for mechanical ventilation (MV) (OR: 2.80, 95%CI: 1.97–3.98, p < 0.001). …”
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Accuracy of the combined method (auscultation and pH measurement) and ultrasonography for confirmation of gastric tube placement: a study protocol for a prospective study by Fernanda Raphael Escobar Gimenes, Rosana Aparecida Pereira, Mayara Carvalho Godinho Rigobello, Jorge Elias Junior, Carlos Alberto Grespan Bonacim, Renata Cristina de Campos Pereira Silveira, Fernanda Caroline Bonardi, Roosevelt Santos Nunes

“…Data will be collected in the clinical and surgical wards, intensive care unit and coronary care unit of a Brazilian teaching hospital. …”
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Creatinine- and Cystatin C-Based Incidence of Chronic Kidney Disease and Acute Kidney Disease in AKI Survivors by Claire Rimes-Stigare, Bo Ravn, Akil Awad, Klara Torlén, Claes-Roland Martling, Matteo Bottai, Johan Mårtensson, Max Bell

“…A prospective cohort study was conducted in a Swedish intensive care unit (ICU) between 2008 and 2010. We included AKI patients alive at 90 days. …”
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2-Brain Regulation for Improved Neuroprotection during Early Development (2-BRAINED): a translational hyperscanning research project by Lucia Billeci, Valentina Riva, Elena Capelli, Serena Grumi, Miriam Paola Pili, Maddalena Cassa, Eleonora Siri, Elisa Roberti, Renato Borgatti, Renato Borgatti, Livio Provenzi, Livio Provenzi

“…., separation and pain exposure) during the neonatal intensive care unit (NICU) stay. Early video-feedback (VF) interventions proved effective in promoting VOT infants’ development and parental wellbeing. …”
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Effectiveness and safety of an emergency department-based rapid response system by Fanny Delfanti, Guido Bertolini, Giovanni Nattino, Giulia Acquistapace, Daniela De Palma, Piergiuseppe Ferrari, Sara Martinenghi, Stefano Maiandi, Marco Rossi, Anna Lilia Ruocco, Maria Teresa Spina, Benedetta Chiodi, Stefano Paglia

“…A significant reduction in Intensive Care Unit (ICU) transfers was observed overall (0.26%, p=0.005), but not in mortality (0.10%, p=0.47). …”
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BRD4 Inhibitor GNE-987 Exerts Anticancer Effects by Targeting Super-Enhancer-Related Gene LYL1 in Acute Myeloid Leukemia by Xu Sang, Yongping Zhang, Fang Fang, Li Gao, Yanfang Tao, Xiaolu Li, Zimu Zhang, Jianwei Wang, Yuanyuan Tian, Zhiheng Li, Di Yao, Yumeng Wu, Xinran Chu, Kunlong Zhang, Li Ma, Lihui Lu, Yanling Chen, Juanjuan Yu, Ran Zhuo, Shuiyan Wu, Zhen Zhang, Jian Pan, Shaoyan Hu

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COVID-19 Mortality in Children: A Referral Center Experience from Iran (Mofid Children’s Hospital, Tehran, Iran) by Shahnaz Armin, Seyed Alireza Fahimzad, Sedigheh Rafiei Tabatabaei, Roxana Mansour Ghanaiee, Noushin Marhamati, Seyyedeh Narjes Ahmadizadeh, Azita Behzad, Seyedeh Masumeh Hashemi, Saeed Sadr, Maryam Rajabnejad, Mahnaz Jamee, Abdollah Karimi

“…Recorded documents of 59 pediatric patients (under 18 years old) assumed to have COVID-19 who had died in the COVID-19 ward and COVID-19 intensive care unit (ICU) were retrospectively evaluated. …”
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Effect of trauma center operation on emergency care and clinical outcomes in patients with traumatic brain injury by Han Kyeol Kim, Yoon Suk Lee, Woo Jin Jung, Yong Sung Cha, Kyoung-Chul Cha, Hyun Kim, Kang Hyun Lee, Sung Oh Hwang, Oh Hyun Kim

“…However, no significant differences existed in the length of intensive care unit stay, ventilator days, and total length of stay for TBI patients who visited the hospital before and after the operation of the trauma center. …”
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Prognostic Value of the Red Blood Cell Distribution Width-to-Albumin Ratio in Critically Ill Older Patients with Acute Kidney Injury: A Retrospective Database Study by Lei Guo, Dezhun Chen, Bihuan Cheng, Yuqiang Gong, Benji Wang

“…The primary endpoint was 90-day all-cause mortality, and the secondary endpoints were 30-day mortality, one-year mortality, renal replacement treatment (RRT), duration of stay in the intensive care unit (ICU), sepsis, and septic shock. We generated Cox proportional hazards and logistic regression models to determine RA’s prognostic values and subgroup analyses to determine the subgroups’ mortality. …”
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Prognostic value of HSP27 in 28-day mortality in septic ICU patients: a retrospective cohort study by Lihua Yao, Lihua Yao, Zaiwei Fan, Fangyi Yao, Xiaozhong Wang

“…BackgroundThis study aimed to investigate the association between serum heat shock protein 27 (HSP27) levels and 28-day mortality in patients with sepsis.MethodsThis retrospective study analyzed the clinical data of 76 septic patients admitted to the intensive care unit (ICU). Fifty non-septic ICU patients and 50 healthy individuals served as control groups. …”
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The effect of educational programs on parents’ knowledge, behavior, and practices regarding aluminum phosphide poisoning and its first-aid measures by Mabrouka Attia Ali Nada, Ahmed Kamal Eldin Elsayed Elfeky, Hamida Ahmed Mustafa Darweesh, Farida Khalil Ibrahim Mohamed, Loujain Saud Sharif, Faten Shawky Kandil, Fatma Ahmed Elsobky, Samah Abdallah Mohamed Amer

“…Children (n = 98) who met the inclusion criteria (aged between 0 and 18 years and who experienced accidental or suicidal aluminum phosphide poisoning) were recruited from the inpatient clinical toxicology department ward, intensive care unit in the emergency department, and critical care unit of Menoufia University Hospital. …”
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Genetically predicted causal link between the plasma lipidome and pancreatic diseases: a bidirectional Mendelian randomization study by Liaoyi Lin, Yingbao Huang, Songzan Qian, Lifang Chen, Houzhang Sun

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SARS-CoV-2 SPIKE Antibody Levels can Indicate Immuno-Resilience to Re-infection: a Real-World Study by Yue Jin, Fei Yang, Christopher M. Rank, Stanley Letovsky, Peter Ramge, Simon Jochum

“…Study outcomes included the first symptomatic SARS-CoV-2 infection (per ICD-10 diagnostic codes, occurring ≥ 7 days post-antibody titer test), and severe SARS-CoV-2 infection, characterized by adverse outcomes including hospitalization, intensive care unit admission, intubation, mechanical ventilation, or death within 30 days of infection. …”
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Advancing a machine learning-based decision support tool for pre-hospital assessment of dyspnoea by emergency medical service clinicians: a retrospective observational study by Wivica Kauppi, Henrik Imberg, Johan Herlitz, Oskar Molin, Christer Axelsson, Carl Magnusson

“…Serious Adverse Event (SAE) was used as outcome, defined as any of the following:1) death within 30 days after call for an ambulance, 2) a final diagnosis defined as time-sensitive, 3) admitted to intensive care unit, or 4) readmission within 72 h and admitted to hospital receiving a final time-sensitive diagnosis. …”
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Comparison of Injury Severity Score, Glasgow Coma Scale, and Revised Trauma Score in Predicting the Mortality and Prolonged ICU Stay of Traumatic Young Children: A Cross-Sectional... by Yii-Ting Huang, Ying-Hsien Huang, Ching-Hua Hsieh, Chao-Jui Li, I-Min Chiu

“…The primary outcomes were mortality and prolonged Intensive Care Unit (ICU) stay, with the latter defined as an ICU stay longer than 14 days. …”
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Severe pregnancy-associated atypical hemolytic uremia syndrome in the context of the COVID-19 pandemic: a novel survival case report by Yan Yang, Xiao-jin Li, Hua-Yan Yuan, Jing-Jing Xiong, Peng-Fei Li, Zhen Wang

“…Abstract Background Pregnancy-associated atypical hemolytic uremic syndrome (aHUS) is a form of thrombotic microangiopathy (TMA) caused by uncontrolled activation of the complement system during pregnancy or the postpartum period. In the intensive care unit, aHUS must be differentiated from sepsis-related multiple organ dysfunction, thrombotic thrombocytopenic purpura (TTP), hemolysis, elevated liver enzymes, and low platelet (HELLP) syndrome. …”
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Patient perspectives on stress after ICU and a short primary care based psychological intervention – results from a qualitative sub‑study of the PICTURE trial by Antina Beutel, Linda Sanftenberg, Chris M. Friemel, Robert Philipp Kosilek, Maggie Schauer, Thomas Elbert, Ulf-Dietrich Reips, Tomke Schubert, Sabine Gehrke-Beck, Konrad Schmidt, Jochen Gensichen, for the PICTURE study group

“…Abstract Background Approximately 20–25% of patients who survive medical treatment at an intensive care unit (ICU) develop post-traumatic stress symptoms. …”
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