IL-23 tunes inflammatory functions of human mucosal-associated invariant T cells by Laetitia Camard, Tharshana Stephen, Hanane Yahia-Cherbal, Vincent Guillemot, Sébastien Mella, Victoire Baillet, Hélène Lopez-Maestre, Daniele Capocefalo, Laura Cantini, Claire Leloup, Julie Marsande, Katherine Garro, Juan Sienes Bailo, Ambre Dangien, Natalia Pietrosemoli, Milena Hasan, Huimeng Wang, Sidonia B.G. Eckle, Anne M. Fourie, Carrie Greving, Barbara Joyce-Shaikh, Raphaelle Parker, Daniel J. Cua, Elisabetta Bianchi, Lars Rogge

“…IL-23, in particular, affects key molecules and pathways related to autoimmunity and cytotoxic functions. Integrated analysis of transcriptomes and chromatin accessibility, supported by CRISPR-Cas9 mediated deletion, shows that AP-1 transcription factors constitute a key regulatory node of the IL-23 pathway in MAIT cells. …”
Get full text

Regulatory Role of rno-miR-30b-5p in IL-10 and Toll-like Receptor 4 Expressions of T Lymphocytes in Experimental Autoimmune Uveitis In Vitro by Yuanyuan Sun, Dadong Guo, Bin Liu, Xuewei Yin, Huixia Wei, Kai Tang, Hongsheng Bi

Get full text

Genome-wide identification of novel flagellar motility genes in Pseudomonas syringae pv. tomato DC3000 by Zichu Yang, Tyler Helmann, Maël Baudin, Maël Baudin, Maël Baudin, Karl J. Schreiber, Karl J. Schreiber, Zhongmeng Bao, Paul Stodghill, Paul Stodghill, Adam Deutschbauer, Adam Deutschbauer, Jennifer D. Lewis, Jennifer D. Lewis, Bryan Swingle, Bryan Swingle

Get full text

Modification and analysis of context-specific genome-scale metabolic models: methane-utilizing microbial chassis as a case study by M. A. Kulyashov, R. Hamilton, Y. Afshin, S. K. Kolmykov, T. S. Sokolova, T. M. Khlebodarova, M. G. Kalyuzhnaya, I. R. Akberdin

“…ABSTRACT Context-specific genome-scale model (CS-GSM) reconstruction is becoming an efficient strategy for integrating and cross-comparing experimental multi-scale data to explore the relationship between cellular genotypes, facilitating fundamental or applied research discoveries. …”
Get full text

Regenerative viticulture and climate change resilience by Flora O'Brien, Alistair Nesbitt, Rebecca Sykes, Belinda Kemp

“… Regenerative viticulture (RV) draws on disciplines and concepts such as ecology, agroecology, functional biodiversity, ecosystem services and permaculture, integrated into vineyard management to enhance both production and environmental outcomes. …”
Get full text

Review of climate-resilient agriculture for ensuring food security: Sustainability opportunities and challenges of India by Satiprasad Sahoo, Chiranjit Singha, Ajit Govind, Armin Moghimi

“…It assesses critical CRA projects and policies in India and explores how CRA can improve water policy by integrating farmers' perspectives in groundwater-based agriculture. …”
Get full text

Practice patterns among early-career primary care (ECPC) physicians and workforce planning implications: protocol for a mixed methods study by Richard J Gibson, Tara Sampalli, Tara Kiran, Richard H Glazier, Agnes Grudniewicz, Kimberlyn McGrail, David Snadden, Ian Scott, M Ruth Lavergne, Laurie J Goldsmith, David Rudoler, Emily Gard Marshall, Megan Ahuja, Doug Blackie, Fred Burge, Steve Hawrylyshyn, Lindsay Hedden, Jacalynne Hernandez-Lee, Kathleen Horrey, Mike Joyce, Adrian MacKenzie, Maria Mathews, Rita McCracken, Madeleine McKay, Charmaine McPherson, Goldis Mitra, Gail Tomblin Murphy, Sabrina T Wong

“…We will also analyse linked administrative health data within each province. Mixed methods integration both within the study and as an end-of-study step will inform how practice intentions, choices and patterns are interrelated and inform policy recommendations.Ethics and dissemination This study was approved by the Simon Fraser University Research Ethics Board with harmonised approval from partner institutions. …”
Get full text

Skin autofluorescence as part of the comprehensive assessment of clinical and metabolic status of patients with end-stage chronic kidney disease by Darya Yu. Konovalova, Peter A. Lebedev, Olga V. Ushakova, Elena E. Potyakina, Dmitriy V. Kornilin, Vladimir N. Grishanov, Marina V. Komarova

“…These facts suggest that SAF is an integral parameter of cardiac remodeling and metabolic profile, primarily in patients receiving PHD, which promotes it as a prognostic parameter.…”
Get full text

Application of 2D polymerase chain reaction for single-tube detection of high-risk human papillomaviruses by Weifeng Wang, Min Jiang, Ying Liu, Xuan Wu, Yan Chen, Xiaoyun Zhang, Weiwei Liu

“…The overall concordance between the two detection methods was 96.17% (Kappa = 0.910).ConclusionThe 2D PCR method, which integrates asymmetric PCR amplification with melting curve analysis, has the capacity to detect 11 types of HR-HPVs across three channels. …”
Get full text

Exploring artificial intelligence-powered virtual assistants to understand their potential to support older adults’ search needs by Emily M. Langston, Varitnan Hattakitjamroen, Mario Hernandez, Hye Soo Lee, Hannah Ç. Mason, Willencia Louis-Charles, Neil Charness, Sara J. Czaja, Wendy A. Rogers, Joseph Sharit, Walter R. Boot

“…Information-seeking, integration, and decision-making are cognitively demanding and can be impacted by age-related cognitive changes. …”
Get full text

A self-configuration framework for balancing services in the fog of things by Edson Mota, Jurandir Barbosa, Gustavo B. Figueiredo, Maycon Peixoto, Cássio Prazeres

“…This integration allows the system to continuously monitor the network state and automatically reconfigure the service distribution in response to changes, such as adding or removing nodes. …”
Get full text

Inductive Power Transfer Coil Misalignment Perception and Correction for Wirelessly Recharging Underground Sensors by John Sanchez, Juan Arteaga, Cody Zesiger, Paul Mitcheson, Darrin Young, Shad Roundy

“…Overall, this work contributes to the field of underground sensor networks by successfully integrating a self-aligning wireless power delivery system with existing agricultural infrastructure. …”
Get full text

Improving Autonomous Vehicle Cognitive Robustness in Extreme Weather With Deep Learning and Thermal Camera Fusion by Mehmood Nawaz, Sheheryar Khan, Muhammad Daud, Muhammad Asim, Ghazanfar Ali Anwar, Ali Raza Shahid, Ho Pui Aaron HO, Tom Chan, Daniel Pak Kong, Wu Yuan

“…In this paper, we address multi-sensor fusion in AVs and present a comprehensive integration of a thermal sensor aimed at enhancing the cognitive robustness of AVs. …”
Get full text

Mobility Aware Spectrum Handoff in 6G-Enabled Cognitive Radio Vehicular Centralized and Ad-Hoc Networks by Shanidul Hoque, Hemanta Kumar Sahu, Mohammed Nazibul Hasan, Rajesh Saha

“…In this paper, we propose an integrated model of the cell-based and pool-based spectrum handoff (SH) process of a non-stationary cognitive user (CU) under a heterogeneous spectrum environment (HetSE) in a 6G-enabled cognitive radio cellular network (CRCN). …”
Get full text

iMESc – an interactive machine learning app for environmental sciences by Danilo Cândido Vieira, Danilo Cândido Vieira, Fabiana S. Paula, Luciana Erika Yaginuma, Gustavo Fonseca

“…As environmental sciences increasingly rely on complex datasets, machine learning (ML) has become crucial for identifying patterns and relationships. However, the integration of ML into workflows can pose challenges due to technical barriers or the time-intensive nature of coding. …”
Get full text

Automatic three-dimensional reconstruction of the oesophagus in achalasia patients undergoing POEM: an innovative approach for evaluating treatment outcomes by Alanna Ebigbo, Helmut Messmann, Vivian Grünherz, Miriam Elia, Alessandra Brunner, Tamara Krafft, Leo Pöller, Pia Schneider, Fabian Stieler, Bernhard Bauer, Anna Muzalyova, Sandra Nagl

“…Novel normative indices for TE (volume×pressure) and LES (volume/pressure) were automatically integrated, facilitating pre-POEM and post-POEM comparisons. …”
Get full text

Protein identification using Cryo-EM and artificial intelligence guides improved sample purification by Kenneth D. Carr, Dane Evan D. Zambrano, Connor Weidle, Alex Goodson, Helen E. Eisenach, Harley Pyles, Alexis Courbet, Neil P. King, Andrew J. Borst

“…This study demonstrates the successful application of a structure-to-sequence protein identification workflow, integrating Cryo-EM, ModelAngelo, Protein BLAST, and AlphaFold 3 predictions, to identify and ultimately help guide the removal of DLST from sample purification efforts. …”
Get full text

A High-Throughput Method as a Diagnostic Tool for HIV Detection in Patient-Specific Induced Pluripotent Stem Cells Generated by Different Reprogramming Methods by Daniela Hübscher, Sabine Rebs, Luis Haupt, Thomas Borchert, Celina Isabell Guessoum, Franziska Treu, Steffen Köhne, Andreas Maus, Mario Hambrecht, Samuel Sossalla, Ralf Dressel, Angela Uy, Mark Jakob, Gerd Hasenfuss, Katrin Streckfuss-Bömeke

“…This fast, cost-effective, robust, and reliable assay demonstrates the feasibility to use high-throughput PCR-based methods for detection of human pathogenic viruses in ps-iPSC lines that were generated with nongenome integrating reprogramming methods.…”
Get full text

THE DIGITAL FRONTIER: STRATEGIES AND TOOLS FOR CULTIVATING EDUCATIONAL-STRATEGIC COMPETENCE  FOR PRE-SERVICE TEACHERS by Vira Svyrydiuk, Ostap Bodyk, Larysa Kalinina, Nataliya Prokopchuk, Nina Khrystych

“… Digital tools constitute an integral component in the organization of contemporary foreign language environment. …”
Get full text

Barriers and facilitators to the implementation of the Assessment of Burden of Chronic Conditions tool in Dutch primary care: a context analysis by Onno C P Van Schayck, Danny Claessens, Esther A Boudewijns, Liset van Dijk, Marcia Vervloet, Lotte C E M Keijsers, Annerika H M Gidding-Slok

“…Objectives The Assessment of Burden of Chronic Conditions (ABCC) tool is developed to facilitate a personalised approach to care through assessment and visualisation of a patient’s experienced burden of disease, and integrating this in the conversation based on shared decision-making and individualised care plans. …”
Get full text