Small mammal communities of Tuva Republic (Southern Siberia, Russia) in a changing climate by Sergey O. Ondar, Sergey N. Kirpotin, Andrey S. Babenko, Bogdan A. Mikhaleiko, Nikolay I. Putintsev, Aleksey V. Surov, Orlan Ch. Oidupaa, Andrey M. Samdan, Aivar V. Kuular, Bailak S. Mondush, Dayana S. Ondar, Pradip Kumar Kar, Aldynay O. Khovalyg, Anatoly F. Chuldum

“…An important indicator of the integrity of the biosphere is biological diversity. …”
Get full text

Assessing the clinical support capabilities of ChatGPT 4o and ChatGPT 4o mini in managing lumbar disc herniation by Suning Wang, Ying Wang, Linlin Jiang, Yong Chang, Shiji zhang, Kun Zhao, Lu Chen, Chunzheng Gao

“…Conclusion While both models are effective, ChatGPT 4o offers more comprehensive clinical responses, making it more suitable for high-integrity medical tasks. However, the difficulty in reading AI-generated content and occasional use of misleading terms, such as “tumor,” indicate a need for further improvements to reduce patient anxiety.…”
Get full text

Activation of lysophagy by a TBK1-SCFFBXO3-TMEM192-TAX1BP1 axis in response to lysosomal damage by Na Yeon Park, Doo Sin Jo, Jae-Yoon Yang, Ji-Eun Bae, Joon Bum Kim, Yong Hwan Kim, Seong Hyun Kim, Pansoo Kim, Dong-Seok Lee, Tamotsu Yoshimori, Eun-Kyeong Jo, Eunbyul Yeom, Dong-Hyung Cho

“…Collectively, our findings highlight the significance of the TBK1-FBXO3-TMEM192-TAX1BP1 axis in lysophagy and emphasize the critical role of FBXO3 in lysosomal integrity.…”
Get full text

Cortical Reorganization following Injury Early in Life by Moran Artzi, Shelly Irene Shiran, Maya Weinstein, Vicki Myers, Ricardo Tarrasch, Mitchell Schertz, Aviva Fattal-Valevski, Elka Miller, Andrew M. Gordon, Dido Green, Dafna Ben Bashat

“…Here we studied changes in brain tissue volume, morphology, perfusion, and integrity in children with hemiplegia compared to typically developing children, using MRI. …”
Get full text

Synthesis and characterization of a magnetic bacterial cellulose-chitosan nanocomposite and evaluation of its applicability for osteogenesis by Nahid Rezazadeh, Effat Alizadeh, Somaieh Soltani, Soodabeh Davaran, Neda Esfandiari

“…FE-SEM images showed the integrity of the fibrillar network. The magnetic nanocomposite has the highest swelling ratio (2445% ± 23.34) and tensile strength (5.08 MPa). …”
Get full text

Big Data Governance Challenges Arising From Data Generated by Intelligent Systems Technologies: A Systematic Literature Review by Yunusa Adamu Bena, Roliana Ibrahim, Jamilah Mahmood, Arafat Al-Dhaqm, Ahmad Alshammari, Maged Nasser, Muhammed Nura Yusuf, Matthew O. Ayemowa

“…Organizations adopting these technologies face challenges in managing the volume, variety, and velocity of data while ensuring quality, security, compliance, and ethical integrity. This study investigates the state of big data governance (BDG) programs in organizations leveraging intelligent systems technologies, using a systematic literature review guided by PRISMA. …”
Get full text

Clinical assessment and transcriptome analysis of host immune responses in a vaccination-challenge study using a glycoprotein G deletion mutant vaccine strain of infectious laryngo... by Gayathri Gopakumar, Mauricio J. C. Coppo, Mauricio J. C. Coppo, Andrés Diaz-Méndez, Carol A. Hartley, Joanne M. Devlin

“…On the contrary, the absence of any difference in the tracheal transcriptome between the vaccinated-challenged and the uninfected birds were reflected by the preservation of tracheal mucosal integrity in both groups and mild infiltration of leukocytes in the vaccinated-challenged birds. …”
Get full text

The potential of aloe vera gel utilization for skin wound healing in rats based on GC–MS and HPLC chemical profile by Nadia Mohamed Said Arafa, Huda Mohammad Ahmad Hummadi, Gehan Moustafa Badr

“…Abstract Background Wound healing is a restoration process of tissue integrity and function targeting reducing the healing time and complications with priority of available, acceptable and affordable medication. …”
Get full text

Protective effects and antioxidant mechanisms of lactobacillus combined with carnosine on the stomach and small intestine by Jian Qin, Ziyi Luo, Xu Yang, Yunqing Zhang, Huiying Li, Conghui Wang, Zhiqiang Zou, Yue Ma, Jing Ma, Daoyou Yue, Dipeng Zhao, Sen Qin, Rong Du

“…Our study sheds light on the synergetic and complementary roles of LAB and CAR in maintaining the structural and functional integrity of stomach and small intestine, offering clues for understanding the regulation of antioxidant enzyme genes through the Nrf2 pathway as a potential mechanism.…”
Get full text

Design of a Mechanised Sorghum Sieving Machine Used in Agriculture Production. by Amanya, Davis

“…The simulation results verified the design's integrity and efficiency, ensuring its suitability for sorghum sieving applications. …”
Get full text

Prophylactic Ozone Administration Reduces Intestinal Mucosa Injury Induced by Intestinal Ischemia-Reperfusion in the Rat by Ozkan Onal, Fahri Yetisir, A. Ebru Salman Sarer, N. Dilara Zeybek, C. Oztug Onal, Banu Yurekli, H. Tugrul Celik, Ayse Sirma, Mehmet Kılıc

“…The intestinal epithelium maintained its integrity and decrease in intestinal injury score was detected in Ozone + IR group. …”
Get full text

Embracing Generative Artificial Intelligence in Clinical Research and Beyond by Henry P. Foote, MD, Chuan Hong, PhD, Mohd Anwar, PhD, Maria Borentain, MD, Kevin Bugin, PhD, Nancy Dreyer, PhD, MPH, Josh Fessel, MD, PhD, Nitender Goyal, MD, Morgan Hanger, MPP, Adrian F. Hernandez, MD, Christoph P. Hornik, MD, PhD, MPH, Jennifer G. Jackman, PhD, MBA, Alistair C. Lindsay, MD, MPH, DPhil, Michael E. Matheny, MD, Kerem Ozer, MD, Jan Seidel, PhD, Norman Stockbridge, MD, PhD, Peter J. Embi, MD, Christopher J. Lindsell, PhD

“…Success is expected to require establishing rigorous data management and security protocols, fostering integrity and trust among stakeholders, and sharing information about the safety and effectiveness of AI applications. …”
Get full text

Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women by Katja Graf, José Martin Murrieta-Coxca, Tobias Vogt, Sophie Besser, Daria Geilen, Tim Kaden, Tim Kaden, Anne-Katrin Bothe, Diana Maria Morales-Prieto, Behnam Amiri, Behnam Amiri, Stephan Schaller, Ligaya Kaufmann, Martin Raasch, Ramy M. Ammar, Ramy M. Ammar, Christian Maass, Christian Maass

“…To address this issue, we used a three-organ microphysiological system (MPS) combined with a digital twin framework, to predict pharmacokinetics and fetal drug exposure.MethodsThe here shown human MPS integrated gut, liver, and placenta models, interconnected via the corresponding vasculature. …”
Get full text

Derivation and Characterization of Isogenic <i>OPA1</i> Mutant and Control Human Pluripotent Stem Cell Lines by Katherine A. Pohl, Xiangmei Zhang, Johnny Jeonghyun Ji, Linsey Stiles, Alfredo A. Sadun, Xian-Jie Yang

“…Within the mitochondrion, proteolytically processed OPA1 proteins form complexes to maintain membrane integrity and the respiratory chain complexity. Although <i>OPA1</i> is broadly expressed, human <i>OPA1</i> mutations predominantly affect retinal ganglion cells (RGCs) that are responsible for transmitting visual information from the retina to the brain. …”
Get full text

Quzhou Aurantii Fructus Flavonoids Ameliorate Inflammatory Responses, Intestinal Barrier Dysfunction in DSS-Induced Colitis by Modulating PI3K/AKT Signaling Pathway and Gut Microbi... by Wang H, Huang W, Pan X, Tian M, Chen J, Liu X, Li Q, Qi J, Ye Y, Gao L

“…In vivo experiments demonstrated that QAFF effectively ameliorated colitis symptoms, reduced IL-6, IL-1β, and TNF-α levels, enhanced intestinal barrier integrity, and downregulated PI3K/AKT pathway activation. …”
Get full text

Safety and Efficacy of Second-Generation Drug-Eluting Stents in Real-World Practice: Insights from the Multicenter Grand-DES Registry by You-Jeong Ki, Kyung Woo Park, Jeehoon Kang, Chee-Hoon Kim, Jung-Kyu Han, Han-Mo Yang, Hyun-Jae Kang, Bon-Kwon Koo, Hyo-Soo Kim

“…In this study, we sought to compare the efficacy and safety of the Xience Prime/Xience V/Promus EES and Biomatrix/Biomatrix Flex/Nobori BES with resolute integrity/resolute ZES using the grand drug-eluting stent (Grand-DES) registry. …”
Get full text

Current methodologies of creating material passports: A systematic literature review by Ioannis Markou, Derek Sinnott, Ken Thomas

“…These limitations affect their ability to accurately track materials and maintain data integrity throughout the building's operational life. …”
Get full text

Polycaprolactone for Hard Tissue Regeneration: Scaffold Design and In Vivo Implications by Fernanda Ramírez-Ruiz, Israel Núñez-Tapia, María Cristina Piña-Barba, Marco Antonio Alvarez-Pérez, Vincenzo Guarino, Janeth Serrano-Bello

“…Recently, several pathologies have led to bone loss or damage, such as malformations, bone resorption associated with benign or malignant tumors, periodontal disease, traumas, and others in which a discontinuity in tissue integrity is observed. Bone tissue is characterized by different stiffness, mechanical traction, and compression resistance as a function of the different compartments, which can influence susceptibility to injury or destruction. …”
Get full text