Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves’ disease through integrated serum metabolomics and network pharmacology with molecular docking techniques by Xiaoju Liu, Xingjia Li, Wenbin Huang, Yifan Cui, Fengyun Cheng, Guofang Chen, Guofang Chen, Xiaodong Mao, Chao Liu, Chao Liu, Shuhang Xu

“…Ethnopharmacological relevanceThe Sihai Shuyu Formula (SHSY) shows promising potential for treating Graves’ disease (GD), although the therapeutic mechanisms and pharmacological basis of SHSY have not been thoroughly evaluated.ObjectiveThis work is aim to investigate the pharmacological basis and mechanism of SHSY in the treatment of GD by integrating non-targeted serum metabolomics and network pharmacology coupled with molecular docking technology.Materials and methodsGD was induced in mice through injections of Ad-TSH289. …”
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The Application of Integrated Assisted History Matching and Embedded Discrete Fracture Model Workflow for Well Spacing Optimization in Shale Gas Reservoirs with Complex Natural Fractures by Qiwei Li, Jianfa Wu, Cheng Chang, Hongzhi Yang, Chuxi Liu, Wei Yu, Kamy Sepehrnoori, Jijun Miao

“…This work applied an integrated well spacing optimization workflow in shale gas reservoirs of the Sichuan Basin in China with both hydraulic and natural fractures. …”
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Integrating general practitioners’ and patients’ perspectives in the development of a digital tool supporting primary care for older patients with multimorbidity: a focus group study by Ingmar Schäfer, Vivienne Jahns, Valentina Paucke, Dagmar Lühmann, Martin Scherer, Julia Nothacker

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Erratum: Integrative genomic analyses combined with molecular dynamics simulations reveal the impact of deleterious mutations of Bcl-2 gene on the apoptotic machinery and implications in carcinogenesis by Frontiers Production Office

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Fracture-healing effects of Rhizoma Musae ethanolic extract: An integrated study using UHPLC-Q-Exactive-MS/MS, network pharmacology, and molecular docking. by Jian Zhang, Wanyan Shen, Fanzhi Liu, Hehe He, Shuquan Han, Lina Luo

“…<h4>Background</h4>Fracture disrupts the integrity and continuity of the bone, leading to symptoms such as pain, tenderness, swelling, and bruising. …”
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Aimi Antonio, Walter Alva y Emilia Perassi (eds), Sipán, una ventana hacia el futuro. Éxitos arqueológicos y desarrollo integral by Nicolas Goepfert

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An Investigation of the Anticancer Mechanism of <i>Caesalpinia sappan</i> L. Extract Against Colorectal Cancer by Integrating a Network Pharmacological Analysis and Experimental Validation by Mibae Jeong, Jaemoo Chun, Sang-Min Park, Heerim Yeo, Se Won Na, In Jin Ha, Bonglee Kim, Mi-Kyung Jeong

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LA NECESIDAD DE UNA LEY INTEGRAL PARA HACER FRENTE A LA VIOLENCIA DE GÉNERO EN ESPAÑA (LO 1/2004) by Perla Elizabeth Bracamontes Ramírez

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Sinistroporomonorchis bolini n. sp. (Trematoda: Monorchiidae) from the Ocellated killifish, Floridichthys polyommus (Cyprinodontidae) in the Yucatán Peninsula, Mexico based on an integrative taxonomy analysis by Leopoldo Andrade-Gómez, Juan F. Espínola-Novelo, Brenda Solórzano-García, Gerardo Pérez-Ponce de León

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Guía para evaluar el desarrollo de las habilidades profesionales del residente de Medicina General Integral en la atención ginecobstétrica by Marta Avilés Martínez, Anays Núñez Herrera, Tania López Otero, Yaan Manuel Quintana Santiago

“…Los profesores de Medicina General Integral realizaron la observación del desempeño mientras ocurría la atención de una paciente. …”
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Mapping Susceptibility and Risk of Land Subsidence by Integrating InSAR and Hybrid Machine Learning Models: A Case Study in Xi&#x0027;an, China by Chen Chen, Mimi Peng, Mahdi Motagh, Xinxin Guo, Mengdao Xing, Yinghui Quan

“…This work provides an integrated assessment approach for subsidence from a new perspective, and the findings can serve as theoretical support for early warning and disaster prevention.…”
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Optimizing composite ecological networks through Synergistic risk Management, ecological Conservation, and recreational Integration: A case study of Beijing’s shallow mountain regions by Lei Cao, Kaiping Wang, Xinyao Zhao, Yunlu Zhang

“…The multifunctional composite ecological network constructed in this study effectively mitigates ecological risks, enhances ecosystem services functions, and promotes the balanced integration of ecological conservation and sustainable economic activities, such as ecotourism and cultural heritage utilization. …”
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Integrating whole-genome re-sequencing and transcriptome data to reveal the molecular mechanism of TBX5 gene regulating feathered feet in Guangxi native chickens by Zhuliang Yang, Yongcui Liu, Jintang Luo, Cong Xiao, Hong Yuan, Wenya Du, Xiurong Yang

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Optimization of land use structure integrating ecosystem service function and economic development—A case study in Dongting Lake Ecological and Economic Zone, China by Yifan Zhu, Min Zhou

“…Therefore, this study established a coupled land use simulation and optimization model based on ecosystem services and economic development, which integrates the ecosystem service evaluation model (InVEST), the interval uncertainty optimization model, and the spatial layout model of land use (PLUS), to simulate and optimize the land use allocation planning practice of Dongting Lake Ecological and Economic Zone in 2030. …”
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Evaluation of Problem Based Gamification Learning (PBGL) Model on Critical Thinking Ability with Artificial Intelligence Approach Integrated with ChatGPT API: An Experimental Study by Remerta Noni Naatonis, Rusijono Rusijono, Miftakhul Jannah, Edwin Ariesto Umbu Malahina

“… This research evaluates the effectiveness of the PBGL model integrated with Artificial Intelligence (A.I) using the ChatGPT API to improve students' critical thinking skills. …”
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Integrated metabolome and transcriptome analysis reveals potential mechanism during the bud dormancy transition of Astragalus membranaceus (Fisch.)... by Huan Guan, Huan Guan, Yuhuan Zhao, Yuhuan Zhao, Qing Chen, Qianqian Zhang, Qianqian Zhang, Pengpeng Yang, Pengpeng Yang, Shuying Sun, Shuying Sun, Guilin Chen, Guilin Chen

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Whole-Genome Sequencing Revealed a Late-Maturing Isogenic Rice Koshihikari Integrated with Hd16 Gene Derived from an Ise Shrine Mutant by Motonori Tomita, Ryotaro Tokuyama, Shosuke Matsumoto, Kazuo Ishii

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Controlled Non-Dominated Sorting Genetic Algorithms for Multi-Objective Optimal Design of Standalone and Grid-Connected Renewable Energy Systems in Integrated Energy Sectors by Hamza El Hafdaoui, Ahmed Khallaayoun, Salah Al-Majeed

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Hybrid parking space prediction model: integrating ARIMA, Long short-term memory (LSTM), and backpropagation neural network (BPNN) for smart city development by Anchal Dahiya, Pooja Mittal, Yogesh Kumar Sharma, Umesh Kumar Lilhore, Sarita Simaiya, Mohd Anul Haq, Mohammed A. Aleisa, Abdullah Alenizi

“…The proposed model works in two phases: in first phase, auto-regressive integrated moving average (ARIMA) and long short-term memory (LSTM) models are integrated. …”
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Time-Optimal Trajectory Planning along Parametric Polynomial Lane-Change Curves with Bounded Velocity and Acceleration: Simulations for a Unicycle Based on Numerical Integration by Chien-Sheng Wu, Zih-Yun Chiu, Jing-Sin Liu

“…We base the time-optimal trajectory simulations on numerical integration on a path basis under two different end conditions representing sufficient and restricted steering spaces with remarkable difference in allowable maximum curvature. …”
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