Achieving reliable patient reported outcomes collection to measure health care improvement in a learning health network: lessons from pediatric rheumatology care and outcomes impro... by Nancy Pan, Nancy Pan, Esi M. Morgan, Meghan Ryan, Beth Gottlieb, Beth Gottlieb, Julia G. Harris, Julia G. Harris, Tzielan Lee, Tzielan Lee, Y. Ingrid Goh, Y. Ingrid Goh

“…Interviews with physician leaders indicated that their site overcame barriers through: integration of PRO collection into workflow, gaining buy-in of stakeholders (clinicians and patients), and automating PRO collection. …”
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Whole-genome analysis of a ST45-SCCmec IVa (2B)-t116 methicillin-resistant Staphylococcus aureus strain isolated from the sputum of a 5-year-old child with pneumonia by Lin Huang, Rui Guo, Jingxian Lin, Xiaowei Li, Zhicong Li, Limei Zhang, Wenting Li, Rui Xue, Cheng Zhang, Xiaosan Feng, Xiaobin Li, Xiaobin Li

“…Mobile genetic elements analysis of SA2107 revealed two plasmids (30,064-bp pSA2107-1 and 8,033-bp pSA2107-2), three prophages, two integrative and conjugative elements (ICEs), and two insertion sequences (ISs, IS431 and IS1272). …”
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Artificial intelligence-assisted platform performs high detection ability of hepatocellular carcinoma in CT images: an external clinical validation study by Rongxue Shan, Chenhao Pei, Qianrui Fan, Junchuan Liu, Dawei Wang, Shifeng Yang, Ximing Wang

“…The AI-assisted platform is designed based on a two-phase segmentation approach, integrating coarse and fine segmentation techniques to accurately identify and delineate hepatic lesions. …”
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Bone Defect Repair Using a Bone Substitute Supported by Mesenchymal Stem Cells Derived from the Umbilical Cord by Michal Kosinski, Anna Figiel-Dabrowska, Wioletta Lech, Lukasz Wieprzowski, Ryszard Strzalkowski, Damian Strzemecki, Lukasz Cheda, Jacek Lenart, Krystyna Domanska-Janik, Anna Sarnowska

“…In animal studies, WJ-MSCs seeded on Bio-Oss® increased the scaffold integration with host bone and changed their morphology to osteoblast-like cells. …”
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Advances in Development of PM2.5-Exposed Animal Models and Their Application in Reproductive Toxicity Research by TIAN Fang, PAN Bin, SHI Jiayi, XU Yanyi, LI Weihua

“…Additionally, interdisciplinary collaboration should be encouraged, involving cooperation between environmental science, toxicology, reproductive medicine, and other disciplines, to comprehensively assess the environmental health risks of PM2.5 and provide scientific support for the development of integrated prevention and control strategies. This review summarizes animal modeling methods, evaluation criteria, and their applications, providing valuable methodological references for future reproductive toxicity research on PM2.5.…”
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Sleep quality during pregnancy following assisted reproductive technology and natural conceiving: a prospective birth cohort study by Yidong Xie, Yidong Xie, Ruoti Peng, Li Xiao, Li Xiao, Shangwei Li, Shangwei Li, Xiaohong Li, Xiaohong Li

“…Data on sleep, anxiety, depression, and stress was collected in the first trimester (T1), second trimester (T2), and third trimester (T3) using integrated questionnaires. Sleep quality is quantified by the Pittsburgh Sleep Quality Index (PSQI) with a cut-point of 5 indicating poor sleep. …”
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Partial Stereotactic Ablative Radiotherapy Boost Before Conventional Radiotherapy (P‐SABR) for Large (> 5 cm) Unresectable Stage III Nonsmall Cell Lung Cancer by Yun Bai, Xianshu Gao, Shangbin Qin, Shanshi Li, Mingwei Ma, Xi Cao, Feng Lyu, Jiayan Chen, Xin Qi, Siwei Liu, Yan Gao, Hongzhen Li, Xiaomei Li, Xiaoying Li, Xueying Ren, Lei Huang

“…In the partial SABR boost plan, the prescription dose for planning target volume (PTV) was 1.8–3 Gy per fraction over 3–4 fractions, and the artificially delineated gross tumor boost volume (GTVb) within GTV received a simultaneously integrated SABR dose (6 or 8 Gy per fraction). In the following CFRT plan, the median dose for the entire PTV was 54 Gy in 22 fractions. …”
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Methodological challenges using routine clinical care data for real-world evidence: a rapid review utilizing a systematic literature search and focus group discussion by Michelle Pfaffenlehner, Max Behrens, Daniela Zöller, Kathrin Ungethüm, Kai Günther, Viktoria Rücker, Jens-Peter Reese, Peter Heuschmann, Miriam Kesselmeier, Flavia Remo, André Scherag, Harald Binder, Nadine Binder, for the EVA4MII project

“…Abstract Background The integration of real-world evidence (RWE) from real-world data (RWD) in clinical research is crucial for bridging the gap between clinical trial results and real-world outcomes. …”
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A qualitative study on the experience of nurses participating in new media health science popularization (护士参与新媒体健康科普真实体验的质性研究) by LI Ting (李婷), XU Jianwen (徐建文), QIANG Hong (羌虹), WEI Xiaoxiao (卫笑笑), WANG Juan (汪娟), WANG Jingting (王婧婷)

“…Conclusion Nurses had benefited experience and encountered some difficulties in participating in new media health science popularization. Managers should integrate resources, improve the support system, encourage nurses to participate in new media health science popularization, enhance their sense of professional value and comprehensive ability, and build satisfaction High-quality new media health science popularization works with complex needs of patients. …”
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Revealing Land-Use Dynamics on Thermal Environment of Riverine Cities Under Climate Variability Using Remote Sensing and Geospatial Techniques by Nazia Iftakhar, Fakhrul Islam, Mohammad Izhar Hussain, Muhammad Nasar Ahmad, Jinwook Lee, Nazir Ur Rehman, Saleh Qaysi, Nassir Alarifi, Youssef M. Youssef

“…While previous studies have investigated factors influencing land surface temperature (LST) variations, gaps persist in integrating Landsat imagery (7 and 8), meteorological data, and Geographic Information System (GIS) tools to evaluate the thermal effects of specific LULC types, including cooling and warming transitions, and their influence on air temperature under variable precipitation patterns. …”
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An examination of ankle joint position sense, postural control and associated neuromuscular deficits in patients with plantar fasciitis: a cross-sectional analysis with advanced bi... by Shaker Hassan S. Alshehri, Mastour Saeed Alshahrani, Saeed Y. Al Adal, Faisal M. Alyazedi, Hani Hassan Alnakhli, Ravi Shankar Reddy

“…Conclusion This study highlights the impact of pain catastrophizing on proprioceptive deficits in plantar fasciitis, emphasizing the importance of addressing psychological as well as biomechanical factors in treatment. Integrating cognitive-behavioral strategies may enhance proprioceptive accuracy and stability outcomes in this population.…”
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Targeted inhibition of Aurora kinase A promotes immune checkpoint inhibition efficacy in human papillomavirus-driven cancers by Pragya Sinha, Faye M Johnson, Soma Ghosh, Jagannadha K Sastry, Madison P O'Hara, Tuhina Mazumdar, Lacin Yapindi

“…Standard-of-care chemotherapy, radiotherapy, and immune checkpoint inhibitors (ICIs) are associated with adverse effects and limited responses in patients with HPV-driven cancers. The integration of targeted therapies with ICIs may improve outcomes. …”
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Achieving 32.9% efficiency in Pb-Based quantum dot solar cells via SCAPS-1D simulation optimization by Md Hasnain, Abdul Wahed, Joyonta Das, Bassim Arkook, Moussab Harb, Nasim Mia

“…The results provide a valuable understanding of designing high-performance QDSCs, paving the way for their integration into sustainable energy solutions.…”
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Development and validation of a nomogram model for prolonged length of stay in spinal fusion patients: a retrospective analysis by Linghong Wu, Xiaozhong Peng, Yao Lu, Cuiping Fu, Liujun She, Guangwei Zhu, Xianglong Zhuo, Wei Hu, Xiangtao Xie

“…Assessment of the models’ capability to improve classification efficiency was achieved using continuous net reclassification improvement (NRI) and integrated discrimination improvement (IDI). The Hosmer–Lemeshow method and calibration curve was utilised to assess the calibration degree, and decision curve to evaluate its clinical practicality. …”
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Elevated blood glucose and unfavourable tuberculosis treatment outcomes in a low-income setting: findings from a prospective cohort study in Eswatini by Diederick E Grobbee, Kerstin Klipstein-Grobusch, Kennedy Otwombe, Victor Williams, Alinda G Vos-Seda, Marianne Calnan, Colani S Ngwenya, Samson Haumba, Lindiwe Mdluli-Dlamini

“…Hypertension (AOR 4.84; 95% CI: 1.48, 15.7), unemployment (AOR 2.01; 95% CI: 1.08, 3.71) and high school education (AOR 0.32; 95% CI: 0.16, 0.64) were associated with unfavourable treatment outcome.Conclusion Our study shows the need to optimise care for patients receiving treatment for tuberculosis by integrating screening for and treatment of diabetes and hypertension, prioritising males, those aged ≥55 years and those with a reactive HIV status to limit unfavourable outcomes and death.…”
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Zero-BertXGB: An Empirical Technique for Abstract Classification in Systematic Reviews by Mohammad Shariful Islam, Mohammad Abu Tareq Rony, Md Rasel Hossain, Samah Alshathri, Walid El-Shafai

“…A novel Zero-BertXGB technique is introduced, integrating a transformer-based language model, zero-shot learning, and an ML classifier to enhance abstract screening and classification into “Include” or “Exclude” categories. …”
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MUC5B modulation of early oral biofilm glucose metabolism by Carolina Robertsson, Carolina Robertsson, Julia Davies, Gunnel Svensäter, Anders Bay Nord, Niclas Norrström, Claes Wickström

“…IntroductionSalivary mucin MUC5B has been suggested to support eubiosis in early oral biofilms by regulating the attachment of commensals, while downregulating dysbiotic activities related to dental caries development, such as microbial carbohydrate transport and metabolism.MethodsTo investigate how the metabolism of glucose, a potential driver for dental caries, in early mono- and dual-species biofilms of oral Actinomyces naeslundii and Streptococcus gordonii clinical isolates was affected by the presence of the complex salivary mucin MUC5B, this study employed nuclear magnetic resonance (NMR)-based metabolomics with the interpretation of network integration.Results and discussionMUC5B reduced early attachment in the presence of glucose compared with uncoated surfaces but maintained even species distribution. …”
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Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation by Yang Z, Kao X, Zhang L, Huang N, Chen J, He M

“…Zhen Yang,1,2 Xingyu Kao,1,2 Lin Zhang,3 Na Huang,1,2 Jingli Chen,2 Mingfeng He2 1The Eighth Clinical Medical College of Guangzhou University of Chinese Medicine, Foshan, Guangdong, People’s Republic of China; 2Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, People’s Republic of China; 3Department of Cardiovascular, Integrated Hospital of Traditional Chinese Medicine, Southern Medical University, Guangzhou, People’s Republic of ChinaCorrespondence: Mingfeng He, Foshan Hospital of Traditional Chinese Medicine, Foshan, Guangdong, People’s Republic of China, Email he-mingfeng@foxmail.comBackground: Dachaihu decoction (DCHD) is a common Chinese medicine formula against sepsis-induced acute lung injury (SALI). …”
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Improving education for incarcerated children and young people: policy recommendations from three transnational projects in Europe by Adeela ahmed Shafi

“…From a practical perspective, these programmes and interventions have been designed to fit into existing structures and timetables with custodial and youth justice settings, making them easily integrated into business as usual. Originality/value – Planned and strategically delivered interventions by expert educators in a holistic way means there is real opportunity to better support justice involved children and young people to successful transitioning back into communities, thereby potentially reducing reoffending. …”
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Urinary human papillomavirus DNA as an indicator of gynaecological infection in young women in Schistosoma and HIV endemic South Africa by P. Pillay, H. N. Galappaththi-Arachchige, M. Taylor, B. Roald, B. Roald, E. F. Kjetland, E. F. Kjetland

“…There was no statistical association between urinary schistosomiasis and HPV or with any atypia.ConclusionUrine has the potential of being optimized as an alternative and possibly more acceptable sample for HPV detection among young adolescent populations at risk in comparison to CVL samples. An integrated targeted intervention incorporating Schistosoma in addition to HPV and HIV testing needs consideration among young women in this age group from endemic areas.…”
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