Preclinical optimization of a GPC2-targeting CAR T-cell therapy for neuroblastoma by Nan Li, Haiying Qin, Rosa Nguyen, Mitchell Ho, Ming Sun, Eytan Ruppin, Michael C Kelly, Yingying Cao, Reona Okada, Jeyshka M Reyes-González, Hannah G Stack, Charlie Seibert, Carol J Thiele

“…Mechanistic studies were performed using single-cell RNA-sequencing.Results Applying stringent in vitro assays and orthotopic in vivo NB models, we demonstrated that our single-chain variable fragment, CT3, integrated into a CAR vector with a CD28 hinge, CD28 transmembrane, and 4-1BB co-stimulatory domain (CT3.28H.BBζ) elicits the best preclinical anti-NB activity compared with other tested CAR constructs. …”
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MultiTax-human: an extensive and high-resolution human-related full-length 16S rRNA reference database and taxonomy by Zhiwei Bao, Bin Zhang, Jianhua Yao, Ming D. Li

“…Our study presents the MultiTax-human database, a high-resolution reference tool specifically designed for human microbiome research. By integrating data from multiple sources and employing advanced classification techniques, this database offers an accurate and detailed map of the human microbiome. …”
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Interdisciplinary collaboration across secondary and primary care to improve medication safety in the elderly (IMMENSE study): study protocol for a randomised controlled trial by Liv Mathiesen, Jeanette Schultz Johansen, Kjerstin Havnes, Kjell H. Halvorsen, Stine Haustreis, Lillann Wilsgård Skaue, Elena Kamycheva, Kirsten K. Viktil, Anne Gerd Granås, Beate H. Garcia

“…Introduction Drug-related problems (DRPs) are common in the elderly, leading to suboptimal therapy, hospitalisations and increased mortality. The integrated medicines management (IMM) model is a multifactorial interdisciplinary methodology aiming to optimise individual medication therapy throughout the hospital stay. …”
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Imaging and Spectral Fitting of Bright Gamma-Ray Sources with the COSI Balloon Payload by Jarred M. Roberts, Steven Boggs, Thomas Siegert, John A. Tomsick, Marco Ajello, Peter von Ballmoos, Jacqueline Beechert, Floriane Cangemi, Savitri Gallego, Pierre Jean, Chris Karwin, Carolyn Kierans, Hadar Lazar, Alex Lowell, Israel Martinez Castellanos, Sean Pike, Clio Sleator, Yong Sheng, Hiroki Yoneda, Andreas Zoglauer

“…Cygnus X-1 was also observed during this flight, and we obtain a measured flux of (1.4 ± 0.2) × 10 ^3 ph cm ^−2 s ^−1 in the same energy band and a best-fit result (including data from NuSTAR, Swift-BAT, and INTEGRAL/IBIS) was a cutoff power law with a high-energy cutoff energy of 138.3 ± 1.0 keV and a photon index of Γ = 1.358 ± 0.002. …”
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Ethnopharmocology, phytochemistry and pharmacology of the genus Orthosiphon: A review by Rui Wang, Ling Qiu, Qing-wen Zhang, Ligen Lin

“…Method: Orthosiphon-related information was collected from the online databases, such as Google Scholar, SciFinder, Web of Science, Elsevier, PubMed and China Knowledge Resource Integrated (CNKI). Results: Plants of the genus Orthosiphon are widely distributed in African, Australia, South Asian, and Southeast Asian, and in China. …”
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Produção de um curso de especialização em Medicina de Família e Comunidade by Alysson Feliciano Lemos, Paula Zeni Miessa Lawall, Rodrigo Luciano Bandeira de Lima, Sara Shirley Belo Lança, Edinalva Neves Nascimento

“…Para enfrentá-lo, é fundamental qualificar profissionais em saúde pública, com ênfase na saúde da família, por meio de uma abordagem reflexiva e problematizadora que integre teoria e prática e utilize tecnologias de informação e comunicação. …”
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Multi-task aquatic toxicity prediction model based on multi-level features fusion by Xin Yang, Jianqiang Sun, Bingyu Jin, Yuer Lu, Jinyan Cheng, Jiaju Jiang, Qi Zhao, Jianwei Shuai

“…Methods: The model integrates molecular fingerprints and molecule graphs to characterize molecules, enabling the simultaneous prediction of acute toxicity for the same organic compound across four distinct fish species. …”
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Menthone lowers H3K27ac levels to inhibit Fusarium proliferatum growth by Li-Yan Zhang, Tian-Tian Li, Hong-Xin Liao, Jin-Rui Wen, Hong-Yan Nie, Fu-Rong Xu, Xiao-Yun Liu, Xian Dong

“…Chromatin immunoprecipitation sequencing (ChIP-seq) analysis revealed that menthone inhibited the growth of F. proliferatum by decreasing H3K27ac levels and interfering with the transcription of energy metabolism-related genes. By integrating the RNA-seq data with the ChIP-seq results, we identified 110 DEGs associated with reduced H3K27ac modification primarily associated with ribosome biogenesis. …”
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Evaluation of learning from Practical Obstetric Multi-Professional Training and its impact on patient outcomes in Australia using Kirkpatrick’s framework: a mixed methods study by Philip DeKoninck, Euan M Wallace, Debra Nestel, Arunaz Kumar, Sam Sturrock, Donna Lucey, Sally Stoyles, Jenny Morgan, Peter Neil, Michelle Schlipalius

“…We explored participants’ acquisition of knowledge and skills, its impact on clinical outcomes and organisational change to integrate the PROMPT programme as a credentialing tool. …”
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Voices from the Amazon: exploring implementor and user perceptions of non-invasive malaria diagnostics in Peru by Lauren Nussbaum, Emma Ortega, E. Jennifer Ríos López, Alfonso Simoné Vizcarra, Jhonny J. Córdova López, Serafina Calarco, Elena Marbán-Castro, Kevin Tetteh, Sonjelle Shilton, Amy C. Morrison, Vanessa Fargnoli, Valerie A. Paz-Soldán

“…As manufacturers evaluate the efficacy and effectiveness of these non-invasive diagnostic tools, international recommendations should be created to ensure their agile integration into national malaria programmes.…”
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Image depth estimation assisted by multi-view projection by Liman Liu, Jinshan Tian, Guansheng Luo, Siyuan Xu, Chen Zhang, Huaifei Hu, Wenbing Tao

“…To address this problem, a multi-view projection-assisted image depth estimation network is proposed, which integrates multi-view stereo vision into a deep learning-based encoding-decoding image depth estimation framework without pre-estimation of view bitmap. …”
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Body composition as an indicator of metabolic changes in mice obtained by <i>in vitro</i> fertilization by M. V. Anisimova, Yanli Gon, G. V. Kontsevaya, A. V. Romashchenko, N. V. Khotskin, A. K. Stanova, L. A. Gerlinskaya, M. P. Moshkin

“…One of the consequences of reduced utilization of IVF energy substrates by offspring is a decrease in their tolerance to glucose loading. The integral criterion for the effectiveness of restoring the initial glucose level is the area under the curve (AUC), the value of which was 2.5 (males) and 3.2 (females) times higher in IVF offspring compared to the corresponding control. …”
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The impact of drought on forest spring phenology in northern China by Haowen Hu, Pengcheng Xue, Shaodong Huang, Zong Wang, Nina Xiong, Liang Shi, Boyi Liang, Jia Wang

“…We utilized a remote sensing dataset with a spatial resolution of 250 m, integrated with meteorological station data, to examine the response mechanisms of SOS to pre-seasonal drought. …”
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Role of Astrocytic Dysfunction in the Pathogenesis of Parkinson’s Disease Animal Models from a Molecular Signaling Perspective by Lucas Udovin, Cecilia Quarracino, María I. Herrera, Francisco Capani, Matilde Otero-Losada, Santiago Perez-Lloret

“…The Wnt-1 (wingless-type MMTV integration site family, member 1) pathway regulates several processes including neuron survival, synapse plasticity, and neurogenesis. …”
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Universal conditional networks (UniCoN) for multi-age embryonic cartilage segmentation with Sparsely annotated data by Nishchal Sapkota, Yejia Zhang, Zihao Zhao, Maria Jose Gomez, Yuhan Hsi, Jordan A. Wilson, Kazuhiko Kawasaki, Greg Holmes, Meng Wu, Ethylin Wang Jabs, Joan T. Richtsmeier, Susan M. Motch Perrine, Danny Z. Chen

“…Extensive experiments on multi-age cartilage segmentation datasets show significant and consistent performance improvements when integrating our conditional modules into popular DL segmentation architectures. …”
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Current update on surgical management for spinal tuberculosis: a scientific mapping of worldwide publications by Romaniyanto Romaniyanto, Muhana Fawwazy Ilyas, Aldebaran Lado, Daffa Sadewa, Daffa Sadewa, Dykall Naf'an Dzikri, Enrico Ananda Budiono, Enrico Ananda Budiono

“…Key topics evolved from basic surgical methods, including early spinal procedures, to integrating pharmacological approaches alongside surgical techniques, such as antitubercular drugs, advancing into imaging research and procedure research involving refined surgical methods like spinal fusion. …”
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Development and validation of a prognostic prediction model for elderly gastric cancer patients based on oxidative stress biochemical markers by Xing-Qi Zhang, Ze-Ning Huang, Ju Wu, Chang-Yue Zheng, Xiao-Dong Liu, Ying-Qi Huang, Qi-Yue Chen, Ping Li, Jian-Wei Xie, Chao-Hui Zheng, Jian-Xian Lin, Yan-Bing Zhou, Chang-Ming Huang

“…The patients were allocated into three cohorts (training, internal, and external validation). The GC-Integrated Oxidative Stress Score (GIOSS) was developed using Cox regression to correlate biochemical markers with patient prognosis. …”
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Urban vegetation benefits in mediterranean cities for climate change adaptation and water usage efficiency – a case study in Algarve, Portugal by Pedro Matias, Pedro Matias, Pedro Matias, Manuela Moreira da Silva, Manuela Moreira da Silva, Manuela Moreira da Silva, João Teigão, Amílcar Duarte, Amílcar Duarte

“…The demand for water, especially for urban and tourism purposes, is rising, particularly in coastal cities. The importance of integrating nature into cities, particularly trees, has been studied for its benefits in adapting to climate change and improving quality of life. …”
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Transcriptomics-based analysis of neurotoxic and reproductive effects in turbot (Scophthalmus maximus) after exposure to tris (2-chloroethyl) phosphate (TCEP) by Xiaoqian Zhou, Weifeng Liu, Bailin Cong, Aifang Deng, Jing Lin, Linlin Zhao, Shenghao Liu

“…This study aimed to investigate the toxic effects of TCEP on turbot by integrating physio-biochemical and transcriptomic analyses. …”
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The clean analysis process of Mn2+ for industries: a comparative study on direct determination of high-concentration Mn2+ in solution using spectrophotometry by Yanli Xu, Fuyuan Xu, Yong Liu, Guangbin Zhu, Ying Chen, Ning Duan

“…The EC method’s minimal time consumption and cost-effectiveness make it suitable for automation and integration into industrial systems for continuous, real-time monitoring. …”
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