Therapeutic effect and potential mechanism of Fufang Danshen dripping pills for stable coronary heart disease: a randomized controlled trial by Li-qin Meng, Li-qin Meng, Pei-ying Huang, Qing-min Li, Yu-chao Feng, Yu-chao Feng, Yu-chao Feng, Ding-jian Li, Guang-long Wu, Bo-wen Ao, Guo-chao Wu, Guo-xiong Zhang, Bo-jun Chen, Bo-jun Chen, Bo-jun Chen

“…Lipidomics further confirmed triglycerides as key lipids affected by FFDS. By integrating these findings with network pharmacology targets, we highlighted the potential roles of LPL, CD36, FABPpm, L-FABP, LCAT, and CEPT in fat digestion, absorption, and metabolism pathways, suggesting their involvement in FFDS's treatment of SCHD by reducing triglycerides.ConclusionIn individuals with SCHD, the administration of FFDS has been shown to effectively reduce circulating triglyceride levels and decrease the frequency of angina episodes. …”
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Non-HDL cholesterol: A valid surrogate marker to apolipoprotein b100 in type 2 diabetes mellitus patients in assessment of risk of cardiovascular diseases by Vidyashree, Lakshmi D, Prashanth D, Indushree T, Hamsaveena

“…Three ml of fasting venous blood sample was taken from each patient and fasting blood sugar, TC, triglycerides, HDL-C and ApoB were estimated on VITROS 5600 Integrated Autoanalyser. LDL-C was calculated using Friedewald formula and non-HDL-C was calculated by subtracting HDL-C from TC. …”
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Variational Approaches for Drug-Disease-Gene Links in Periodontal Inflammation by Pradeep Kumar Yadalam, Prabhu Manickam Natarajan, Musab Hamed Saeed, Carlos M. Ardila

“…Their roles in various biological processes were evaluated using gene set enrichment analysis, employing tools like Enrichr, which integrates diverse gene sets from sources such as DSigDB, DisGeNET, and Lincs_l1000.drug. …”
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Advancements and challenges in agriculture: a comprehensive review of machine learning and IoT applications in vertical farming and controlled environment agriculture by Binoy Sasmal, Gobinda Das, Preeti Mallick, Sneha Dey, Suman Ghorai, Subrata Jana, Chiranjibe Jana

“…The innovative idea, also known as Vertical Farming (VF), integrates agricultural design with building design in a tall structure inside of cities. …”
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可穿戴设备在卒中风险预测及卒中后管理中的应用进展 Research Progress on the Application of Wearable Devices in Stroke Risk Prediction and Post-Stroke Management... by 吴雅婷1，魏宸铭1，桑振华1，陈乐1，梁怡凡1，武剑1，2，3 (WU Yating1, WEI Chenming1, SANG Zhenhua1, CHEN Le1, LIANG Yifan1, WU Jian1,2,3)

“…Wearable devices, with their real-time capabilities and portability features, present new solutions for stroke risk prediction and post-stroke management. By integrating with health management platforms and artificial intelligence algorithms, wearable devices can significantly enhance the accuracy of risk assessment, optimize rehabilitation treatment plans, and thus improve the patients’ outcomes. …”
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Limitations of the Boston Carpal Tunnel Questionnaire in Assessing Severity in a Homogeneous Occupational Cohort by Venera Cristina Dinescu, Marius Bica, Ramona Constantina Vasile, Andrei Gresita, Bogdan Catalin, Alexandra Daniela Rotaru-Zavaleanu, Florentin Ananu Vreju, Lorena Sas, Marius Bunescu

“…Future refinements, such as tailored scoring systems and integration with clinical measures, could enhance its diagnostic utility and ensure comprehensive assessment of CTS severity.…”
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Dysfunction in mitochondrial electron transport chain drives the pathogenesis of pulmonary arterial hypertension: insights from a multi-omics investigation by Xin Zhang, Jieling Li, Minyi Fu, Xijie Geng, Junjie Hu, Ke-Jing Tang, Pan Chen, Jianyong Zou, Xiaoman Liu, Bo Zeng

“…Mitochondrial dysfunction is implicated in the development of PAH, but the key mitochondrial functional alterations in the pathogenesis have yet to be elucidated. Methods We integrated three microarray datasets from the Gene Expression Omnibus (GEO), including 222 lung samples (164 PAH, 58 controls), for differential expression and functional enrichment analyses. …”
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The clinical evaluation of the triglyceride-glucose index as a risk factor for coronary artery disease and severity of coronary artery stenosis in patients with chronic kidney dise... by Dan Liu, Xiaoyang Guan, Ruoxin Chen, Ci Song, Shanhu Qiu, Shengchun Xu, Jingyuan Cao, Hong Liu

“…Patients in the CAD group were divided into three groups according to the Gensini integral quantile level. Multivariate logistic regression analysis showed that the TyG index was an independent related factor for severe CAS after adjusting for relevant confounding factors (p < 0.001).Conclusions The TyG index is associated with CAD and the severity of CAS in patients with nondialysis stages 3–5 CKD. …”
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A qualitative study of how clinicians reach agreement in perioperative pathway development: the Consensus Model for Standardising Healthcare by Lisa Pagano, Janet C. Long, Emilie Francis-Auton, Andrew Hirschhorn, Gaston Arnolda, Jeffrey Braithwaite, Mitchell N. Sarkies

“…Results Seven individual and contextual factors crucial for building consensus, and eight mechanisms for reaching agreement were identified and integrated into a conceptual model. Seeking evidence to support decision-making emerged as the primary driver of consensus. …”
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A Cross-Stage Focused Small Object Detection Network for Unmanned Aerial Vehicle Assisted Maritime Applications by Gege Ding, Jiayue Liu, Dongsheng Li, Xiaming Fu, Yucheng Zhou, Mingrui Zhang, Wantong Li, Yanjuan Wang, Chunxu Li, Xiongfei Geng

“…At the same time, in each detection layer, a lightweight CRE module was integrated, leveraging attention mechanisms and detection heads to enhance precision for small object detection. …”
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Evaluating implementation of a hospital‐based cancer registry to improve childhood cancer care in low‐ and middle‐income countries by Melissa R. Maas, Allison Yang, Michele A. Muir, James B. Collins IV, Courtney Canter, Gevorg Tamamyan, Inam Chitsike, Francine Kouya, Kim Hoa Nguyen, Alia Ahmad, Ana Patricia Alcasabas, Yi‐Jin Gao, Kimberly J. Johnson, Gia Ferrara, Nickhill Bhakta, Benyam Muluneh

“…Several barrier themes were identified, including: difficulty integrating the registry into existing workflow; lack of resources; lack of government or administrative support; and damaged, misplaced, or illegible medical records. …”
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Serum IL-18 Is a Potential Biomarker for Predicting Severe Dengue Disease Progression by Josephine Diony Nanda, Chiau-Jing Jung, Rahmat Dani Satria, Ming-Kai Jhan, Ting-Jing Shen, Po-Chun Tseng, Yung-Ting Wang, Tzong-Shiann Ho, Chiou-Feng Lin

“…In this study, we created an integrated and precise multiplex panel of cytokine/chemokine assays based on our literature analysis to monitor dengue CRS. …”
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A novel multimodality anthropomorphic phantom enhances compliance with quality assurance guidelines for magnetic resonance imaging in radiotherapy by Meshal Alzahrani, David A Broadbent, Irvin Teh, Bashar Al-Qaisieh, Emily Johnstone, Richard Speight

“…IPEM and AAPM-recommended QA tests were conducted, including informatics/connectivity/data transfer, MRI-CT registration, end-to-end QA, and signal-to-noise ratio (SNR)/percentage integral uniformity (PIU) assessments using RT accessories. …”
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Detection and Classification of Teacher-Rated Children&#x2019;s Activity Levels Using Millimeter-Wave Radar and Machine Learning: A Pilot Study in a Real Primary School Environment by Tianyi Wang, Takuya Sakamoto, Yu Oshima, Itsuki Iwata, Masaya Kato, Haruto Kobayashi, Manabu Wakuta, Masako Myowa, Tokomo Nishimura, Atsushi Senju

“…Despite limitations such as a short monitoring duration and a small sample size, this pilot study lays the foundation for future research in non-invasive restlessness detection using non-contact monitoring technologies. The integration of millimeter-wave radar and machine learning offers a promising avenue for efficient and ethical trait assessments in real-world educational environments, contributing to the advancement of child psychology and education. …”
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Ecological niche and phenotypic differences among two alpine Rhododendron species and their natural hybrids in a common landscape by Yanghui Zhao, Ying Zhang, Liang Xu, Yadan Yan, Chuncheng Wang, Yafeng Wen, Donglin Zhang

“…Quantifying ecological niche and phenotypic traits among sympatric species is crucial for understanding ecologically moderated biodiversity. We integrate ecological and phenotypic datasets to investigate the extent to which three sympatric alpine Rhododendron species in the mountainous southwest of China (parents: Rhododendron delavayi and R. irroratum; natural hybrid: R. agastum) differed in their adaptations to co-exist in a shared environment. …”
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Next generation bioelectronic medicine: making the case for non-invasive closed-loop autonomic neuromodulation by Imanuel Lerman, Yifeng Bu, Rahul Singh, Harold A. Silverman, Anuj Bhardwaj, Alex J. Mann, Alik Widge, Joseph Palin, Christopher Puleo, Hubert Lim

“…Abstract The field of bioelectronic medicine has advanced rapidly from rudimentary electrical therapies to cutting-edge closed-loop systems that integrate real-time physiological monitoring with adaptive neuromodulation. …”
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Degradation of amyloid β-peptides catalyzed by nattokinase in vivo and in vitro by Aixin Ni, He Li, Ruya Wang, Rentong Sun, Yingjiu Zhang

“…The C-terminal region of Aβ42/Aβ40 (Gly29 to Val40) was primarily required for NK capture, and the integrated conformation in Aβ42/Aβ40 aggregates was a more efficient target for NK catalysis. …”
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Genomic scans for selection and runs of homozygosity in southern Italian turkey populations by Medhat S. Saleh, Vincenzo Landi, Martijn F.L. Derks, Gerardo Centoducati, Martien A.M. Groenen, Pasquale De Palo, Elena Ciani, Nicola Pugliese, Elena Circella, Antonio Camarda

“…In this study, we characterized runs of homozygosity (ROH), and selection signatures using the integrated haplotype score (iHS) and ROH approaches. …”
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Trends in incidence, mortality, and DALYs of cystic echinococcosis in Central Asia from 1992 to 2021: an age-period-cohort analysis by Wulan Talafuhan, Kaibinuer Tuoheti, Ye Lixia, Qi Shuang, Mieyier Yeerjiang, Guzalinuer Aizezi, Wei Jingjing, Peierdun Mijiti, Peierdun Mijiti

“…Future research should continue to monitor these trends and explore targeted prevention strategies within diverse socioeconomic contexts, such as integrating regional socioeconomic factors and public health resources.…”
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EDF1 accelerates ganglioside GD3 accumulation to boost CD52-mediated CD8+ T cell dysfunction in neuroblastoma by Di Li, Meng Li, Zhenjian Zhuo, Huiqin Guo, Weixin Zhang, Yile Xu, Hai-Yun Wang, Jiabin Liu, Huimin Xia, Huiran Lin, Jue Tang, Jing He, Lei Miao

“…Modulating NB-associated GD3 levels through metabolic intervention is beneficial for tuning the depth and duration of responses to current NB therapies. The integration of transcriptomic and lipidomic data offers a more comprehensive understanding of the interaction between LacCer metabolites and the immune status in NB. …”
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