Integrin Trafficking and Tumor Progression by Sejeong Shin, Laura Wolgamott, Sang-Oh Yoon

“…Integrins are major mediators of cancer cell adhesion to extracellular matrix. …”
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Expression of Selected Integrins and Selectins in Bullous Pemphigoid by Elżbieta Waszczykowska, Anna Erkiert-Polguj, Ewa Joss-Wichman, Małgorzata Wągrowska-Danilewicz, Anna Sysa-Jędrzejowska, Agnieszka Żebrowska

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Expression of Integrin Alpha10 Is Induced in Malignant Melanoma by Ann-Kathrin Wenke, Christian Kjellman, Evy Lundgren-Akerlund, Christian Uhlmann, Nikolas K. Haass, Meenhard Herlyn, Anja K. Bosserhoff

“…Recently, integrin alpha10 was described as a collagen type II-binding integrin expressed mainly in chondrocytes. …”
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Integrins and Their Extracellular Matrix Ligands in Lymphangiogenesis and Lymph Node Metastasis by Jie Chen, J. Steven Alexander, A. Wayne Orr

“…Recent works highlight a role for integrins in lymphangiogenesis and suggest that integrin inhibitors may serve as therapeutic targets to limit lymphangiogenesis and lymph node metastasis. …”
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Cancer Cell Adhesion and Metastasis: Selectins, Integrins, and the Inhibitory Potential of Heparins by Gerd Bendas, Lubor Borsig

“…While P- and L-selectin facilitation of cellular contacts during hematogenous metastasis is being accepted as a potential target of heparin, here we propose that heparin may also interfere with integrin activity and thereby affect cancer progression. …”
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From the ECM to the Cytoskeleton and Back: How Integrins Orchestrate T Cell Action by Jennifer A. Epler, Rugao Liu, Yoji Shimizu

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Unchain My Heart: Integrins at the Basis of iPSC Cardiomyocyte Differentiation by Rosaria Santoro, Gianluca Lorenzo Perrucci, Aoife Gowran, Giulio Pompilio

“…The cellular response to the extracellular matrix (ECM) microenvironment mediated by integrin adhesion is of fundamental importance, in both developmental and pathological processes. …”
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Activated α4 Integrins are Preferentially Expressed on Immature Thymocytes and Activated T Cells by Fengyu Shu, Bernhard Holzmann, Frank Seibold, David Erle, John F. Kearney

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Integrin α8 is a useful cell surface marker of alveolar lipofibroblasts by Atsuki Fukada, Yasunori Enomoto, Ryo Horiguchi, Yoichiro Aoshima, Shiori Meguro, Hideya Kawasaki, Isao Kosugi, Tomoyuki Fujisawa, Noriyuki Enomoto, Naoki Inui, Takafumi Suda, Toshihide Iwashita

“…Methods and results Using cell surface markers applicable even into wild-type mouse lungs, we could classify PDGFRα+ total lung resident fibroblasts into at least two major distinct subpopulations: integrin α8 (ITGA8)+ and SCA-1+ fibroblasts. We analyzed their characteristics, including lipid content, transcriptome profiles, and alveolar stem cell niche capacity. …”
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Aberrant Development of Thymocytesin Mice Lacking Laminin-2 by William J. Magner, Andrew C. Chang, Jennie Owens, M-J. P. Hong, Andrew Brooks, John E. Coligan

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Tc-Labeled Cyclic RGD Peptides for Noninvasive Monitoring of Tumor Integrin αβ Expression by Yang Zhou, Young-Seung Kim, Sudipta Chakraborty, Jiyun Shi, Haijuan Gao, Shuang Liu

“…There is a linear relationship between the radiotracer injected dose per gram tumor uptake and the total integrin β 3 expression levels. On the basis of these, it was concluded that radiotracer tumor uptake is contributed by integrin α V β 3 expressed on tumor cells and activated endothelial cells of the tumor neovasculature. 99m Tc-3P-RGD 2 has the capability to monitor integrin α v β 3 expression in a noninvasive fashion.…”
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Upregulation of α3β1-Integrin in Podocytes in Early-Stage Diabetic Nephropathy by Kaichiro Sawada, Masao Toyoda, Noriko Kaneyama, Sawako Shiraiwa, Hitomi Moriya, Han Miyatake, Eitaro Tanaka, Naoyuki Yamamoto, Masaaki Miyauchi, Moritsugu Kimura, Takehiko Wada, Masafumi Fukagawa

“…To determine the mechanism of podocyte detachment, we analyzed the expression levels of α3β1-integrin in podocytes in early and advanced stages of DN. …”
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Micro-PET Imaging of αβ-Integrin Expression with F-Labeled Dimeric RGD Peptide by Xiaoyuan Chen, Michel Tohme, Ryan Park, Yingping Hou, James R. Bading, Peter S. Conti

“…The α v integrins, which act as cell adhesion molecules, are closely involved with tumor invasion and angiogenesis. …”
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Integrin-mediated host cell invasion by type 1-piliated uropathogenic Escherichia coli. by Danelle S Eto, Tiffani A Jones, Jamie L Sundsbak, Matthew A Mulvey

“…FimH-mediated bacterial invasion of host bladder cells is inhibited by beta1 and alpha3 integrin-specific antibodies and by disruption of the beta1 integrin gene in the GD25 fibroblast cell line. …”
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β2 integrin regulates neutrophil trans endothelial migration following traumatic brain injury by Lei Li, Ruilong Peng, Cong Wang, Xin Chen, Dilmurat Gheyret, Siyu Guan, Bo Chen, Yafan Liu, Xilei Liu, Yiyao Cao, Cha Han, Jianhua Xiong, Fanjian Li, Taoyuan Lu, Haoran Jia, Kaiji Li, Jinchao Wang, Xu Zhang, Jianye Xu, Yajuan Wang, Xin Xu, Tuo Li, Jianning Zhang, Shu Zhang

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Role of β2 Integrins in the Binding of Thymocytes to RatThymic Macrophages by Miodrag Čolić, Vesna Ilić, Takuya Tamatani, Masayuki Miyasaka, Miloš D. Pavlović

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Integrins identified as potential prognostic markers in osteosarcoma through multi-omics and multi-dataset analysis by Lei Cui, Shuai Zhao, Hai long Teng, Biao Yang, Qian Liu, An Qin

“…Assessing its prognosis is challenging due to the complex roles of integrins in tumor development and metastasis. This study utilized 209,268 osteosarcoma cells from the GEO database to identify integrin-associated genes using advanced analysis methods. …”
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BlockingαVβ3 Integrin Ligand Occupancy Inhibits the Progression of Albuminuria in Diabetic Rats by Laura A. Maile, Katherine Gollahon, Christine Wai, Paul Dunbar, Walker Busby, David Clemmons

“…This study determined if blocking ligand occupancy of the αVβ3 integrin could inhibit the pathophysiologic changes that occur in the early stages of diabetic nephropathy (DN). …”
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Enhanced breast cancer cell targeting: RGD integrin ligand potentiates RWQWRWQWR’s cytotoxicity and inhibits migration by Andrea Barragán-Cárdenas, Daniel Castellar-Almonacid, Yerly Vargas-Casanova, Claudia Parra-Giraldo, Adriana Umaña-Pérez, Joel López-Meza, Zuly Rivera-Monroy, Javier García-Castañeda

“…Aim: Evaluate the selective cytotoxic effect of the palindromic sequence RWQWRWQWR and its analogues obtained by replacement of L-amino acids by D-amino acids or the functionalization by adding the RGD (integrin ligand motif) to the peptide. Methods: Peptides were obtained by SPPS, characterized by RP-HPLC and ESI-QTOF and its biological activity was evaluated using MTT assays. …”
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Exosomes and their distinct integrins transfer the characteristics of oxaliplatin- and 5-FU-resistant behaviors in colorectal cancer cells by Zeynab Vakili-Ghartavol, Hoda Deli, Amir Shadboorestan, Roxana Sahebnasagh, Elahe Motevaseli, Mohammad Hossein Ghahremani

“…However, the role of exosome integrins in chemoresistant colorectal cancer remained unclear. …”
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