Semaphorin 3A Increases FAK Phosphorylation at Focal Adhesions to Modulate MDA-MB-231 Cell Migration and Spreading on Different Substratum Concentrations by Scott Gehler, Frances V. Compere, Alex M. Miller

“…Interactions between integrin-mediated adhesions and the extracellular matrix (ECM) are important regulators of cell migration and spreading. …”
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Antioxidant Peptide Derived from Spirulina maxima Suppresses HIF1α-Induced Invasive Migration of HT1080 Fibrosarcoma Cells by Won Suk Kim, Won Kyo Jung, Sun Joo Park

“…Moreover, CoCl2-induced HIF1α expression was associated with an increase in the expression of molecules downstream of β-integrin, such as N-cadherin, vimentin, and β-catenin. …”
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Targeting the Vasculature of Colorectal Carcinoma with a Fused Protein of (RGD)3-tTF by Zheng-jie Huang, Yilin Zhao, Wei-yuan Luo, Jun You, Shui-wen Li, Wen-cheng Yi, Sheng-yu Wang, Jiang-hua Yan, Qi Luo

“…Here, we generated (RGD)3-tTF in which three arginine-glycine-aspartic (RGD) targeting integrin αvβ3 and tTF induce blood coagulation in tumor vessels. …”
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Evaluation of the effect of 48 weeks of BIC/F/TAF and DRV/c/F/TAF on platelet function in the context of rapid ART start by Akif A. Khawaja, Gary Whitlock, Sarah Fidler, Alfredo Soler-Carracedo, Merle Henderson, Graham P. Taylor, Marta Boffito, Michael Emerson

“…Platelet activation was assessed by real-time flow cytometry to examine integrin activation and granule release and platelet aggregation was evaluated by light transmission aggregometry. …”
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Heterogeneous focal adhesion cytoskeleton nanoarchitectures from microengineered interfacial curvature to oversee nuclear remodeling and mechanotransduction of mesenchymal stem cel... by Huayu Fan, Hui Zhao, Yan Hou, Danni Meng, Jizong Jiang, Eon-Bee Lee, Yinzheng Fu, Xiangdong Zhang, Rui Chen, Yongtao Wang

“…Immunofluorescent staining of integrin, vinculin, and talin-1 was conducted to evaluate adhesion-related expression levels. …”
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Clinical Perspectives - Biologics in IBD: What's All the Fuss? by Hillary Steinhart

“…This article examines the evidence behind the use of biologic therapies such as anti-tumour necrosis factor-alpha, interleukin-10, interleukin-11, anti-integrin antibody and antisense intercellular adhesion molecule-1 oligonucleotide.…”
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ITGA4 as a potential prognostic and immunotherapeutic biomarker in human cancer and its clinical significance in gastric cancer: an integrated analysis and validation by Jiaxing Zhang, Jiaxing Zhang, Gang Wang, Jie Liu, Futian Tang, Song Wang, Yumin Li, Yumin Li

“…BackgroundIntegrin Subunit Alpha 4 (ITGA4), a member of the integrin protein family, is involved in the progression of malignant tumors. …”
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MicroRNA Regulation of Endothelial Junction Proteins and Clinical Consequence by Yugang Zhuang, Hu Peng, Victoria Mastej, Weiguo Chen

“…Integrin β4 has been regulated by miR-184, miR-205, and miR-9. …”
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Crossing the Vascular Wall: Common and Unique Mechanisms Exploited by Different Leukocyte Subsets during Extravasation by Michael Schnoor, Pilar Alcaide, Mathieu-Benoit Voisin, Jaap D. van Buul

“…Engagement of these molecules by their leukocyte integrin receptors initiates the activation of several signaling pathways within both leukocytes and endothelium. …”
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Lowering Caveolin-1 Expression in Human Vascular Endothelial Cells Inhibits Signal Transduction in Response to Shear Stress by A. D. van der Meer, M. M. J. Kamphuis, A. A. Poot, J. Feijen, I. Vermes

“…However, activation of integrin-mediated signaling during cell adhesion onto fibronectin was not hampered by lowered caveolin-1 levels. …”
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Humoral Immune Response to Keyhole Limpet Haemocyanin, the Protein Carrier in Cancer Vaccines by A. Kantele, M. P. Häkkinen, J. Zivny, C. O. Elson, J. Mestecky, J. M. Kantele

“…The proportion of L-selectin+ plasmablasts proved high and integrin α4β7+ low. KLH serving as protein carrier in several vaccines, the homing profile of KLH-specific response may be applicable to the cancer antigen parts in the same vaccines. …”
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Combination Treatment of C16 Peptide and Angiopoietin-1 Alleviates Neuromyelitis Optica in an Experimental Model by Yuanyuan Zhang, Kewei Tian, Hong Jiang, Beibei Wang, Shu Han

“…We then tested whether the combination of C16, an αvβ3 integrin-binding peptide, and angiopoietin-1 (Ang1), a member of the endothelial growth factor family, could alleviate NMO in the model. …”
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Nuclear talin-1 provides a bridge between cell adhesion and gene expression by Alejandro J. Da Silva, Hendrik S.E. Hästbacka, Mikael C. Puustinen, Jenny C. Pessa, Jens C. Luoto, Erika Sundström, Benjamin T. Goult, Guillaume Jacquemet, Eva Henriksson, Lea Sistonen

“…Summary: Talin-1 (TLN1) is best known to activate integrin receptors and transmit mechanical stimuli to the actin cytoskeleton at focal adhesions. …”
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Transient Complete Recovery of Chronic Refractory Idiopathic Thrombocytopenic Purpura after Treatment with Monoclonal Antibody Targeting SARS-CoV-2 Spike Protein by Pooja Gogia, Yiqing Xu

“…Studies on autoantigens on the platelets suggested epitopes to be located predominantly on the GP IIb/IIIa receptor or integrin αIIbβ3, though the trigger for the development of ITP is unclear. …”
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Improved Excitation Light Rejection Enhances Small-Animal Fluorescent Optical Imaging by Kildong Hwang, Jessica P. Houston, John C. Rasmussen, Amit Joshi, Shi Ke, Chun Li, Eva M. Sevick-Muraca

“…The addition of collimating optics resulted in a 51% to 75% reduction in the ratio of ( S (Λ x ))/( S (Λ m )– S (Λ x )) for the phantom studies and an improvement of TBR from 11% to 31% and of signal-to-noise ratio from 11% to 142% for an integrin-targeting conjugate in human glioma xenografts.…”
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Regulation of enzymatic lipid peroxidation in osteoblasts protects against postmenopausal osteoporosis by Qiong-Yi Zhang, Hai-Biao Gong, Man-Ya Jiang, Fujun Jin, Guan Wang, Chang-Yu Yan, Xiang Luo, Wan-Yang Sun, Shu-Hua Ouyang, Yan-Ping Wu, Wen-Jun Duan, Lei Liang, Yun-Feng Cao, Xin-Xin Sun, Meijing Liu, Gen-Long Jiao, Hua-Jun Wang, Kurihara Hiroshi, Xiaogang Wang, Rong-Rong He, Yi-Fang Li

“…Mechanistically, 4-hydroxynonenal, an end-product of phospholipid peroxidation, binds to integrin-linked kinase and triggers its protein degradation, disrupting RUNX2 signaling and inhibiting osteoblastogenesis. …”
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Negative regulation of lymphangiogenesis by Tenascin-C delays the resolution of inflammation by Daisuke Katoh, Yoshiyuki Senga, Kento Mizutani, Kazuaki Maruyama, Daishi Yamakawa, Tadashi Yamamuro, Michiaki Hiroe, Keiichi Yamanaka, Akihiro Sudo, Naoyuki Katayama, Toshimichi Yoshida, Kyoko Imanaka-Yoshida

“…Mechanistically, TNC facilitates integrin αvβ1 heterodimer formation, leading to the activation of non-canonical (TAK1/p38MAPK/ATF-2) TGFβ signaling to suppress lymphangiogenesis. …”
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Tumor cells escape immunosurveillance by hampering LFA-1 by Shishir Upadhyay, Lewis Murugu, Lena Svensson, Lena Svensson

“…Integral to this process is the integrin Lymphocyte Function-Associated Antigen 1 (LFA-1). …”
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Progress in Pathogenesis of Proteinuria by Aihua Zhang, Songming Huang

“…The close relationships of slit diaphragm (SD) molecules such as nephrin, podocin, CD2-associated protein (CD2AP), a-actinin-4, transient receptor potential cation channel 6 (TRPC6), Densin and membrane-associated guanylate kinase inverted 1 (MAGI-1), α3β1 integrin, WT1, phospholipase C epsilon-1 (PLCE1), Lmx1b, and MYH9, and mitochondrial disorders and circulating factors in the pathogenesis of glomerular proteinuria were also gradually discovered. …”
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Thrombin Cleavage of Osteopontin Modulates Its Activities in Human Cells In Vitro and Mouse Experimental Autoimmune Encephalomyelitis In Vivo by Elena Boggio, Chiara Dianzani, Casimiro Luca Gigliotti, Maria Felicia Soluri, Nausicaa Clemente, Giuseppe Cappellano, Erika Toth, Davide Raineri, Benedetta Ferrara, Cristoforo Comi, Umberto Dianzani, Annalisa Chiocchetti

“…Interestingly, thrombin cleavage of osteopontin unmasks a cryptic domain of interaction with α4β1 integrin that is the main adhesion molecule involved in lymphocyte transmigration to the brain and is the target for natalizumab, the most potent drug preventing relapses. …”
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