Atlas of multilineage stem cell differentiation reveals TMEM88 as a developmental regulator of blood pressure by Sophie Shen, Tessa Werner, Samuel W. Lukowski, Stacey Andersen, Yuliangzi Sun, Woo Jun Shim, Dalia Mizikovsky, Sakurako Kobayashi, Jennifer Outhwaite, Han Sheng Chiu, Xiaoli Chen, Gavin Chapman, Ella M. M. A. Martin, Di Xia, Duy Pham, Zezhuo Su, Daniel Kim, Pengyi Yang, Men Chee Tan, Enakshi Sinniah, Qiongyi Zhao, Sumedha Negi, Meredith A. Redd, Joseph E. Powell, Sally L. Dunwoodie, Patrick P. L. Tam, Mikael Bodén, Joshua W. K. Ho, Quan Nguyen, Nathan J. Palpant

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Characterization of a novel covS SNP identified in Australian group A Streptococcus isolates derived from the M1UK lineage by Johanna Richter, Amanda J. Cork, Yvette Ong, Nadia Keller, Andrew J. Hayes, Mark A. Schembri, Amy V. Jennison, Mark R. Davies, Kate Schroder, Mark J. Walker, Stephan Brouwer

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Connecting genomic results for psychiatric disorders to human brain cell types and regions reveals convergence with functional connectivity by Shuyang Yao, Arvid Harder, Fahimeh Darki, Yu-Wei Chang, Ang Li, Kasra Nikouei, Giovanni Volpe, Johan N. Lundström, Jian Zeng, Naomi R. Wray, Yi Lu, Patrick F. Sullivan, Jens Hjerling-Leffler

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Coronavirus Host Genomics Study: South Africa (COVIGen-SA) by Andrew K. May, Heather Seymour, Harriet Etheredge, Heather Maher, Marta C. Nunes, Shabir A. Madhi, Simiso M. Sokhela, W. D. Francois Venter, Neil Martinson, Firdaus Nabeemeeah, Cheryl Cohen, Jocelyn Moyes, Sibongile Walaza, Stefano Tempia, Jackie Kleynhans, Anne von Gottberg, Jeremy Nel, Halima Dawood, Ebrahim Variava, Stephen Tollman, Kathleen Kahn, Kobus Herbst, Emily B. Wong, Caroline T. Tiemessen, Alex van Blydenstein, Lyle Murray, Michelle Venter, June Fabian, Michéle Ramsay

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Building coherence in the regulation of health research: A reply to Thaldar by V Bronstein, D T Nyachowe

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Heritable human genome editing in South Africa – time for a reality check by M Ramsay, M Pepper, J de Vries, S Mahomed, E Flack-Davison

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Right of reply - Response to: In defence of South Africa’s National Health Research Ethics Council guidelines on heritable human genome editing by M Ramsay, M S Pepper, J de Vries, S Mahomed, E Flack-Davison

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A synthetic cyclic peptide for promoting antigen presentation and immune activation by Jiahui Zhang, Harrison Y. R. Madge, Asmaa Mahmoud, Lantian Lu, Wanyi Wang, Wenbin Huang, Prashamsa Koirala, Jazmina L. Gonzalez Cruz, Wei Yang Kong, Sahra Bashiri, Ahmed O. Shalash, Waleed M. Hussein, Zeinab G. Khalil, James W. Wells, Istvan Toth, Rachel J. Stephenson

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Impact of donor CYP3A5 genotype on pharmacokinetics of tacrolimus in South African paediatric liver transplant patients by C Wheeler, C Masimirembwa, B Mthembu, J Botha, J Scholefield, J Fabian

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Predictors of interferon-gamma release assay results and their association with COVID-19 infection outcomes by S.J.W. Kang, G.W. Eather, F. Qureshi, J.R. Scott

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Factors associated with ABCDEF bundle implementation for critically ill patients: An international cross-sectional survey in 54 countries by Junpei Haruna, Takeshi Unoki, Keibun Liu, Kensuke Nakamura, Shigeaki Inoue, Osamu Nishida

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Whole genome sequencing in early onset advanced heart failure by Erik Linnér, Tomasz Czuba, Olof Gidlöf, Jakob Lundgren, Entela Bollano, Maria Hellberg, Selvi Celik, Neha Pimpalwar, Philipp Rentzsch, Molly Martorella, Anders Gummesson, Olle Melander, Sebastian Albinsson, Göran Dellgren, Jan Borén, Anders Jeppsson, R. Thomas Lumbers, Sonia Shah, Johan Nilsson, Pradeep Natarajan, Tuuli Lappalainen, Malin Levin, Hans Ehrencrona, J. Gustav Smith

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Nebulized aminoglycosides for ventilator-associated pneumonia: Methodological considerations and lessons from experimental studies by Jean-Jacques Rouby, Jing Xia, Jayesh Dhanani, Gianluigi Li Bassi, Antoine Monsel, Antoni Torres, Kostoula Arvaniti, Mona Assefi, Matteo Bassetti, Stijn Blot, Matthieu Boisson, Adrien Bouglé, Jean-Michel Constantin, Jayesh Dhanani, George Dimopoulos, Jonathan Dugernier, Pauline Dureau, Stephan Ehrmann, Timothy Felton, Marin Kollef, Antonia Koutsoukou, Anna Kyriakoudi, Pierre-François Laterre, Marc Leone, Victoria Lepère, Gianluigi Li Bassi, Xuelian Liao, Shakti Bedanta Mishra, Olivier Mimoz, Antoine Monsel, Girish B Nair, Michael Niederman, Lucy B Palmer, Jose Manuel Pereira, Konstantinos Pontikis, Garyphalia Poulakou, Jérôme Pugin, Chuanyun Qian, Jie-ming Qu, Jordi Rello, Jason Roberts, Jean-Jacques Rouby, Christina Routsi, Gerald C. Smaldone, Antoni Torres, Melda Türkoğlu, Tobias Welte, Michel Wolff, Xia Jing, Li Yang, Ting Yang, Ying-gang Zhu

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Ribosomal Proteins in Ribosome Assembly by Brigitte Pertschy, Ingrid Zierler

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Iron induces blood-brain barrier alteration contributing to cognitive impairment in β-thalassaemia mice by Parinda Jamrus, Nuttanan Pholngam, Benjaporn Kiatpakdee, Kittikun Viwatpinyo, Jim Vadolas, Sukonthar Ngampramuan, Saovaros Svasti, Pornthip Chaichompoo

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Evolution of the RNA alternative decay cis element into a high-affinity target for the immunomodulatory protein Roquin by Jan-Niklas Tants, Katharina Friedrich, Jasmina Neumann, Andreas Schlundt

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The Involvement of Microglial Cells in Japanese Encephalitis Infections by Thananya Thongtan, Chutima Thepparit, Duncan R. Smith

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Ten years preceding a diagnosis of neurodegenerative disease in Europe and Australia: medication use, health conditions, and biomarkers associated with Alzheimer's disease, Parkins... by Dang Wei, Anna Freydenzon, Octave Guinebretiere, Karim Zaidi, Fen Yang, Weimin Ye, Niklas Hammar, Karin Modig, Naomi R. Wray, Maria Feychting, Nadine Hamieh, Bruno Ventelou, Beranger Lekens, Laurene Gantzer, Stanley Durrleman, Allan McRae, Baptiste Couvy-Duchesne, Fang Fang, Thomas Nedelec, Stanley Durrleman, Bruno Ventelou, Thomas Nedelec, Octave Guinebretiere, Karim Zaidi, Fang Fang, Dang Wei, Fen Yang, Allan McRae, Naomi Wray, Baptiste Couvy-Duchesne, Anna Freydenzon, Lydie Tran, Evans Cheruiyot

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Increased DNA Dicarbonyl Glycation and Oxidation Markers in Patients with Type 2 Diabetes and Link to Diabetic Nephropathy by Sahar Waris, Brigitte M. Winklhofer-Roob, Johannes M. Roob, Sebastian Fuchs, Harald Sourij, Naila Rabbani, Paul J. Thornalley

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Decorin, an exercise-induced secretory protein, is associated with improved prognosis in breast cancer patients but does not mediate anti-tumorigenic tissue crosstalk in mice by Marit Hjorth, Casey L. Egan, Guilherme D. Telles, Martin Pal, David Gallego-Ortega, Oliver K. Fuller, Emma D. McLennan, Ryan D. Gillis, Tae Gyu Oh, George E.O. Muscat, Surafel Tegegne, Michael S.M. Mah, Joanna Skhinas, Emma Estevez, Timothy E. Adams, Matthew J. McKay, Mark Molloy, Kevin I. Watt, Hongwei Qian, Paul Gregorevic, Thomas R. Cox, Pernille Hojman, Julie Midtgaard, Jesper F. Christensen, Martin Friedrichsen, Renato V. Iozzo, Erica K. Sloan, Brian G. Drew, Jørgen F.P. Wojtaszewski, Martin Whitham, Mark A. Febbraio

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