Potential source of bias in AI models: lactate measurement in the ICU in sepsis patients as a template by Pratiksha Pradhan, Pratiksha Pradhan, Fredrik Willumsen Haug, Fredrik Willumsen Haug, Nebal S. Abu Hussein, Nebal S. Abu Hussein, Dana Moukheiber, Lama Moukheiber, Mira Moukheiber, Sulaiman Moukheiber, Luca Leon Weishaupt, Jacob G. Ellen, Helen D'Couto, Ishan C. Williams, Leo Anthony Celi, Leo Anthony Celi, Leo Anthony Celi, Joao Matos, Joao Matos, Joao Matos, Tristan Struja, Tristan Struja, Tristan Struja

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Mortality Prediction Performance Under Geographical, Temporal, and COVID-19 Pandemic Dataset Shift: External Validation of the Global Open-Source Severity of Illness Score Model by Takeshi Tohyama, MD, PhD, Liam G. McCoy, MD, MSc, Euma Ishii, MD, PhD, Sahil Sood, Jesse Raffa, PhD, Takahiro Kinoshita, MD, MPH, Leo Anthony Celi, MD, MPH, MSc, Satoru Hashimoto, MD, PhD

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GRACE-ICU: A multimodal nomogram-based approach for illness severity assessment of older adults in the ICU by Xiaoli Liu, Wesley Yeung, Ziyue Chen, Sicheng Hao, Zhicheng Yang, Xiaowei Sun, Chao Liu, Zhi Mao, Muyang Yan, Wei Yan, Desen Cao, Mengling Feng, Deyu Li, Zhengbo Zhang, Leo Anthony Celi

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Genetic and hypoxic alterations of the microRNA‐210‐ISCU1/2 axis promote iron–sulfur deficiency and pulmonary hypertension by Kevin White, Yu Lu, Sofia Annis, Andrew E Hale, B Nelson Chau, James E Dahlman, Craig Hemann, Alexander R Opotowsky, Sara O Vargas, Ivan Rosas, Mark A Perrella, Juan C Osorio, Kathleen J Haley, Brian B Graham, Rahul Kumar, Rajan Saggar, Rajeev Saggar, W Dean Wallace, David J Ross, Omar F Khan, Andrew Bader, Bernadette R Gochuico, Majed Matar, Kevin Polach, Nicolai M Johannessen, Haydn M Prosser, Daniel G Anderson, Robert Langer, Jay L Zweier, Laurence A Bindoff, David Systrom, Aaron B Waxman, Richard C Jin, Stephen Y Chan

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Multi-photon, label-free photoacoustic and optical imaging of NADH in brain cells by Tatsuya Osaki, W. David Lee, Xiang Zhang, Rebecca E. Zubajlo, Mercedes Balcells-Camps, Elazer R. Edelman, Brian W. Anthony, Mriganka Sur, Peter T. C. So

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How many plasmids can bacteria carry? A synthetic biology perspective by Cholpisit Kiattisewee

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scRNA-seq reveals elevated interferon responses and TNF-α signaling via NFkB in monocytes in children with uncomplicated malaria by Collins M. Morang’a, Riley S. Drake, Riley S. Drake, Riley S. Drake, Riley S. Drake, Vincent N. Miao, Vincent N. Miao, Vincent N. Miao, Vincent N. Miao, Nancy K. Nyakoe, Dominic S. Y. Amuzu, Vincent Appiah, Yaw Aniweh, Yaw Bediako, Saikou Y. Bah, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Alex K. Shalek, Gordon A. Awandare, Thomas D. Otto, Lucas Amenga-Etego

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Author Correction: Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats by Jakob Steinfeldt, Benjamin Wild, Thore Buergel, Maik Pietzner, Julius Upmeier zu Belzen, Andre Vauvelle, Stefan Hegselmann, Spiros Denaxas, Harry Hemingway, Claudia Langenberg, Ulf Landmesser, John Deanfield, Roland Eils

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RETRACTED ARTICLE: Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats by Jakob Steinfeldt, Benjamin Wild, Thore Buergel, Maik Pietzner, Julius Upmeier zu Belzen, Andre Vauvelle, Stefan Hegselmann, Spiros Denaxas, Harry Hemingway, Claudia Langenberg, Ulf Landmesser, John Deanfield, Roland Eils

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Human Brain Organoids: A New Model to Study <i>Cryptococcus neoformans</i> Neurotropism by Alfred T. Harding, Lee Gehrke, Jatin M. Vyas, Hannah Brown Harding

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Congenital T-cell activation impairs transitional-to-follicular B-cell maturation in humans by Hugues Allard-Chamard, Kirsty Hillier, Michelle L. Ramseier, Alice Bertocchi, Naoki Kaneko, Katherine Premo, Grace Yuen, Marshall Karpel, Vinay S. Mahajan, Christina Tsekeri, Joseph S. Hong, Jean Vencic, Rory Crotty, Anish V. Sharda, Sara Barmettler, Emma Westermann-Clark, Jolan E. Walter, Musie Ghebremichael, Alex K. Shalek, Jocelyn R. Farmer, Shiv Pillai

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Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats by Jakob Steinfeldt, Benjamin Wild, Thore Buergel, Maik Pietzner, Julius Upmeier zu Belzen, Andre Vauvelle, Stefan Hegselmann, Spiros Denaxas, Harry Hemingway, Claudia Langenberg, Ulf Landmesser, John Deanfield, Roland Eils

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AI‐Powered Multimodal Modeling of Personalized Hemodynamics in Aortic Stenosis by Caglar Ozturk, Daniel H. Pak, Luca Rosalia, Debkalpa Goswami, Mary E. Robakowski, Raymond McKay, Christopher T. Nguyen, James S. Duncan, Ellen T. Roche

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Effective and Engaging Active Learning in the Medical School Classroom: Lessons from Case-Based Collaborative Learning by Henrike C. Besche, Randall W. King, Keri M. Shafer, Sarah E. Fleet, Julia F. Charles, Tamara B. Kaplan, Katie A. Greenzang, Melanie P. Hoenig, Richard M. Schwartzstein, Barbara A. Cockrill, Krisztina Fischer

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A Reinforcement Learning Model for Optimal Treatment Strategies in Intensive Care: Assessment of the Role of Cardiorespiratory Features by Cristian Drudi, Maximiliano Mollura, Li-wei H. Lehman, Riccardo Barbieri

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Machine learning analysis of cardiovascular risk factors and their associations with hearing loss by Ali Nabavi, Farimah Safari, Ali Faramarzi, Mohammad Kashkooli, Meskerem Aleka Kebede, Tesfamariam Aklilu, Leo Anthony Celi

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REcovery from DEXmedetomidine-Induced Unresponsiveness (REDEX): A Study Protocol for a Single Center, Parallel Arm, Non-Randomized, Controlled Pilot Trial in Healthy Volunteers by Schreier DR, Fecchio M, Guay CS, Kovacs RG, Olchanyi M, Mueller AL, Houle TT, Edlow BL, Brown EN, Solt K

“…David R Schreier,1– 4 Matteo Fecchio,3 Christian S Guay,1,2,5 Reid G Kovacs,1,6– 8 Mark Olchanyi,2,3,6 Ariel L Mueller,1 Timothy T Houle,1 Brian L Edlow,3,9 Emery N Brown,1,2,6,7 Ken Solt1 1Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital and Department of Anaesthesia, Harvard Medical School, Boston, MA, USA; 2Picower Institute for Learning and Memory, Massachusetts Institute of Technology, Cambridge, MA, USA; 3Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; 4Department of Neurology, Inselspital, Bern University Hospital, and University of Bern, Bern, Switzerland; 5Department of Anesthesiology, Perioperative and Pain Medicine, The University of Utah, Salt Lake City, UT, USA; 6Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA, USA; 7Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA, USA; 8Department of Electrical Engineering and Computer Science, Massachusetts Institute of Technology, Cambridge, MA, USA; 9Athinoula A. …”
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TRIPOD+AI statement: updated guidance for reporting clinical prediction models that use regression or machine learning methods: a Korean translation by Gary S. Collins, Karel G. M. Moons, Paula Dhiman, Richard D. Riley, Andrew L. Beam, Ben Van Calster, Marzyeh Ghassemi, Xiaoxuan Liu, Johannes B. Reitsma, Maarten van Smeden, Anne-Laure Boulesteix, Jennifer Catherine Camaradou, Leo Anthony Celi, Spiros Denaxas, Alastair K. Denniston, Ben Glocker, Robert M. Golub, Hugh Harvey, Georg Heinze, Michael M. Hoffman, André Pascal Kengne, Emily Lam, Naomi Lee, Elizabeth W. Loder, Lena Maier-Hein, Bilal A. Mateen, Melissa D. McCradden, Lauren Oakden-Rayner, Johan Ordish, Richard Parnell, Sherri Rose, Karandeep Singh, Laure Wynants, Patricia Logullo

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Exercise Improves Myocardial Deformation But Not Cardiac Structure in Preterm-Born Adults by Winok Lapidaire, PhD, Afifah Mohamed, DPhil, Wilby Williamson, DPhil, Odaro J. Huckstep, DPhil, Maryam Alsharqi, DPhil, Cheryl M.J. Tan, DPhil, Samuel Burden, PhD, Cameron Dockerill, PhD, William Woodward, BSc, Annabelle McCourt, MSc, Holger Burchert, DPhil, Yvonne Kenworthy, BSc, Luca Biasiolli, DPhil, Helen Dawes, PhD, Charlie Foster, PhD, Paul Leeson, MB, PhD, Adam J. Lewandowski, DPhil

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De novo mutations mediate phenotypic switching in an opportunistic human lung pathogen by Alexandra J. Poret, Matthew Schaefers, Christina Merakou, Kathryn E. Mansour, Connor D. Ahern, Georgia K. Lagoudas, Alyssa Haynes, Ashley R. Cross, Joanna B. Goldberg, Roy Kishony, Ahmet Z. Uluer, Alexander J. McAdam, Paul C. Blainey, Sara O. Vargas, Tami D. Lieberman, Gregory P. Priebe

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