Prevalence and temporal trends in myopia and high myopia children in China: a systematic review and meta-analysis with projections from 2020 to 2050Research in context by Wei Pan, Seang-Mei Saw, Tien Yin Wong, Ian Morgan, Zhikuan Yang, Weizhong Lan

“…Interpretation: China is facing a substantial and potentially worsening epidemic of childhood myopia. This information will provide data for guiding implementation and evaluating the effectiveness of existing and new nationwide myopia prevention and control programs. …”
Get full text

Are dizziness/lightheadedness helpful symptoms for telephone triage of females and males calling the out-of-hours service for acute chest discomfort? A cross-sectional study by Frans H Rutten, Hester M den Ruijter, Sander van Doorn, Dorien L Zwart, Loes T C M Wouters, Anna S M Dobbe, Laurens van der Hem, D Carmen Erkelens

“…Recordings were excluded if (1) they were of poor quality, (2) the conversation was not a triage conversation, (3) patients were <18 years, (4) patients did not live in the vicinity of the OHS-PC, and (4) general practitioners did not want to provide follow-up information including the final diagnosis.Primary and secondary outcome measures The prevalence of dizziness/lightheadedness among patients calling the OHS-PC with acute chest discomfort and the relation between dizziness/lightheadedness and (1) urgency allocation and (2) a final diagnosis of ACS.Results Among 2195 patients who called the OHS-PC with acute chest discomfort, 251 (11.4%) had an ACS (8.3% females, 15.3% males). …”
Get full text

Determinants of Anemia among HIV-Positive Children on Highly Active Antiretroviral Therapy Attending Hospitals of North Wollo Zone, Amhara Region, Ethiopia, 2019: A Case-Control St... by Biruk Beletew, Ayelign Mengesha, Mohammed Ahmed, Awet Fitwi, Mesfin Wudu

“…In Ethiopia, there is limited information about the determinant factors associated with anemia among HIV positive children. …”
Get full text

Enabling participation in community-dwelling children and young people with acquired brain injuries and their families: a theory-based, evidence-based and person-based approach to... by Jane Williams, Rachel Keetley, Emily Bennett, Joseph C Manning, Victoria Lyon, Jade Kettlewell, Kate Radford

“…Objective To codesign and develop an intervention to promote participation and well-being in children and young people (CYP) with acquired brain injury (ABI) and family caregivers.Design A complex intervention development study including a scoping review, mixed-methods study, co-design workshop and theoretical modelling.Setting Community-dwelling participants in one geographical region of the UK.Participants CYP with ABI (5–18 years) and their parents, health, education, social care and voluntary/third-sector practitioners.Results The intervention development process using a theory-driven and evidence-informed approach, combining the Behaviour Change Wheel and the person-based approach is described. …”
Get full text

Exploring the barriers to cervical screening and perspectives on new self-sampling methods amongst under-served groups by Stephanie Gillibrand, Helen Gibson, Kelly Howells, Sean Urwin, Jennifer C. Davies, Emma J. Crosbie, Caroline Sanders

“…The introduction of self-sampling alongside traditional methods may reduce barriers to screening, and may boost screening rates for under-screened groups but only if they are implemented with appropriate information and sufficient communication. Failure to implement self-sampling without these considerations may threaten to undermine the identified and important benefits of self-sampling methods.…”
Get full text

Total neoadjuvant therapy based on short-course radiotherapy versus standard long-course chemoradiotherapy for locally advanced rectal cancer: a systematic review and meta-analysis... by Wenji Pu, Wenji Pu, Wenji Pu, Wenqi Chen, Haiman Jing, Jishi Li, Yong Jiang, Shasha Li, Weijie Wen, Zhiyuan Xu, Jing Jin

“…BackgroundWe conducted the meta-analysis to compare the therapeutic effects of total neoadjuvant therapy (TNT) based on short-course radiotherapy followed by consolidation chemotherapy (SCRT/CCT) and long-course chemoradiotherapy (LCCRT) for locally advanced rectal cancer (LARC) according to certain significant randomized controlled trials (RCTs).MethodsThe researchers retrieved several databases, including PubMed, Embase, Web of Science, and the Cochrane Library, to collect all the relevant literature published since the establishment of the databases until July 30, 2024, and then screened to determine the qualified literature and extracted the relevant information. Finally, RevMan 5.4 software was utilized to conduct the meta-analysis for determining the 95% confidence interval (CI) and pooled risk ratio (RR). …”
Get full text

Awareness, knowledge, and attitudes of the Belgian general population towards paternal perinatal depression: a descriptive cross-sectional study by Ayse Akalin, Ayse Akalin, Florence D’haenens, Sandra Tricas-Sauras, Sandra Tricas-Sauras, Joeri Vermeulen, Joeri Vermeulen, Joeri Vermeulen, Dennis Demedts, Dennis Demedts, Ronald Buyl, Maaike Fobelets, Maaike Fobelets

“…The recommended treatment for paternal depression was mostly non-pharmacological, with family support ranking first (79.9%) and seeking support from informal networks being the most recommended approach (45.2%). …”
Get full text

Cloning and Expression Characteristics of BhARF4 Gene in Wax Gourd (Benincasa hispida) by Xiaoxin CHENG, Xuling ZHAI, Jinqiang YAN, Baochen WANG, Renliang MO, Wenrui LIU, Zhiming WU, Biao JIANG

“…【Conclusion】The gene structure of BhARF4, the conserved domain of the BhARF4 protein and other biological information characteristics, as well as the gene expression pattern were identified. …”
Get full text

Association between the cumulative estimated glucose disposal rate and incident cardiovascular disease in individuals over the age of 50 years and without diabetes: data from two l... by Jin Zhang, Ziyi Sun, Yufei Li, Yuhan Yang, Wenjie Liu, Mengwen Huang, Kuiwu Yao

“…In regions with limited healthcare resources, among individuals with limited ability to access, process, and understand health information and services, cumulative eGDR may offer improved clinical applicability.…”
Get full text

No Need to Know: Toward Astrophysics-free Gravitational-wave Cosmology by Amanda M. Farah, Thomas A. Callister, Jose María Ezquiaga, Michael Zevin, Daniel E. Holz

“…Gravitational waves (GWs) from merging compact objects encode direct information about the luminosity distance to the binary. …”
Get full text

Changes in Physical Activity Across Cancer Diagnosis and Treatment Based on Smartphone Step Count Data Linked to a Japanese Claims Database: Retrospective Cohort Study by Yoshihide Inayama, Ken Yamaguchi, Kayoko Mizuno, Sachiko Tanaka-Mizuno, Ayami Koike, Nozomi Higashiyama, Mana Taki, Koji Yamanoi, Ryusuke Murakami, Junzo Hamanishi, Satomi Yoshida, Masaki Mandai, Koji Kawakami

“…ConclusionsThe analysis of objective pre- and postdiagnostic step count data provided fundamental information crucial for understanding changes in PA among patients with cancer. …”
Get full text

Trisomy 21 screening with αlpha software and the Fetal Medicine Foundation algorithm by L Pistorius, C A Cluver, I Bhorat, L Geerts

“…Screening for trisomy 21 provides pregnant women with accurate risk information. Different algorithms are used to screen for trisomy 21 in South Africa (SA). …”
Get full text

Identifying subgroup of severe community-acquired pneumonia based on clinical metagenomics, a multicenter retrospective cohort study by Mingqiang Wang, Mingqiang Wang, Yue Jin, Yue Jin, Wenxiao Zhang, Wenxiao Zhang, Ling Ye, Ling Ye, Huanzhang Shao, Huanzhang Shao

“…We collected data on potentially pathogenic species reported by clinical metagenomics and clinical information for all patients. Latent class analysis (LCA) was applied to routine clinical parameters such as gender, age, white blood cell (WBC), lymphocytes, C-reactive protein (CRP), and Procalcitonin (PCT), identifying two optimally fitting models.ResultsA total of 569 patients were enrolled. …”
Get full text

Levodopa Challenge Test Predicts STN-DBS Outcomes in Various Parkinson’s Disease Motor Subtypes: A More Accurate Judgment by Zijian Zheng, Zixiao Yin, Bohan Zhang, Houyou Fan, Dan Liu, Yuancheng Zhou, Jian Duan, Dongwei Zhou, Xi Wu, Guohui Lu

“…LDCT provides limited information for TD patients.…”
Get full text

Regulation of human papillomavirus E6 oncoprotein function via a novel ubiquitin ligase FBXO4 by Arushi Vats, Luca Braga, Nezka Kavcic, Paola Massimi, Edoardo Schneider, Mauro Giacca, Laimonis A. Laimins, Lawrence Banks

“…However, there is no information available about the ubiquitin ligases that regulate the stability and activity of the human papillomavirus (HPV) E6 oncoprotein in the absence of E6AP. …”
Get full text

A qualitative study exploring the acceptability of the TEXTPAD telehealth and virtual supervised exercise intervention and trial for patients with peripheral arterial disease livin... by Maddey Patterson, MPH, Letitia Sermin-Reed, MSc, James Prentis, MBBS, Arathi Radhakrishnan, MBBS, Eileen Kaner, PhD, Sandip Nandhra, MBBS, Maisie Rowland, BSc, Gabriel Cucato, PhD, Mackenzie Fong, PhD

“…TEXTPAD participants wanted more interaction with other participants to share experiences, advice, and information (theme 1). Participants in both groups perceived a range of benefits to their health and well-being (theme 2) and considered the study procedures to be acceptable and not overly burdensome (theme 3). …”
Get full text

Radiogenomics and machine learning predict oncogenic signaling pathways in glioblastoma by Abdul Basit Ahanger, Syed Wajid Aalam, Tariq Ahmad Masoodi, Asma Shah, Meraj Alam Khan, Ajaz A. Bhat, Assif Assad, Muzafar Ahmad Macha, Muzafar Rasool Bhat

“…The best models achieved high AUC scores, namely 0.7 for RTK-RAS, 0.8 for PI3K, 0.75 for TP53, and 0.4 for NOTCH, and therefore, demonstrated the potential of ML models in accurately predicting oncogenic signaling pathways from radiomic features, thereby informing personalized therapeutic approaches and improving patient outcomes. …”
Get full text

Nonlinear association between glycated hemoglobin levels and mortality in elderly patients with non-diabetic chronic kidney disease: a national health and nutrition examination sur... by Lihua Huang, Liuliu He, Qingfeng Zeng, Jinjing Huang, Xiaoyan Luo, Qiuming Zhong

“…This study aimed to investigate the correlation between HbA1c levels and all-cause and cardiovascular disease (CVD) mortality in elderly individuals with non-diabetic CKD.MethodsData from the NHANES (1999-2018) were analyzed to measure HbA1c levels in whole blood using high-performance liquid chromatography (HPLC). Information on deaths and subsequent details was collected through the National Mortality Index until December 31, 2019. …”
Get full text

The influence of legal compliance in farmer group on the growth and development of sustainable mangrove ecosystem by E.K. Purwendah, N.A. Sasongko, H. Susanto, R. Mawardi, T. Cahyono, H.L. Susilawati, T. Wahyuni, D. Juhandi, T. Rahman, A. Gustina, I.D.S. Triana, E. Pudyastiwi, O. Kusumaningsih, T. Martini

“…Ecosystem protection is ensured through monitoring efforts within the Segara Anakan mangrove area, as well as through informal sanctions imposed by the local community in collaboration with the Nature Conservation Agency and the Village Trustee Non-Commissioned Officer.CONCLUSION: The limited role of law enforcement agencies provides opportunities for community to contribute to the protection. …”
Get full text

Selective dorsal rhizotomy long-term effects on functional motility in Jordanian children with spastic cerebral palsy by Yazan E. Al-kharabsheh, Anas Said, Ismail A. Ismaiel, Issam Khawaja, Marwan Altaher, Ali Bani-Ahmed, Carmen M. Cirstea, Carmen M. Cirstea

“…These findings provide critical information that may aid in identifying “the best” therapeutic window and “the best” candidate for SDR in Jordan.…”
Get full text