DNA methylation inhibitors adverse reaction characteristic analysis: an analysis based on the European spontaneous adverse event reporting system by Xia Zhang, Yuyu Liu, Qingwang Hou, Yongxin Guo, Youfu He

“…., Myelosuppression, Thrombocytopenia, etc.).ConclusionThe analysis regarding ADRs of DNA methylation inhibitors was consistent with the literature information disclosed. AZACITIDINE and DECITABINE each have ADRs with a high probability of being reported. …”
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PMAIP1 regulates the progression of follicular thyroid carcinoma through the Wnt3/FOSL1 pathway by Haobo Wang, Fangjian Shang, Yifang Wang, Bo Pang, Bo Pang, Longfei Kang, Longfei Kang, Chuanmin Zhou, Chuanmin Zhou, Dongyun Li, Dongyun Li, Zhongxin Li, Zhongxin Li, Xia Jiang, Xia Jiang, Bo Liu, Zengren Zhao

“…Investigating the role and mechanism of PMAIP1 in FTC is crucial for enhancing our understanding of FTC and informing clinical treatment strategies. MethodsThis study examined the expression level of PMAIP1 in FTC through comprehensive analysis of databases, tumor tissues, and cell lines. …”
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Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China by Xiaowu Jiang, Abubakar Siddique, Li Chen, Lexin Zhu, Haiyang Zhou, Li Na, Chenghao Jia, Yan Li, Min Yue

“…The gained knowledge provided essential baseline information that may be utilized for regular tracking of MDR Salmonella transmission in the food chain to minimize potential future outbreaks.…”
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Herpes Simplex Virus Type 2 (HSV-2) and Cytomegalovirus (CMV) among Women with Macerated Stillbirth: A Cross-Sectional Hospital-Based Study from Mwanza, Tanzania by Helmut A. Nyawale, Elieza Chibwe, Fridolin Mujuni, Lidya Maiga, Albert Silvin, Alda Ester Chongo, Bertrand Msemwa, Vitus Silago, Mtebe Majigo, Doreen Kamori, Stephen E. Mshana, Mariam M. Mirambo

“…Despite high rates of stillbirths and high viral prevalence in LMICs, there is limited information regarding their association. This study investigated the magnitude of herpes simplex 2 virus (HSV-2) and human cytomegalovirus (HCMV) among women with macerated stillbirth. …”
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Factors affecting implementation of interventions for oral health, substance use, smoking and diet for people with severe and multiple disadvantage: a community-based qualitative s... by Sheena E Ramsay, Richard G Watt, Falko F Sniehotta, Eileen Kaner, Martha Paisi, Neha Jain, Martin Burrows, Emma A Adams, Gillian McLellan, Emma C Joyes, Laura J McGowan, David Landes, Lorenzo Iafrate

“…This study aimed to understand the factors that affect implementation (relevance of setting, acceptability and adverse effects of interventions) and the sustainability of interventions targeting oral health, substance use, smoking and diet for people experiencing SMD.Methods Between August 2021 and April 2023, interviews and focus group discussions were conducted with two groups of participants: (1) people experiencing SMD in Newcastle Upon Tyne/Gateshead and (2) frontline staff, volunteers, policymakers and commissioners from London, Plymouth and Newcastle Upon Tyne/Gateshead. Information was gathered on factors related to the implementation and acceptability of interventions related to oral health and related behaviours. …”
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Identification of highly expressed genes and efficient core promoters specific to buffalo skeletal muscles by J. Huang, J. Huang, D. Guo, R. Zhu, H. Wang, C. Yang, D. Shi, J. Shang

“…These results provide significant information for the targeted improvement of meat quality in buffaloes and other livestock animals.…”
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Efficacy of Chinese traditional quadruple single pill combination versus valsartan/hydrochlorothiazide for the treatment of hypertension (COSPQ-BP): study protocol for randomised c... by Kai Liu, Yu Yan, Xin Zhang, Yanan Li, Yuanyuan Yao, Lu Liu, Runyu Ye, Si Wang, Xiangyu Yang, Xiaoping Chen, Shanshan Jia, Qingtao Meng, Xianghao Zuo

“…The secondary outcomes have been predetermined and will primarily encompass the following: (1) changes in other BP measures, as well as changes in blood lipids, blood glucose and uric acid at 12 weeks and (2) evaluation of the impact of starting antihypertensive therapy with compound reserpine and triamterene tablets or valsartan/hydrochlorothiazide on the depressive and anxiety statess of patients.Ethics and dissemination The study protocol (version number: V5.0, version date: 17 January 2023) has been approved by the ethics committee (Biomedical Ethics Committee of West China Hospital of Sichuan University, approval number: Review (51) in 2023). Written informed consent will be obtained from each participant by researchers. …”
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Assessing the resilience of child immunisation programmes using geospatial modelling and interrupted time series analysis in Ethiopia and Kenya amidst the COVID-19 pandemic: tracki... by McEwen Khundi, Themba Mzembe, Michael Give Chipeta, Chimwemwe Chifungo, Nyovani Janet Madise, Chifuniro Somanje Mankhwala, Tabitha Ngwira, Maame B Peterson

“…This paper examines the impact of the COVID-19 pandemic on routine child immunisation coverage in Ethiopia and Kenya at both national and subnational levels.Methods Health management information systems data were used to estimate changes in child immunisation. …”
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Association of immune-related adverse events with the outcomes of immune checkpoint inhibitors in patients with dMMR/MSI-H metastatic colorectal cancer by Chiara Cremolini, Sara Lonardi, Filippo Pietrantonio, Francesca Corti, Elisabetta Fenocchio, Massimiliano Salati, Margherita Ambrosini, Michael J Overman, Lisa Salvatore, Rossana Intini, Priya Jayachandran, Javier Ros, Maria Elena Elez, Marwan Fakih, Aakash Tushar Shah, Rosalba Miceli, Monica Niger, Vincenzo Nasca, Giacomo Mazzoli, Francesco Barretta

“…Clearly, the irAE burden is not a baseline information, thus it was modeled as a time-dependent variable in univariable and multivariable Cox models.Results Among 331 patients, irAEs were reported in 144 (43.5%) patients. …”
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Approaches to implementing and financing primary health care in Kenya: a case of seven counties by Janette Karimi, Salim Hussien, Elizabeth Wangia, Mercy-Irene Kimani, Mohamud Mohamed, Melissa Wanda, Rosemarie Muganda, Rachel Ndirangu, Daniel Mwai, Mercy Wanjala, Fadhila Richter

“…This scholarly article delineates the outcomes of an investigative assessment reviewing the current state and trajectory of PHC implementation, focusing on the PCN implementation, and analyzing PHC financing modalities in 7 counties in Kenya.MethodsThis study employed a mixed-methodological approach to gather data from seven counties; Garissa, Nyeri, Makueni, Vihiga, Kisumu, Nakuru, and Mombasa. Key informant interviews were conducted with county health officials and partners. …”
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Risk Factors of Bacteremia following Multiple Traumas by Hak-Jae Lee, Eol Choi, Nak-Joon Choi, Hyun-Woo Sun, Jae-Suk Lee, Jeong-Woo Lee, Tae-Yoon Kim, Yoon-Joong Jung, Suk-Kyung Hong

“…We retrospectively reviewed medical records of all trauma patients admitted to the surgical intensive care unit and general ward between January 2011 and December 2015. The information was collected for each patient and recorded in a computer database: early onset bacteremia (EOB) was defined as when onset occurred within 7 days after trauma, and late onset bacteremia (LOB) was defined as when onset occurred after 7 days from trauma. …”
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Ethnic Architectural Heritage Identification Using Low-Altitude UAV Remote Sensing and Improved Deep Learning Algorithms by Ting Luo, Xiaoqiong Sun, Weiquan Zhao, Wei Li, Linjiang Yin, Dongdong Xie

“…Ethnic minority architecture is a vital carrier of the cultural heritage of ethnic minorities in China, and its quick and accurate extraction from remote sensing images is highly important for promoting the application of remote sensing information in urban management and architectural heritage protection. …”
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Assessing the Experiences of Sexual and Gender Minority Applicants to Orthopaedic Surgery Residency by Douglas J. Weaver, MD, Tanios Dagher, BS, Ngoc Duong, MS, Sara Winfrey, MD, Alexander Koo, MD, Tessa Balach, MD, FAOA

“…The recognition of such challenges can help to optimize the establishment of informed policies regarding mistreatment and practices regarding diversity and inclusion.…”
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Understanding the Molecular Mechanisms of Incomptine A in Treating Non-Hodgkin Lymphoma Associated with U-937 Cells: Bioinformatics Approaches, Part I by Fernando Calzada, Normand García-Hernández, Elihú Bautista, José Manuel Sánchez-López, Miguel Valdes, Claudia Velázquez, Elizabeth Barbosa

“…<b>Conclusions</b>: The results obtained using the five bioinformatic approaches provide information and show that <b>IA</b> could be used to treat non-Hodgkin lymphoma induced with the U-937 cell line. …”
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A Speckle-Tracking Echocardiography Study: Cardiac Effect of Sleep Duration by Gülsüm Bingöl, Fulya Avcı Demir, Özge Özden, Emre Özmen, Serkan Ünlü

“…The patients who were eligible for the study design were called by the investigator to obtain information on average sleep duration, and two groups were defined by the self-reported sleep duration (≤7 hours, >7 hours per day) and were used in the statistical analyses. …”
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Comparative Evaluation of Functional Outcomes in High Condylar Fractures Treated with Closed Methods with and without Temporomandibular Joint Arthrocentesis: A Research Protocol fo... by Sachindra Dubey, Nitin Bhola, Anchal Agarwal

“…Patients with suspected fractures will undergo radiographic examinations, and those meeting the inclusion criteria will be included in the study after providing informed consent. Arthrocentesis will be performed using a specialised needle with two lumens, inlet and outlet bevels, and a silicone stopper for maximal insertion depth. …”
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Prevalence of TB symptoms, diagnosis and treatment among people living with HIV (PLHIV) not on ART presenting at outpatient clinics in South Africa and Kenya: baseline results from... by Mhairi Maskew, Matthew Fox, Alana Brennan, Bruce A Larson, Isaac Tsikhutsu, Margaret Bii, Lungisile Vezi, Willem Daniel Francois Venter, Peter D Ehrenkranz, Sydney Rosen

“…We compared the performance of the WHO four-symptom TB screening tool with a baseline Xpert test.Setting Outpatient HIV clinics in South Africa and Kenya.Participants Eligible patients were non-pregnant, PLHIV, &gt;18 years of age, not on ART, willing to provide written informed consent. A total of 594 patients in South Africa and 240 in Kenya were eligible.Results Prevalence of any TB symptom was 38% in Kenya, 35% (SLATE I) and 47% (SLATE II) in South Africa. …”
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Evolutionary dynamics of mitochondrial genomes and intracellular transfers among diploid and allopolyploid cotton species by Jiali Kong, Jie Wang, Liyun Nie, Luke R. Tembrock, Changsong Zou, Shenglong Kan, Xiongfeng Ma, Jonathan F. Wendel, Zhiqiang Wu

“…Using long-read data, we quantified alternative conformations mediated by recombination events between repeats, and phylogenetically informative structural variants were noted. Nucleotide substitution rate comparisons between coding and non-coding regions revealed low mutation rates across the entire mitogenome. …”
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Towards using virtual acoustics for evaluating spatial ecoacoustic monitoring technologies by Neel P. Le Penru, Becky E. Heath, Jamie Dunning, Lorenzo Picinali, Robert M. Ewers, Sarab S. Sethi

“…We thus provide guidelines for the use and refinement of such systems towards more standardised, controlled benchmarking of PAM technologies, empowering practitioners to make more informed decisions on using these vital tools.…”
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Distress and coping mechanisms among people with diabetes: cross-sectional assessment from an NCD screening clinic of a tertiary care hospital in North India by Madhur Verma, Shivani Sidana, Prakash Kumar, Omna Singh, Vandana Esht, Karthick Balasubramanian, Nitin Kapoor, Rakesh Kakkar, Sanjay Kalra

“…The study was ethically approved, and written informed consent was obtained from the patients. Results Of the 596 study participants, 17.4% depicted uncontrolled diabetes, while 18.1% PWD experienced moderate to severe DD, with emotional distress depicting the highest prevalence (23.8%). …”
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