Predicting the impact of missense mutations on an unresolved protein’s stability, structure, and function: A case study of Alzheimer’s disease-associated TREM2 R47H variant by Joshua Pillai, Kijung Sung, Chengbiao Wu

“…However, AF2 falls short of predicting the effects of missense mutations on unresolved protein structures that may be informative to efforts in personalized medicine. Over the last decade, countless in-silico methods have been developed to predict the pathogenicity of point mutations on resolved structures, but no studies have evaluated their capabilities on unresolved protein structures predicted by AF2. …”
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Policy instrument terms in patriotic health campaign documents issued by Chinese national government agencies from 1952 to 2023: a quantitative textual analysis by Yuanyuan LA, He ZHU, Qiqi WANG, Hongyan YAO, Xiaoyun LIANG

“…Capacity building instruments (23.57%) and information and persuasion instruments (16.28%), as commonly used policy instruments, played an important role in achieving policy objectives. …”
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Masticatory muscle changes on magnetic resonance imaging of dogs with Neospora caninum compared to meningoencephalitis of unknown origin by Jessica Zilli, Kathryn Fleming, Chloe Fisher, Chloe Fisher, Tim Sparks, Tom Harcourt-Brown, Edward Ives

“…In these cases, whether immunosuppressive or antimicrobial treatments are started prior to receiving further test results should still be based on the clinical status of the animal and index of suspicion using a combination of all available clinical information at that time.…”
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Prevalence of Undernutrition and Associated Factors among Pregnant Women in a Public General Hospital, Tigray, Northern Ethiopia: A Cross-Sectional Study Design by Ebud Ayele, Guesh Gebreayezgi, Teklewoini Mariye, Degena Bahrey, Gebrekiros Aregawi, Gebregziabher Kidanemariam

“…Despite the limited studies performed in different parts of Ethiopia, the information about the prevalence of undernutrition of pregnant women in the current study area is not documented. …”
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Prognostic significance of albumin corrected anion gap in patients with acute pancreatitis: a novel perspective by Jianjun Wang, Pei Yang, Xintao Zeng, Sirui Chen, Xi Chen, Lan Deng, Ruizi Shi, Chuan Qin, Huiwen Luo, Jianping Gong, Hua Luo, Decai Wang

“…We conducted a retrospective analysis utilizing data extracted from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database. …”
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Technical efficiency of public hospitals in east Africa: a systematic review and meta-analysis by Anteneh Lamesgen, Bekalu Endalew, Aysheshim Belaineh Haimanot, Tigabu Kidie Tesfie, Elyas Melaku Mazengia, Mulat Belay Simegn, Werkneh Melkie Tilahun, Molla Yigzaw Birhanu, Lakew Asmare, Habtamu Geremew, Muluye Gebrie Mengie

“…Systematic reviews on public hospital efficiency, which are currently rare in Africa, should be conducted on a much larger scale in order to create more, and validated information for use in policy-making. Trial registration This review protocol was registered and approved by the international prospective register of systematic reviews with a Protocol ID: CRD42023444729.…”
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The study of miRNA-211 affects melanogenesis progress in Cashmere goats via suppressing <i>AP1S2</i> by B. Zhang, R. Liu, T. Ma, X. Li, Y. Zhao, H. Su, J. Li, Y. Li, H. Jiang, Q. Zhang

“…And their opposite expression trends were confirmed in B16-F10 cells by immunofluorescence. The information above showed miRNA-211 downregulated the expression of <i>AP1S2</i>. …”
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First detection and molecular characterization of Jingmen tick virus with a high occurrence in Rhipicephalus (Boophilus) microplus collected from livestock in Cameroon (2024) by Paloma Kiwan, Eva Lopez, Morena Gasparine, Geraldine Piorkowski, Agathe Colmant, Achille Paguem, Stephanie Mvodo, Laurence Thirion, Xavier de Lamballerie, Remi Charrel, Alessandra Falchi

“…To date, there is no information regarding the circulation of JMTV in ticks collected from livestock in Cameroon. …”
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Safety assessment of tolvaptan: real-world adverse event analysis using the FAERS database by Peiyang Cao, Qian Wang, Yan Wang, Qing Qiao, Liyuan Yan

“…Notably, strong ADE signals were detected for decreased urine osmolality [n = 5, ROR 149.74, PRR 149.7, IC (Information Component) 7.13, EBGM (Empirical Bayes Geometric Mean) 139.79], osmotic demyelination syndrome (n = 38, ROR 128.47, PRR 128.25, IC 6.92, EBGM 120.91), and pulmonary-related tumors such as bronchial metastatic carcinoma, bronchial carcinoma, metastatic small cell lung carcinoma, and small cell lung carcinoma. …”
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Client perspectives on creating supportive sexual health environments for people with persistent anxiety: a qualitative study by Mark Gilbert, Travis Salway, Stéphanie Black, Sarah Watt, Aidan Ablona, Hsiu-Ju Chang, Heather Nicole Pedersen

“…Participants described anxiety related to sexual health service access and experiences due to sexual health-related stigma and privacy concerns; provider judgement and lack of communication or information regarding test results. They suggested that routinely integrating discussions with providers about mental health in sexually transmitted and bloodborne infection (STBBI) testing appointments may help clients feel safer and could connect them to support. …”
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Status survey of uncrossmatched type O suspended RBCs in patients with emergency transfusion by PENG Zhuoyue, XU Shilan, YANG Xinxin, CHEN Chunxia, TAN Bin

“…[Methods] A retrospective analysis of the information of patients who received uncrossmatched type O suspended RBCs in West China Hospital of Sichuan University from August 2019 to April 2024 was conducted. …”
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The association between body composition and overall survival in patients with advanced non-small cell lung cancer by Liang Fu, Haiming Ding, Liupei Mo, Xiaoyu Pan, Lijuan Feng, Shenglian Wen, Qiaoqing Lan, Liling Long

“…CT-measured body composition parameters provide precise prognostic information and are superior to BMI; an increased OS rate in advanced NSCLC is associated with a greater SFI and a lower PVMD.…”
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Psychophysiological components of the activities of operators of nuclear power plants as a factor of accidents in the conditions of the threat of social catastrophe by O.A. Shevchenko, O.V. Sheviakov, V.V. Kornienko, I.A. Burlakova, Y.A. Slavska, N.I. Zhyhaylo, V.V. Vakulik, I.S. Ostapenko, O.A. Gerasimchuk, E.Y. Doroshenko, V.V. Prykhodko, S.A. Chernihivska, O.M. Ivchenko, V.M. Tychonovych, S.B. Dorogan

“…To study the dynamics of the psychophysiological state of operators of nuclear power plants, a verbal-communicative diagnostic method was used to collect information about the operators investigated using Google Form and traditional physiological, psychological and psychophysiological methods. …”
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Diagnostic investigation, intervention, and outcome for post-subtotal gastrectomy patients who present with jaundice by Duan Wang, Duan Wang, Liang Zhu, Fanyi Kong, Fanyi Kong, Yingyu Pan, Yingyu Pan, Wei Liu, Xuan Wang, Weidong Pan, Jian Cao, Qiang Xu, Dong Wu, Dong Wu, Dong Wu

“…The interventional methods for biliary drainage, their success rate and patient outcome were also investigated.MethodsElectronic medical records were reviewed to identify patients hospitalized for obstructive jaundice at Peking Union Medical College Hospital, who had previously undergone subtotal gastrectomy. The clinical information, imaging and interventional examination data of those patients were retrospectively collected.ResultsBetween 2018 and 2023, 36 patients with previous subtotal gastrectomy were hospitalized for ob-structive jaundice at our hospital. …”
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Analysis of the MYB gene family in tartary buckwheat and functional investigation of FtPinG0005108900.01 in response to drought by Jinbo Li, Xin Yang, Bianling Tian, Tian Tian, Yu Meng, Fei Liu

“…Our results provided detailed evolution and comparative genomic information of FtMYBs in tartary buckwheat and dissected the function of a FtMYB gene FtPinG0005108900.01 in response to drought.…”
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Outcomes of psychiatric interviews and self-rated symptom scales in people on sick leave for common mental disorders: an observational study by Cecilia Björkelund, Dominique Hange, Jeanette Westman, Anna Nager, Jonas Hällgren, Ingmarie Skoglund, Sandra af Winklerfelt Hammarberg, Anna Finnes

“…This finding is relevant to the interpretation of information from health data registers, including studies and guidelines based on these data. …”
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Down syndrome and outcomes in critically ill pediatric patients by José Tantaleán Da Fieno, Rosa León Paredes, Patricia Palomo Luck, Carlos Del Águila Villar, Emiliana Rizo Patrón

“…IntroductionInformation regarding children with Down syndrome (DS) in the Pediatric Intensive Care Unit (PICU) is limited and conflicting. …”
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Characterizing Wellness Initiatives in Academic Radiation Oncology Departments by Sara Beltrán Ponce, MD, Crystal Seldon Taswell, MD, Idalid Franco, MD, MPH, Malcolm D. Mattes, MD, Tracy Kelly, MD, Leah Katz, MD, MPH

“…Methods and Materials: Academic RO department chairs were contacted to inquire whether they had a departmental wellness leader with a request for leader contact information, if applicable. Wellness leaders were invited to complete an anonymous survey in January and February 2023 using Qualtrics. …”
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Impact of infection in patients with non-ST elevation acute coronary syndrome undergoing percutaneous coronary intervention: insight from a multicentre observational cohort from Ch... by Jun Li, Lei Jiang, Wei Chen, Ning Tan, Wei Guo, Ji-yan Chen, Yuan-hui Liu, Peng-cheng He, Peng-Yuan Chen, Chong-Yang Duan, Xue-Biao Wei, Yin-Lin Zhou, Zhu-Jun Chen, Jian-Fang Luo, Dan-Qing Yu, Qing-Shan Geng, Chun-Ying Lin, Zhi-Qiang Guo, Yan-Song Guo, Yi-Yue Chen, Wen-Sheng Li

“…Only patients with adequate information to diagnose or rule out infection were included. …”
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Sleep duration, sleep disturbances and skeletal muscle mass change over time: A population-based longitudinal analysis in Peru [version 4; peer review: 1 approved, 2 approved with... by Enrique S. Nuñez-del-Arco, Renzo A. Agurto-García, Rodrigo M. Carrillo-Larco, J. Jaime Miranda, Antonio Bernabe-Ortiz

“…Materials and Methods Secondary analysis using information of a population-based intervention. The outcome was SMM assessed using bioimpedance and the second version of the Lee’s formula. …”
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