Five lessons from a mid-level health manager intervention to increase uptake of tuberculosis prevention therapy in Uganda: ‘it is a completely different thing to implement what you... by Jason Johnson-Peretz, Canice Christian, Cecilia Akatukwasa, Fred Atwine, Elijah Kakande, Moses R. Kamya, Diane V. Havlir, Carol S. Camlin, Gabriel Chamie

“…Methods We performed a thematic analysis of six focus-group discussions from this intervention (held in May 2019, January 2020, September 2021) and 23 key informant interviews with control group participants (between February and August 2019 and September and December 2020). …”
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Integrated Transcriptomic and Targeted Metabolomic Analysis Reveals the Key Genes Involved in Triterpenoid Biosynthesis of <i>Ganoderma lucidum</i> by Xiaolan Xu, Chunxia Li, Fangjing Wu, Shuangshuang Zhao, Tiqiang Chen, Haihong You, Yijie Lin, Xiaoxing Zou

“…This study provides useful information about key genes involved in GT biosynthesis, but further exploration and in-depth research are needed to better understand the functions of these genes.…”
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Cross sectional associations of physical activity and sleep with mental health among Chinese university students by Bo Li, Shan-shan Han, Yu-peng Ye, Ya-xing Li, Shu-qiao Meng, Shuo Feng, Han Li, Zhong-lei Cui, Yang-Sheng Zhang, Yao Zhang, Qing Zhang, Guang-xu Wang, Hu Lou, Weidong Zhu, Yang Liu

“…The participants’ PA behaviors, sleep patterns, depressive symptoms (use the CES-D), anxiety symptoms (use the GAD-7), smoking and drinking behaviors, and demographic information were assessed through an online questionnaire using Questionnaire Star software. …”
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An endoscopic ultrasound-based interpretable deep learning model and nomogram for distinguishing pancreatic neuroendocrine tumors from pancreatic cancer by Nan Yi, Shuangyang Mo, Yan Zhang, Qi Jiang, Yingwei Wang, Cheng Huang, Shanyu Qin, Haixing Jiang

“…The optimal DL model was identified and used to establish a clinical signature, which subsequently informed the construction and evaluation of a nomogram. …”
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Prognostic factors for outcomes of idiopathic sudden sensorineural hearing loss: protocol for the SeaSHeL national prospective cohort study by Helen Blackshaw, Anne GM Schilder, Rishi Mandavia, Gerjon Hannink, Muhammad Nayeem Ahmed, Yaami Premakumar, Timothy Shun Man Chu, Tanjinah Ferdous, Nishchay Mehta, Joseph Manjaly, Maha Khan

“…For such trials to be run effectively, reliable information is needed on patients with SSNHL: where they present, numbers, demographics, treatment pathways, as well as outcomes. …”
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Longitudinal changes in factors affecting postoperative patient satisfaction after robot-assisted radical prostatectomy: an assessment using a patient-reported questionnaire by Soichiro Ogawa, Kei Yaginuma, Yuki Harigane, Shunta Makabe, Hitomi Imai, Satoru Meguro, Ryo Tanji, Akifumi Onagi, Ruriko Honda-Takinami, Kanako Matsuoka, Seiji Hoshi, Junya Hata, Yuichi Sato, Hidenori Akaihata, Masao Kataoka, Motohide Uemura, Yoshiyuki Kojima

“…Our results suggest that giving sufficient information before treatment choice is both important and useful for patients’ decision-making, leading to improved patient QOL.…”
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Associations between specific and cumulative adverse childhood experiences, childhood obesity, and obesogenic behaviours by Ladan Hashemi, Maryam Ghasemi, Brooklyn Mellar, Pauline Gulliver, Barry Milne, Fiona Langridge, Tracey McIntosh, Christa Fouche, Boyd Swinburn

“…Our findings highlight the importance of a holistic understanding of the determinants of obesity, reinforcing calls for ACEs prevention and necessitating incorporation of ACEs-informed services into obesity reduction initiatives.…”
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Prognostic implications of system inflammation response index in atrial fibrillation patients with type 2 diabetes mellitus by Yang Chen, Bin Zhou, Chaoquan Peng, Yong Liu, Weiyan Lai

“…Utilizing the Medical Information Mart for Intensive Care IV (MIMIC-IV) (v2.2) repository, subjects divided into three groups based on the SIRI index. …”
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Candidate SNP markers of changes in the expression levels of the human <i>SCN9A</i> gene as a hub gene for pain generation, perception, response and anesthesia by P. A. Dotsenko, K. A. Zolotareva, R. A. Ivanov, I. V. Chadaeva, N. L. Podkolodnyy, V. A. Ivanisenko, P. S. Demenkov, S. A. Lashin, M. P. Ponomarenko

“…It was found that SCN9A as a hub gene for pain generation, perception, pain response and anesthesia is acted on by natural selection against its downregulation, to keep the nervous system highly informed on the status of the organism and the environment.…”
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Aspectos clínicos de los casos de mpox humana en el escenario mundial: revisión integradora by Ana Clara Dantas, Cyntia Leenara Bezerra da Silva, Dase Luyza Barbosa de Sousa Alves, Amanda Barbosa da Silva, Hanna Priscilla da Silva Medeiros, Allyne Fortes Vitor

“…La selección de estudios y el informe de la revisión siguieron las recomendaciones de la guía Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). …”
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Relationship between maternal pre-pregnancy BMI and neonatal birth weight in pregnancies with gestational diabetes mellitus: a retrospective cohort study by Qiuping Liao, Qiuping Liao, Qiuping Liao, Tiantian Yu, Tiantian Yu, Tiantian Yu, Jiajia Chen, Jiajia Chen, Jiajia Chen, Xiuqiong Zheng, Xiuqiong Zheng, Xiuqiong Zheng, Lianghui Zheng, Lianghui Zheng, Lianghui Zheng, Jianying Yan, Jianying Yan, Jianying Yan

“…These findings highlight the importance of providing information, offering preconception counseling, and delivering health education on weight management to ensure healthy pregnancies.…”
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In Vitro Effect of Estradiol and Progesterone on Ovine Amniotic Epithelial Cells by Annunziata Mauro, Hashimita Sanyal, Angelo Canciello, Paolo Berardinelli, Valentina Russo, Nicola Bernabò, Luca Valbonetti, Barbara Barboni

“…In contrast, there is no information to date on the role of the other pregnancy steroids in culture. …”
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A pan-cancer analysis: predictive role of ZNF32 in cancer prognosis and immunotherapy response by Minghan Li, Chang Su, Qianru Wang, Yuetong Chen, Di Jiang, Weijia Wang, Shunjin Chen, Xiangping Li, Ming Fu, Juan Lu

“…ZNF32 was notably linked to various immune characteristics, including immune cell infiltration, MSI, TMB and immune checkpoint gene expression, indicating its potential in informing immunotherapy approaches. Interestingly, in FaDu and CAL27 cell lines, the group with elevated ZNF32 expression exhibited increased levels of immune checkpoint markers, such as CTLA-4 and PD-L1. …”
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Abnormal Operation Detection of Automated Orchard Irrigation System Actuators by Power Consumption Level by Shahriar Ahmed, Md Nasim Reza, Md Rejaul Karim, Hongbin Jin, Heetae Kim, Sun-Ok Chung

“…Information and communication technology (ICT) components, especially actuators in automated irrigation systems, are essential for managing precise irrigation and optimal soil moisture, enhancing orchard growth and yield. …”
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How do palliative care doctors recognise imminently dying patients? A judgement analysis by Nicola White, Priscilla Harries, Adam JL Harris, Victoria Vickerstaff, Philip Lodge, Catherine McGowan, Ollie Minton, Christopher Tomlinson, Adrian Tookman, Fiona Reid, Patrick Stone

“…A mixed model regression analysis was completed using the percentage estimate as the outcome and the patient information included in the vignettes as the predictors.Results The mean Brier score of all participants was 0.237 (95% CI 0.235 to 0.239). …”
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Multimedia: multimodal mediation analysis of microbiome data by Hanying Jiang, Xinran Miao, Margaret W. Thairu, Mara Beebe, Dan W. Grupe, Richard J. Davidson, Jo Handelsman, Kris Sankaran

“…Multimedia is a modular R package with close ties to the wider microbiome software ecosystem that makes statistically rigorous, flexible mediation analysis easily accessible, setting the stage for precise and causally informed microbiome engineering.…”
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VIBE: an R-package for VIsualization of Bulk RNA Expression data for therapeutic targeting and disease stratification by Indu Khatri, Saskia D. van Asten, Leandro F. Moreno, Brandon W. Higgs, Christiaan Klijn, Christiaan Klijn, Francis Blokzijl, Iris C. R. M. Kolder

“…VIBE integrates statistics in all graphics, enabling data-informed decision-making.ConclusionsVIBE facilitates detailed visualization of individual and cohort-level summaries such as concordant or discordant expression of two genes or pathways. …”
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Childhood overweight and obesity and back pain risk: a cohort study of 466 997 children by Daniel Prieto-Alhambra, Andrew J Carr, Antony J Palmer, Talita Duarte-Salles, Jose Luis Poveda, Daniel Martinez-Laguna, Carlen Reyes, Jeroen de Bont, Alan Silman

“…Objectives To assess the association between age, sex, socioeconomic group, weight status and back pain risk in a large general population cohort of children.Design and setting A dynamic cohort of children aged 4 years in the Information System for Research in Primary Care (SIDIAP) electronic primary care records data in Catalonia. …”
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Prospective study of factors associated with asthma attack recurrence (ATTACK) in children from three Ecuadorian cities during COVID-19: a study protocol by Cristina Ardura-Garcia, Max Bachmann, Alejandro Rodriguez, Philip Cooper, Michael Richard Perkin, Irina Chis Ster, Natalia Cristina Romero, Martha E Chico, Alvaro Cruz, Diana Morillo, Santiago Mena-Bucheli, Angélica Ochoa, Claudia Rodas, Augusto Maldonado, Karen Arteaga, Jessica Alchundia, Karla Solorzano, Camila Figueiredo

“…The study results will be disseminated through presentations at conferences and to key stakeholder groups including policy-makers, postgraduate theses, peer-review publications and a study website. Participants gave informed consent to participate in the study before taking part.…”
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Supervision, performance assessment, and recognition strategy (SPARS) – a multipronged strategy to strengthen medicines management in Nepal: pilot study methods and baseline result... by Nirajan Bhusal, Anup Bastola, Reekesh Shrestha, Narendra Kumar Khanal, Birna Trap

“…The overall score did not differ significantly by level of care; however, hospitals had the lowest overall baseline score and individual domain scores.Conclusion: The baseline assessment using the SPARS tool provides valuable information on the current state of MM in Nepal, which was poor, assessed by the 25 SPARS indicators covering stock and storage management, ordering and reporting, prescribing, and dispensing. …”
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