Faecalibacterium prausnitzii: A Next-Generation Probiotic in Gut Disease Improvement by Xiaoya He, Shuyang Zhao, Yan Li

“…It has been widely demonstrated that dysbiosis, which means the alternations of the gut microbial structure, is closely associated with development of intestinal chronic inflammation-related diseases such as inflammatory bowel disease (IBD), and even infectious diseases including bacterial and viral infection. …”
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Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach by Misbah Misdaq, Sonia Ziegler, Nicolas von Ahsen, Michael Oellerich, Abdul R. Asif

“…Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. …”
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Five-Aminosalicylic Acid: An Update for the Reappraisal of an Old Drug by Cristiana Perrotta, Paolo Pellegrino, Eliana Moroni, Clara De Palma, Davide Cervia, Piergiorgio Danelli, Emilio Clementi

“…Inflammatory bowel disease (IBD) comprises several conditions with chronic or recurring immune response and inflammation of the gastrointestinal apparatus, of which ulcerative colitis and Crohn’s disease are the commonest forms. …”
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Hyaluronan Synthase 3 Null Mice Exhibit Decreased Intestinal Inflammation and Tissue Damage in the DSS-Induced Colitis Model by Sean P. Kessler, Dana R. Obery, Carol de la Motte

“…Hyaluronan (HA) overproduction is a hallmark of multiple inflammatory diseases, including inflammatory bowel disease (IBD). Hyaluronan can act as a leukocyte recruitment molecule and in the most common mouse model of intestinal inflammation, the chemically induced dextran sodium sulfate (DSS) experimental colitis model, we previously determined that changes in colon distribution of HA occur before inflammation. …”
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METTL14 modulates the progression and ferroptosis of colitis by regulating the stability of m6A-modified GPX4 by Yuhua Chen, Weicong Fan, Ying Lyu, Jingsheng Liao, Ying Zhou

“…Abstract Ulcerative colitis (UC) is non-specific inflammatory bowel disease. UC development and progression were closely associated with epigenetic modifications. …”
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Colonic Mucosal Ulceration and Gastrointestinal Bleeding Associated with Sevelamer Crystal Deposition in a Patient with End Stage Renal Disease by Sudheer Nambiar, Unnikrishnan Kunjan Pillai, Joe Devasahayam, Tony Oliver, Asha Karippot

“…Common causes of lower gastrointestinal bleed include diverticulosis, ischemia, hemorrhoids, neoplasia, angiodysplasia, and inflammatory bowel disease. ESRD patients are known to retain phosphate alone or in combination with calcium which has been associated with high mortality. …”
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Gastroenterological Surgery and Management of Clostridioides difficile Infection: A Review by Tomonori Takano, Hiroyuki Aiba, Mitsuo Kaku, Hiroyuki Kunishima

“…The risk factors for CDI include age 65 years; history of antimicrobial use; previous hospitalization; history of gastrointestinal surgery, chronic kidney disease, or inflammatory bowel disease; nasal tube feeding; and use of proton pump inhibitors and histamine H2 receptor antagonists. …”
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The injectable hydrogel loading cannabidiol to regulate macrophage polarization in vitro for the treatment of chronic enteritis by Ye Wang, Xingming Ji, Xinyi Wang, Mengyu Sun, Cheng Li, Dongmei Wu

“…This study aims to treat chronic inflammatory bowel disease by preparing a CBD-loaded hydrogel system (GelMA + CBD) that can deliver CBD in situ and improve its bioavailability through slow release. …”
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The Critical Role of Bach2 in Shaping the Balance between CD4+ T Cell Subsets in Immune-Mediated Diseases by Lingyi Yang, Shuli Chen, Qiuyu Zhao, Ying Sun, Hong Nie

“…Genetic variations within Bach2 locus are associated with numerous immune-mediated diseases including multiple sclerosis (MS), rheumatoid arthritis (RA), chronic pancreatitis (CP), type 2 chronic airway inflammation, inflammatory bowel disease (IBD), and type 1 diabetes. Here, we reveal a critical role of Bach2 in regulating T cell biology and the correlation with these immune-mediated diseases.…”
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Il-6 and MSH3 in colorectal carcinoma: Expression, relationship, and prognostic significance in 171 colorectal carcinoma cases by Elif Kolay Bayram, Betul Ogut, Mehmet Arda Inan, Ayse Dursun

“…Inflammation is a relatively uncommon but crucial contributor to its etiology, and inflammation is also thought to pose a risk in patients without a clinical diagnosis of inflammatory bowel disease. In cell lines, the proinflammatory cytokine interleukin-6 (IL-6) causes a cytosolic shift in the mismatch repair protein MSH3, accompanied by functional loss. …”
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Fecal Lactoferrin: Reliable Biomarker for Intestinal Inflammation in Pediatric IBD by Stephan Buderus, James H. Boone, Michael J. Lentze

“…Optimal management of pediatric patients with inflammatory bowel disease (IBD) requires early diagnosis. Aim of the study is to compare fecal lactoferrin (FL) as biomarker of intestinal inflammation to CRP in pediatric patients with new-onset IBD. …”
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Autosplenectomy in a Patient with Paroxysmal Nocturnal Hemoglobinuria (PNH) by Ethan Burns, Kartik Anand, Gonzalo Acosta, Malcolm Irani, Betty Chung, Abhishek Maiti, Ibrahim Ibrahim, Lawrence Rice

“…Autosplenectomy (AS) is a known complication of diseases such as sickle cell anemia, celiac disease, and inflammatory bowel disease. We report the first known case of AS due to paroxysmal nocturnal hemoglobinuria (PNH). …”
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Rising Healthcare Costs and Utilization among Young Adults with Cirrhosis in Ontario: A Population-Based Study by Jeffrey B. Ames, Maya Djerboua, Norah A. Terrault, Christopher M. Booth, Jennifer A. Flemming

“…Young adults (aged 18–40 years) with cirrhosis, inflammatory bowel disease (IBD), and asthma were identified based on validated case definitions. …”
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The Causal Relationship between Immune-Mediated Inflammatory Diseases and Aortic Aneurysm: A Bidirectional Two-Sample Mendelian Randomization Study by Sijia Sun, Jie Li, Mengxian Sun, Jie He, Songtao Tan, Ge Wang, Yuan Zheng, Xiaoping Fan

“…Additionally, there was no evidence to suggest that AA may increase the risk of inflammatory bowel disease (IBD), Crohn’s disease (CD), ulcerative colitis (UC), systemic lupus erythematosus (SLE), and psoriasis (PSO). …”
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Serology of Viral Infections and Tuberculosis Screening in an IBD Population Referred to a Tertiary Centre of Southern Italy by Marco Ardesia, Giuseppe Costantino, Placido Mondello, Angela Alibrandi, Walter Fries

“…With the introduction of more potent immunosuppressive agents in inflammatory bowel disease, prevention of opportunistic infections has become necessary by introducing screening programs. …”
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Major heavy metals and human gut microbiota composition: a systematic review with nutritional approach by Mahsa Rezazadegan, Bita Forootani, Yeganeh Hoveyda, Niloufar Rezazadegan, Reza Amani

“…Evidently, it is related to leaky gut, oxidative stress, and several diseases such as inflammatory bowel disease and cancers. Probiotic treatment and nutritional strategies such as high fiber intake and following antioxidant-rich diets should be considered in terms of HMs exposure.…”
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Gastrointestinal Bleeding in Antithrombotic Therapy in Patients with Coronary Heart Disease: Risk Factors, Pathogenesis and Treatment by N. S. Lapina, A. A. Alekseeva, A. D. Vershinina, N. S. Khruleva, F. N. Muradova, L. Y. Koroleva

“…Risk factors of GIB during antithrombotic therapy in CHD patients include: GIB, gastric and/or duodenal ulcer in the history, reflux esophagitis, presence of H. pylori, inflammatory bowel disease, diverticula, haemorrhoids, angiodysplasia, gastrointestinal neoplasia, age above 65 years, concomitant treatment with non-steroidal anti-inflammatory drugs (NSAIDs), glomerular filtration rate <50 mL/min, high doses of direct oral anticoagulants (DOACs) ≥3 in HAS-BLED score. …”
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Transperineal Ultrasonography in Perianal Crohn Disease: A Valuable Imaging Modality by Emily K Wright, Kerri L Novak, Cathy Lu, Remo Panaccione, Subrata Ghosh, Stephanie R Wilson

“…Improvements in sonographic technology over recent years have facilitated a growing enthusiasm among radiologists and gastroenterologists in the use of ultrasound for the assessment of inflammatory bowel disease. Transabdominal intestinal ultrasound is accurate, affordable and safe for the assessment of lumi-nal inflammation and complications in Crohn disease, and can be performed with or without the use of intravenous contrast enhancement. …”
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Alleviation of DSS-induced colitis by Meconopsis polysaccharides correlated with reduced PI3K/AKT signaling and gut microbiome diversity by Jun Dai, Weidong Wang, Fangfang He, Yujuan Wang, Denglang Zou

“…IntroductionInflammatory bowel disease (IBD) is a recurrent gastrointestinal disorder that significantly impacts patients’ quality of life globally. …”
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Probiotic Bacterium-Derived p40, p75, and HM0539 Proteins as Novel Postbiotics and Gut-Associated Immune System (GAIS) Modulation: Postbiotic-Gut-Health Axis by Feray Gençer Bingöl, Duygu Ağagündüz, Ferenc Budán

“…HM0539 enhances intestinal barrier integrity, exhibits antiinflammatory properties, and protects against bacterial infection, suggesting its possible as a therapeutic for inflammatory bowel disease. This review may contribute to future studies on the therapeutic use of p40, p75, and HM0539 postbiotic proteins in inflammatory gastrointestinal system diseases.…”
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