Management of Primary Sclerosing Cholangitis: Conventions and Controversies by Natasha Chandok, Gideon M Hirschfield

“…PSC is uncommon, occurs predominantly in males and has a strong association with inflammatory bowel disease. While the pathogenesis of PSC has not been fully elucidated, emerging evidence supports roles for the innate and adaptive immune systems, and genome-wide analyses have identified several genetic associations. …”
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Risk of cancer in patients with bile acid diarrhoea: a Danish nationwide matched cohort study by Tine Jess, Nynne Nyboe Andersen, Gry Poulsen, Signe Wildt, Lars Kristian Munck, Aske Thorn Iversen, Christian Borup

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Hepatic Portal Venous Gas: A Report of Two Cases and a Review of the Epidemiology, Pathogenesis, Diagnosis and Approach to Management by Saleh Alqahtani, Carla S Coffin, Kelly Burak, Fred Chen, John MacGregor, Paul Beck

“…The most common precipitating factors include ischemia, intra-abdominal abscesses and inflammatory bowel disease. However, HPVG has recently been recognized as a rare complication of endoscopic and radiological procedures. …”
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Multiple Abscess Collections: Antibiotics or Steroids? by Philippe Raphael Dias, Levin Bolt, Christof Iking-Konert, Mattia Arrigo, Lars C. Huber

“…The combination of multiple abscess collections in different organs, negative microbiological studies, and the association with an inflammatory bowel disease is highly suggestive for an AAS. …”
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Keeping an Eye on Crohn’s Disease: Orbital Myositis as the Presenting Symptom by Carol A Durno, Robert Ehrlich, Robert Taylor, J Raymond Buncic, Peter Hughes, Anne Marie Griffiths

“…Orbital myositis, a very rare extraintestinal manifestation of inflammatory bowel disease (IBD), likely represents a process of impaired immunoregulation related to the underlying intestinal inflammation. …”
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The Role of Human Gut Microbe Ruminococcus gnavus in Inflammatory Diseases by Sasmitra Kandasamy, Vengadesh Letchumanan, Kar Wai Hong, Kah-Ooi Chua, Nurul Syakima Ab Mutalib, Alvin Lai Oon Ng, Long Chiau Ming, Hui Xuan Lim, Sivakumar Thurairajasingam, Jodi Woan-Fei Law, Loh Teng-Hern Tan

“… Dysbiosis is a prominent factor in numerous inflammatory conditions, with Ruminococcus gnavus, a prevalent gut microbe, implicated in inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), eczema, metabolic disorders, and rheumatic diseases. …”
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2009 Canadian Association of Gastroenterology Educational Needs Assessment Report by Alaa Rostom, Sandra Daniels

“…Similar to previous years, inflammatory bowel disease (IBD) topics – particularly Crohn’s disease and ulcerative colitis (UC) therapeutics, and difficult IBD cases – were most in demand for future educational events. …”
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Mendelian randomization studies of risk and protective factors for osteoporosis: a systematic review and meta-analysis by Wenhao Ji, Wenhao Ji, Bin Pan, Bin Pan, Xin Chen, Xin Chen, Zhaobai Lao, Zhaobai Lao, Wanlei Yang, Wanlei Yang, Yu Qian, Yu Qian

“…The combined findings from these 30 studies revealed that rheumatoid arthritis, inflammatory bowel disease, sex hormone binding globulin, depression, non-alcoholic fatty liver disease, primary biliary cholangitis and asthma are associated with increased risk of osteoporosis, while basal metabolic rate and gut microbiota (NB1n) serves as a protective factor. …”
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Intestinal Organoids in Colitis Research: Focusing on Variability and Cryopreservation by Talke F. zur Bruegge, Andrea Liese, Sören Donath, Stefan Kalies, Maike Kosanke, Oliver Dittrich-Breiholz, Sandra Czech, Verena N. Bauer, André Bleich, Manuela Buettner

“…Taken together, our findings demonstrate that organoid culture, if standardized, constitutes a good tool for reducing the need for animal experiments and might further improve our understanding of, for example, the role of epithelial cells in inflammatory bowel disease development.…”
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Futuristic Developments and Applications in Endoluminal Stenting by Joel Ferreira-Silva, Renato Medas, Mohit Girotra, Monique Barakat, James H. Tabibian, Eduardo Rodrigues-Pinto

“…Our discussion specifically focuses on (i) biodegradable as well as (ii) irradiating and drug-eluting stents for esophageal, gastroduodenal, biliary, and colonic indications, (iii) endoscopic stenting in inflammatory bowel disease, and (iv) lumen-apposing metal stent.…”
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Seasonal Pattern in the Relapses of Crohn's Disease and Ulcerative Colitis in British Columbia by Frank H Anderson, Lecheng Zeng

“…A retrospective study of the monthly distribution in the relapses of inflammatory bowel disease (IBD) demonstrated seasonality in both UC and CD. …”
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Role of Genetic Alterations in the NLRP3 and CARD8 Genes in Health and Disease by G. V. Paramel, A. Sirsjö, K. Fransén

“…Several studies have been performed on the association of the genetic alterations in genes encoding NLRP3 and CARD8 with the complex diseases with inflammatory background, like inflammatory bowel disease, cardiovascular diseases, rheumatoid arthritis, and type 1 diabetes. …”
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The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 I... by Geir Hetland, Egil Johnson, Torstein Lyberg, Gunnar Kvalheim

“…Agaricus blazei M is rich in the immunomodulating polysaccharides, β-glucans, and has been shown to have antitumor, anti-infection, and antiallergic/-asthmatic properties in mouse models, in addition to anti-inflammatory effects in inflammatory bowel disease patients. These effects are mediated through the mushroom's stimulation of innate immune cells, such as monocytes, NK cells, and dendritic cells, and the amelioration of a skewed Th1/Th2 balance and inflammation.…”
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Henoch-Schönlein Purpura with Adalimumab Therapy for Ulcerative Colitis: A Case Report and Review of the Literature by Joseph J. LaConti, Jean A. Donet, Jeong Hee Cho-Vega, Daniel A. Sussman, Dana Ascherman, Amar R. Deshpande

“…Tumor necrosis factor-α (TNFα) inhibitor therapy has signified an important milestone in the fight against many rheumatological disorders and inflammatory bowel disease (IBD). Cutaneous adverse events caused by this class of medications are well known but relatively uncommon. …”
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Th17 Cells in Immunity and Autoimmunity by Simone Kennedy Bedoya, Brandon Lam, Kenneth Lau, Joseph Larkin

“…However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. …”
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Pitfalls in Labelled Leukocyte Scanning by H Hodgson, M Roddie

“…Radiolabelled leukocyte scanning is a valuable tool in the diagnosis and management of inflammatory bowel disease (IBO). As well as determining the presence or absence of disease and its complications, the degree of inflammation may be quantified either visually or numerically following four day fecal collection. …”
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Regulation of electrolyte transport with IL-1β in rabbit distal colon by F. R. Homaidan, H. Desai, L. Zhao, G. Broutman, R. Burakoff

“…Interletrkin-1β levels are elevated in inflammatory bowel disease. In this study the mechanism by which interleukin-1β affects electrolyte transport in the rabbit distal colon, was investigated. …”
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Multifocal Osteonecrosis Secondary to Chronic Alcohol Ingestion by Kazu Matsumoto, Hiroyasu Ogawa, Haruhiko Akiyama

“…Multifocal osteonecrosis is caused by the several conditions including corticosteroid treatment, coagulation disorders, connective tissue disorders including systemic lupus erythematosus (SLE), inflammatory bowel disease, renal transplantation, and underlying malignancies. …”
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Does Smoking Reduce Infliximab’s Effectiveness against Crohn’s Disease? by Neeraj Narula, Richard N Fedorak

“…Crohn’s disease (CD) is an idiopathic inflammatory bowel disease and has no known cure. CD symptoms are treated using an array of medicines, including biological agents such as infliximab. …”
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Genital and Intertriginous Rashes Refractory to Antimicrobial Treatments: Have You Thought about Crohn’s Disease? by Candelaria O’Farrell, Annette Roberts, Claudia Riera Canales, Carrie Firestone Baum, Lina Maria Felipez

“…Crohn’s disease is an inflammatory bowel disease that can have multiple extraintestinal manifestations and can develop prior to, following, or simultaneously with gastrointestinal tract involvement (Aberumand et al. (2017), Georgious et al. (2006), Larsen et al. (2010), Levine and Burakoff (2011), Louis et al. (2018)). …”
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