Stereospecific α-glucosidase inhibition, kinetics, and molecular docking studies on isolated diastereomeric alkaloids from Uncaria longiflora by Nurul Aina Suzlin Sulaiman, Muhammad Farhan Syakir Nor Azman, Mohd Fadhlizil Fasihi Mohd Aluwi, Zainul Amiruddin Zakaria, Mohammad Jemain Mohammad Ridhwana, Fatimah Salim

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Evaluating the association between lipidome and female reproductive diseases through comprehensive Mendelian randomization analyses by Ye Ma, Fang Wu, Zeming Yu, Lu Yang

“…Furthermore, it was determined that the causal associations between these lipidome profiles and FRDs were independent of BMI, obesity, diabetes, smoking, alcohol use, physical activity, inflammation, depression, waist-hip ratio, vitamin D, dehydroepiandrosterone sulphate, sex hormone binding globulin, and testosterone levels. …”
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Adult hypophosphatasia presenting with recurrent acute joint pain by Hayao Yoshida, Takaaki Murakami, Atsubumi Ogawa, Takashi Sunouchi, Naoko Hidaka, Nobuaki Ito, Hiromi Murakami, Hidenori Kawasaki, Tomoyuki Akiyama, Katsumi Nakajima, Daisuke Yabe, Taizo Yamamoto

“…Magnetic resonance imaging and joint ultrasonography showed joint effusions indicating chronic inflammation. Blood biochemical tests revealed a remarkably low serum ALP level, and repeated examination confirmed a sustained low ALP level; urine phosphoethanolamine, plasma inorganic pyrophosphate and plasma pyridoxal-5′-phosphate levels were elevated, raising concern for HPP. …”
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Therapeutic drug monitoring and neutralizing anti-drug antibody detection to optimize TNF-alpha inhibitor treatment for uveitis by Howard C. Chen, Jenny Shunyakova, Amit K. Reddy, Srujay Pandiri, Lynn Hassman

“…Patients who have a suboptimal response to this treatment may suffer from recurrent inflammation and vision loss. Here, we investigated the use of therapeutic drug monitoring and neutralizing anti-drug antibody detection as a strategy to optimize tumor necrosis factor (TNF)-alpha inhibitor treatment in patients who have a suboptimal response to the initial dosing of adalimumab.MethodRetrospective cohort study performed in two tertiary referral uveitis services in the United States between 2015 to 2023. …”
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Fusobacterium nucleatum upregulates the immune inhibitory receptor PD-L1 in colorectal cancer cells via the activation of ALPK1 by Coco Duizer, Moniek Salomons, Merel van Gogh, Sanne Gräve, Freke A. Schaafsma, Maaike J. Stok, Merel Sijbranda, Raghuvandhanan Kumarasamy Sivasamy, Rob J. L. Willems, Marcel R. de Zoete

“…However, the exact manner in which F. nucleatum promotes inflammation in the tumor microenvironment and subsequent tumor promotion remains underexplored. …”
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Circulating Galectin-3 and Aldosterone for Predicting Atrial Fibrillation Recurrence after Radiofrequency Catheter Ablation by Zhong-bao Ruan, Run-feng Gao, Fei Wang, Ge-cai Chen, Jun-guo Zhu, Yin Ren, Li Zhu

“…Circulating galectin-3 (Gal-3) and aldosterone (ALD) are involved in fibrosis and inflammation. However, their potential value as predictors of atrial fibrillation (AF) recurrence after radiofrequency catheter ablation (RFCA) is unknown or controversial. …”
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Effects of Tremella fuciformis -Derived Polysaccharides with Different Molecular Weight on D-Galactose-Induced Aging of Mice by Donghui Luo, Xiaofei Liu, Jingjing Guan, Guili Jang, Yanglin Hua, Xinfei Zhang, Xiaofei Xu

“…The TFPs markedly relieved skin aging, effectively attenuated oxidative stress, and significantly decreased inflammation in D-galactose-induced aging mice. MM exhibited the best anti-aging effect among the TFPs. …”
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Sodium butyrate attenuates oxidative stress, apoptosis, and excessive mitophagy in sodium fluoride-induced hepatotoxicity in rats by Jing Xia, Xiaolin Zhang, Leiyu Xu, Nan Yan, Zhenxiang Sun, Xiaoxu Duan, Lu Meng, Rong Qi, Fu Ren, Zhengdong Wang

“…Sodium butyrate (NaB), a short-chain fatty acid produced in the intestinal tract, maintains normal mitochondrial function in vivo and reduces liver inflammation and oxidative stress. This study aims to investigate the protective effect and potential mechanism of NaB on liver injury in fluoride poisoned rats, particularly through the mitophagy pathway. …”
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Interactions of miR-34b/c and TP53 Polymorphisms on the Risk of Intracranial Aneurysm by Lijuan Li, Xiutian Sima, Peng Bai, Lushun Zhang, Hong Sun, Weibo Liang, Jianxing Liu, Lin Zhang, Linbo Gao

“…Recently, polymorphisms in the TP53 gene were shown to be associated with inflammation and inflammatory disease. The aim of this study was to investigate the interactions of miR-34b/c and TP53 Arg72-Pro polymorphisms on the risk of IA in a Chinese population. …”
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Amyand’s Hernia: Rare Presentation of a Common Ailment by Sanjeev Singhal, Anu Singhal, Sanjay Singh Negi, Rahul Tugnait, Pankaj Kumar Arora, Bishwanath Tiwari, Pawan Malik, Lav Gupta, Amit Bimal, Abhishek Gupta, Rahul Gupta, Pushkar Chouhan, ChandraKant Singh

“…A 63-year-old male with an obstructed right sided hernia underwent emergency inguinal exploration which revealed edematous caecum and appendix as content without any inflammation. Contents were reduced without any resection. …”
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Imaging Diagnostics, Biomarkers, and Emerging Trends in Orthopedic Research and Treatment by Gabriela Oliwia Trestka, Wiktoria Domino, Urszula Zelik, Maria Przygoda, Joanna Śnieżna, Kamila Stępień, Sabina Adamczyk, Wojciech Florczak, Jagienka Włodyka, Jakub Dziewic, Karol Dzwonnik

“…Biomarkers, such as those used in osteoarthritis, osteoporosis, joint inflammation, and bone regeneration, complement imaging techniques by enabling early diagnosis, monitoring disease progression, and predicting treatment outcomes. …”
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GPIHBP1 increase accounts for rheumatic arthritis-related hypotriglyceridemia by facilitating lipids uptake of white adipose tissues by Meng-Ke Song, Meng-Fan Gu, Ling Liu, Lian-Jun He, Peng Ye, Kui Yang, Dan-Dan Wang, Opeyemi Joshua Olatunji, Qin Yin, Jian Zuo

“…Conclusion RA-associated inflammation induces GPIHBP1 secretion of endothelial cells, which facilitates blood TG hydrolysis and uptake to compensate the loss in WAT.…”
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RNA m6A-mediated post-transcriptional repression of glucocorticoid receptor in LPS-activated Kupffer cells on broilers by Yulan Zhao, Yidan Jiang, Yue Feng, Ruqian Zhao

“…Our study indicates successive roles of RNA m6A modification in the down regulation of GR expression, which provides new drug targets for epigenetic therapy of liver inflammation.…”
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The Promising Effect of Tocilizumab on Chronic Antibody-Mediated Rejection (cAMR) of Kidney Transplant by Łukasz Świątek, Miłosz Miedziaszczyk, Dominik Lewandowski, Filip Robakowski, Piotr Tyburski, Marta Jakubowska, Marek Karczewski, Ilona Idasiak-Piechocka

“…It is associated with donor-specific antibodies (DSAs) which activate a complement pathway in response to the presence of human leukocyte antigens (HLAs) on the graft, which results in chronic inflammation and leads to graft dysfunction. One of the recent promising methods of cAMR treatment is a recombinant humanized anti-interleukin-6 receptor (IL-6R) monoclonal antibody referred to as Tocilizumab (TCZ). …”
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Circulating, Extracellular Vesicle-Associated Tissue Factor in Cancer Patients with and without Venous Thromboembolism by Valentina Lami, Dario Nieri, Marta Pagnini, Mario Gattini, Claudia Donati, Mariella De Santis, Alessandro Cipriano, Erica Bazzan, Andrea Sbrana, Alessandro Celi, Tommaso Neri

“…Cancer is characterized by chronic inflammation and hypercoagulability, with an excess of venous thromboembolism (VTE). …”
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Relationship of monocyte to high-density lipoprotein ratio (MHR) and other inflammatory biomarkers with sarcopenia: a population-based study by Zhiwei Xue, Jian Cao, Jianhui Mou, Rui Wang, Peng Liu

“…Abstract Objectives In previous studies, several inflammatory biomarkers derived from complete blood cell counts (CBC), such as systemic immune inflammation index (SII), neutrophil-to-lymphocyte ratio (NLR), and non‑high‑density lipoprotein cholesterol to high‑density lipoprotein cholesterol ratio (NHHR) have been identified as predictors of sarcopenia. …”
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A novel surgical technique for cranial cruciate ligament repair in dogs using autologous lateral digital extensor muscle tendon graft combined with platelet-rich plasma: A prelimin... by Mousa H. Daradka, Mays A. Malkawi, Zuhair Banni Ismail1, Hanan M. Hammouri, Mahmoud A. Abu-Abeeleh, Saba A. Rihani

“…PRP-treated dogs exhibited faster recovery and enhanced tissue regeneration, with reduced inflammation and improved graft-bone attachment. Conclusion: This novel surgical approach demonstrates significant potential for improving outcomes in CrCL repair by combining autologous tendon grafting with PRP. …”
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Machine learning models reveal microbial signatures in healthy human tissues, challenging the sterility of human organs by Anargyros Skoulakis, Anargyros Skoulakis, Giorgos Skoufos, Giorgos Skoufos, Armen Ovsepian, Armen Ovsepian, Artemis G. Hatzigeorgiou, Artemis G. Hatzigeorgiou

“…Exploring the microbiome of internal tissues holds promise for elucidating the pathophysiology underlying both health and a spectrum of diseases, including sepsis, inflammation, and cancer.…”
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Impact of copper stress in the intestinal barriers and gut microbiota of Chinese stripe-necked turtle (Mauremys sinensis) by Zeeshan Ali, Ijaz Khan, Muhammad Shahid Iqbal, Haitao Shi, Li Ding, Meiling Hong

“…Copper stress caused intestinal damage, characterized by shortened villi, inflammatory cell infiltration, and reduced epithelial layer thickness, as well as decreased acidic mucins, increased villi edema and inflammation. The mRNA expression level of bacteriostatic enzymes significantly reduced. …”
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DOCK4 Is a Platinum-Chemosensitive and Prognostic-Related Biomarker in Ovarian Cancer by Qianqian Zhao, Jie Zhong, Ping Lu, Xiao Feng, Ying Han, Chenqi Ling, Wenke Guo, Weijin Zhou, Fudong Yu

“…PPARs as important transcriptional regulators regulate important physiological processes such as lipid metabolism, inflammation, and wound healing. Several reports point out that PPARs can also have an effect on the sensitivity of tumor cells to platinum-based chemotherapy drugs. …”
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