Role of Lysosomes in Silica-Induced Inflammasome Activation and Inflammation in Absence of MARCO by Rupa Biswas, Raymond F. Hamilton, Andrij Holian

“…Furthermore, in MARCO−/− AM there was greater cathepsin B release from phagolysosomes, Caspase-1 activation, and acid sphingomyelinase activity compared to WT AM, supporting the critical role played by lysosomal membrane permeabilization (LMP) in triggering silica-induced inflammation. The difference in sensitivity to LMP appears to be in cholesterol recycling since increasing cholesterol in AM by treatment with U18666A decreased silica-induced NLRP3 inflammasome activation, and cells lacking MARCO were less able to sequester cholesterol following silica treatment. …”
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Role of Cox-2 in Vascular Inflammation: An Experimental Model of Metabolic Syndrome by Nicolás F. Renna, Emiliano R. Diez, Carina Lembo, Roberto M. Miatello

“…Mediators of Inflammation…”
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Galectin-1 as an Emerging Mediator of Cardiovascular Inflammation: Mechanisms and Therapeutic Opportunities by Ignacio M. Seropian, Germán E. González, Sebastián M. Maller, Daniel H. Berrocal, Antonio Abbate, Gabriel A. Rabinovich

“…Mediators of Inflammation…”
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Heart and skeletal muscle inflammation – novel dangerous disease of farmed Salmonidae by V. P. Melnikov, V. V. Pronin

Subjects: “…heart and skeletal muscle inflammation (hsmi)…”
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C-Reactive Protein Knockout Attenuates Temporomandibular Joint Inflammation in Rats by Yao He, Mengjiao Zhou, Zixiang Jian, Lingli Fang, Lan Huang, Jinlin Song

“…In this study, we evaluated the biological effect of CRP on temporomandibular joint (TMJ) inflammation. Methods. Freund’s complete adjuvant (CFA) was used to induce TMJ inflammation in CRP-knockout (CRP-/-) and control rats. …”
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ADAMTS13 Improves Endothelial Function and Reduces Inflammation in Diabetic Retinopathy by Ahmed M. Abu El-Asrar, Mohd I. Nawaz, Ajmal Ahmad, Mairaj Siddiquei, Eef Allegaert, Lowie Adyns, Lotte Vanbrabant, Priscilla W. Gikandi, Gert De Hertogh, Sofie Struyf, Ghislain Opdenakker

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Gut Microbiome and Inflammation: A Study of Diabetic Inflammasome-Knockout Mice by Roma Pahwa, Miriam Balderas, Ishwarlal Jialal, Xinpu Chen, Ruth Ann Luna, Sridevi Devaraj

“…Recent reports have elucidated the role of the gut microbiome in diabetes, but there is limited data on the gut microbiome in NLRP-KO mice and its effect on diabetes-induced inflammation. Methods. Gut microbiome composition and biomarkers of inflammation (IL-18, serum amyloid A) were assessed in streptozotocin- (STZ-) induced diabetic mice on a NLRP3-knockout (KO) background versus wild-type diabetic mice. …”
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The Enteric Nervous System in Inflammation and Pain: The Role of Proteinase-Activated Receptors by Nathalie Vergnolle

“…In particular, experiments in animal models suggest that PAR2 is important to neurogenic inflammation in the intestine. Moreover, PAR2 agonists seem to induce intestinal hypersensitivity and hyperalgesic states, suggesting a role for this receptor in visceral pain perception. …”
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Expression and Regulation of Hypoxia-Inducible Factor Signalling in Acute Lung Inflammation by Nikolaos S. Lotsios, Chrysi Keskinidou, Sotirios P. Karagiannis, Kostas A. Papavassiliou, Athanasios G. Papavassiliou, Anastasia Kotanidou, Ioanna Dimopoulou, Stylianos E. Orfanos, Alice G. Vassiliou

“…We explore the potential dual role of HIF signalling in acute lung inflammation. Furthermore, its role in key biological processes and its potential prognostic significance in clinical scenarios are discussed. …”
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Poly-γ-Glutamic Acid Attenuates Angiogenesis and Inflammation in Experimental Colitis by Munkhtugs Davaatseren, Jin-Taek Hwang, Jae Ho Park, Myung-Sunny Kim, Shuaiyu Wang, Mi Jeong Sung

“…Mediators of Inflammation…”
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Nonpharmacological Modulation of Chronic Inflammation in Parkinson’s Disease: Role of Diet Interventions by Stefania Kalampokini, Anouck Becker, Klaus Fassbender, Epameinondas Lyros, Marcus M. Unger

“…Diet targets mediators of inflammation with various mechanisms and combined with dopaminergic treatment can exert various beneficial effects in PD. …”
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Role of the Kaiso gene in the development of inflammation in Mucin-2 defcient mice by E. A. Litvinova, K. M. Achasova, M. A. Borisova, S. V. Zhenilo, E. B. Prokhortchouk, E. N. Kozhevnikova

Subjects: “…mice, intestine inflammation, mucin-2, kaiso gene…”
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Airway Function, Inflammation and Regulatory T Cell Function in Subjects in Asthma Remission by Louis-Philippe Boulet, Hélène Turcotte, Sophie Plante, Jamila Chakir

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Dose-dependent effects of Nrf2 on the epidermis in chronic skin inflammation by Michael Koch, Luca Ferrarese, Maya Ben-Yehuda Greenwald, Sabine Werner

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Markers of Inflammation Associated with Plaque Progression and Instability in Patients with Carotid Atherosclerosis by Enrico Ammirati, Francesco Moroni, Giuseppe Danilo Norata, Marco Magnoni, Paolo G. Camici

“…Mediators of Inflammation…”
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Innate and Adaptive Cell Populations Driving Inflammation in Dry Eye Disease by José L. Reyes, Danielle T. Vannan, Bertus Eksteen, Imelda Juárez Avelar, Tonathiu Rodríguez, Marisol Ibet González, Alicia Vázquez Mendoza

“…Mediators of Inflammation…”
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The Role of Inflammation in the Pathogenesis of Macular Edema Secondary to Retinal Vascular Diseases by Francisco J. Ascaso, Valentín Huerva, Andrzej Grzybowski

“…Mediators of Inflammation…”
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Lipoxins and Annexin-1: Resolution of Inflammation and Regulation of Phagocytosis of Apoptotic Cells by Michael Scannell, Paola Maderna

“…Phagocytosis of apoptotic cells plays a pivotal role in developmental processes and in the resolution of inflammation. Failed or delayed clearance of apoptotic cells can result in chronic inflammation. …”
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Improved Systemic Inflammation is Associated with Functional Prognosis in Post-Stroke Patients by Kota Hori, Yoshihiro Yoshimura, Hidetaka Wakabayashi, Fumihiko Nagano, Ayaka Matsumoto, Sayuri Shimazu, Ai Shiraishi, Yoshifumi Kido, Takahiro Bise, Aomi Kuzuhara, Takenori Hamada, Kouki Yoneda, Kenichiro Maekawa

Subjects: “…systemic inflammation…”
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The Initial Vascular Access Type Contributes to Inflammation in Incident Hemodialysis Patients by Mala Sachdeva, Adriana Hung, Oleksandr Kovalchuk, Markus Bitzer, Michele H. Mokrzycki

“…The contribution of the hemodialysis (HD) vascular access type to inflammation is unclear. Methods. We conducted a prospective observational study in an incident HD population. …”
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