Role of Interferons in the Development of Diagnostics, Vaccines, and Therapy for Tuberculosis by Kai Ling Chin, Fadhilah Zulkipli Anis, Maria E. Sarmiento, Mohd Nor Norazmi, Armando Acosta

“…It is estimated that each case of active TB may cause 10–20 new infections. Host immune response to Mtb is influenced by interferon- (IFN-) signaling pathways, particularly by type I and type II interferons (IFNs). …”
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Exploring Immune Responses through Dynamic Modeling of Cell-Immune Interactions in Viral Infection and Vaccination by Kwang Su Kim, Il Hyo Jung, Jong Hyuk Byun

“…This study examines the dynamics of viral infections and immune responses, with a particular focus on the roles of antibodies and CD8+ T cells induced by vaccination. …”
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Structurally convergent antibodies derived from different vaccine strategies target the influenza virus HA anchor epitope with a subset of VH3 and VK3 genes by Ting-Hui Lin, Chang-Chun David Lee, Monica L. Fernández-Quintero, James A. Ferguson, Julianna Han, Xueyong Zhu, Wenli Yu, Jenna J. Guthmiller, Florian Krammer, Patrick C. Wilson, Andrew B. Ward, Ian A. Wilson

“…Identification and characterization of bnAbs elicited in natural infection and immunization to influenza virus hemagglutinin (HA) can provide insights for development of a universal influenza vaccine. …”
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The Successful Use of Extracorporeal Membrane Oxygenation in a Newly Diagnosed HIV Patient with Acute Respiratory Distress Syndrome (ARDS) Complicated by Pneumocystis and Cytomegal... by Jin Kook Kang, Matthew Acton, Bo Soo Kim

“…Background: We report a case of an adult patient with newly diagnosed human immunodeficiency virus (HIV) infection, acquired immune deficiency syndrome (AIDS), and acute respiratory distress syndrome (ARDS) secondary to pneumocystis and cytomegalovirus pneumonia that were present on presentation, which were successfully managed with venovenous extracorporeal membrane oxygenation (VV-ECMO). …”
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Anti-SARS-CoV-2 Antibody Level among Renal Transplant Recipients: A Case Report from Nepal by Kamal Ranabhat, Bhuvan Saud, Saroj Adhikari, Suraj Bhattarai, Rojan Adhikari, Bhoj Raj Luitel, Mahesh Raj Sigdel

“…Although two out of three patients in the study acquired COVID-19 infection after immunization, they recovered with mild clinical course. …”
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Modelling Peroxisomal Disorders in Zebrafish by Chenxing S. Jiang, Michael Schrader

“…They have been linked to healthy ageing, neurodegeneration, cancer, the combat of pathogens and viruses, and infection and immune responses. Their biogenesis relies on several peroxins (encoded by <i>PEX</i> genes), which mediate matrix protein import, membrane assembly, and peroxisome multiplication. …”
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Anti-Biofilm Agents to Overcome <i>Pseudomonas aeruginosa</i> Antibiotic Resistance by Marie Hanot, Elodie Lohou, Pascal Sonnet

“…Particularly, its ability to form biofilms that protect colonies from antimicrobial agents is a major cause of chronic and hard-to-treat infections in immune-compromised patients. This protective barrier also ensures cell growth on abiotic surfaces and thus enables bacterial survival on medical devices. …”
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BA inhibits LPS-stimulated inflammatory response and apoptosis in human middle ear epithelial cells by regulating the Nf-Kb/Iκbα axis by He Qian, Cai Yanzhi, Kong Meihua

“…The pathogenesis of OM is multifaceted, encompassing a variety of factors including bacterial or viral infections, host immune responses, and the function of middle ear epithelial cells. …”
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The JN.1 variant of COVID-19: immune evasion, transmissibility, and implications for global health by Araj Naveed Siddiqui, Imshaal Musharaf, Bashar Haruna Gulumbe

“…Findings reveal that JN.1 exhibits higher infectivity and immune evasion than previous variants, largely due to the L4555 mutation. …”
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Novel drug targets for monkeypox: From viral to host proteins by Zhaozhong Zhu, Qin Sun, Yunhai Xu, Youya Niu, Fei Yang, Shuidong Feng

“…Functional enrichment of MIPs indicated their roles in infection and immune-related pathways. Conclusions: In total, we identified 112 drugs targeting MPXV proteins and 371 drugs targeting MMIPs, with fostamatinib, trilostane, and raloxifene being able to inhibit both viral and host proteins. …”
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The rapid rise of SARS‐CoV‐2 Omicron subvariants with immune evasion properties: XBB.1.5 and BQ.1.1 subvariants by Danyi Ao, Xuemei He, Weiqi Hong, Xiawei Wei

“…During the Omicron wave, several subvariants have emerged, with some exhibiting greater infectivity and immune evasion, accounting for their fast spread across many countries. …”
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Toxoplasmosis in Pregnant Women and HIV/AIDS Patients in Ethiopia: A Systematic Review and Meta-Analysis by Daniel Getacher Feleke, Angesom Gebreweld, Gashaw Zewde

“…Although Toxoplasma gondii infection in immune-competent individuals is usually asymptomatic or causes a mild flu-like illness, it may become severe and can occasionally be fatal in immune-compromised people, such as AIDS patients or pregnant women. …”
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Investigation of TORCH seroprevalence in a tertiary university hospital by Samet Kirat

“…The seroprevalence of TORCH infections in pregnant women at a tertiary university hospital was determined, with a higher proportion of previous infections and immunized individuals in the older age group. …”
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Inferring the energy cost of resistance to parasitic infection and its link to a trade-off by Frédéric Douhard, Carole Moreno-Romieux, Andrea B. Doeschl-Wilson

“…Abstract Background In infected hosts, immune responses trigger a systemic energy reallocation away from energy storage and growth, to fuel a costly defense program. …”
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Genomic characterization and evolutionary analysis of a Getah virus variant from piglets in central China by Zhenhua Guo, Yao Jiang, Peng Li, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang, Gaiping Zhang

“…Most of these special sites were distributed in domain A, B, and C of E2 protein, which are usually associated with the GETV infection and immune response.DiscussionOur study expands knowledge of GETV pathogenicity and deepens understanding of GETV genetic and adaptive evolution, which would be valuable for the development of diagnosis and prevention for GETV.…”
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The interplay between persistent pathogen infections with tumor microenvironment and immunotherapy in cancer by Si Chen, Caihong Yao, Na Tian, Chunying Zhang, Yuemei Chen, Xuting Wang, Yue Jiang, Tonghao Zhang, Tingting Zeng, Yali Song

“…The influence of these infections on immune checkpoints emphasizes the crucial role of the immune system in cancer treatment. …”
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Resveratrol Inhibits Hepatic Stellate Cell Activation via the Hippo Pathway by Chunxue Li, Rongrong Zhang, Yating Zhan, Jianjian Zheng

“…Liver fibrosis, which results from chronic liver injury due to factors such as chronic alcohol consumption, hepatitis virus infections, and immune attacks, is marked by excessive deposition of extracellular matrix (ECM). …”
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Monitoring for respiratory viruses among wild canids, Texas by Lyudmyla V. Marushchak, Laura A. Pulscher, Judith U. Oguzie, Diego B. Silva, Kenneth A. Waldrup, Douglas M. Watts, Gregory C. Gray

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Autoimmune hepatitis under the COVID-19 veil: an analysis of the nature of potential associations by Chaojie Yu, Wenrui Wang, Qian Zhang, Zhenjing Jin

“…Currently, the overall mutational trend of SARS-CoV-2 indicates heightened infectivity and immune evasion capabilities. Consequently, vaccination remains crucial for universal protection against this disease. …”
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Downmodulation of Vaccine-Induced Immunity and Protection against the Intracellular Bacterium Francisella tularensis by the Inhibitory Receptor FcγRIIB by Brian J. Franz, Ying Li, Constantine Bitsaktsis, Bibiana V. Iglesias, Giang Pham, Raju Sunagar, Sudeep Kumar, Edmund J. Gosselin

“…Thus, the generation of Ag-specific IgG in response to infection or immunization has the potential to downmodulate immune protection against infection. …”
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