The periplasmic protein HslJ is the first-line of defense against oxidative stress in Acinetobacter baumannii by Daniela Scribano, Martina Pasqua, Dolores Limongi, Lucia Nencioni, Anna Teresa Palamara, Cecilia Ambrosi

“…Abstract Background Acinetobacter baumannii poses a significant threat globally, causing infections primarily in healthcare settings, with high mortality rates. …”
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Short-term evolution and dispersal patterns of fluconazole-resistance in Candida auris clade III by Irving Cancino-Muñoz, Juan Vicente Mulet-Bayona, Carme Salvador-García, Nuria Tormo-Palop, Remedios Guna, Concepción Gimeno-Cardona, Fernando González-Candelas

“…ABSTRACT The rapid increase in infections caused by the emerging fungal pathogen Candida auris is of global concern, and understanding its expansion is a priority. …”
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Leptospirosis Prevalence in Patients with Initial Diagnosis of Dengue by A. Dircio Montes Sergio, E. González Figueroa, Verdalet Guzmán María Saadia, Soler Huerta Elizabeth, Rivas Sánchez Beatriz, M. Altuzar Aguilar Víctor, J. Navarrete Espinosa

“…Leptospirosis prevalence in subjects under suspicion of dengue fever is high, as well as the coincidence of both infections. The results show the coexistence of overlapped outbreaks of several diseases sharing the side of transmission. …”
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Standardization of the Agar Plate Method for Bacteriophage Production by Su Jin Jo, Young Min Lee, Kevin Cho, Seon Young Park, Hyemin Kwon, Sib Sankar Giri, Sung Bin Lee, Won Joon Jung, Jae Hong Park, Mae Hyun Hwang, Da Sol Park, Eun Jae Park, Sang Wha Kim, Jin Woo Jun, Sang Guen Kim, Ji Hyung Kim, Se Chang Park

“…Phage therapy offers a targeted approach to combat bacterial infections, particularly those resistant to conventional antibiotics. …”
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Seropositivity to tick-borne pathogens in nature management workers in the Netherlands by B.J.A. Hoeve-Bakker, G. Çelik, O.E. van den Berg, C.C. van den Wijngaard, A. Hofhuis, J.H.J. Reimerink, S.F.T. Thijsen, K. Kerkhof

“…The incidence of tick-borne infections other than Lyme borreliosis and tick-borne encephalitis is rising in Europe, including the Netherlands. …”
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Cross-transmission of resistant gastrointestinal nematodes between wildlife and transhumant sheep by Beaumelle, Camille, Toïgo, Carole, Papet, Rodolphe, Benabed, Slimania, Beurier, Mathieu, Bordes, Léa, Brignone, Anaïs, Curt-Grand-Gaudin, Nadine, Garel, Mathieu, Ginot, Justine, Jacquiet, Philippe, Miquel, Christian, Poirel, Marie-Thérèse, Serafino, Anna, Vannard, Eric, Bourgoin, Gilles, Yannic, Glenn

“…Wild and domestic ungulates can be infected with the same species of gastrointestinal parasitic nematodes. …”
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Generation of Inducible CRISPRi and CRISPRa Human Stromal/Stem Cell Lines for Controlled Target Gene Transcription during Lineage Differentiation by Li Chen, Kaikai Shi, Weimin Qiu, Lars Aagaard, Moustapha Kassem

“…However, mechanistic studies employing hMSC have been hampered by the difficulty of deriving genetically modified cell lines due to the low and unstable transfection efficiency. Methods. We infected hMSC with a CRISPR/Cas9 lentivirus system, with specific inducible dCas9-coupled transcription activator or repressor: dCas9-KRAB or dCas9-VP64, respectively, and established two hMSC lines (hMSC-CRISPRi and hMSC-CRISPRa) that can inhibit or activate gene expression, respectively. …”
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Genomic insights into a multidrug-resistant pandoraea apista clinical isolate carrying blaOXA-153 from China by Lirong Li, Yawen Zhang, Fang He, Ningjun wu

“…Objectives: Pandoraea apista is notable for its multidrug resistance and is frequently identified in patients with cystic fibrosis or other chronic lung diseases, where it contributes to persistent lung infections. In this study, we describe a strain of P. apista harboring the blaOXA-153, isolated from the bronchoalveolar lavage (BAL) fluid of an inpatient in China. …”
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Multi-Omics and Network-Based Drug Repurposing for Septic Cardiomyopathy by Pei-Pei Liu, Xin-Yue Yu, Qing-Qing Pan, Jia-Jun Ren, Yu-Xuan Han, Kai Zhang, Yan Wang, Yin Huang, Tao Ban

“…Results: Network analysis identified 129 drugs associated with SCM, which were refined to 14 drug candidates based on strong network predictions, proven anti-infective effects, suitability for ICU use, and minimal side effects. …”
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Efficacy of Bacillus clausii UBBC-07 in the prevention of antibiotic-associated diarrhea in children by H.V. Beketova, O.O. Koiro, S.S. Bohdanova, M.S. Bulhakova, K.M. Heorhitsa, O.B. Il’kiv, О.R. Kavka, О.Z. Kmit’, О.V. Kukhar, V.І. Liubetska, V.V. Maleiko, І.А. Matiukhina, К.О. Medvedska, N.B. Pavchak, К.А. Percheklii, V.V. Semenchuk, Y.О. Sotnichenko, U.М. Tomashiuk, N.І. Tsvynda, М.Y. Shalimanova

“…The study analyzed the treatment outcomes of 939 patients aged 28 days to 18 years with bacterial infections of various localizations, receiving systemic antibacterial therapy. …”
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Novel coumarin-based acetohydrazide-1,2,3-triazole derivatives as urease enzyme inhibitors: Synthesis, in vitro evaluation, and molecular dynamics simulation studies by Hassan Sepehrmansourie, Mohammad Azimi, Ahmad Ebadi, Gholamabbas Chehardoli, Mohammad Ali Zolfigol, Massoud Amanlou, Mohammad Nazari Montazer, Mohammad Mahdavi, Zahra Najafi

“…Urease enzyme inhibition is a well-established and promising strategy for preventing the harmful effects of ureolytic bacterial infections, particularly those caused by H. pylori. …”
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Reducing antibiotic duration for acute otitis media: clinician, administrator, and parental insights to inform implementation of system-level interventions by Deborah J. Rinehart, Aiden Gilbert, Sonja O’Leary, Sophie E. Katz, Holly M. Frost

“…Clinical trials identifier: RELAX: Reducing Length of Antibiotics for Children with Ear Infections (RELAX), NCT05608993, https://clinicaltrials.gov/study/NCT05608993. …”
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High-dose dual therapy for Helicobacter pylori eradication inducing less impact on the gut microbiota by Jia-Lun Guan, Ting-Ting Xu, Ya Lin, Yan-Shuai Mo, Bi-Yu He, Ying-Ying Han, Ji-Yan Li, Su-Hong Xia, Ya-Ni Zhou, Jia-Zhi Liao, Pei-Yuan Li

“…Patients and methods H. Pylori-infected treatment-naive patients were recruited and screened from September 2023 to April 2024 and randomly assigned to the HDDT group (esomeprazole 20 mg, amoxicillin 750 mg, qid, 14 days) or BQT group (esomeprazole 20 mg, amoxicillin 1000 mg, clarithromycin 500 mg, and bismuth potassium citrate 600 mg, bid, 14 days). …”
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COVID-19 and pediatric out-of-hospital cardiac arrest using U.S. registry database by Christopher Schmitt, Gary Beasley, Karine Guerrier, Jennifer Kramer, Maryam Y. Naim, Heather Griffis, Bryan McNally, Paul S. Chan, Rabab Al-Araji, Joseph Rossano

“…Infants, however, had slightly decreased rates, which may be related to changes in other respiratory infections, and parental behavioral changes during the pandemic.…”
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Altered Toll-Like Receptor Signalling in Children with Down Syndrome by Dean Huggard, W. J. Koay, Lynne Kelly, Fiona McGrane, Emer Ryan, Niamh Lagan, Edna Roche, Joanne Balfe, T. Ronan Leahy, Orla Franklin, Ana Moreno-Oliveira, Ashanty M. Melo, Derek G. Doherty, Eleanor J. Molloy

“…Children with Down syndrome (DS) are prone to infections from these pathogens and have an increased risk of autoimmunity. …”
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First whole genome report of Mangrovibacter phragmitis PSU-3885–11 isolated from a patient in Thailand by Nattarika Chaichana, Thunchanok Yaikhan, Mingkwan Yingkajorn, Nonthawat Thepsimanon, Sirikan Suwannasin, Kamonnut Singkhamanan, Sarunyou Chusri, Rattanaruji Pomwised, Monwadee Wonglapsuwan, Komwit Surachat

“…The findings also emphasize the importance of continued surveillance and genomic analysis of environmental bacteria that may emerge as opportunistic pathogens in human infections.…”
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Current Updates on Molecular Diagnostic Assays Used for Detection of <i>Candida auris</i>: A Systematic Review by River Chun-Wai Wong, Alfred Lok-Hang Lee, Ingrid Yu-Ying Cheung, Viola Chi-Ying Chow, Margaret Ip, Christopher Koon-Chi Lai

“…<b>Background/Objectives</b>: <i>Candida auris</i> is an emerging multidrug-resistant pathogen with the potential to cause invasive fungal infections and healthcare-associated outbreaks. Currently, there is no systematic review explicitly focusing on the up-to-date molecular diagnostics of this pathogen to cover the entire process, including sample pre-extraction procedures, nucleic acid extraction, and DNA-based detection. …”
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Liver sinusoidal endothelial cells regulate the balance between hepatic immunosuppression and immunosurveillance by Kimberly N. Kremer, Hadeel A. Khammash, Anjelica M. Miranda, Lauren N. Rutt, Shannon M. Twardy, Paige E. Anton, Margaret L. Campbell, Christian Garza-Ortiz, David J. Orlicky, Roberta Pelanda, Rebecca L. McCullough, Raul M. Torres

“…Hepatocellular carcinoma (HCC) is initiated by chronic viral infections, chronic alcohol consumption, and/or a fatty diet that leads to liver injury, fibrosis, and cirrhosis. …”
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Clinical features and outcomes of pseudolithiasis induced by ceftriaxone in Chinese children: a single-center observational study by Chen Jin, Chen Jin, Wen-Li Xiu, Wen-Li Xiu, Yao Liu, Yao Liu, Xi-Wei Hao, Qian Dong, Qian Dong

“…Patients with PL also had higher rates of digestive and neurological infections (both p &lt; 0.001). Serum analysis revealed distinct liver and kidney function markers in the PL group, including lower levels of total bile acids, adenosine deaminase, and lactate dehydrogenase, and higher creatinine levels (all p &lt; 0.05). …”
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Impact in Clinical Practice of the European Medicines Agency Health Alert About the Restriction of the Use of JAK Inhibitors by Elisabet Castañeda-Estévez, Cristina Vergara-Dangond, Martina Steiner, Maria Beatriz Paredes-Romero, Ana Esteban-Vázquez, Tatiana Cobo-Ibañez, Laura Trives-Folguera, Maria Liz Romero-Bogado, Isabel De La Cámara-Fernández, Patricia Richi-Alberti, Ana Acosta-Alfaro, Iría De la Osa-Subtil, Santiago Muñoz-Fernández

“…The most frequent adverse events were infections (5.9%) and neoplasms (2.9%). Deep vein thrombosis and haemorrhagic stroke each occurred in 1% of patients, with no cases of ischemic stroke or ischemic heart disease. …”
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