The liver’s dilemma: sensing real danger in a sea of PAMPs: the (arterial) sinusoidal segment theory by Andrea Henriques-Pons, Natália Vacani-Martins, Carina de Lima Pereira dos Santos, Marcelo Meuser-Batista

“…The liver is susceptible to viruses and bacterial infections, tumors, and sterile tissue damage, but immunological danger recognition in the liver is highly unconventional. …”
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Peri Cholecystectomy Bile Analysis for Fasciola hepatica Eggs in Sulaimani Teaching Hospital by Seerwan Hama Shareef, Taher Abdullah Hawramy, Osman jamal nasrulla, Karwn Hama amin, Dara Ahmed Mohammed, Raz Seerwan Hama

“…It is a widespread disease throughout the world; nearly (2.4 – 17) millions of people is infected. Human is an accidental final host by ingestion of contaminated plants and water by metacircaria. …”
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Identification of two new genetic loci for high-resolution genotyping of Enterocytozoon bieneusi by Meng Xinan, Ou Yonglin, Jiang Wen, Guo Yaqiong, Xiao Lihua, Feng Yaoyu, Li Na

“…., the public health significance of E. bieneusi in animals, and sources of E. bieneusi infections in humans.…”
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Onychomycosis in Psoriatic Patients with Nail Disorders: Aetiological Agents and Immunosuppressive Therapy by Núbia Carvalho Pena de Oliveira Praeiro Alves, Tomaz de Aquino Moreira, Lucivânia Duarte Silva Malvino, José Joaquim Rodrigues, Roberto Ranza, Lúcio Borges de Araújo, Reginaldo dos Santos Pedroso

“…And we highlight that it is also worth investigating in the future the possible role of immunosuppressive therapy (mainly methotrexate) as a predisposing factor for the development of fungal infections in psoriatic patients.…”
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Whole-genome amplification as a tool to improve bacterial detection by PCR in microbiological samples after endodontic treatment by Gabriela Ceccon Chianca, Gabriela Ceccon Chianca, Caroline Corrêa Fendeler, Caroline Corrêa Fendeler, Sérgio Pinto Chaves Junior, Sérgio Pinto Chaves Junior, Gabriella Lorena Dias Pereira, Helvécio Cardoso Corrêa Póvoa, Helvécio Cardoso Corrêa Póvoa, Helvécio Cardoso Corrêa Póvoa, Lívia Azeredo Alves Antunes, Lívia Azeredo Alves Antunes, Lívia Azeredo Alves Antunes, Leonardo Santos Antunes, Leonardo Santos Antunes, Leonardo Santos Antunes, Natalia Lopes Pontes Póvoa Iorio, Natalia Lopes Pontes Póvoa Iorio, Natalia Lopes Pontes Póvoa Iorio

“…The aim of the present study is to compare culture and whole-genome amplification (WGA) followed by PCR assays in the detection of bacteria before and after chemical mechanical preparation (CMP) of root canals.MethodsTen uniradicular teeth with primary endodontic infections were analyzed. Microbiological samples were collected before and after CMP using paper points, which were separated into two groups: (i) culture assay samples were plated onto Brucella agar with 5% defibrinated sheep's blood, menadione and hemin and incubated anaerobically for 14 days at 36°C; (ii) DNA was extracted from molecular assay samples and subject to WGA by isothermal strand displacement with Phi29 DNA polymerase followed by PCR to determine the presence of bacteria.ResultsIn both assays, samples before CMP showed the presence of bacteria in all 10 teeth. …”
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In-vitro effectiveness of aqueous extract of organic compost against Helminthosporium turcicum (cryptogamic disease pathogen of maize) by Daouda Kutnjem, Anne Ayo, Ecclèsiaste Marien Ambombo Onguene, Carole Christèle Egono Ndemé, Ndongo Bekolo, Tofel Haman Katamssadan, Asseng Charles Carnot

“…The study was carried out in the laboratory using a pure strain of Helminthosporium turcicum previously isolated from infected maize leaves showing symptoms of the disease. …”
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The Use of Specific Non-<i>Saccharomyces</i> Yeasts as Sustainable Biocontrol Solutions Against <i>Botrytis cinerea</i> on Apples and Strawberries by Zukisani Gomomo, Morris Fanadzo, Maxwell Mewa-Ngongang, Boredi Silas Chidi, Justin Wallace Hoff, Marieta van der Rijst, Lucky Mokwena, Mathabatha Evodia Setati, Heinrich Wilbur du Plessis

“…Apples and strawberries hold significant commercial and nutritional value but face pre- and post-harvest spoilage due to infections by <i>Botrytis cinerea.</i> While spoilage is conventionally managed using synthetic chemicals, there is a growing interest in utilising yeasts as biological control agents. …”
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Effects of different vaccination regimes on the immunodiagnosis of tuberculosis in goats and evaluation of defined antigens by Patricia Cuenca-Lara, Patricia Cuenca-Lara, Miriam Blay-Benach, Miriam Blay-Benach, Zoraida Cervera, Zoraida Cervera, Cristian Melgarejo, Cristian Melgarejo, Julia Moraleda, Julia Moraleda, Iker A. Sevilla, Joseba M. Garrido, Mahavir Singh, Gareth J. Jones, Bernat Pérez de Val, Bernat Pérez de Val

“…There is still a need for the development of an effective TB vaccine and, concurrently, diagnostic methods that allow differentiation between infected and vaccinated animals (DIVA approach). In this study, we investigated the interferences caused by the tuberculin (PPD)-based TB diagnostic tests in goats immunized by different mucosal and parenteral vaccination strategies: three single-dose strategies based on intranasal administration of BCG and two heat-inactivated M. bovis (HIMB) vaccines, and two prime-boost strategies based on parenteral BCG or HIMB priming and intranasal HIMB boosting. …”
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Thymus ad astra, or spaceflight-induced thymic involution by Wataru Muramatsu, Wataru Muramatsu, Maria Maryanovich, Maria Maryanovich, Maria Maryanovich, Taishin Akiyama, Taishin Akiyama, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis, George S. Karagiannis

“…These models reveal that long-duration missions result in diminished naive T-cell output, leaving astronauts vulnerable to infections and possibly at high risk for developing neoplasia. …”
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An electrolyte-gated transistor for the monitoring of a CRISPR/Cas activity by Pierre Guermonprez, Le Tu Anh, Louis Renaud, Pierre Nioche, Eric Krejci, Aurélie Alleaume-Butaux, Nicolas Battaglini, Vu Thi Thu, Sébastien Sanaur, Benoît Piro

“…Detection of Ribonucleic acids (RNA) is a critical step in the identification of viral or bacterial infections in humans and animals. Reverse transcriptase-polymerase chain reaction (RT-PCR) remains the gold standard, but clustered regularly interspaced short palindromic repeats linked to a Cas endoribonuclease particle (CRISPR/Cas) have recently revolutionized the recognition step of two RNAs, i.e. the CRISPR-RNA (crRNA) and the target, providing a much better selectivity compared to the naked hybridization on which RT-PCR is based. …”
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Risk factors for African swine fever spread in wild boar in the Russian Federation by O. I. Zakharova, A. A. Blokhin, O. A. Burova, I. V. Yashin, F. I. Korennoy

“…However, on the whole, for all the infected Subjects, the regression model demonstrated the failure of the wild boar population density factor to explain the observed ASF outbreak distribution, and this may be indicative of the existence of other epizootic drivers of the disease spread in the wild. …”
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Detection and Phylogenetic Analysis of an Exotic Strain of Porcine Epidemic Diarrhea Virus and Its Effect on an Affected Herd Immunized Against the Endemic Strain in Thailand by Christopher James Stott, Patumporn Jermsutjarit, Pornchai Pornpanom, Hongyao Lin, Angkana Tantituvanont, Dachrit Nilubol

“…The results revealed no significant differences in colostrum and milk profiles between the farms. However, piglets infected with <b>G2b</b> showed significantly more severe intestinal damage. …”
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An Evidence-Based Update on the Impact of Local Antimicrobials as Adjunct to Periodontal Therapy by Nabaz Yahya Hussein, Sadat Abdulla Aziz, Twana Mohammed M. Ways, Omed Amiri, Hisham Al-Obaidi, Dianne Ford

“…MTZ showed the lowest clinical improvement among the agents reviewed, but it remains valuable due to its targeted action against anaerobic bacteria, which are prominent in periodontal infections. The findings of this study will help the general practitioners select the most suitable local antimicrobial therapy as adjunct to mechanical periodontal therapy. …”
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Impaired Growth during Childhood in Patients with Primary Ciliary Dyskinesia by Tamara Svobodová, Jana Djakow, Daniela Zemková, Adam Cipra, Petr Pohunek, Jan Lebl

“…Primary ciliary dyskinesia (PCD) leads to recurrent/chronic respiratory infections, resulting in chronic inflammation and potentially in chronic pulmonary disease with bronchiectasis. …”
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Characterization of the C5H11ORF96 gene in chickens: cloning, tissue distribution and investigation of its potential function in stress response regulation by Yiping Wan, Jiannan Zhang, Xiao Zhang, Jiliang He, Ningkun Shi, Yuanyou Li, Juan Li, Yajun Wang

“…Chicken is an important economic animal that encounter various stressors including high temperature, high stocking density, bacterial infections and transportation, etc. affecting the poultry production with serious economic loss. …”
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Performance evaluation of the Qiagen BK virus ASR on the NeuMoDx system by Amorce Lima, Luciano Soares, Caroline Simmons, Laura Rowe, Dominic Uy, Deanna Becker, Suzane Silbert

“…BKV quantitation by PCR is crucial in diagnostic and therapeutic management of transplant patients infected with BKV. We evaluated the performance of the Qiagen BKV ASR for the quantification of BKV on the NeuMoDx™ 96 System and compared the results to our standard of care (SOC) test, the Diasorin BKV ASR on the Liaison® MDX. …”
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Myocarditis in malaria—current evidence and future directions: a literature review by Gbolahan Olatunji, Emmanuel Kokori, Ikponmwosa Jude Ogieuhi, Olumide Akinmoju, Oluwatobi Omoworare, Doyin Olatunji, David Timilehin Isarinade, God-dowell O. Odukudu, Israel Charles Abraham, Samuel Owolabi, Jamil Nasrallah, Emmanuel Egbunu, Babafemi Oluwadarasimi Jaiyeoba, Ismaila Ajayi Yusuf, Olawale Olanisa, Nicholas Aderinto

“…Despite its primarily recognized impact on the hematological system, recent studies shed light on severe cardiac complications, particularly myocarditis, associated with Plasmodium infections. This review examines the literature on malaria-induced myocarditis to elucidate its mechanisms, clinical manifestations, regional perspectives, treatment outcomes, and diagnostic challenges. …”
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Exploration of the anti-inflammatory potential of Polygonum bistorta L.: protection against LPS-induced acute lung injury in rats via NF-ĸβ pathway inhibition by Sajida Parveen, Kashif ur Rehman Khan, Shahid Muhammad Iqbal, Hanan Y. Aati, Areej M. Al-taweel, Liaqat Hussain, Musaddique Hussain, Musaddique Hussain

“…(Polygonaceae) to treat cough, bronchitis, and other respiratory infections. Our goal was to gain insights into the lung protective effects of the roots of P. bistorta L. against lipopolysaccharide-induced acute lung injury in rats, along with the possible mechanism(s). …”
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Left Coronary Artery—Right Ventricle Fistula Case Report: Optimal Treatment Decision by Stefan Veljković, Ana Peruničić, Jovana Lakčević, Armin Šljivo, Dragana Radoičić, Mihajlo Farkić, Darko Boljević, Jelena Kljajević, Milovan Bojić, Aleksandra Nikolić

“…Clinical manifestations can include heart failure, myocardial ischemia due to coronary steal, arrhythmias, or infective endocarditis. We report a case of a 39-year-old man initially evaluated in 2016 for peripheral edema and suspected right ventricular (RV) abnormality. …”
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Comprehensive profiling of gut bacterial communities in hybrid red tilapia with and without streptococcosis by Pathamawan Amthungphong, Natthaphong Sombuttra, Triwit Rattanarojpong, Kanthida Kusonmano, Saengchan Senapin, Satid Chatchaiphan, Watanalai Panbangred, Jirayut Euanorasetr

“…Red tilapia (Oreochromis niloticus × Oreochromis mossambicus) with and without streptococcosis were collected from a river cage culture farm in Central Thailand. The infected streptococcal isolates were confirmed by 16S rRNA sequencing. …”
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