In Situ Aqueous Spice Extract-Based Antifungal Lock Strategy for Salvage of Foley’s Catheter Biofouled with <i>Candida albicans</i> Biofilm Gel by Bindu Sadanandan, Vaniyamparambath Vijayalakshmi, Kalidas Shetty, Adithya Rathish, Harshala Shivkumar, Malavika Gundreddy, Nikhil Kumar Kagganti Narendra, Nethra Machamada Devaiah

“…<i>Candida</i> forms a gel-like biofilm in the Foley’s catheter (FC) causing tenacious biofouling and severe urinary tract infections (UTIs). For the first time, a spice extract-based antifungal lock therapy (ALT) has been developed to inhibit the <i>Candida albicans</i> gel matrix in FC. …”
Get full text

Isolation, identification and optimization of fermentation conditions against Sclerotinia sclerotiorum strains in high salt Doenjang by Xian Zhang, Hongmei Li, Xiaoyu Kang, Seongil Lim, Fanzhu Li

“…With the global warming, the cultivation and storage of northern Chinese cabbage has been infected by Sclerotium bacteria, resulting in the whole plant rot. …”
Get full text

Antimalarial Combination Therapies Increase Gastric Ulcers Through an Imbalance of Basic Antioxidative‑Oxidative Enzymes in Male Wistar Rats. by Kalange, Muhamudu, Nansunga, Miriam, Keneth Iceland, Kasozi, Kasolo, Josephine, Namulema, Jackline, Kasande Atusiimirwe, Jovile, Tiyo Ayikobua, Emanuel, Ssempijja, Fred, Munanura, Edson Ireeta, Matama, Kevin, Semuyaba, Ibrahim, Zirintunda, Gerald Gerald, Okpanachi, Alfred Omachonu

“…Objective: Antimalarials are globally used against plasmodium infections, however, information on the safety of new antimalarial combination therapies on the gastric mucosa is scarce. …”
Get full text

CLONING OF GENES ENCODING TRANSMEMBRANE PROTEINS AND PROTEINS RESPONSIBLE FOR AFRICAN SWINE FEVER VIRUS VIRULENCE by Ali Mazloum, N. G. Zinyakov, A. S. Igolkin, N. N. Vlasova

“…Clones containing X69R, A179L, E248R, I215L and DP96R genes of ASF virus Krasnodar 07/17 isolate will be used for recombinant protein obtaining and testing for their effect on in vitro virus reproduction and their role in the virus infectivity, level of clinical manifestations and virulence. …”
Get full text

Influence Factors of Reproductive Organ Maintenance Among Adolescent Girls in Coastal Areas by Armyla Eka Wahyu Yuliani, Lu'lu Nafisah, Bambang Hariyadi

“…Adolescent girls are vulnerable to reproductive health problems such as vaginal discharge and reproductive tract infections, which are triggered by poor maintenance of their reproductive organs. …”
Get full text

Nature-inspired and medicinally relevant short peptides by Maria G. Ciulla, Monica Civera, Sara Sattin, Kamal Kumar

Get full text

Molecular and Cellular Mechanisms of Immunosenescence: Modulation Through Interventions and Lifestyle Changes by Luca Pangrazzi, Andreas Meryk

“…This phenomenon, characterized by alterations in both innate and adaptive immunity, increases susceptibility to infections, reduces vaccine efficacy, and contributes to the development of age-related diseases. …”
Get full text

Genetics and Molecular Biology of Epstein-Barr Virus-Encoded BART MicroRNA: A Paradigm for Viral Modulation of Host Immune Response Genes and Genome Stability by David H. Dreyfus

“…In this review, the author summarizes evidence that recently discovered noncoding RNAs termed microRNA encoded by Epstein-Barr virus BARF (BamHI A right frame) termed BART (BamHI A right transcripts) are modulators of human immune response genes and genome stability in infected and bystander cells. BART expression is apparently regulated by complex feedback loops with the host immune response regulatory NF-κB transcription factors. …”
Get full text

An Emerging Role for IQGAP1 in Regulating Protein Traffic by Mahasin Osman

“…Membrane traffic mediates infections by intracellular pathogens and a range of degenerative human diseases arise from dysfunctions in intracellular traffic; thus, elucidating the mechanisms of cellular traffic will be important in order to understand the basis of a wide range of inherited and acquired human diseases. …”
Get full text

A Cytokine That Is Involved in Immune Responses in Chronic Hepatitis B Virus Patients by Noor R. Abady, Zeana Shakir Al-Al Hindi

“…Abstract Background: The present research examines the part interleukin-17 (IL-17) plays in the progression of liver disease in people infected with the long-term hepatitis B virus. A proinflammatory cytokine called IL-17, linked to a number of autoimmune disorders, was examined in serum samples taken from different participant groups. …”
Get full text

Spatial spread of sexually transmitted diseases within susceptible populations at demographic steady state by Carlos Castillo-Chavez, Bingtuan Li

“…In this study, we expand on the susceptible-infected-susceptible(SIS) heterosexual mixing setting by including the movement ofindividuals of both genders in a spatial domain in order to morecomprehensively address the transmission dynamics of competingstrains of sexually-transmitted pathogens. …”
Get full text

IAPSM’s Position Paper on Typhoid Vaccines for Adult Immunization in India by Kapil Goel, Madhur Verma, Nikita Sharma, Swayam Pragyan Parida, Anu Bhardwaj, Anuradha Nadda, Sahil Sharma, Arunima Sen, Jacob John, Adarsh Bansal, Madhu Gupta

“…IAPSM encourages members to take front-line efforts in their community health service areas, and finally appeals for the development of vaccines to cover a more extensive range of Salmonella infections so that control over typhoid can be strengthened.…”
Get full text

Identification and Characterization of a Novel Rat MAVS Variant Modulating NFκB Signaling by Ihsan Nalkiran, Hatice Sevim Nalkiran

“…The innate immune response serves as the primary defense against viral infections, with the recognition of viral nucleic acids by pattern recognition receptors (PRRs) initiating antiviral responses. …”
Get full text

Clinical Profile And Liver Functions In Dengue Fever by Saeeda Sadiq, Amna Mobeen, Naveed Ashraf, Fasih Hashmi, Shahzad Munir, Anam Ahmad

“…It becomes clear that monitoring liver function in dengue-infected individuals is essential for prompt intervention and improved clinical care. …”
Get full text

Plasmablastic Lymphoma: A Review of Current Knowledge and Future Directions by Ghaleb Elyamany, Eman Al Mussaed, Ali Matar Alzahrani

“…Plasmablastic lymphoma (PBL) is an aggressive subtype of non-Hodgkin’s lymphoma (NHL), which frequently arises in the oral cavity of human immunodeficiency virus (HIV) infected patients. PBL shows diffuse proliferation of large neoplastic cells resembling B-immunoblasts/plasmablasts, or with plasmacytic features and an immunophenotype of plasma cells. …”
Get full text

Clinical, genetic aspects and molecular pathogenesis of osteopetrosis by D. D. Nadyrshina, R. I. Khusainova

“…Most patients die within the first decade due to secondary infections, bone marrow suppression and/or bleeding. …”
Get full text

Ethnopharmacology, Biological Evaluation, and Chemical Composition of Ziziphus spina-christi (L.) Desf.: A Review by Mahmoud Dogara Abdulrahman, Ali Muhammad Zakariya, Harmand A. Hama, Saber W. Hamad, Sawsan S. Al-Rawi, Sarwan W. Bradosty, Ahmad H. Ibrahim

“…Biological reports and traditional applications including management of diabetes and treatment of malaria, digestive issues, typhoid, liver complaints, weakness, skin infections, urinary disorders, obesity, diarrhoea, and sleeplessness have all been treated with different parts of Z. spina all over the globe. …”
Get full text

Specificity and tunability of efflux pumps: A new role for the proton gradient? by Matthew Gerry, Duncan Kirby, Boian S Alexandrov, Dvira Segal, Anton Zilman

“…Efflux pumps that transport antibacterial drugs out of bacterial cells have broad specificity, commonly leading to broad spectrum resistance and limiting treatment strategies for infections. It remains unclear how efflux pumps can maintain this broad spectrum specificity to diverse drug molecules while limiting the efflux of other cytoplasmic content. …”
Get full text

COMPARATIVE ASSESSMENT OF RATIONAL ANTIBIOTIC USAGE AMONG NON-PHYSICIAN HEALTH PROFESSIONALS AND LAY INDIVIDUALS by Ersan Gürsoy, Mehmet Vatansever

“…The study showed that healthcare workers and people who preferred to visit a healthcare facility for upper respiratory tract infections tended to have more negative attitudes towards antibiotic use (p=0.021 and p&lt;0.001 respectively). …”
Get full text

Retained multiple contact lenses in a vulnerable dementia patient by Rohit SHARMA, Zuhair SHARIF

“…Eversion of the upper eye lid revealed an infected foreign body which turned out to be multiple contact lenses stacked on top of each other. …”
Get full text