Positive and Negative Regulation of Cellular Immune Responses in Physiologic Conditions and Diseases by S. Viganò, M. Perreau, G. Pantaleo, A. Harari

“…The potential to revert exhausted or inactivated T-cell responses following selective blocking of their function made these markers interesting targets for therapeutic interventions in patients with persistent viral infections or cancer.…”
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Mathematical model for managing vector-borne pathogen outbreaks in chickens using impulsive vaccination and drug treatment by Kamonchat Trachoo, Din Prathumwan, Darunee Padasee, Supatcha Paopan, Inthira Chaiya

“…Numerical simulations demonstrate that impulsive vaccination significantly reduces the number of exposed and infected chickens, leading to disease eradication in approximately 270 days, compared to over 360 days without impulsive vaccination. …”
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Designing a Neural Observer to Estimate the State Variables of the Dynamical System of a Specific Class of Leukaemia by Yousef Farshidi, Reza Ghasemi, Aminin Sharafian Ardekani

“…This article aims to present a novel neural network observer-based approach in order to estimate the state variables of the nonlinear dynamical system of chronic myelogenous leukemia (CML), specially the number of the infected cells. For this purpose, a two-layer feed forward neural network was applied. …”
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Towards Inhibition of Vif-APOBEC3G Interaction: Which Protein to Target? by Iris Cadima-Couto, Joao Goncalves

“…The antiretroviral activity of some of these proteins is overtaken by the action of HIV-1 Viral Infectivity Factor (Vif) protein. Since the discovery of APOBEC3G (A3G) as an antiviral factor, many advances have been made to understand its mechanism of action in the cell and how Vif acts in order to counteract its activity. …”
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Lake salinization on the Qinghai–Tibetan Plateau alters viral community composition and lifestyles by Yuan-Guo Xie, Yan-Ling Qi, Zhen-Hao Luo, Yan-Ni Qu, Jian Yang, Shi-Qiang Liu, Hai-long Yang, Dan-Wei Xie, Zimeng Wang, Hong-Chen Jiang, Zheng-Shuang Hua

“…These shifts are mirrored in the prokaryotic communities, with Alphaproteobacteria and their infecting temperate viruses, notably Casadabanvirus, becoming more prevalent in higher salinity zones. …”
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Eosinophils: old cells, new directions by Alejandra Sanchez Santos, Iovanna Socorro Avila, Helena Galvan Fernandez, Sara Cazorla Rivero, Sara Cazorla Rivero, Angelina Lemes Castellano, Carlos Cabrera Lopez

“…Their well-known roles range from asthma and parasitic infections to less prevalent diseases such as eosinophilic granulomatosis with polyangiitis, eosinophilic esophagitis, and hypereosinophilic syndrome. …”
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Diogenes Syndrome: A Case Report by Projna Biswas, Anusree Ganguly, Sanchaita Bala, Falguni Nag, Nidhi Choudhary, Sumit Sen

“…These debris can be secondarily infected by bacteria, fungus, and so forth. These skin lesions are not usually seen in individual with proper hygiene. …”
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Use of miRNAs as Biomarkers in Sepsis by Raluca Dumache, Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Mirela Sarandan, Alina Carmen Cradigati, Marius Papurica, Corina Maria Dumbuleu, Radu Nartita, Dorel Sandesc

“…Severe generalized inflammation, infections, and severe physiological imbalances significantly decrease the survival rate with more than 50%. …”
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Immunization against Lamb Haemonchosis with a Recombinant Somatic Antigen of Haemonchus contortus (rHcp26/23) by Leticia García-Coiradas, Francisco Angulo-Cubillán, Basilio Valladares, Enrique Martínez, Concepción de la Fuente, José María Alunda, Montserrat Cuquerella

“…Immunization did not induce any significant protection after challenge with 16000 infective larvae of H. contortus, and comparable values for parasite faecal egg output, packed cell volume, and abomasal parasite burdens were found in vaccinated and control animals.…”
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A novel homozygous mutation of CFAP300 identified in a Chinese patient with primary ciliary dyskinesia and infertility by Zheng Zhou, Qi Qi, Wen-Hua Wang, Jie Dong, Juan-Juan Xu, Yu-Ming Feng, Zhi-Chuan Zou, Li Chen, Jin-Zhao Ma, Bing Yao

“…Primary ciliary dyskinesia (PCD) is a clinically rare, genetically and phenotypically heterogeneous condition characterized by chronic respiratory tract infections, male infertility, tympanitis, and laterality abnormalities. …”
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Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis by Filippo Vascon, Sofia De Felice, Matteo Gasparotto, Stefan T. Huber, Claudio Catalano, Monica Chinellato, Riccardo Mezzetti, Alessandro Grinzato, Francesco Filippini, Lorenzo Maso, Arjen J. Jakobi, Laura Cendron

“…These results provide the groundwork for designing novel antimicrobial strategies and exploring the potential translation of Escherichia coli-derived approaches, to address the implications of P. aeruginosa infections.…”
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Composition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery by Celien Bollen, Sofie Louwagie, Femke Deroover, Wouter Duverger, Ladan Khodaparast, Laleh Khodaparast, Dieter Hofkens, Joost Schymkowitz, Frederic Rousseau, Liselot Dewachter, Jan Michiels

“…Abstract Recalcitrant bacterial infections can be caused by various types of dormant bacteria, including persisters and viable but nonculturable (VBNC) cells. …”
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Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke by Surajit Hansda, Hiranmoy Das

“…Cancer might influence stroke pathophysiology either directly or through coagulation that creates a hypercoagulative state, in addition to infections. Treatment methods for cancer, including chemotherapy, radiotherapy, and surgery, have all been demonstrated to increase the risk of stroke as well. …”
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Current Concepts of Hyperinflammation in Chronic Granulomatous Disease by Nikolaus Rieber, Andreas Hector, Taco Kuijpers, Dirk Roos, Dominik Hartl

“…Consequently, CGD phagocytes are impaired in destroying phagocytosed microorganisms, rendering the patients susceptible to bacterial and fungal infections. Besides this immunodeficiency, CGD patients suffer from various autoinflammatory symptoms, such as granuloma formation in the skin or urinary tract and Crohn-like colitis. …”
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Adult Presentation of Anomalous Left Coronary Artery from the Pulmonary Artery with Severe Mitral Valve Regurgitation from Flail Posterior Leaflet by Digvijay D Nalawade, Prakyath Shetty, Anirudha Sadgir, Sanket Bari

“…There were no features suggestive of infective endocarditis, rheumatic or myxomatous affection of mitral valve. …”
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Plasmid Profiles and Prevalence of Intermediately Virulent Rhodococcus equi from Pigs in Nakhonpathom Province, Thailand: Identification of a New Variant of the 70-kb Virulence Pla... by Chaithep Poolkhet, Suksun Chumsing, Worawidh Wajjwalku, Chihiro Minato, Yukiko Otsu, Shinji Takai

“…Investigation of the prevalence and plasmid profiles of VapB-positive R. equi in pigs should be extended throughout Thailand to evaluate potential sources of zoonotic infections.…”
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Real-time multimodal imaging of daptomycin action on the cell wall of adherent Staphylococcus aureus by Alexis Canette, Rym Boudjemaa, Julien Deschamps, Karine Steenkeste, Christian Marlière, Romain Briandet, Marie-Pierre Fontaine-Aupart

“…Abstract Objectives This study investigated the efficacy of daptomycin against adherent Staphylococcus aureus (S. aureus), a common colonizer of medical devices that leads to severe infections. For the first time, we evaluated the bactericidal effects of daptomycin on S. aureus immediately after adhesion, mimicking early-stage contamination of biomaterials. …”
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Aortoesophageal Fistula after Endovascular Aortic Aneurysm Repair of a Mycotic Thoracic Aneurysm by Elizabeth Gavens, Zehra Zaidi, Wissam Al-Jundi, Palepu Kumar

“…However, the uncommon aortoenteric fistula formation remains a potentially fatal complication when repairing such infective aneurysms. We present the case of an 80-year-old woman with thoracic and abdominal aortic mycotic aneurysms, which were successfully treated with endografting. …”
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Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology by Mafalda Jesus, Ana P. J. Martins, Eugenia Gallardo, Samuel Silvestre

“…This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the treatment of various types of disorders such as cancer, hypercholesterolemia, inflammation, and several types of infections. Due to its pharmacological and industrial importance, several extraction and analytical procedures have been developed and applied over the years to isolate, detect, and quantify diosgenin, not only in its natural sources and pharmaceutical compositions, but also in animal matrices for pharmacodynamic, pharmacokinetic, and toxicological studies. …”
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Crystallographic and computational characterization and in silico target fishing of six aromatic and aliphatic sulfonamide derivatives by Anh Van Nguyen, Anh Thi Ngoc Vu, Andrey N. Utenyshev, Valeriy Tkachev, Nadezhda Polyanskaya, Dmitriy Shchevnikov, Magrarita Vasil’eva, Hieu Tran-Trung, Xuan Ha Nguyen, Olga V. Kovalchukova

“…Consequently, these compounds may serve as promising lead-like molecules for drug development targeting protozoan infections.…”
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