Systemic and Local Administration of Antimicrobial and Cell Therapies to Prevent Methicillin-Resistant Staphylococcus epidermidis-Induced Femoral Nonunions in a Rat Model by Arianna B. Lovati, Lorenzo Drago, Marta Bottagisio, Matilde Bongio, Marzia Ferrario, Silvia Perego, Veronica Sansoni, Elena De Vecchi, Carlo L. Romanò

“…This study compares the response to S. epidermidis-infected fractures in rats systemically or locally injected with vancomycin or bone marrow mesenchymal stem cells (BMSCs) in preventing the nonunion establishment. …”
Get full text

Severe ARDS due to disseminated toxoplasmosis in a person with HIV successfully treated with ECMO: a case report by Daniel Medina, Renzo Ávila, Graciela Rodríguez-Sevilla, Víctor Gumucio, María Bonilla, Gabriela Abelenda-Alonso, Jordi Niubó, Maria Saumoy, Juan Tiraboschi, María Paz Fuset, Arkaitz Imaz

Get full text

Point Prevalence Survey of Antimicrobial Use among Hospitalized Patients in a Referral Hospital in Northwest Ethiopia: A Hospital-Based Cross-Sectional Study by Mengistie Yirsaw Gobezie, Minimize Hassen, Nuhamin Alemayehu Tesfaye, Mulat Belete Demessie, Tewodros Solomon, Ermiyas Alemayehu

“…Empirical prescriptions for community-acquired infections were prevalent. These results underscore the need for robust antimicrobial stewardship programs in Ethiopian hospitals.…”
Get full text

High-Resolution Melting Analysis to Detect Antimicrobial Resistance Determinants in South African Neisseria gonorrhoeae Clinical Isolates and Specimens by Nireshni Mitchev, Ravesh Singh, Veron Ramsuran, Arshad Ismail, Mushal Allam, Stanford Kwenda, Florah Mnyameni, Nigel Garrett, Khine Swe Swe-Han, Abraham J. Niehaus, Koleka P. Mlisana

“…Antimicrobial resistance is limiting treatment options for Neisseria gonorrhoeae infections. To aid or replace culture and the syndromic management approach, molecular assays are required for antimicrobial susceptibility testing to guide appropriate and rapid treatment. …”
Get full text

Screening of the Dichloromethane: Methanolic Extract of Centella asiatica for Antibacterial Activities against Salmonella typhi, Escherichia coli, Shigella sonnei, Bacillus subtili... by Berick Moturi Sieberi, George Isanda Omwenga, Rachael Kitondo Wambua, Judith Chemutai Samoei, Mathew Piero Ngugi

“…Bacterial infections are responsible for a large number of deaths every year worldwide. …”
Get full text

Characterization of YdgH: a mediator of beta-lactam susceptibility in Enterobacterales by Jacob E. Lazarus, Matthew K. Waldor, David C. Hooper

“…ABSTRACT Beta-lactam antibiotics are often the treatment of choice for serious bacterial infections. In a previous screen for novel genetic mediators affecting beta-lactam susceptibility, we discovered that deletion of ydgH, a conserved gene of unknown function, leads to increased resistance to beta-lactams, as well as increased susceptibility to detergent compounds. …”
Get full text

Procalcitonin and High APACHE (Acute Physiological and Chronic Health Evaluation) Level Are Associated with the Course of Acute Kidney Injury in Patients with SARS-CoV-2 by Jorge Andrade Sierra, Claudia Delgado Astorga, Miriam Gabriela Nava Vargas, Enrique Rojas Campos, Kevin Javier Arrelano Arteaga, Karla Hernández Morales, Carlos A. Andrade Castellanos, Antonio de Jesús Andrade-Ortega, Luis Gerardo González Correa

“…Acute kidney injury (AKI) is associated with poor outcomes in patients infected with SARS-CoV-2. Sepsis, direct injury to kidney cells by the virus, and severe systemic inflammation are mechanisms implicated in its development. …”
Get full text

An Evaluation of the Antibacterial Properties of Tormentic Acid Congener and Extracts From Callistemon viminalis on Selected ESKAPE Pathogens and Effects on Biofilm Formation by Tafadzwa Chipenzi, Genuine Baloyi, Tatenda Mudondo, Simbarashe Sithole, Godloves Fru Chi, Stanley Mukanganyama

“…ESKAPE pathogens, namely, Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and Enterobacter species, are responsible for a majority of all healthcare-acquired infections (HAI). The bacteria cause nosocomial infections in immunocompromised patients. …”
Get full text

Amputations of Lower Limb in Subjects with Diabetes Mellitus: Reasons and 30-Day Mortality by Magdalena Walicka, Marta Raczyńska, Karolina Marcinkowska, Iga Lisicka, Arthur Czaicki, Waldemar Wierzba, Edward Franek

“…Vascular pathologies, infections, and ulcerations were the most common causes of LEA. …”
Get full text

Baicalein inhibits PRRSV through direct binding, targeting EGFR, and enhancing immune response by Jing Wu, Qi Lu, Jing Hou, Yueqin Qiu, Min Tian, Li Wang, Kaiguo Gao, Xuefen Yang, Zongyong Jiang

“…Therefore, it is urgent to identify new strategies for preventing and controlling PRRSV infections. Baicalein, a flavonoid derived from Scutellaria baicalensis, has gained attention for its potential antiviral properties. …”
Get full text

Bacteria-Inspired Synthesis of Silver-Doped Zinc Oxide Nanocomposites: A Novel Synergistic Approach in Controlling Biofilm and Quorum-Sensing-Regulated Virulence Factors in <i>Pseu... by Abirami Karthikeyan, Manoj Kumar Thirugnanasambantham, Fazlurrahman Khan, Arun Kumar Mani

“…Multidrug-resistant <i>Pseudomonas aeruginosa</i> infections pose a critical challenge to healthcare systems, particularly in nosocomial settings. …”
Get full text

Assessing the Short-Term Efficacy and Safety of Guselkumab for Moderate-to-Severe Plaque Psoriasis: Meta-Analysis of Randomized Controlled Trials by Jing Yang, Zongming Wang, Xilin Zhang

“…Meanwhile, there was no statistically significant association of infections and serious infections compared with the placebo or adalimumab group. …”
Get full text

IMAGING ASPECTS OF NON-CHOLESTEATOMATOUS CHRONIC OTITIS AND INTRACEREBRAL COMPLICATIONS OF CHOLESTEATOMA IN PATIENTS HOSPITALIZED AND TREATED AT “PROF. N. OBLU” HOSPITAL IN IAȘI... by Ariadna Mocrei, Andreea Diana Ilinca, Alexandra Chichirău, Teodora Buznea, Bianca Vornicu, Ana Elena Sirghe, Danisia Haba

“…Intracranial infectious complications (such as abscess) are commonly seen in patients with maxillo-facial area infections/inflammation or temporal bone area (generally ear) infections/inflammation. …”
Get full text

Ecological analysis of the fish trematode fauna of the Lower Kura by Y.V. Shakaraliyeva

“…Apparently, these parasites enter the body of ichthyophages for the most part by eating fish infected by them. In the remaining trophic groups, the fauna of trematodes was significantly dominated by species parasitizing fish at the metacercaria stage. …”
Get full text

Contribution of Arginine Catabolic Mobile Element and Copper and Mercury Resistance Element in Methicillin-Resistant Staphylococcus aureus: A Vantage Point by Parya Shokrollahi, Alka Hasani, Mohammad Aghazadeh, Mohammad Yousef Memar, Akbar Hasani, Maryam Zaree, Mohammad Ahangarzadeh Rezaee, Javid Sadeghi

“…Evidence suggests that ACME and COMER have a more prominent role in enhancing biofilm capacity and ultimately persistent infections. Interestingly, ACME strains have been shown to possess the ability to counteract skin acidity, thereby allowing increased skin colonization. …”
Get full text

Antibiotic Resistance Profile of Enterovirulent E. coli Isolates Harboring Broad-Spectrum Beta-Lactamase Genes in Cancer Patients at the Laquintinie Hospital in Douala, Littoral Re... by Michael F. Kengne, Armelle T. Mbaveng, Wiliane J. T. Marbou, Ousenu Karimo, Ballue S. T. Dadjo, Delano G. T. Fonjou, Ornella D. Tsobeng, Victor Kuete

“…Cases of antibiotic-resistant Escherichia coli (E. coli) infections are becoming increasingly frequent and represent a major threat to our ability to treat cancer patients. …”
Get full text

Lactococcus lactis and Bifidobacterium bifidum alleviate postmenopausal symptoms by suppressing NF-κB signaling and microbiota dysbiosis by Yoon-Jung Shin, Xiaoyang Ma, Min-Kyung Joo, Ji-Su Baek, Dong-Hyun Kim

“…They partially shifted vaginal and gut dysbiosis in Gv-infected mice to the gut microbiota composition in normal control mice. …”
Get full text

Modeling Ebola Virus Disease transmissions with reservoir in a complex virus life ecology by Tsanou Berge, Samuel Bowong, Jean Lubuma, Martin Luther Mann Manyombe

“…The role of a contaminated environment is assessed by comparing the human infected component for the sub-model without the environment with that of the full model. …”
Get full text

Risk factors of multidrug resistant tuberculosis among patients with tuberculosis at selected multidrug resistance treatment initiative centres in southern Ethiopia: a case-control... by Fantahun Admassu, Ermias Abera, Addisalem Gizachew, Tagesse Sedoro, Taye Gari

“…Both bivariate and multivariable logistic regression analysis was used to identify risk factors of MDR-TB infections.Main outcome measure Identifying the risk factors for MDR-TB.Results A total of 392 participants (79 cases and 313 controls) were interviewed. …”
Get full text

The role of epigenetic factors in the pathogenesis of dysmetabolic nephropathy with calcium oxalate crystalluria in children by N.R. Aib, O.Z. Hnateyko, N.S. Lukyanenko, A.B. Volosyanko

“…The most significant postnatal epigenetic factors influencing children's susceptibility to a more severe course of dysmetabolic nephropathy included low birth weight, early artificial feeding, frequent acute respiratory infections, atopic diathesis, and physiological jaundice in the first year of life, as well as the presence of concomitant diseases such as chronic tonsillitis, dental caries, frequent acute respiratory infections, chronic gastritis, atopy, and chronic cholecystitis later in life. …”
Get full text