Selected Biomarkers Correlate with the Origin and Severity of Sepsis by Michal Holub, Olga Džupová, Michaela Růžková, Alžběta Stráníková, Eva Bartáková, Jan Máca, Jiří Beneš, Heiko Herwald, Ondřej Beran

“…Plasma concentrations of MCP-1, sCD14, IL-6, and IL-10 were significantly higher in patients with community-acquired pneumonia (CAP; n=10) and infective endocarditis (IE; n=11) compared to those with bacterial meningitis (BM; n=18). …”
Get full text

Novel method for classification of prion diseases by detecting PrPres signal patterns from formalin-fixed paraffin-embedded samples by Sachiko Koyama, Kaoru Yagita, Hideomi Hamasaki, Hideko Noguchi, Masahiro Shijo, Kosuke Matsuzono, Kei-Ichiro Takase, Keita Kai, Shin-Ichi Aishima, Kyoko Itoh, Toshiharu Ninomiya, Naokazu Sasagasako, Hiroyuki Honda

“…FFPE samples were prepared after formic acid treatment to inactivate infectivity. After deparaffinization, PK digestion was performed, and the protein was extracted. …”
Get full text

Clinical Microbiological Aspects of Epileptic Seizures in the Tropical Countries with Specific Focus on Nigeria by Ijeoma Kanu, Ebere C. Anyanwu, Nkechi C. Nwachukwu, John E. Ehiri, Joav Merrick

“…A literature review was carried out to identify the extent to which microbial infections were involved in the elicitation of epileptic seizures. …”
Get full text

Effect of Fusion to the LTB Carrier Protein on Coronavirus Spike Protein Vaccine Candidates Produced in Maize by Erin Egelkrout, Magdalena Maj, Rodrigo Manjarin, Gina Fake, Muneaki Watanabe, Jenna Williams, Nate Blanchard, John Walker, Celine Hayden, John Howard

“…Despite the availability of commercial vaccines for both viruses, there is still a high occurrence of infections and a great need for enhanced efficacy and lower costs. …”
Get full text

Loss-of-function variant in MAGT1 leading to XMEN disease in a Colombian patient with a common variable immunodeficiency by Sebastián Gutiérrez-Hincapié, Julio César Orrego, José Luis Franco, Claudia M. Trujillo-Vargas

“…The patient suffered from upper respiratory and urinary tract infections, autoimmune hemolytic anemia, and hepatopathy. …”
Get full text

FcRn-enhancing mutations lead to increased and prolonged levels of the HIV CCR5-blocking monoclonal antibody leronlimab in the fetuses and newborns of pregnant rhesus macaques by Joanna Zikos, Gabriela M. Webb, Helen L. Wu, Jason S. Reed, Jennifer Watanabe, Jodie L. Usachenko, Ala M. Shaqra, Celia A. Schiffer, Koen K. A. Van Rompay, Jonah B. Sacha, Diogo M. Magnani

“…To test this hypothesis, we measured the transplacental transfer of leronlimab, an anti-CCR5 mAb, in clinical development for preventing HIV infections, using pregnant rhesus macaques to model in utero mAb transfer. …”
Get full text

PREVALENCE OF GASTROINTESTINAL HELMINTHS IN FREE-RANGE POULTRY (GALLUS GALLUS DOMESTICUS) IN THE NORTHEAST OF TUNISIA by Khaled Kaboudi, Nesrine Rhif, Rafika Ben Romdhane, Nadine Abdallah, Mokhtar Dhibi

“…Results showed that 38.86% (192 birds), as overall prevalence, were infected by at least one parasite species. The prevalence of gastrointestinal helminth infections was higher in young animals (under 18 weeks) (32.79%) than adults (6.07%) (p < 0.05) and during rainy and cold seasons (autumn: 59.18%; spring: 41.72%; summer: 30.7%; winter: 28.84%) (p < 0.05). …”
Get full text

Effect of Curry Leaf (Murraya koenigii) as Edwardsiellosis Treatment on Gourami Fish (Osphronemus goramy) by Muyassar H. Abualreesh, Agus Pariawan, Annisa Isti Fauziyyah, Farid Mukhtar Riyadi, Mohammad Fadjar, Arief Prajitno, Arif Syaifurrisal, Muhammad Browijoyo Santanumurti, Suciyono Suciyono

“…The second stage involved applying the crude extract of M. koenigii, known for its antibacterial properties, to gourami fish infected with E. tarda. The findings revealed that M. koenigii predominantly contains alkaloids, terpenoids, saponins, flavonoids, and tannins, all of which exhibit antibacterial activity. …”
Get full text

Codon optimized influenza H1 HA sequence but not CTLA-4 targeting of HA antigen to enhance the efficacy of DNA vaccines in an animal model by Dito Anurogo, Chia-Yuan Chen, Chu-Chi Lin, Jeanne Adiwinata Pawitan, Daniel W. Qiu, J. Timothy Qiu

“…Infections caused by the influenza virus lead to both epidemic and pandemic outbreaks in humans and animals. …”
Get full text

Development of a water-dispersible antimicrobial lipid mixture to inhibit African swine fever virus and other enveloped viruses by Joshua A. Jackman, Roza Izmailyan, Rafayela Grigoryan, Tun Naw Sut, Abel Taye, Hovakim Zakaryan, Charles C. Elrod

“…The lipid mixture reduced the viral infectivity of membrane-enveloped ASFV and IAV in aqueous solution in a dose-dependent manner but was inactive against non-enveloped encephalomyocarditis virus (EMCV). …”
Get full text

Supramolecular discrimination and diagnosis-guided treatment of intracellular bacteria by Jia-Hong Tian, Siyuan Huang, Ze-Han Wang, Juan-Juan Li, Xianhui Song, Ze-Tao Jiang, Bing-Sen Shi, Ying-Ying Zhao, Hui-Yan Zhang, Ke-Rang Wang, Xin-Yue Hu, Xinge Zhang, Dong-Sheng Guo

“…By fingerprinting specimens collected from bacteria-infected mice, the facilitated accurate diagnosis offers valuable guidance for selecting appropriate antibiotics. …”
Get full text

Astrocytic HIV-1 Nef Expression Decreases Glutamate Transporter Expression in the Nucleus Accumbens and Increases Cocaine-Seeking Behavior in Rats by Jessalyn Pla-Tenorio, Bethzaly Velazquez-Perez, Yainira Mendez-Borrero, Myrella L. Cruz, Marian T. Sepulveda-Orengo, Richard J. Noel

“…Understanding these interactions better may inform therapeutic strategies for managing cocaine use disorder in HIV-infected individuals.…”
Get full text

Comparison of Two Methodologies for CD4+ T Lymphocytes Relative Counting on Immune Monitoring of Patients with Human Immunodeficiency Virus by Danielle Cristyane Kalva Borato, Emerson Carraro, Sônia Regina Weber Ribas, Carlos Augusto Kalva-Filho, José Carlos Rebuglio Vellosa

“…The differences in the percentages of CD4+ T lymphocytes obtained by different methodologies could lead to conflict when used in clinical decisions related to the treatment and care of people infected with HIV.…”
Get full text

High-Performance Liquid Chromatography Assay for Moxifloxacin in Brain Tissue and Plasma: Validation in a Pharmacokinetic Study in a Murine Model of Cerebral Listeriosis by Renaud Respaud, Solene Grayo, Eric Singlas, Sophie Dubouch, Alban Le Monnier, Marie-Catherine Lott

“…Moxifloxacin pharmacokinetics are modeled in an infected model compared to control mice.…”
Get full text

Molecular Detection of Anaplasma spp. and Ehrlichia spp. in Ruminants from Twelve Provinces of China by Haixiang Qiu, Patrick John Kelly, Jilei Zhang, Qinghua Luo, Yi Yang, Yongjiang Mao, Zhangping Yang, Jing Li, Hongzhuan Wu, Chengming Wang

“…Anaplasma spp. and Ehrlichia spp. are tick-transmitted bacteria that are of significant economic importance as they can infect large and small ruminants and also people. …”
Get full text

Influenza A virus hemagglutinin: from classical fusion inhibitors to proteolysis targeting chimera-based strategies in antiviral drug discovery by Francisco Javier Hermoso-Pinilla, Aitor Valdivia, María-José Camarasa, Tiziana Ginex, Francisco Javier Luque

“…Due to its crucial involvement in the initial phases of influenza A infections, HA emerges as a promising target in the search of novel drug-like candidates. …”
Get full text

Alpha-defensins increase NTHi binding but not engulfment by the macrophages enhancing airway inflammation in Alpha-1 antitrypsin deficiency by Jungnam Lee, Naweed Mohammad, Kyudong Han, Kyudong Han, Tammy Flagg-Dowie, Maria Magallon, Mark L. Brantly, Karina A. Serban, Karina A. Serban

“…Despite the antimicrobial activities of α-defensins by direct bacterial killing and by modulation of immune responses, AATD individuals are paradoxically burdened by recurrent exacerbation triggered by bacterial infections, frequently with nontypeable Haemophilus influenzae (NTHi). …”
Get full text

Cardiac Aspergilloma: A Rare Case of a Cardiac Mass Involving the Native Tricuspid Valve, Right Atrium, and Right Ventricle in an Immunocompromised Patient by Christina S. Chen-Milhone, Kalyan Chakravarthy Potu, Sudhir Mungee

“…Aspergillus can cause devastating opportunistic infections in immunocompromised patients. Rarely does this fungus invade the heart, and when it does, survival is especially poor despite optimal medical and surgical treatment. …”
Get full text

Prosthetic Valve Candida Endocarditis: A Case Report with 18F-FDG-PET/CT as Part of the Diagnostic Workup by Soile Pauliina Salomäki, Antti Saraste, Päivi Jalava-Karvinen, Laura Pirilä, Ulla Hohenthal

“…Diagnosis of Candida spp. infective endocarditis (IE) is challenging, and diagnostic delays are common. …”
Get full text

Short Review for Design and Implementation of a New Low-Cost Prototype Portable Smart Ventilator by Shereen Q. Blais, Jameel K. Abed, Mohannad J. Mnati, Tareq S. El-Hasan

“…Mechanical ventilation has become a lifesaver, especially during the outbreak of the Coronavirus COVID-19 where the patient needs continuous ventilation in order to help the respiratory system to perform its functions correctly due to the accumulation of fluid in the lungs resulting from viruses that infect the respiratory system, thus improving survival. …”
Get full text