Central Diabetes Insipidus in Children and Adolescents: Twenty-Six Year Experience from a Single Centre by Hüseyin Anil Korkmaz, Ritika R Kapoor, Jennifer Kalitsi, Simon JB Aylwin, Charles R Buchanan, Ved Bhushan Arya

“…Patients with CNS malformations/infections presented with CDI at a younger age compared to patients with CNS tumours p<0.0001. …”
Get full text

Retrospective Cohort Analysis of Outpatient Antibiotic Use for Clostridioides difficile-Indicated Agents in British Columbia, from 2000 to 2018 by Ariana Saatchi, Sungeun Kim, Fawziah Marra

“…Clostridioides difficile (CDI) is the most common cause of nosocomial diarrheal infections. Historically, metronidazole was the first-line treatment, but guidelines now indicate oral vancomycin and fidaxomicin as primary antibiotics for initial episodes. …”
Get full text

The Association between Noncommercial Partnerships and Risk of HIV among Female Sex Workers: Evidences from a Cross-Sectional Behavioral and Biological Survey in Southern India by Renuka Pulikallu Somanath, Ram Manohar Mishra, Niranjan Saggurti, Prabhakar Parimi

“…Participants were asked about their sexual partnerships, condom use, and vulnerability factors and tested for HIV and sexually transmitted infections. The key independent variables considered were presence of a noncommercial sexual partner (no, yes) and the nature of such partnerships (regular, nonregular). …”
Get full text

Replication-transcription complex of coronaviruses: functions of individual viral non-structural subunits, properties and architecture of their complexes by E. L. Mishchenko, V. A. Ivanisenko

“…Clinically tested vaccines are widely used to control rapidly spreading, acute, and often severe infections; however, effective drugs are still not available. …”
Get full text

The Potential of Emergency Medical Response to CBRNE Threats in the Context of Military-Civilian Cooperation by Arkadiusz Trzos, Karol Łyziński

“…In their work, the authors focused on presenting the concepts of CBRNEmed specialised teams, applying new solutions on using protective suits and respiratory protection equipment, innovative methods of decontamination of contaminated patients, options of point-of-care testing and identification of hazardous agents (POCT-CBRNE), isolation and transport of contaminated and highly infective patients and new CBRNE triage methods. In the publication, they demonstrated the compatibility of the developed solutions with the tactics, equipment and command system operating in the armed forces of NATO member states. …”
Get full text

MYCOLOGICAL ASSESSMENT OF INDOOR AIR QUALITY: CROSS-SECTIONAL STUDY OF SELECTED PRIVATE HOSPITALS IN DUTSE, JIGAWA STATE, NORTHWEST NIGERIA by Adeniyi Olarewaju Adeleye, Sunday Nicholas, Peter Gimba Shiaka, Mohammed Bello Yerima

“…The findings in this study indicate that fungal aerosols were able to accumulate in the examined indoor environment of the hospitals regardless of the sampling intervals, suggesting that they may have the ability to act as a reservoir of fungal infections. Therefore, it is advised that safety precautions should be taken in order to lessen fungal contamination in the hospitals’ indoor environment.…”
Get full text

A study on beneficial impact of the use of medium-molecular-weight hydroxyethyl starch in granulocyte apheresis using continuous-flow cell separator Spectra Optia: A retrospective... by Amardeep Pathak, Devasis Panda, Narender Tejwani, Anurag Mehta

“…INTRODUCTION: Granulocyte transfusion is one of the best therapeutic modalities in prolonged neutropenic patients with severe bacterial/fungal infections. Granulocyte harvest using conventional acid citrate dextrose (ACD) anticoagulant (ACD-A) by apheresis is not satisfactory in comparison to the use of hydroxyethyl starch (HES), but the latter is associated with various adverse events, especially with high-molecular-weight HES. …”
Get full text

The expression of powdery mildew resistance in spring bread wheat cultivars from the VIR collection of plant genetic resources by T. V. Lebedeva, E. V. Zuev, A. N. Brykova

“…Marchal. is a widespread foliar disease of common wheat in regions with cool and wet conditions. The disease infects the foliage, stem and spike of the wheat host. …”
Get full text

Pharmacokinetic/pharmacodynamic analysis of tedizolid phosphate against Staphylococcus aureus and Streptococcus pneumoniae in children, adolescents, and adults by Monte Carlo simul... by Xiao-Chen Wei, Ming-Feng Zhao, Hai-Rong Lv, Xia Xiao

“…Results: According to the results of the Monte Carlo simulations, currently approved dosage regimens of tedizolid phosphate were effective in the treatment of acute bacterial skin and skin structure infections (ABSSSIs) caused by methicillin-susceptible S. aureus and methicillin-resistant S. aureus (MRSA) including vancomycin-intermediate, heterogeneous vancomycin-intermediate, and daptomycin-non-susceptible MRSA in adult and paediatric patients aged 12 y and older. …”
Get full text

Reduced NLRP3 Gene Expression Limits the IL-1β Cleavage via Inflammasome in Monocytes from Severely Injured Trauma Patients by Shinwan Kany, Johann-Philipp Horstmann, Ramona Sturm, Katharina Mörs, Borna Relja

“…IL-1β plays an important role in host immunity and protection against infections. Its biological activation via IL-1β-precursor processing requires the transcription of inflammasome components and their activation. …”
Get full text

Prevalence, Antibiotic Susceptibility Pattern and Associated Factors of Streptococcus pyogenes among Pediatric Patients with Acute Pharyngitis in Sidama, Southern Ethiopia by Alemitu Beyene Gebre, Demissie Assegu Fenta, Abel Abera Negash, Betelihem Jima Hayile

“…Streptococcus pyogenes is the most frequent cause of pharyngitis and skin infections in children and causes immune complications like rheumatic fever and rheumatoid heart disease (RHD), particularly in developing countries like Ethiopia. …”
Get full text

Haemophagocytic Lymphohistiocytosis with Leptospirosis: A Rare but Devastating Complication by B. M. Munasinghe, A. G. Arambepola, N. Pathirage, U. P. M. Fernando, N. Subramaniam, S. Nimalan, T. Gajanthan

“…Secondary haemophagocytic lymphohistiocytosis (sHLH), often associated with an array of infections, malignancies, and autoimmune diseases, is rarely seen with leptospirosis, which carries a relatively poor prognosis even with modern state-of-the-art medical care. …”
Get full text

Pregnancy and COVID-19: Comparing ICU Outcomes for Pregnant and Nonpregnant Women by Małgorzata Lipińska-Gediga, Waldemar Goździk, Jakub Śmiechowicz, Barbara Adamik

“…Background: This study compares organ dysfunction, treatment strategies, and unfavorable outcome rates between pregnant and nonpregnant women admitted to the ICU with severe COVID-19, highlighting the increased susceptibility of pregnant women to respiratory infections due to physiological changes. Methods: A retrospective, age-matched study was conducted at a referral center specializing in critical care for pregnant women. …”
Get full text

Geospatial Analysis and Molecular Epidemiologic Study of Emerging Pulmonary Lophomoniasis in Iran: A National Registry-Based Study by Mohammad Amin Ghatee, Maryam Nakhaei, Ali Sharifpour, Mahdi Fakhar, Niloufar Mohamadi, Mostafa Soleymani, Siavash Abedi, Masoud Aliyali, Hossein Mehravaran

“…Higher rates of BPL in lower latitudes may be due to warmer weather and longer days, which can confine individual activities indoors and result in more contact with domestic insects and infected dust.…”
Get full text

Evaluation of extracts from Phyllostachys makinoi for their antibacterial and accelerated wound healing potential by Te-Hua Liu, Ju-Yun Wu, Meng-Chun Cheng, Bang-Yuan Chen, Tsung-Yu Tsai

“…In conclusion, P. makinoi water and ethanol extracts demonstrated antibacterial and anti-inflammatory effects, showing potential for treating wound infections and accelerating healing, making them promising candidates for wound-healing therapies.…”
Get full text

Longitudinal observational (single cohort) study on the causes of trypanocide failure in cases of African animal trypanosomosis in cattle near wildlife protected areas of Northern... by Shauna Richards, Davide Pagnossin, Paul Samson Buyugu, Oliver Manangwa, Furaha Mramba, Emmanuel Sindoya, Edith Paxton, Steve J Torr, Ryan Ritchie, Giovanni E Rossi, Lawrence Nnadozie Anyanwu, Michael P Barrett, Liam J Morrison, Harriet Auty

“…One-third of trypanocide administrations were not given adequately, and many trypanocides were given to animals that tested negative for trypanosome infections by PCR. Failures occurred in 7% (95% CI 3.0-14%) of curative treatments, and 44% (95% CI 35-42%) of prophylactic administrations. …”
Get full text

Assessment of the Bacteriological Profile and Antibiotic Susceptibility Patterns of Wastewater in Health Facilities of Ethiopia by Belayneh Regasa Dadi, Eyayu Girma, Mheret Tesfaye, Mohamed Seid

“…Antimicrobials used for the treatment and prevention of bacterial infections are mainly released nonmetabolized into the aquatic environment via wastewater. …”
Get full text

Testing of diagnostic test-systems for detection of antibodies to foot-and-mouth disease virus structural proteins with enzyme-linked immunosorbent assay for their serotype specifi... by N. N. Lugovskaya, E. A. Silanteva, T. V. Okovytaya, A. A. Kharitonova, Y. M. Gochmuradov, E. A. Razgulyaeva, O. O. Budina, E. A. Yasneva

“…A total of 138 serum samples from pigs and cattle vaccinated against foot-and-mouth disease virus (FMDV) of one or two serotypes or infected with FMDV were used for testing of 24 enzyme-linked immunosorbent assay (ELISA) diagnostic tests-systems for detection of antibodies against FMDV structural proteins produced by 6 manufacturers (Federal Centre for Animal Health, Prionics, IZSLER, Innovative Diagnostics, BIONOTE and MEDIAN Diagnostics) for their serotype-specificity. …”
Get full text

Antibacterial Activity of Defatted and Nondefatted Methanolic Extracts of Aframomum melegueta K. Schum. against Multidrug-Resistant Bacteria of Clinical Importance by Olufunmiso Olusola Olajuyigbe, Otunola Adedayo, Roger Murugas Coopoosamy

“…This study indicated that DME was more active with higher antibacterial activity than the NDME of this plant, and extracting the fatty portion of plant materials prior susceptibility testing would allow plant extracts to be more effective as well as justifying the use of Aframomum melegueta in traditional medicine for the treatment of bacterial infections.…”
Get full text

Aqueous spice extracts as alternative antimycotics to control highly drug resistant extensive biofilm forming clinical isolates of Candida albicans. by Bindu Sadanandan, Vaniyamparambath Vijayalakshmi, Priya Ashrit, Uddagiri Venkanna Babu, Lakavalli Mohan Sharath Kumar, Vasulingam Sampath, Kalidas Shetty, Amruta Purushottam Joglekar, Rashmi Awaknavar

“…The results of this study indicated that the alternate approach in controlling high biofilm-forming, multi-drug resistant clinical isolates of C. albicans M-207 and S-470 using whole aqueous extracts of garlic, clove, and Indian gooseberry is a safe, potential, and cost-effective one that can benefit the health care needs with additional effective therapeutics to treat biofilm infections.…”
Get full text