Epidemiology and transmission patterns of Cryptosporidium spp., and Giardia duodenalis within a One Health framework in rural areas of Eastern Algeria by Sadiya Maxamhud, Nassiba Reghaissia, AbdElKarim Laatamna, Eleni Gentekaki, Anastasios D. Tsaousis

“…Gastrointestinal infections constitute a significant global health concern, particularly in tropical and subtropical regions, caused by various pathogens. …”
Get full text

Flunarizine as a Candidate for Drug Repurposing Against Human Pathogenic Mammarenaviruses by Chukwudi A. Ofodile, Ikemefuna C. Uzochukwu, Fortunatus C. Ezebuo, InnocentMary Ejiofor, Mercy Adebola, Innocent Okpoli, Beatrice Cubitt, Haydar Witwit, Chetachi B. Okwuanaso, Ngozi Onyemelukwe, Juan Carlos de la Torre

“…Flunarizine is being used in several countries worldwide to treat vertigo and migraine, supporting the interest in exploring its repurposing as a candidate drug to treat LASV infections.…”
Get full text

Antibacterial Activity of Rationally Designed Antimicrobial Peptides by Marius B. Tincho, Thureyah Morris, Mervin Meyer, Ashley Pretorius

“…Due to these reasons, there is a need to seek and develop novel therapeutic regimens to reduce the rapid scale of bacterial infections. Antimicrobial Peptides (AMPs) are components of the first line of defense for prokaryotes and eukaryotes and have a wide range of activities against Gram-negative and Gram-positive bacteria, fungi, cancer cells, and protozoa, as well as viruses. …”
Get full text

ANALYSIS OF CHANGES IN AFRICAN SWINE FEVER VIRUS GENETIC STRUCTURE AND BIOLOGICAL PROPERTIES DURING ADAPTATION TO CONTINUOUS CELL CULTURE by Ali Mazloum, N. G. Zinyakov, A. S. Pershin, I. V. Shevchenko, I. Yu. Zhukov, D. N. Fedoseyeva, D. V. Sharypova, A. S. Igolkin, N. N. Vlasova

“…Lethality level was 16.7% when pigs were infected with adapted variant virus at 30th passage and survived animals became resistant to reinfection with homologous virulent ASFV Arm07 isolate. …”
Get full text

Case report: Novel multi-exon homozygous deletion of ZBTB24 causes immunodeficiency, centromeric instability, and facial anomalies syndrome 2 by Yan Long, Chenghan Wang, Jie Xiao, Yunhua Huang, Xiaoting Ling, Chaoyu Huang, Ying Chen, Jiaqi Luo, Rongheng Tang, Faquan Lin, Yifang Huang

“…During the follow-up, the patient’s pneumonia continued to progress despite receiving intravenous immunoglobulin (IVIG) replacement and anti-infective therapy. These results indicated that this novel multi-exon deletion variant of ZBTB24 may be the genetic etiology of ICF2. …”
Get full text

Genomic, Evolutionary, and Pathogenic Characterization of a New <i>Polerovirus</i> in Traditional Chinese Medicine <i>Viola philippica</i> by Yuanling Chen, Gaoxiang Chen, Jiaping Yu, Yali Zhou, Shifang Fei, Haorong Chen, Jianxiang Wu, Shuai Fu

“…An infectious cDNA clone of VPPV was successfully constructed and shown to infect <i>Nicotiana benthamiana</i>. Using a PVX-based heterologous expression system, the VPPV P0 protein was shown to trigger a systemic hypersensitive response (HR)-like reaction in <i>N. benthamiana</i>, indicating that P0 functions as the main pathogenicity determinant. …”
Get full text

Surface Modification by Combination of Dip-Pen Nanolithography and Soft Lithography for Reduction of Bacterial Adhesion by Santiago Arango-Santander, Alejandro Pelaez-Vargas, Sidónio C. Freitas, Claudia García

“…A reduction in bacterial adhesion to patterned surfaces might have a major impact since adhesion is a key step in biofilm formation and development of biomaterial-related infections.…”
Get full text

Antimicrobial Susceptibility of <i>Glaesserella parasuis</i> to Macrolides and Characterization of <i>erm</i>(T)-Carrying Mobile Elements on Chromosome by Peng Zhang, Changmin Li, Shuna Shang, Ting Huang, Junqi Liu, Qianwen Ge, Xiaoping Liao, Liangxing Fang, Yang Yu

“…Macrolide resistance poses an urgent threat to their treatment, as macrolides are widely used for preventing and treating <i>G. parasuis</i> infections. Here, we determined the susceptibilities to five macrolides and characterized the genetic markers of macrolide resistance. …”
Get full text

Production and characterization of nervous necrosis virus vaccine antigens in wild type and CRISPR/Cas9 genome edited Nicotiana benthamiana and edible crop lettuce Lactuca sativa by Iva Andrasevic, Hang Su, Espen Rimstad, Jihong Liu Clarke

“…Disease outbreaks cause more than 6 billion USD loss worldwide annually and possess high risks of spreading to the wild fauna especially by viral infections. Vaccination has been proved to be effective to mitigate these problems and widely used as prophylaxis in aquaculture, but available vaccines against viral nervous necrosis (VNN) are limited currently. …”
Get full text

Assessment of Vaccination Impact in PPR-Control Program Implemented in Southern States of India: A System Dynamics Model Approach by Govindaraj Gurrappanaidu, Naveen Kumar Gajalavarahalli Subbanna, Francis Wanyoike, Sirak Bahta, Yeswanth Raghuram Reddy, Dwaipayan Bardhan, Balamurugan Vinayagamurthy, Kennady Vijayalakshmy, Rahman Habibur

“…The SD model results showed a systemic increase in flock size and offtakes and a decline in the number of infected and death cases under high vaccination coverage (75% and 100% coverage) compared to the low-coverage scenario. …”
Get full text

Prevalence and Antimicrobial Resistance of Escherichia coli in Chicken Meat and Edible Poultry Organs Collected from Retail Shops and Supermarkets of North Western Province in Sri... by R. A. S. S. Ranasinghe, D. A. Satharasinghe, P. S Anwarama, P. M. S. D. K. Parakatawella, L. J. P. A. P. Jayasooriya, R. M. S. B. K. Ranasinghe, R. P. V. J. Rajapakse, J. T. Y. Huat, Y. Rukayadi, Y. Nakaguchi, M. Nishibuchi, S. Radu, J. M. K. J. K. Premarathne

“…Shiga toxin-producing strains of E. coli STECs are responsible for most food-related E. coli infections. Pathogenic E. coli transmits to human bodies due to the consumption of contaminated, raw, or undercooked food. …”
Get full text

Pediatric kidney transplant recipients are at an increased risk for dysbiosis by Gizem Yılmaz, Seha Saygılı, Ayşe Ağbaş, Esra Karabağ Yılmaz, Ahmet Variş, Nur Canpolat

“…In addition, KTx recipients with a history of frequent urinary tract infections, diarrhea and reduced GFR showed significant increases in bacterial abundance (p &lt; 0.05 for all).DiscussionPediatric KTx recipients demonstrated significant alterarions in gut microbiota composition, indicating dysbiosis. …”
Get full text

Routine antibiotics for infants less than 6 months of age with growth failure/faltering: a systematic review by Jai K Das, Zulfiqar Ahmed Bhutta, Abigail Smith, Aamer Imdad, Olivia Tsistinas, Emily Tanner-Smith, Melissa François, Fanny F Chen, Momal Sana

“…The comparison group was infants who received antibiotics according to the aforementioned guidelines.Primary and secondary outcomes The primary outcome was all-cause mortality, and secondary outcomes: clinical deterioration, antimicrobial resistance, recovery from comorbidity, adverse events, markers of intestinal inflammation, markers of systemic inflammation, hospital-acquired infections and non-response. The Grading of Recommendations Assessment, Development and Evaluation approach was considered to report the overall evidence quality for an outcome.Results We screened 5137 titles and abstracts and reviewed the full text of 157 studies. …”
Get full text

Exploration of analgesic and anthelmintic activities of Artocarpus chaplasha ROXB. leaves supported by in silico molecular docking by S M Sohag, Sharmin Nur Toma, Md. Niaj Morshed, Md. Al Imran Imon, Md. Monirul Islam, Md. Ibnul Piash, Naznin Shahria, Imran Mahmud

“…Our present study suggests that Aartocarpus chaplasha leaves can be a potential source of lead compounds for pain management and helminth infections and further advanced investigations are required in the future.…”
Get full text

Known and novel parvoviruses identified in domestic pigeons by Ewa Łukaszuk, Daria Dziewulska, Anthony Khalifeh, Joy M. Custer, Simona Kraberger, Arvind Varsani, Tomasz Stenzel

“…Abstract Background Parvoviridae is a family of single-stranded linear DNA viruses whose members infect both vertebrate and invertebrate species of animals, causing diseases of various systems and often associated with pathology of the gastrointestinal tract. …”
Get full text

Bile cast nephropathy (cholemic nephropathy) associated with hepatitis A-induced acute liver failure and haemolysis in a patient with glucose-6-phosphate dehydrogenase deficiency by Ali Hamdan, Johny Salem, Karam Karam, Maria Ziadeh, Pierre Hani

“…Discussion: G6PD deficiency increases the risk of haemolysis, especially during infections such as hepatitis A. This can lead to severe hyperbilirubinemia and complications including bile cast nephropathy. …”
Get full text

Ascertainment and Verification of End-Stage Renal Disease and End-Stage Liver Disease in the North American AIDS Cohort Collaboration on Research and Design by Mari M. Kitahata, Daniel R. Drozd, Heidi M. Crane, Stephen E. Van Rompaey, Keri N. Althoff, Stephen J. Gange, Marina B. Klein, Gregory M. Lucas, Alison G. Abraham, Vincent Lo Re, Justin McReynolds, William B. Lober, Adell Mendes, Sharada P. Modur, Yuezhou Jing, Elizabeth J. Morton, Margaret A. Griffith, Aimee M. Freeman, Richard D. Moore

“…Our methods proved robust for ascertainment of ESRD and ESLD in persons infected with HIV.…”
Get full text

The role of the interleukin family in liver fibrosis by Zixin Zhang, Zixin Zhang, Jiahui Wang, Hui Li, Qun Niu, Qun Niu, Yujing Tao, Yujing Tao, Xin Zhao, Xin Zhao, Zijian Zeng, Zijian Zeng, Haijian Dong, Haijian Dong

“…Liver fibrosis represents a wound-healing response to chronic liver injury caused by viral infections, alcohol, and chemicals agents. It is a critical step in the progression from chronic liver disease to cirrhosis and hepatocellular carcinoma. …”
Get full text

Greenness assessment approach for spectrofluorimetric detection of daptomycin using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of organizing... by Maha F. El-Tohamy, Amal M. Al-Mohaimeed, Haitham AlRabiah, Gamal A.E. Mostafa

“…Daptomycin (DPT) is a lipopeptide antibiotic used primarily to treat severe infections caused by Gram-positive bacteria. A spectrofluorimetric detection of DPT using metal oxide nanosensors synthesized via Commiphora myrrha extract in the presence of an organizing solution is presented in this study. …”
Get full text

Triatomine Fauna and Recent Epidemiological Dynamics of Chagas Disease in an Endemic Area of Northeast Brazil by Cláudia M. Melo, Ana Carla F. G. Cruz, Antônio Fernando V. A. Lima, Luan R. Silva, Rubens R. Madi, Veronica de Lourdes S. Jeraldo, Ruben Mercado

“…Optical microscopy revealed that 13.2% of triatomines examined were infected by Trypanosoma cruzi-like flagellates. The distribution of triatomines exhibits an expanding south-central to northern dispersion, with a preference for semiarid and agreste areas and occasional observations in humid coastal areas due to anthropogenic actions reflected in the environment. …”
Get full text