29 m6A-RNA Methylation (Epitranscriptomic) Regulators Are Regulated in 41 Diseases including Atherosclerosis and Tumors Potentially via ROS Regulation – 102 Transcriptomic Dataset... by Ming Liu, Keman Xu, Fatma Saaoud, Ying Shao, Ruijing Zhang, Yifan Lu, Yu Sun, Charles Drummer, Li Li, Sheng Wu, Satya P. Kunapuli, Gerard J. Criner, Jianxin Sun, Huimin Shan, Xiaohua Jiang, Hong Wang, Xiaofeng Yang

“…We performed a database mining on 102 transcriptomic datasets for the expressions of 29 m6A-RNA methylation (epitranscriptomic) regulators (m6A-RMRs) in 41 diseases and cancers and made significant findings: (1) a few m6A-RMRs were upregulated; and most m6A-RMRs were downregulated in sepsis, acute respiratory distress syndrome, shock, and trauma; (2) half of 29 m6A-RMRs were downregulated in atherosclerosis; (3) inflammatory bowel disease and rheumatoid arthritis modulated m6A-RMRs more than lupus and psoriasis; (4) some organ failures shared eight upregulated m6A-RMRs; end-stage renal failure (ESRF) downregulated 85% of m6A-RMRs; (5) Middle-East respiratory syndrome coronavirus infections modulated m6A-RMRs the most among viral infections; (6) proinflammatory oxPAPC modulated m6A-RMRs more than DAMP stimulation including LPS and oxLDL; (7) upregulated m6A-RMRs were more than downregulated m6A-RMRs in cancer types; five types of cancers upregulated ≥10 m6A-RMRs; (8) proinflammatory M1 macrophages upregulated seven m6A-RMRs; (9) 86% of m6A-RMRs were differentially expressed in the six clusters of CD4+Foxp3+ immunosuppressive Treg, and 8 out of 12 Treg signatures regulated m6A-RMRs; (10) immune checkpoint receptors TIM3, TIGIT, PD-L2, and CTLA4 modulated m6A-RMRs, and inhibition of CD40 upregulated m6A-RMRs; (11) cytokines and interferons modulated m6A-RMRs; (12) NF-κB and JAK/STAT pathways upregulated more than downregulated m6A-RMRs whereas TP53, PTEN, and APC did the opposite; (13) methionine-homocysteine-methyl cycle enzyme Mthfd1 downregulated more than upregulated m6A-RMRs; (14) m6A writer RBM15 and one m6A eraser FTO, H3K4 methyltransferase MLL1, and DNA methyltransferase, DNMT1, regulated m6A-RMRs; and (15) 40 out of 165 ROS regulators were modulated by m6A eraser FTO and two m6A writers METTL3 and WTAP. …”
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Chemical Synthesis, Efficacy, and Safety of Antimalarial Hybrid Drug Comprising of Sarcosine and Aniline Pharmacophores as Scaffolds by Jean Baptiste Niyibizi, Peter G. Kirira, Francis T. Kimani, Fiona Oyatsi, Joseph K. Ng’ang’a

“…Malaria is a disease caused by protozoans transmitted to humans by infected female Anopheles mosquitoes. According to the WHO report of 2015, there were 214 million cases of malaria with 438,000 deaths worldwide. …”
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Are we serologically prepared against an avian influenza pandemic and could seasonal flu vaccines help us? by Iván Sanz-Muñoz, Javier Sánchez-Martínez, Carla Rodríguez-Crespo, Corina S. Concha-Santos, Marta Hernández, Silvia Rojo-Rello, Marta Domínguez-Gil, Ahmed Mostafa, Luis Martinez-Sobrido, Jose M. Eiros, Aitor Nogales

“…Moreover, multiple zoonotic infections in humans have been reported. Importantly, HPAI H5N1 viruses with genetic markers of adaptation to mammals have been detected. …”
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Molecular epidemiology of extended-spectrum beta-lactamases and carbapenemases-producing Shigella in Africa: a systematic review and meta-analysis by Namwin Siourimè Somda, Rabbi Nyarkoh, Abel Tankoano, Ouindgueta Juste Isidore Bonkoungou, Patience B. Tetteh-Quarcoo, Eric S. Donkor

“…Abstract Background The treatment of Shigella infections has become a major challenge due to the emergence of multidrug-resistant Shigella. …”
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OXA β-lactamases from Acinetobacter spp. are membrane bound and secreted into outer membrane vesicles by Lucia Capodimonte, Fernando Teixeira Pinto Meireles, Guillermo Bahr, Robert A. Bonomo, Matteo Dal Peraro, Carolina López, Alejandro J. Vila

“…The ubiquity of this phenomenon suggests that it may have influenced the dissemination of resistance mediated by Acinetobacter spp., particularly in polymicrobial infections, being a potent evolutionary advantage.…”
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Development of a real-time duplex PCR assay for simultaneously diagnosis of KHV and CEV in common carp and koi by Khumaira Puspasari, Adityawati Fajar Rini, Noviana Dewi, Ratih Ismayasari

“…Due to the severe impact of both viruses, a robust diagnostic tool was required, capable of detecting and distinguishing both infections with high accuracy and precision. The aim of this study was to describe a real-time duplex TaqMan PCR assay for simultaneous detection of KHV and CEV in common carp and koi. …”
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Inflammation and Immune Response in COPD: Where Do We Stand? by Nikoletta Rovina, Antonia Koutsoukou, Nikolaos G. Koulouris

“…Furthermore, viral and bacterial infections interfere with the chronic inflammation seen in stable COPD and exacerbations via pathogen-associated molecular patterns (PAMPs). …”
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Using In Silico Methods to Identify Protein Tyrosine Kinase A (PtkA) Homolog in Non-Tuberculous Mycobacteria (NTM) by Swati Jaiswal, Sanjay Kumar

“…Non-tuberculous mycobacteria (NTM) represent a diverse group of mycobacterial species known for causing opportunistic infections, especially in individuals with underlying health conditions. …”
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High-Grade Leiomyosarcoma Arising in a Previously Replanted Limb by Tiffany J. Pan, Liron Pantanowitz, Kurt R. Weiss

“…Sarcoma development has been associated with genetics, irradiation, viral infections, and immunodeficiency. Reports of sarcomas arising in the setting of prior trauma, as in burn scars or fracture sites, are rare. …”
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Tumor-Derived CXCL1 Promotes Lung Cancer Growth via Recruitment of Tumor-Associated Neutrophils by Ming Yuan, Ha Zhu, Junfang Xu, Yuanyuan Zheng, Xuetao Cao, Qiuyan Liu

“…Neutrophils have a traditional role in inflammatory process and act as the first line of defense against infections. Although their contribution to tumorigenesis and progression is still controversial, accumulating evidence recently has demonstrated that tumor-associated neutrophils (TANs) play a key role in multiple aspects of cancer biology. …”
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Influence of Zinc Supplementation in Acute Diarrhea Differs by the Isolated Organism by Archana B. Patel, Michael J. Dibley, Manju Mamtani, Neetu Badhoniya, Hemant Kulkarni

“…Using prespecified subgroup analyses, multidimensionality reduction analyses, tests of heterogeneity, and stepwise logistic regression for tests of interactions, we found that the influence of zinc on the risk of diarrhea for more than 3 days depended on the isolated organism—beneficial in Klebsiella, neutral in Esherichia coli and parasitic infections, and detrimental in rotavirus coinfections. …”
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Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders by D. Pagliari, A. Saviano, E. E. Newton, M. L. Serricchio, A. A. Dal Lago, A. Gasbarrini, R. Cianci

“…It plays a central role in several physiological functions, in the modulation of inflammatory signaling and in the protection against infections. In healthy states, there is a perfect balance between commensal and pathogens, and microbiota and the immune system interact to maintain gut homeostasis. …”
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High-Dose Glycine Treatment of Refractory Obsessive-Compulsive Disorder and Body Dysmorphic Disorder in a 5-Year Period by W. Louis Cleveland, Robert L. DeLaPaz, Rashid A. Fawwaz, Roger S. Challop

“…Major exacerbations following ear infections involving Group A 𝛽-hemolytic streptococcus at ages 19 and 20 led to intravenous immune globulin therapy, which was also ineffective. …”
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Leptospirosis, melioidosis, and rickettsioses in the vicious circle of neglect. by Tshokey Tshokey, Ablert I Ko, Bart J Currie, Claudia Munoz-Zanzi, Cyrille Goarant, Daniel H Paris, David A B Dance, Direk Limmathurotsakul, Emma Birnie, Eric Bertherat, Gyanendra Gongal, Jackie Benschop, Jelmer Savelkoel, John Stenos, Kartika Saraswati, Matthew T Robinson, Nicholas P J Day, Stephen R Graves, Steven R Belmain, Stuart D Blacksell, Willem J Wiersinga

“…While emerging viral infections have regularly dominated public health attention, which has only intensified after the COVID-19 pandemic, numerous bacterial diseases have previously caused, and continue to cause, significant morbidity and mortality-deserving equal attention. …”
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Emergence of Non-Serotype b Encapsulated Haemophilus influenzae as a Cause of Pediatric Meningitis in Northwestern Ontario by Pouya Sadeghi-Aval, Raymond SW Tsang, Frances B Jamieson, Marina Ulanova

“…The findings point to the clonal nature of circulating Hia strains as well as to an increase in frequency and severity of pediatric invasive H influenzae infections in northwestern Ontario.…”
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Better Outcomes in Severe and Morbid Obese Patients (BMI>35 kg/m2) in Primary Endo-Model Rotating-Hinge Total Knee Arthroplasty by Luis M. Lozano, Vicente López, José Ríos, Dragos Popescu, Pere Torner, Félix Castillo, Francisco Maculé

“…Joint balance enhancement and limbs mechanical axis correction were achieved after surgery. There were 6 deep infections and 16 patients referred postoperative anterior knee pain. …”
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Liver Transplantation and Hepatitis C by Nobuhisa Akamatsu, Yasuhiko Sugawara

“…Although immunosuppressive regimens have a considerable impact on the outcome, the optimal regimen after liver transplantation for HCV-infected patients remains unclear. Disease progression monitoring with protocol biopsy and new noninvasive methods is essential for predicting patient/graft outcome and starting antiviral treatment with the appropriate timing. …”
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Modulation of Human Colostrum Phagocyte Activity by the Glycine-Adsorbed Polyethylene Glycol Microspheres by Paulo Celso Leventi Guimarães, Adenilda Cristina Honorio-França, Cristiane de Castro Pernet Hara, Danny Laura Gomes Fagundes, Silvia Hanna Bilotti Ratto, Eduardo Luzía França

“…This material may represent a possible alternative therapy for future clinical applications on patients with gastrointestinal infections.…”
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Assessment of the Effectiveness of Ectomycorrhizal Inocula to Promote Growth and Root Ectomycorrhizal Colonization in Pinus patula Seedlings Using the Most Probable Number Techniqu... by Manuel Restrepo-Llano, Nelson W. Osorio, Juan D. León

“…The MPN method allowed establishing differences in the number of infective ectomycorrhizal propagules’ density (EPD) (ES=34 per g; EM=156 per g). …”
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A Case of Spondyloarthritis in Patient Affected by Unicentric Castleman’s Disease Effectively Managed with Surgery Resection and Tocilizumab Treatment by M. Filippini, S. Cartella, O. Bonzanini, E. Morello, A. Tincani

“…A 38-year-old woman was referred to our hospital for rheumatologic manifestations (migrant arthritis and tenosynovitis), without psoriasis or family history of psoriasis, gastroenteric manifestations, or recent genitourinary infections. The instrumental and laboratory tests have suggested a diagnosis of undifferentiated seronegative HLA-B27-positive spondyloarthritis with predominantly peripheral involvement. …”
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