Towards Inhibition of Vif-APOBEC3G Interaction: Which Protein to Target? by Iris Cadima-Couto, Joao Goncalves

“…The antiretroviral activity of some of these proteins is overtaken by the action of HIV-1 Viral Infectivity Factor (Vif) protein. Since the discovery of APOBEC3G (A3G) as an antiviral factor, many advances have been made to understand its mechanism of action in the cell and how Vif acts in order to counteract its activity. …”
Get full text

Lake salinization on the Qinghai–Tibetan Plateau alters viral community composition and lifestyles by Yuan-Guo Xie, Yan-Ling Qi, Zhen-Hao Luo, Yan-Ni Qu, Jian Yang, Shi-Qiang Liu, Hai-long Yang, Dan-Wei Xie, Zimeng Wang, Hong-Chen Jiang, Zheng-Shuang Hua

“…These shifts are mirrored in the prokaryotic communities, with Alphaproteobacteria and their infecting temperate viruses, notably Casadabanvirus, becoming more prevalent in higher salinity zones. …”
Get full text

Diogenes Syndrome: A Case Report by Projna Biswas, Anusree Ganguly, Sanchaita Bala, Falguni Nag, Nidhi Choudhary, Sumit Sen

“…These debris can be secondarily infected by bacteria, fungus, and so forth. These skin lesions are not usually seen in individual with proper hygiene. …”
Get full text

Use of miRNAs as Biomarkers in Sepsis by Raluca Dumache, Alexandru Florin Rogobete, Ovidiu Horea Bedreag, Mirela Sarandan, Alina Carmen Cradigati, Marius Papurica, Corina Maria Dumbuleu, Radu Nartita, Dorel Sandesc

“…Severe generalized inflammation, infections, and severe physiological imbalances significantly decrease the survival rate with more than 50%. …”
Get full text

Immunization against Lamb Haemonchosis with a Recombinant Somatic Antigen of Haemonchus contortus (rHcp26/23) by Leticia García-Coiradas, Francisco Angulo-Cubillán, Basilio Valladares, Enrique Martínez, Concepción de la Fuente, José María Alunda, Montserrat Cuquerella

“…Immunization did not induce any significant protection after challenge with 16000 infective larvae of H. contortus, and comparable values for parasite faecal egg output, packed cell volume, and abomasal parasite burdens were found in vaccinated and control animals.…”
Get full text

Snapshots of Pseudomonas aeruginosa SOS response reveal structural requisites for LexA autoproteolysis by Filippo Vascon, Sofia De Felice, Matteo Gasparotto, Stefan T. Huber, Claudio Catalano, Monica Chinellato, Riccardo Mezzetti, Alessandro Grinzato, Francesco Filippini, Lorenzo Maso, Arjen J. Jakobi, Laura Cendron

“…These results provide the groundwork for designing novel antimicrobial strategies and exploring the potential translation of Escherichia coli-derived approaches, to address the implications of P. aeruginosa infections.…”
Get full text

Composition and liquid-to-solid maturation of protein aggregates contribute to bacterial dormancy development and recovery by Celien Bollen, Sofie Louwagie, Femke Deroover, Wouter Duverger, Ladan Khodaparast, Laleh Khodaparast, Dieter Hofkens, Joost Schymkowitz, Frederic Rousseau, Liselot Dewachter, Jan Michiels

“…Abstract Recalcitrant bacterial infections can be caused by various types of dormant bacteria, including persisters and viable but nonculturable (VBNC) cells. …”
Get full text

Insights into Cancer-Associated Thrombosis Leading Towards Ischemic Stroke by Surajit Hansda, Hiranmoy Das

“…Cancer might influence stroke pathophysiology either directly or through coagulation that creates a hypercoagulative state, in addition to infections. Treatment methods for cancer, including chemotherapy, radiotherapy, and surgery, have all been demonstrated to increase the risk of stroke as well. …”
Get full text

Current Concepts of Hyperinflammation in Chronic Granulomatous Disease by Nikolaus Rieber, Andreas Hector, Taco Kuijpers, Dirk Roos, Dominik Hartl

“…Consequently, CGD phagocytes are impaired in destroying phagocytosed microorganisms, rendering the patients susceptible to bacterial and fungal infections. Besides this immunodeficiency, CGD patients suffer from various autoinflammatory symptoms, such as granuloma formation in the skin or urinary tract and Crohn-like colitis. …”
Get full text

Plasmid Profiles and Prevalence of Intermediately Virulent Rhodococcus equi from Pigs in Nakhonpathom Province, Thailand: Identification of a New Variant of the 70-kb Virulence Pla... by Chaithep Poolkhet, Suksun Chumsing, Worawidh Wajjwalku, Chihiro Minato, Yukiko Otsu, Shinji Takai

“…Investigation of the prevalence and plasmid profiles of VapB-positive R. equi in pigs should be extended throughout Thailand to evaluate potential sources of zoonotic infections.…”
Get full text

Real-time multimodal imaging of daptomycin action on the cell wall of adherent Staphylococcus aureus by Alexis Canette, Rym Boudjemaa, Julien Deschamps, Karine Steenkeste, Christian Marlière, Romain Briandet, Marie-Pierre Fontaine-Aupart

“…Abstract Objectives This study investigated the efficacy of daptomycin against adherent Staphylococcus aureus (S. aureus), a common colonizer of medical devices that leads to severe infections. For the first time, we evaluated the bactericidal effects of daptomycin on S. aureus immediately after adhesion, mimicking early-stage contamination of biomaterials. …”
Get full text

Aortoesophageal Fistula after Endovascular Aortic Aneurysm Repair of a Mycotic Thoracic Aneurysm by Elizabeth Gavens, Zehra Zaidi, Wissam Al-Jundi, Palepu Kumar

“…However, the uncommon aortoenteric fistula formation remains a potentially fatal complication when repairing such infective aneurysms. We present the case of an 80-year-old woman with thoracic and abdominal aortic mycotic aneurysms, which were successfully treated with endografting. …”
Get full text

Diosgenin: Recent Highlights on Pharmacology and Analytical Methodology by Mafalda Jesus, Ana P. J. Martins, Eugenia Gallardo, Samuel Silvestre

“…This bioactive phytochemical not only is used as an important starting material for the preparation of several steroidal drugs in the pharmaceutical industry, but has revealed also high potential and interest in the treatment of various types of disorders such as cancer, hypercholesterolemia, inflammation, and several types of infections. Due to its pharmacological and industrial importance, several extraction and analytical procedures have been developed and applied over the years to isolate, detect, and quantify diosgenin, not only in its natural sources and pharmaceutical compositions, but also in animal matrices for pharmacodynamic, pharmacokinetic, and toxicological studies. …”
Get full text

Crystallographic and computational characterization and in silico target fishing of six aromatic and aliphatic sulfonamide derivatives by Anh Van Nguyen, Anh Thi Ngoc Vu, Andrey N. Utenyshev, Valeriy Tkachev, Nadezhda Polyanskaya, Dmitriy Shchevnikov, Magrarita Vasil’eva, Hieu Tran-Trung, Xuan Ha Nguyen, Olga V. Kovalchukova

“…Consequently, these compounds may serve as promising lead-like molecules for drug development targeting protozoan infections.…”
Get full text

FRUIT DAMAGES CAUSED BY BROWN MARMORATED STINK BUGS IN APPLES AND QUINCES by Attila Keseru, Flavia-Andreea Andrecan, Horia Alexandru Pop, Mihai Buta, Orsolya Borsai

“…Feeding injuries also made both fruits more susceptible to secondary infections by pathogens, further reducing their marketability. …”
Get full text

Delayed Presentation of Suture Erosion following Burch Colposuspension by Robert Shapiro, Ali Hajiran, Stanley Zaslau

“…They presented with irritative voiding symptoms and recurrent urinary tract infections. Both were discovered years after a Burch colposuspension. …”
Get full text

Myasthenia gravis and Lambert-Eaton myasthenic syndrome: treatment options and guidance for management during COVID-19 pandemic by A. Klimašauskienė, R. Bunevičiūtė

“…Immune depleting agents should not be given if symptoms and signs of serious infections appear. …”
Get full text

NIAID Workshop Report: Systematic Approaches for ESKAPE Bacteria Antigen Discovery by Inka Sastalla, Keehwan Kwon, Clayton Huntley, Kimberly Taylor, Liliana Brown, Tamika Samuel, Lanling Zou

“…The workshop consisted of four sessions that addressed ESKAPE infections, antigen discovery and vaccine efforts, and new technologies including systems immunology and vaccinology approaches. …”
Get full text

Multidisciplinary Vulvar Cancer Management: The Dermatologist’s Perspective by Marta Cebolla-Verdugo, Victor Alfredo Cassini-Gómez de Cádiz, Juan Pablo Velasco-Amador, María Zulaika-Lloret, Francisco Manuel Almazán-Fernández, Ricardo Ruiz-Villaverde

“…This review highlights the dermatologist’s role in supporting early diagnosis, addressing predisposing conditions such as lichen sclerosus, and managing postoperative wound complications, including surgical site infections and dehiscence. Through two clinical cases, we illustrate how dermatological expertise complements surgical efforts by employing advanced wound care techniques such as negative pressure wound therapy and tailored dressing protocols. …”
Get full text

Advances in the detection of virulence genes of Staphylococcus aureus originate from food by Yingying Zhao, Dandan Xia, Panpan Ma, Xiaofeng Gao, Wenyi Kang, Jinfeng Wei

“…It can cause food poisoning when we are infected, therefore, it is necessary to detect pathogenic bacteria. …”
Get full text