Coronil effectively inhibits the interaction of clinically relevant Omicron mutants of SARS-CoV-2 spike proteins with human ACE2 receptor by Acharya Balkrishna, Rishabh Dev, Sandeep Kumar, Anurag Varshney

“…Conclusion: This capability of Coronil to inhibit the binding of S-protein variants with ACE2 receptor may interfere with viral binding and internalization resulting in reduced infectivity of these Omicron spike protein variants. …”
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The prevalence of hand pathology in regional orthopaedic hospitals in KwaZulu-Natal: A cross-sectional study by S Thabit, M O'Connor, W Parker, T Mashishi, K Moodley, A Peer, K Matanzima, A J de Villiers, O Adewusi, R Aboobaker, A Rocher

“…The remainder of HP cases comprised the non-traumatic group (4%, 91/2 335) and were predominantly infections (68%, 62/91), and many patients with non-traumatic hand pathology required surgery (60%, 55/91) and admission (56%, 52/91). …”
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Recombinase-based amplification coupled with lateral flow chromatography for the specific and sensitive detection and identification of Leishmania major in cutaneous leishmaniasis... by Insaf Bel Hadj Ali, Yusr Saadi-Ben Aoun, Imen Khammeri, Hejer Souguir, Emna Harigua-Souiai, Hamed Chouaieb, Ahmed S. Chakroun, Meryem Lemrani, Aicha Kallel, Kalthoum Kallel, Nabil Haddad, Oussaima El Dbouni, Rhea N. Coler, Rhea N. Coler, Rhea N. Coler, Steven G. Reed, Akila Fathallah-Mili, Akila Fathallah-Mili, Ikram Guizani

“…The efficiency of treatment highly depends on the infecting Leishmania species. Diagnosis is mainly based on microscopic direct examination (DE) of Giemsa-stained smears needing experienced microscopists. …”
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Development of a horizontal transmission model to assess the effects of exposure to pathogenic E. cecorum during the hatching phase in broiler chickens by James Higuita, Marcela Arango, Aaron Forga, Mitch Rowland, Jundi Liu, Ross Wolfenden, Danielle Graham

“…Seeders were comingled with non-infected embryos, or contacts, for the remainder of embryogenesis. …”
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Malaria prevalence, transmission potential and efficacy of artemisinin-based combination therapy in the Kenyan Central highlands: a zone previously characterized as malaria-free by Francis T. Kimani, Kelvin K. Thiongó, Maureen A. Otinga, Lewis K. Mbabu, Mary N. Ombati, Stanley K. Kitur, Sarah A. Ochieng’, Lucy N. Wachira, Damaris K. Matoke-Muhia, Luna Kamau

“…Conclusion The Plasmodium infections positivity rate observed in the study site was very low but significant. …”
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Mycobiome analyses of critically ill COVID-19 patients by Danielle Weaver, Sara Gago, Matteo Bassetti, Daniele Roberto Giacobbe, Juergen Prattes, Martin Hoenigl, Florian Reizine, Hélène Guegan, Jean-Pierre Gangneux, Michael John Bromley, Paul Bowyer

“…However, further studies are warranted on this topic.IMPORTANCEInvasive fungal infections are a serious complication affecting up to a third of patients with severe COVID-19. …”
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HIV-1 transcription start sites usage and its impact on unspliced RNA functions in people living with HIV by Saiful Islam, Frank Maldarelli, Olga A. Nikolaitchik, Zetao Cheng, Robert Gorelick, Maria A. Nikolaitchik, Vinay K. Pathak, Wei-Shau Hu

“…Using paired samples collected from the same participants on the same date, we examined the HIV-1 unspliced RNA species in infected cells (PBMC) and in viruses (plasma). Our findings demonstrate that in people living with HIV, the virus uses multiple transcription start sites to generate several unspliced transcripts, including 3G and 1G RNA. …”
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Classification of Prominent Cacao Pod Diseases Using Multi-Feature Visual Analysis and k-Nearest Neighbors Algorithm by Earl Clarence San Diego, Seph Gerald Rodrin, Edwin Arboleda

“…In response to this problem, the study devised an algorithm based on k-Nearest Neighbors that can detect whenever a cacao pod was infected with the three most prominent diseases: black pod rot, Monilia, and pod borer infestations. …”
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Novel Regulatory Mechanisms of Pathogenicity and Virulence to Combat MDR in Candida albicans by Saif Hameed, Zeeshan Fatima

“…Continuous deployment of antifungals in treating infections caused by dimorphic opportunistic pathogen Candida albicans has led to the emergence of drug resistance resulting in cross-resistance to many unrelated drugs, a phenomenon termed multidrug resistance (MDR). …”
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Recurrent Pneumonia and a Normal Heart: Late Complication after Repair of Hemianomalous Pulmonary Venous Drainage—A Cautionary Tale by Maryanne Caruana, Victor Grech, Jane Somerville

“…Dyspnoea and recurrent chest infections started 7 months after surgery when he was seen by a respiratory physician without cardiac followup. …”
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Enhanced testing can substantially improve defense against several types of respiratory virus pandemic by James Petrie, James A. Hay, Oraya Srimokla, Jasmina Panovska-Griffiths, Charles Whittaker, Joanna Masel

“…Mass testing to identify and isolate infected individuals is a promising approach for reducing harm from the next acute respiratory virus pandemic. …”
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The PIC Cystogram: Its Place in the Treatment Algorithm of Recurrent Febrile UTIs by Jennifer A. Hagerty, Max Maizels, Earl Y. Cheng

“…A common pediatric dilemma involves management of children with recurrent febrile urinary tract infections (UTIs) who have normal voiding cystourethrograms. …”
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Systemic Embolization from an Unusual Intracardiac Mass in the Left Ventricular Outflow Tract by Kelechukwu U. Okoro, Timothy R. Larsen, John C. Lystash

“…It is exceedingly rare to develop infective endocarditis on the endocardium of the left ventricular outflow tract due to the high velocity of blood that traverses this area. …”
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Beta-Defensin-2 and Beta-Defensin-3 Reduce Intestinal Damage Caused by Salmonella typhimurium Modulating the Expression of Cytokines and Enhancing the Probiotic Activity of Enteroc... by Alessandra Fusco, Vittoria Savio, Marcella Cammarota, Alberto Alfano, Chiara Schiraldi, Giovanna Donnarumma

“…Based on the literature data, the purpose of this work was to create a line of intestinal epithelial cells able to stably express gene encoding human β-defensin-2 (hBD-2) and human β-defensin-3 (hBD-3), in order to test their role in S. typhimurium infections and their interaction with the bacteria of the gut microbiota.…”
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Geographic Distribution of Vaccinia Virus, Diagnosis and Demographic Aspects of Affected Populations, Minas Gerais, Brazil, 2000–2023 by Pedro H. B. e Silva, Maycon D. de Oliveira, Iara M. de Almeida, Iago J. S. Domingos, Ana G. Stoffella-Dutra, Galileu Barbosa Costa, Jaqueline S. de Oliveira, Felipe C. M. Iani, Márcio R. de Castro, Jonatas S. Abrahão, Erna G. Kroon, Giliane de S. Trindade

“…Laboratory findings indicate high levels of anti-OPXV antibodies in most individuals, with some showing acute infections confirmed by qPCR testing. This analysis informs public health policies, emphasizing the need for enhanced surveillance of and preventive measures for dairy farming communities.…”
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Late Onset Cobalamin Disorder and Hemolytic Uremic Syndrome: A Rare Cause of Nephrotic Syndrome by Gianluigi Ardissino, Michela Perrone, Francesca Tel, Sara Testa, Amelia Morrone, Ilaria Possenti, Francesco Tagliaferri, Robertino Dilena, Francesca Menni

“…Hemolytic uremic syndrome (HUS) is an unrare and severe thrombotic microangiopathy (TMA) caused by several pathogenetic mechanisms among which Shiga toxin-producing Escherichia coli infections and complement dysregulation are the most common. …”
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Inhibitory Effects of Litsea cubeba Oil and Its Active Components on Aspergillus flavus by Shiqi Xia, Hong Lin, Peilin Zhu, Peiling Wang, Shengliang Liao, Shangxing Chen, Zongde Wang, Guorong Fan

“…Aspergillus flavus (A. flavus) is a frequent harmful fungal pathogen. It can infect traditional Chinese medicine materials and release aflatoxin, to cause both economic and human health effects. …”
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Anterior mediastinal tracheostomy – a salvage procedure for tracheal necrosis after thyroidectomy for medullary thyroid cancer: a case-report by Hanan Hemead, Akshay J. Patel, Hannah Jesani, Sajith Kumar, Irfan Ahmed, Sat Parmar, Robert Warner, Neil Sharma, Maninder S. Kalkat

“…He developed ischaemic necrosis of the upper two thirds of the trachea presenting with marked surgical emphysema and an infective wound. The wound was opened, drained and an endotracheal tube was negotiated through the sloughed trachea into the distal intrathoracic trachea with the cuff inflated just above the carina. …”
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Pleuroparenchymal Fibroelastosis: A New Entity within the Spectrum of Rare Idiopathic Interstitial Pneumonias by Karina Portillo, Ignasi Guasch, Caroline Becker, Felipe Andreo, Maria Teresa Fernández-Figueras, José Ramirez Ruz, Carlos Martinez-Barenys, Samuel García-Reina, Pedro Lopez de Castro, Irene Sansano, Ana Villar, Juan Ruiz-Manzano

“…The etiology of the disease is unclear, although some cases have been associated as a complication after bone marrow transplantation, lung transplantation (LT), chemotherapy, and recurrent respiratory infections. The patients usually report progressive dyspnea and dry cough and are predisposed to develop spontaneous or iatrogenic pneumothoraces after surgical lung biopsy (SLB) for its diagnosis. …”
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Apparent Prevalence of Beef Carcasses Contaminated with Mycobacterium avium subsp. paratuberculosis Sampled from Danish Slaughter Cattle by Hisako Okura, Nils Toft, Nicola Pozzato, Annalucia Tondo, Søren Saxmose Nielsen

“…Presence of Mycobacterium avium subsp. paratuberculosis (MAP) in beef has been reported as a public health concern because asymptomatically infected cattle may contain MAP in tissues that are used for human consumption. …”
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